Linking Pain Sensation to the Autonomic Nervous System: The Role of the Anterior Cingulate and Periaqueductal Gray Resting-State Networks

• Published in: Frontiers in neuroscience Vol. 14; p. 147
• Main Authors: Hohenschurz-Schmidt, David Johannes, Calcagnini, Giovanni, Dipasquale, Ottavia, Jackson, Jade B., Medina, Sonia, O’Daly, Owen, O’Muircheartaigh, Jonathan, de Lara Rubio, Alfonso, Williams, Steven C. R., McMahon, Stephen B., Makovac, Elena, Howard, Matthew A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 27.02.2020; Frontiers Media S.A
• Subjects: Autonomic nervous system; Brain; Brain mapping; Cold; Cortex (cingulate); Cortex (parietal); fMRI; Functional magnetic resonance imaging; Heart rate; heart rate variability; Nervous system; Neural networks; Neuroscience; Pain; Pain perception; periaqueductal gray; Periaqueductal gray area; Prefrontal cortex; resting state; fMRI; pain; resting state; autonomic nervous system; heart rate variability; anterior cingulate cortex; periaqueductal gray
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2020.00147

There are bi-directional interactions between the autonomic nervous system (ANS) and pain. This is likely underpinned by a substantial overlap between brain areas of the central autonomic network and areas involved in pain processing and modulation. To date, however, relatively little is known about the neuronal substrates of the ANS-pain association. Here, we acquired resting state fMRI scans in 21 healthy subjects at rest and during tonic noxious cold stimulation. As indicators of autonomic function, we examined how heart rate variability (HRV) frequency measures were influenced by tonic noxious stimulation and how these variables related to participants' pain perception and to brain functional connectivity in regions known to play a role in both ANS regulation and pain perception, namely the right dorsal anterior cingulate cortex (dACC) and periaqueductal gray (PAG). Our findings support a role of the cardiac ANS in brain connectivity during pain, linking functional connections of the dACC and PAG with measurements of low frequency (LF)-HRV. In particular, we identified a three-way relationship between the ANS, cortical brain networks known to underpin pain processing, and participants' subjectively reported pain experiences. LF-HRV both at rest and during pain correlated with functional connectivity between the seed regions and other cortical areas including the right dorsolateral prefrontal cortex (dlPFC), left anterior insula (AI), and the precuneus. Our findings link cardiovascular autonomic parameters to brain activity changes involved in the elaboration of nociceptive information, thus beginning to elucidate underlying brain mechanisms associated with the reciprocal relationship between autonomic and pain-related systems.