Evidence-Based Medicine Comes of Age in Pediatric Cardiology
Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative clinical trials, fundamental molecular investigations, genetics and genomics, and outreach to families, emphasizing the importance of particip...
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| Published in | Journal of the American College of Cardiology Vol. 61; no. 25; pp. 2565 - 2567 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
25.06.2013
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0735-1097 1558-3597 1558-3597 |
| DOI | 10.1016/j.jacc.2013.03.054 |
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| Abstract | Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative clinical trials, fundamental molecular investigations, genetics and genomics, and outreach to families, emphasizing the importance of participating in research. We describe several such efforts and provide a vision of the future for pediatric cardiovascular research. |
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| AbstractList | Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative clinical trials, fundamental molecular investigations, genetics and genomics, and outreach to families, emphasizing the importance of participating in research. We describe several such efforts and provide a vision of the future for pediatric cardiovascular research. Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative clinical trials, fundamental molecular investigations, genetics and genomics, and outreach to families, emphasizing the importance of participating in research. We describe several such efforts and provide a vision of the future for pediatric cardiovascular research. Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative clinical trials, fundamental molecular investigations, genetics and genomics, and outreach to families, emphasizing the importance of participating in research. We describe several such efforts and provide a vision of the future for pediatric cardiovascular research.Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative clinical trials, fundamental molecular investigations, genetics and genomics, and outreach to families, emphasizing the importance of participating in research. We describe several such efforts and provide a vision of the future for pediatric cardiovascular research. |
| Author | Kaltman, Jonathan R. Pearson, Gail D. Lauer, Michael S. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23623909$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s00246-005-1151-9 10.1056/NEJMoa0912461 10.1038/477529a 10.1136/jamia.2009.002063 10.1161/RES.0b013e3182125662 10.1161/CIRCRESAHA.112.279596 10.1001/jama.2008.646 10.1016/j.jacc.2009.11.055 10.1377/hlthaff.23.5.113 10.1016/j.ahj.2007.06.024 |
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| Copyright | 2013 American College of Cardiology Foundation American College of Cardiology Foundation Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. Copyright Elsevier Limited Jun 25, 2013 |
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| Keywords | B2B NHLBI congenital heart surgery PHN congenital heart disease pediatric cardiovascular research GUID PCGC NIH CHD Bench to Bassinet Program National Heart, Lung, and Blood Institute National Institutes of Health Global Unique Identifier Pediatric Cardiac Genomics Consortium Pediatric Heart Network |
| Language | English |
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| References | Kuehn (bib4) 2008; 300 Lacro, Dietz, Wruck (bib11) 2007; 154 Johnson, Whitney, McAuliffe (bib10) 2010; 17 Galis, Hoots, Kiley, Lauer (bib9) 2012; 111 Gitterman, Greenwood, Kocis, Mayes, McKethan (bib1) 2004; 23 Ohye, Sleeper, Mahony (bib3) 2010; 362 Liang L, Southard AE, Mei H, et al. Enrichment of 16p13.1 copy number variants in infants with single ventricle heart defects. Presented at: American College of Medical Genetics and Genomics Annual Meeting, Charlotte, NC, March 2012. Kaltman, Schramm, Pearson (bib5) 2010; 55 Mahony, Sleeper, Anderson (bib2) 2006; 27 Ioannidis (bib7) 2011; 477 Lauer (bib8) 2011; 108 10.1016/j.jacc.2013.03.054_bib6 Mahony (10.1016/j.jacc.2013.03.054_bib2) 2006; 27 Kaltman (10.1016/j.jacc.2013.03.054_bib5) 2010; 55 Lacro (10.1016/j.jacc.2013.03.054_bib11) 2007; 154 Kuehn (10.1016/j.jacc.2013.03.054_bib4) 2008; 300 Johnson (10.1016/j.jacc.2013.03.054_bib10) 2010; 17 Lauer (10.1016/j.jacc.2013.03.054_bib8) 2011; 108 Ohye (10.1016/j.jacc.2013.03.054_bib3) 2010; 362 Ioannidis (10.1016/j.jacc.2013.03.054_bib7) 2011; 477 Galis (10.1016/j.jacc.2013.03.054_bib9) 2012; 111 Gitterman (10.1016/j.jacc.2013.03.054_bib1) 2004; 23 |
