Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: A preliminary report
Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver d...
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| Published in | Hepatology research Vol. 37; no. 1; pp. 13 - 17 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Melbourne, Australia
Blackwell Publishing Asia
01.01.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1386-6346 1872-034X |
| DOI | 10.1111/j.1872-034X.2007.00002.x |
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| Abstract | Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty‐three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty‐six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 ± 1.26 IU/L vs 7.56 ± 0.82 IU/L in controls; P≤ 0.001) and chronic (2.98 ± 1.18 IU/L vs 7.56 ± 0.82 IU/L in controls; P≤ 0.001) liver disease. Using receiver–operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease. |
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| AbstractList | Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty‐three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty‐six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 ± 1.26 IU/L vs 7.56 ± 0.82 IU/L in controls; P≤ 0.001) and chronic (2.98 ± 1.18 IU/L vs 7.56 ± 0.82 IU/L in controls; P≤ 0.001) liver disease. Using receiver–operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease. Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty‐three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty‐six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 ± 1.26 IU/L vs 7.56 ± 0.82 IU/L in controls; P ≤ 0.001) and chronic (2.98 ± 1.18 IU/L vs 7.56 ± 0.82 IU/L in controls; P ≤ 0.001) liver disease. Using receiver–operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease. Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty-three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty-six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 +/- 1.26 IU/L vs 7.56 +/- 0.82 IU/L in controls; P</= 0.001) and chronic (2.98 +/- 1.18 IU/L vs 7.56 +/- 0.82 IU/L in controls; P</= 0.001) liver disease. Using receiver-operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease.Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty-three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty-six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 +/- 1.26 IU/L vs 7.56 +/- 0.82 IU/L in controls; P</= 0.001) and chronic (2.98 +/- 1.18 IU/L vs 7.56 +/- 0.82 IU/L in controls; P</= 0.001) liver disease. Using receiver-operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease. Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty-three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty-six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 +/- 1.26 IU/L vs 7.56 +/- 0.82 IU/L in controls; P</= 0.001) and chronic (2.98 +/- 1.18 IU/L vs 7.56 +/- 0.82 IU/L in controls; P</= 0.001) liver disease. Using receiver-operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease. Biotinidase is an enzyme synthesized predominantly by the liver. Serum activity of this enzyme has been shown to be low in chronic liver disease. In this study, we endeavored to assess the diagnostic value of serum biotinidase as a marker of hepatic biosynthetic function in acute and chronic liver dysfunction. Twenty-three patients with acute liver disease and 46 with chronic liver disease, as diagnosed by clinical examination, laboratory tests, histopathology and tests for viral markers, were inducted into the study. Forty-six healthy volunteers were selected as controls. Serum biotinidase activity was estimated in all the subjects. Biotinidase activity was found to be significantly lower in the serum of patients with acute (4.59 plus or minus 1.26 IU/L vs 7.56 plus or minus 0.82 IU/L in controls; P less than or equal to 0.001) and chronic (2.98 plus or minus 1.18 IU/L vs 7.56 plus or minus 0.82 IU/L in controls; P less than or equal to 0.001) liver disease. Using receiver-operator characteristic curves, serum biotinidase was found to have high values of sensitivity and specificity when applied as a diagnostic test in both acute and chronic liver disease. These results suggest that serum biotinidase may be a sensitive and specific diagnostic marker of hepatic biosynthetic function in both acute and chronic liver disease. |
