Plasma polyunsaturated fatty acid profile is associated with vascular endothelial function in patients with type 2 diabetes
Decreased plasma n-3 polyunsaturated fatty acid levels or the n-3/n-6 polyunsaturated fatty acid ratios are associated with a risk of cardiovascular events. In this cross-sectional study, we measured plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid and investigated...
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| Published in | Diabetes & vascular disease research Vol. 15; no. 4; pp. 352 - 355 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.07.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1479-1641 1752-8984 1752-8984 |
| DOI | 10.1177/1479164118774314 |
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| Abstract | Decreased plasma n-3 polyunsaturated fatty acid levels or the n-3/n-6 polyunsaturated fatty acid ratios are associated with a risk of cardiovascular events. In this cross-sectional study, we measured plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid and investigated the association between the plasma polyunsaturated fatty acid profile and vascular endothelial function in 396 patients with type 2 diabetes. Endothelium-dependent, flow-mediated dilatation of the brachial artery was measured using ultrasonography. Multiple regression analyses, including age, sex, body mass index, and other cardiovascular risk factors, revealed that plasma eicosapentaenoic acid levels (β = 0.140, p = 0.008) and the eicosapentaenoic acid/arachidonic acid ratio (β = 0.127, p = 0.019), but not plasma docosahexaenoic acid levels (β = 0.067, p = 0.220) or the docosahexaenoic acid/arachidonic acid ratio (β = 0.034, p = 0.559), were independently and positively associated with flow-mediated dilatation. In conclusion, plasma eicosapentaenoic acid levels and the eicosapentaenoic acid/arachidonic acid ratio are independently associated with endothelial function in patients with type 2 diabetes. This study indicates a positive association between eicosapentaenoic acid, rather than docosahexaenoic acid, and endothelial function in type 2 diabetes. |
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| AbstractList | Decreased plasma n-3 polyunsaturated fatty acid levels or the n-3/n-6 polyunsaturated fatty acid ratios are associated with a risk of cardiovascular events. In this cross-sectional study, we measured plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid and investigated the association between the plasma polyunsaturated fatty acid profile and vascular endothelial function in 396 patients with type 2 diabetes. Endothelium-dependent, flow-mediated dilatation of the brachial artery was measured using ultrasonography. Multiple regression analyses, including age, sex, body mass index, and other cardiovascular risk factors, revealed that plasma eicosapentaenoic acid levels (β = 0.140, p = 0.008) and the eicosapentaenoic acid/arachidonic acid ratio (β = 0.127, p = 0.019), but not plasma docosahexaenoic acid levels (β = 0.067, p = 0.220) or the docosahexaenoic acid/arachidonic acid ratio (β = 0.034, p = 0.559), were independently and positively associated with flow-mediated dilatation. In conclusion, plasma eicosapentaenoic acid levels and the eicosapentaenoic acid/arachidonic acid ratio are independently associated with endothelial function in patients with type 2 diabetes. This study indicates a positive association between eicosapentaenoic acid, rather than docosahexaenoic acid, and endothelial function in type 2 diabetes. Decreased plasma n-3 polyunsaturated fatty acid levels or the n-3/n-6 polyunsaturated fatty acid ratios are associated with a risk of cardiovascular events. In this cross-sectional study, we measured plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid and investigated the association between the plasma polyunsaturated fatty acid profile and vascular endothelial function in 396 patients with type 2 diabetes. Endothelium-dependent, flow-mediated dilatation of the brachial artery was measured using ultrasonography. Multiple regression analyses, including age, sex, body mass index, and other cardiovascular risk factors, revealed that plasma eicosapentaenoic acid levels ( β = 0.140, p = 0.008) and the eicosapentaenoic acid/arachidonic acid ratio ( β = 0.127, p = 0.019), but not plasma docosahexaenoic acid levels ( β = 0.067, p = 0.220) or the docosahexaenoic acid/arachidonic acid ratio ( β = 0.034, p = 0.559), were independently and positively associated with flow-mediated dilatation. In conclusion, plasma eicosapentaenoic acid levels and the eicosapentaenoic acid/arachidonic acid ratio are independently associated with endothelial function in patients with type 2 diabetes. This study indicates a positive association between eicosapentaenoic acid, rather than docosahexaenoic acid, and endothelial function in type 2 diabetes.Decreased plasma n-3 polyunsaturated fatty acid levels or the n-3/n-6 polyunsaturated fatty acid ratios are associated with a risk of cardiovascular events. In this cross-sectional study, we measured plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid and investigated the association between the plasma polyunsaturated fatty acid profile and vascular endothelial function in 396 patients with type 2 diabetes. Endothelium-dependent, flow-mediated dilatation of the brachial artery was measured using ultrasonography. Multiple regression analyses, including age, sex, body mass index, and other cardiovascular risk factors, revealed that plasma eicosapentaenoic acid levels ( β = 0.140, p = 0.008) and the eicosapentaenoic acid/arachidonic acid ratio ( β = 0.127, p = 0.019), but not plasma docosahexaenoic acid levels ( β = 0.067, p = 0.220) or the docosahexaenoic acid/arachidonic acid ratio ( β = 0.034, p = 0.559), were independently and positively associated with flow-mediated dilatation. In conclusion, plasma eicosapentaenoic acid levels and the eicosapentaenoic acid/arachidonic acid ratio are independently associated with endothelial function in patients with type 2 diabetes. This study indicates a positive association between eicosapentaenoic acid, rather than docosahexaenoic acid, and endothelial function in type 2 diabetes. |
| Author | Mori, Katsuhito Fukumoto, Shinya Morioka, Tomoaki Shoji, Tetsuo Inaba, Masaaki Emoto, Masanori Shioi, Atsushi Imamura, Satoshi Yamazaki, Yuko Motoyama, Koka Kakutani, Yoshinori |
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| Cites_doi | 10.1016/j.metabol.2014.08.003 10.1016/S0021-9150(02)00307-6 10.1017/S0029665112000080 10.1053/j.ajkd.2013.02.362 10.1186/s12933-016-0437-y 10.1016/j.atherosclerosis.2012.01.006 10.1111/j.1464-5491.2009.02869.x 10.1007/BF00399090 10.1210/edrv.22.1.0417 10.7326/0003-4819-158-7-201304020-00003 10.1016/S0735-1097(01)01746-6 10.1001/jama.296.15.1885 |
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| References | Woodman, Mori, Burke 2003; 166 Mozaffarian, Rimm 2006; 296 Wang, Liang, Wang 2012; 221 Imamura, Morioka, Yamazaki 2014; 63 Corretti, Anderson, Benjamin 2002; 39 McVeigh, Brennan, Johnston 1993; 36 Sawada, Tsubata, Hashimoto 2016; 15 Calles-Escandon, Cipolla 2001; 22 Wong, Yiu, Li 2010; 27 Kelley, Adkins 2012; 71 Shoji, Kakiya, Hayashi 2013; 62 Mozaffarian, Lemaitre, King 2013; 158 bibr3-1479164118774314 bibr4-1479164118774314 Sawada T (bibr6-1479164118774314) 2016; 15 bibr7-1479164118774314 bibr8-1479164118774314 bibr9-1479164118774314 bibr12-1479164118774314 bibr5-1479164118774314 bibr11-1479164118774314 bibr2-1479164118774314 bibr10-1479164118774314 bibr1-1479164118774314 |
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| Title | Plasma polyunsaturated fatty acid profile is associated with vascular endothelial function in patients with type 2 diabetes |
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