| References_xml | – volume: 111 start-page: 833 year: 2012 end-page: 836 ident: bib9 article-title: On the value of portfolio diversity in heart, lung, and blood research publication-title: Circ Res – volume: 55 start-page: 1262 year: 2010 end-page: 1265 ident: bib5 article-title: The National Heart, Lung, and Blood Institute Bench to Bassinet Program: a new paradigm for translational research publication-title: J Am Coll Cardiol – volume: 108 start-page: 405 year: 2011 end-page: 409 ident: bib8 article-title: Thought exercises on accountability and performance measures at the National Heart, Lung, and Blood Institute (NHLBI): an invited commentary publication-title: Circ Res – volume: 23 start-page: 112 year: 2004 end-page: 124 ident: bib1 article-title: Did a rising tide lift all boats? The NIH budget and pediatric research portfolio publication-title: Health Affairs – volume: 477 start-page: 529 year: 2011 end-page: 530 ident: bib7 article-title: Fund people not projects publication-title: Nature – volume: 362 start-page: 1980 year: 2010 end-page: 1992 ident: bib3 article-title: Comparison of shunt types in the Norwood procedure for single-ventricle lesions publication-title: N Engl J Med – volume: 154 start-page: 624 year: 2007 end-page: 631 ident: bib11 article-title: Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome publication-title: Am Heart J – volume: 27 start-page: 191 year: 2006 end-page: 198 ident: bib2 article-title: The Pediatric Heart Network: a primer for the conduct of multicenter studies in children with congenital and acquired heart disease publication-title: Pediatr Cardiol – volume: 17 start-page: 689 year: 2010 end-page: 695 ident: bib10 article-title: Using global unique identifiers to link autism collections publication-title: J Am Med Inform Assoc – volume: 300 start-page: 2357 year: 2008 end-page: 2358 ident: bib4 article-title: Pediatric research gets boost from web publication-title: JAMA – reference: Liang L, Southard AE, Mei H, et al. Enrichment of 16p13.1 copy number variants in infants with single ventricle heart defects. Presented at: American College of Medical Genetics and Genomics Annual Meeting, Charlotte, NC, March 2012. – volume: 27 start-page: 191 year: 2006 ident: 10.1016/j.jacc.2013.03.054_bib2 article-title: The Pediatric Heart Network: a primer for the conduct of multicenter studies in children with congenital and acquired heart disease publication-title: Pediatr Cardiol doi: 10.1007/s00246-005-1151-9 – volume: 362 start-page: 1980 year: 2010 ident: 10.1016/j.jacc.2013.03.054_bib3 article-title: Comparison of shunt types in the Norwood procedure for single-ventricle lesions publication-title: N Engl J Med doi: 10.1056/NEJMoa0912461 – ident: 10.1016/j.jacc.2013.03.054_bib6 – volume: 477 start-page: 529 year: 2011 ident: 10.1016/j.jacc.2013.03.054_bib7 article-title: Fund people not projects publication-title: Nature doi: 10.1038/477529a – volume: 17 start-page: 689 year: 2010 ident: 10.1016/j.jacc.2013.03.054_bib10 article-title: Using global unique identifiers to link autism collections publication-title: J Am Med Inform Assoc doi: 10.1136/jamia.2009.002063 – volume: 108 start-page: 405 year: 2011 ident: 10.1016/j.jacc.2013.03.054_bib8 article-title: Thought exercises on accountability and performance measures at the National Heart, Lung, and Blood Institute (NHLBI): an invited commentary publication-title: Circ Res doi: 10.1161/RES.0b013e3182125662 – volume: 111 start-page: 833 year: 2012 ident: 10.1016/j.jacc.2013.03.054_bib9 article-title: On the value of portfolio diversity in heart, lung, and blood research publication-title: Circ Res doi: 10.1161/CIRCRESAHA.112.279596 – volume: 300 start-page: 2357 year: 2008 ident: 10.1016/j.jacc.2013.03.054_bib4 article-title: Pediatric research gets boost from web publication-title: JAMA doi: 10.1001/jama.2008.646 – volume: 55 start-page: 1262 year: 2010 ident: 10.1016/j.jacc.2013.03.054_bib5 article-title: The National Heart, Lung, and Blood Institute Bench to Bassinet Program: a new paradigm for translational research publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.11.055 – volume: 23 start-page: 112 year: 2004 ident: 10.1016/j.jacc.2013.03.054_bib1 article-title: Did a rising tide lift all boats? The NIH budget and pediatric research portfolio publication-title: Health Affairs doi: 10.1377/hlthaff.23.5.113 – volume: 154 start-page: 624 year: 2007 ident: 10.1016/j.jacc.2013.03.054_bib11 article-title: Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome publication-title: Am Heart J doi: 10.1016/j.ahj.2007.06.024 |
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| Snippet | Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative... Outcomes have improved significantly in pediatric cardiovascular disease in recent decades. The challenge now is to sustain these advances through innovative... |
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| SubjectTerms | Autism Babies Budgets Cardiology Cardiology - methods Cardiology - trends Cardiovascular Cardiovascular disease Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - surgery Child Children & youth Clinical trials congenital heart disease congenital heart surgery Evidence-based medicine Evidence-Based Medicine - methods Evidence-Based Medicine - trends Heart Heart Defects, Congenital - diagnosis Heart Defects, Congenital - epidemiology Heart Defects, Congenital - surgery Humans Medical treatment Medicine Mortality Pediatrics - methods Pediatrics - trends pediatric cardiovascular research Physiology Studies |
| Title | Evidence-Based Medicine Comes of Age in Pediatric Cardiology |
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