Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients
Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients. In the present study, muscle biopsies from weight-losing patien...
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| Published in | Clinical nutrition (Edinburgh, Scotland) Vol. 26; no. 5; pp. 614 - 618 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Kidlington
Elsevier Ltd
01.10.2007
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0261-5614 1532-1983 |
| DOI | 10.1016/j.clnu.2007.06.005 |
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| Abstract | Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients.
In the present study, muscle biopsies from weight-losing patients with upper gastro-intestinal cancer showed a significant increase in muscle DNA fragmentation (three-fold), as compared with control subjects. The increase in DNA laddering was associated with an increase in poly(ADP-ribose) polymerase (PARP) cleavage (four-fold) as measured by western blotting. These two events indicate the presence of muscle apoptosis. These changes were associated with a decrease in MyoD protein content, suggesting important alterations in skeletal muscle physiology.
The results presented therefore confirm that apoptosis is also present in human subjects undergoing cancer cachexia. |
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| AbstractList | Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients.
In the present study, muscle biopsies from weight-losing patients with upper gastro-intestinal cancer showed a significant increase in muscle DNA fragmentation (three-fold), as compared with control subjects. The increase in DNA laddering was associated with an increase in poly(ADP-ribose) polymerase (PARP) cleavage (four-fold) as measured by western blotting. These two events indicate the presence of muscle apoptosis. These changes were associated with a decrease in MyoD protein content, suggesting important alterations in skeletal muscle physiology.
The results presented therefore confirm that apoptosis is also present in human subjects undergoing cancer cachexia. Summary Background & aims Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients. Methods and results In the present study, muscle biopsies from weight-losing patients with upper gastro-intestinal cancer showed a significant increase in muscle DNA fragmentation (three-fold), as compared with control subjects. The increase in DNA laddering was associated with an increase in poly(ADP-ribose) polymerase (PARP) cleavage (four-fold) as measured by western blotting. These two events indicate the presence of muscle apoptosis. These changes were associated with a decrease in MyoD protein content, suggesting important alterations in skeletal muscle physiology. Conclusions The results presented therefore confirm that apoptosis is also present in human subjects undergoing cancer cachexia. Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients.BACKGROUND & AIMSPrevious studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients.In the present study, muscle biopsies from weight-losing patients with upper gastro-intestinal cancer showed a significant increase in muscle DNA fragmentation (three-fold), as compared with control subjects. The increase in DNA laddering was associated with an increase in poly(ADP-ribose) polymerase (PARP) cleavage (four-fold) as measured by western blotting. These two events indicate the presence of muscle apoptosis. These changes were associated with a decrease in MyoD protein content, suggesting important alterations in skeletal muscle physiology.METHODS AND RESULTSIn the present study, muscle biopsies from weight-losing patients with upper gastro-intestinal cancer showed a significant increase in muscle DNA fragmentation (three-fold), as compared with control subjects. The increase in DNA laddering was associated with an increase in poly(ADP-ribose) polymerase (PARP) cleavage (four-fold) as measured by western blotting. These two events indicate the presence of muscle apoptosis. These changes were associated with a decrease in MyoD protein content, suggesting important alterations in skeletal muscle physiology.The results presented therefore confirm that apoptosis is also present in human subjects undergoing cancer cachexia.CONCLUSIONSThe results presented therefore confirm that apoptosis is also present in human subjects undergoing cancer cachexia. |
| Author | Deans, Chris Busquets, Sílvia Moore-Carrasco, Rodrigo López-Soriano, Francisco J. Figueras, Maite Fearon, Kenneth C.H. Argilés, Josep M. |
| Author_xml | – sequence: 1 givenname: Sílvia surname: Busquets fullname: Busquets, Sílvia organization: Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain – sequence: 2 givenname: Chris surname: Deans fullname: Deans, Chris organization: Department of Surgery, Royal Infirmary of Edinburgh, Scotland, UK – sequence: 3 givenname: Maite surname: Figueras fullname: Figueras, Maite organization: Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain – sequence: 4 givenname: Rodrigo surname: Moore-Carrasco fullname: Moore-Carrasco, Rodrigo organization: Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain – sequence: 5 givenname: Francisco J. surname: López-Soriano fullname: López-Soriano, Francisco J. organization: Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain – sequence: 6 givenname: Kenneth C.H. surname: Fearon fullname: Fearon, Kenneth C.H. organization: Department of Surgery, Royal Infirmary of Edinburgh, Scotland, UK – sequence: 7 givenname: Josep M. surname: Argilés fullname: Argilés, Josep M. email: jargiles@ub.edu organization: Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain |
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| Keywords | Cancer cachexia PARP MyoD Apoptosis Human Nutrition Intestinal cancer Digestive diseases Intestinal disease Patient Malignant tumor Striated muscle Cancer |
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| Snippet | Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason... Summary Background & aims Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to... |
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| SubjectTerms | Aged Apoptosis Biological and medical sciences C-Reactive Protein - metabolism Cachexia - complications Cachexia - metabolism Cachexia - pathology Cancer cachexia Case-Control Studies DNA Fragmentation Etanercept Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Neoplasms - complications Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gene Expression Regulation, Neoplastic Humans Immunoglobulin G - metabolism Interleukin-6 - blood Male Medical sciences Metabolic diseases Muscle, Skeletal - metabolism Muscle, Skeletal - pathology MyoD PARP Receptors, Tumor Necrosis Factor - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| Title | Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients |
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