Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin - Chen, Huabing; Zhu, Hongda; Zheng, Jingnan; Mou, Dongsheng; Wan, Jiangling; Zhang, Junyong; Shi, Tielin; Zhao, Yingjun; Xu, Huibi; Yang, Xiangliang (Journal of controlled release, 2009)
Keywords: Administration, Cutaneous; Animals; Biological and medical sciences; Blood Glucose - metabolism; Chromatography, High Pressure Liquid; Drug Compounding; Electrochemistry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; General pharmacology; Guinea Pigs; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - pharmacokinetics; In Vitro Techniques; Insulin; Insulin - administration & dosage; Insulin - pharmacokinetics; Iontophoresis; Iontophoresis - methods; Male; Medical sciences; Microneedles; Microscopy, Electron, Transmission; Molecular Weight; Nanoparticles; Nanotechnology; Nanovesicles; Needles; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Skin Absorption; Transdermal delivery; Transdermal delivery; Iontophoresis; Microneedles; Insulin; Nanovesicles; Penetration; Pharmaceutical technology; Skin; Microneedle; Percutaneous route