A musculoskeletal model of human locomotion driven by a low dimensional set of impulsive excitation primitives

• Published in: Frontiers in computational neuroscience Vol. 7; p. 79
• Main Authors: Sartori, Massimo, Gizzi, Leonardo, Lloyd, David G., Farina, Dario
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2013; Frontiers Media S.A
• Subjects: Ankle; Biomechanics; Electromyography; EMG-driven modeling; Force; Hip; Hypotheses; Interfaces; Kinematics; Knee; Locomotion; Lower Extremity; multiple degrees of freedom; muscle dynamics; Muscle Synergy; musculoskeletal modeling; Neurology; Neuromuscular system; Neuroscience; Physiology; Prosthetics; Rehabilitation; Studies; Walking; Germany; multiple degrees of freedom; muscle dynamics; musculoskeletal modeling; muscle synergy; EMG-driven modeling; lower extremity
• ISSN: 1662-5188; 1662-5188
• DOI: 10.3389/fncom.2013.00079

Human locomotion has been described as being generated by an impulsive (burst-like) excitation of groups of musculotendon units, with timing dependent on the biomechanical goal of the task. Despite this view being supported by many experimental observations on specific locomotion tasks, it is still unknown if the same impulsive controller (i.e., a low-dimensional set of time-delayed excitastion primitives) can be used as input drive for large musculoskeletal models across different human locomotion tasks. For this purpose, we extracted, with non-negative matrix factorization, five non-negative factors from a large sample of muscle electromyograms in two healthy subjects during four motor tasks. These included walking, running, sidestepping, and crossover cutting maneuvers. The extracted non-negative factors were then averaged and parameterized to obtain task-generic Gaussian-shaped impulsive excitation curves or primitives. These were used to drive a subject-specific musculoskeletal model of the human lower extremity. Results showed that the same set of five impulsive excitation primitives could be used to predict the dynamics of 34 musculotendon units and the resulting hip, knee and ankle joint moments (i.e., NRMSE = 0.18 ± 0.08, and R (2) = 0.73 ± 0.22 across all tasks and subjects) without substantial loss of accuracy with respect to using experimental electromyograms (i.e., NRMSE = 0.16 ± 0.07, and R (2) = 0.78 ± 0.18 across all tasks and subjects). Results support the hypothesis that biomechanically different motor tasks might share similar neuromuscular control strategies. This might have implications in neurorehabilitation technologies such as human-machine interfaces for the torque-driven, proportional control of powered prostheses and orthoses. In this, device control commands (i.e., predicted joint torque) could be derived without direct experimental data but relying on simple parameterized Gaussian-shaped curves, thus decreasing the input drive complexity and the number of needed sensors.