| Author | Jacob, Molly Eapen, Chundamannil Eapen Faith, Minnie Wilfred, Gnanaiah Ramachandran, Jeyamani |
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| References | Nagamine T, Saifo S, Yamadu S, Avai T, Takechara K, Fukui T. Biotinidase activity in patients with liver disease. Scan J Gastroenterol 1993; 28: 899-906. Feinstein AR. Clinical Epidemiology. The Architecture of Clinical Research. Philadelphia: W.B. Saunders, 1985. Chauhan J, Dakshinamurti K. The role of human serum biotinidase as biotin-binding protein. Biochem J 1988; 256: 265-70. Wolf B, Feldman GL. The biotin-dependent carboxylase deficiencies. Am J Hum Genet 1981; 33: 692-701. Pispa J. Animal biotinidase. Ann Med Exp Biol Fenn 1965; 43 (Suppl 5): 5-39. Abraham P, Wilfred G, Ramakrishna B. Decrease in plasma biotinidase activity with normal albumin concentrations in experimental liver fibrosis. Clin Chim Acta 2003; 334: 245-7. Abraham P. Increase in plasma biotinidase activity in rats with paracetamol-induced acute liver injury. Clin Chim Acta 2004; 339: 61-5. Wolf B, Grier RG, Allen RJ, Goodman SI, Kien CL. Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase deficiency. Clin Chim Acta 1983; 131: 273-81. Kamath PS, Wiesner RH, Malinchoc M et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-70. Wolf B, Grier RE, Secor Mcvoy JR, Heard GS. Biotinidase deficiency: a novel vitamin-recycling defect. J Inherit Metab Dis 1985; 8 (Suppl 1): 53-8. Chauhan J, Dakshinamurti J. Purification and characterization of human serum biotinidase. J Biol Chem 1986; 261: 4268-74. Grier RE, Heard GS, Watkins P, Wolf B. Low biotinidase activities in the serum of patients with impaired liver function: evidence that the liver is the source of serum biotinidase. Clin Chim Acta 1990; 186: 397-400. Pugh RN, Murray-Lyon IM, Dawsin JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-9. Wright LD, Driscoll CA, Boyer WP. Biocytinase, an enzyme concerned with hydrolytic cleavage of biocytin. Proc Soc Exp Biol Med 1954; 86: 335-7. Pabuccuoglu A, Aydogdu S, Bas M. Serum biotinidase activity in children with chronic liver disease and its clinical significance. J Pediatr Gastroenterol Nutr 2002; 34: 59-62. 1973; 60 1965; 43 1993; 28 1983; 131 2002; 34 1985; 8 1954; 86 1986; 261 1988; 256 1985 2001; 33 2004; 339 2003; 334 1990; 186 1981; 33 e_1_2_7_5_2 e_1_2_7_4_2 e_1_2_7_2_2 e_1_2_7_9_2 e_1_2_7_8_2 e_1_2_7_6_2 e_1_2_7_16_2 e_1_2_7_15_2 Feinstein AR. (e_1_2_7_13_2) 1985 e_1_2_7_14_2 e_1_2_7_12_2 e_1_2_7_11_2 Pispa J. (e_1_2_7_7_2) 1965; 43 e_1_2_7_10_2 Wolf B (e_1_2_7_3_2) 1981; 33 |
| References_xml | – reference: Nagamine T, Saifo S, Yamadu S, Avai T, Takechara K, Fukui T. Biotinidase activity in patients with liver disease. Scan J Gastroenterol 1993; 28: 899-906. – reference: Wolf B, Feldman GL. The biotin-dependent carboxylase deficiencies. Am J Hum Genet 1981; 33: 692-701. – reference: Wolf B, Grier RE, Secor Mcvoy JR, Heard GS. Biotinidase deficiency: a novel vitamin-recycling defect. J Inherit Metab Dis 1985; 8 (Suppl 1): 53-8. – reference: Chauhan J, Dakshinamurti K. The role of human serum biotinidase as biotin-binding protein. Biochem J 1988; 256: 265-70. – reference: Abraham P, Wilfred G, Ramakrishna B. Decrease in plasma biotinidase activity with normal albumin concentrations in experimental liver fibrosis. Clin Chim Acta 2003; 334: 245-7. – reference: Grier RE, Heard GS, Watkins P, Wolf B. Low biotinidase activities in the serum of patients with impaired liver function: evidence that the liver is the source of serum biotinidase. Clin Chim Acta 1990; 186: 397-400. – reference: Abraham P. Increase in plasma biotinidase activity in rats with paracetamol-induced acute liver injury. Clin Chim Acta 2004; 339: 61-5. – reference: Pabuccuoglu A, Aydogdu S, Bas M. Serum biotinidase activity in children with chronic liver disease and its clinical significance. J Pediatr Gastroenterol Nutr 2002; 34: 59-62. – reference: Wright LD, Driscoll CA, Boyer WP. Biocytinase, an enzyme concerned with hydrolytic cleavage of biocytin. Proc Soc Exp Biol Med 1954; 86: 335-7. – reference: Pugh RN, Murray-Lyon IM, Dawsin JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-9. – reference: Feinstein AR. Clinical Epidemiology. The Architecture of Clinical Research. Philadelphia: W.B. Saunders, 1985. – reference: Chauhan J, Dakshinamurti J. Purification and characterization of human serum biotinidase. J Biol Chem 1986; 261: 4268-74. – reference: Pispa J. Animal biotinidase. Ann Med Exp Biol Fenn 1965; 43 (Suppl 5): 5-39. – reference: Wolf B, Grier RG, Allen RJ, Goodman SI, Kien CL. Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase deficiency. Clin Chim Acta 1983; 131: 273-81. – reference: Kamath PS, Wiesner RH, Malinchoc M et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-70. – volume: 43 start-page: 5 year: 1965 end-page: 39 article-title: Animal biotinidase publication-title: Ann Med Exp Biol Fenn – year: 1985 – volume: 131 start-page: 273 year: 1983 end-page: 81 article-title: Biotinidase deficiency: the enzymatic defect in late‐onset multiple carboxylase deficiency publication-title: Clin Chim Acta – volume: 256 start-page: 265 year: 1988 end-page: 70 article-title: The role of human serum biotinidase as biotin‐binding protein publication-title: Biochem J – volume: 339 start-page: 61 year: 2004 end-page: 5 article-title: Increase in plasma biotinidase activity in rats with paracetamol‐induced acute liver injury publication-title: Clin Chim Acta – volume: 34 start-page: 59 year: 2002 end-page: 62 article-title: Serum biotinidase activity in children with chronic liver disease and its clinical significance publication-title: J Pediatr Gastroenterol Nutr – volume: 33 start-page: 464 year: 2001 end-page: 70 article-title: A model to predict survival in patients with end‐stage liver disease publication-title: Hepatology – volume: 86 start-page: 335 year: 1954 end-page: 7 article-title: Biocytinase, an enzyme concerned with hydrolytic cleavage of biocytin publication-title: Proc Soc Exp Biol Med – volume: 28 start-page: 899 year: 1993 end-page: 906 article-title: Biotinidase activity in patients with liver disease publication-title: Scan J Gastroenterol – volume: 33 start-page: 692 year: 1981 end-page: 701 article-title: The biotin‐dependent carboxylase deficiencies publication-title: Am J Hum Genet – volume: 261 start-page: 4268 year: 1986 end-page: 74 article-title: Purification and characterization of human serum biotinidase publication-title: J Biol Chem – volume: 8 start-page: 53 year: 1985 end-page: 8 article-title: Biotinidase deficiency: a novel vitamin‐recycling defect publication-title: J Inherit Metab Dis – volume: 186 start-page: 397 year: 1990 end-page: 400 article-title: Low biotinidase activities in the serum of patients with impaired liver function: evidence that the liver is the source of serum biotinidase publication-title: Clin Chim Acta – volume: 60 start-page: 646 year: 1973 end-page: 9 article-title: Transection of the oesophagus for bleeding oesophageal varices publication-title: Br J Surg – volume: 334 start-page: 245 year: 2003 end-page: 7 article-title: Decrease in plasma biotinidase activity with normal albumin concentrations in experimental liver fibrosis publication-title: Clin Chim Acta – ident: e_1_2_7_16_2 doi: 10.1016/S0009-8981(03)00195-5 – ident: e_1_2_7_14_2 doi: 10.1097/00005176-200201000-00014 – volume: 43 start-page: 5 year: 1965 ident: e_1_2_7_7_2 article-title: Animal biotinidase publication-title: Ann Med Exp Biol Fenn – ident: e_1_2_7_6_2 doi: 10.1042/bj2560265 – ident: e_1_2_7_4_2 doi: 10.1016/S0021-9258(17)35656-9 – ident: e_1_2_7_9_2 doi: 10.1016/j.cccn.2004.06.002 – ident: e_1_2_7_5_2 doi: 10.1007/BF01800660 – ident: e_1_2_7_15_2 doi: 10.3109/00365529309103132 – ident: e_1_2_7_2_2 doi: 10.3181/00379727-86-21090 – volume: 33 start-page: 692 year: 1981 ident: e_1_2_7_3_2 article-title: The biotin‐dependent carboxylase deficiencies publication-title: Am J Hum Genet – ident: e_1_2_7_8_2 doi: 10.1016/0009-8981(90)90326-N – ident: e_1_2_7_10_2 doi: 10.1002/bjs.1800600817 – ident: e_1_2_7_11_2 doi: 10.1053/jhep.2001.22172 – volume-title: Clinical Epidemiology. The Architecture of Clinical Research year: 1985 ident: e_1_2_7_13_2 – ident: e_1_2_7_12_2 doi: 10.1016/0009-8981(83)90096-7 |
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| Title | Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: A preliminary report |
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