Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation - Kraft, John C.; McConnachie, Lisa A.; Koehn, Josefin; Kinman, Loren; Sun, Jianguo; Collier, Ann C.; Collins, Carol; Shen, Danny D.; Ho, Rodney J.Y. (Journal of controlled release, 2018)
Keywords: absorption; Animals; Anti-HIV Agents - blood; Anti-HIV Agents - pharmacokinetics; Anti-Retroviral Agents - blood; Anti-Retroviral Agents - pharmacokinetics; antiretroviral agents; Antiretrovirals; blood circulation; Delayed-Action Preparations - pharmacokinetics; Drug Combinations; drugs; HIV drug combination treatment; Human immunodeficiency virus; humans; hydrophilicity; injection site; lipids; Long-acting; Lopinavir - blood; Lopinavir - pharmacokinetics; lymph nodes; Lymphatic drug insufficiency; Lymphatic targeted drug delivery; Macaca nemestrina; Male; Mechanism-based pharmacokinetic modeling; Models, Biological; mononuclear leukocytes; Nanoparticles; pharmacokinetics; Ritonavir - blood; Ritonavir - pharmacokinetics; Tenofovir - blood; Tenofovir - pharmacokinetics; therapeutics; tissues; Antiretrovirals; 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) (PubChem CID: 94190); Long-acting; Lymphatic targeted drug delivery; Lymphatic drug insufficiency; Tenofovir (PubChem CID: 464205); 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) (DSPE-mPEG2000) (PubChem CID: 406952); Mechanism-based pharmacokinetic modeling; HIV drug combination treatment; Lopinavir (PubChem CID: 92727); Ritonavir (PubChem CID: 392622); 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) (DSPE-mPEG) (PubChem CID: 406952)