Features of trunk muscle weakness in patients with ankylosing spondylitis: A cross-sectional study

• Published in: Biomedical Journal Vol. 42; no. 2; pp. 124 - 130
• Main Authors: Wang, Chin-Man, Hong, Wei-Hsien, Ho, Huei-Huang, Chen, Ji-Yih, Tsai, Yu-Lin, Pei, Yu-Cheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.04.2019; Chang Gung University; Elsevier
• Subjects: Adult; Ankylosing spondylitis; Arthritis; Autoimmune diseases; Back pain; Cross-Sectional Studies; Female; Humans; Inflammation; Inflammation - physiopathology; Male; Middle Aged; Muscle contraction; Muscle strength; Muscle Weakness - physiopathology; Muscle, Skeletal - physiopathology; Muscles; Original; Patients; Posture; Quality of life; Radiography - methods; Sacroiliitis; Spine - physiopathology; Spondylitis; Spondylitis, Ankylosing - physiopathology; Studies; Thorax; Trunk muscles; Trunk; Muscle strength; Sacroiliitis; Syndesmophyte; Ankylosing spondylitis (AS)
• ISSN: 2319-4170; 2320-2890; 2320-2890
• DOI: 10.1016/j.bj.2019.01.001

Ankylosing spondylitis (AS) is an inflammatory autoimmune disorder that manifested with sacroiliitis at its early stage and developed extensive inflammation with syndesmophytes of the lumbar, thoracic and cervical spines at its later stage. In the present study, we characterized the trunk isometric strength in patients with AS with different disease severity, defined by the radiological images. In a cross-sectional study conducted in a university-affiliated hospital, thirty-eight male AS patients (23 in the early AS group whose radiological findings showed no syndesmophyte, Modified Stoke Ankylosing Spinal Score (m-SASSS <3); and 15 in the syndesmophyte group, m-SASSS ≥24), and 22 healthy controls were recruited. All subjects received assessments of maximum isometric strength of trunk flexor and extensor muscles at a variety of trunk postures measured by an isokinetic device. Under all examined trunk postures, the syndesmophyte AS patient group had the lowest isometric trunk muscle strength among the three groups. The flexion/extension ratio, defined by the ratio between isometric trunk flexor and extensor strengths, was highest among the three groups. Trunk muscle strength significantly decreases in patients with syndesmophyte AS. The decrease of trunk muscle is inhomogeneous, which is more profound in extensor than in flexor muscles.