Pathogenesis and biomarkers of colorectal cancer by epigenetic alteration

Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angioge...

Full description

Saved in:
Bibliographic Details
Published inIntestinal research Vol. 22; no. 2; pp. 131 - 151
Main Authors Oh, Chang Kyo, Cho, Young-Seok
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Association for the Study of Intestinal Diseases 01.04.2024
대한장연구학회
Subjects
biomarkers
colorectal neoplasms
diagnosis
epigenetic
prognosis
Review
내과학
Biomarkers
Prognosis
Colorectal neoplasms
Diagnosis
Epigenetic
Online AccessGet full text
ISSN1598-9100
2288-1956
DOI10.5217/ir.2023.00115

Cover

Abstract Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis, and treatment response prediction.
AbstractList Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis, and treatment response prediction. KCI Citation Count: 8
Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis, and treatment response prediction.
Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis, and treatment response prediction.Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results from a cumulative set of genetic and epigenetic alterations, disrupting cancer-regulatory processes like cell proliferation, metabolism, angiogenesis, cell death, invasion, and metastasis. Key epigenetic modifications observed in cancers encompass abnormal DNA methylation, atypical histone modifications, and irregularities in noncoding RNAs, such as microRNAs and long noncoding RNAs. The advancement in genomic technologies has positioned these genetic and epigenetic shifts as potential clinical biomarkers for CRC patients. This review concisely covers the fundamental principles of CRC-associated epigenetic changes, and examines in detail their emerging role as biomarkers for early detection, prognosis, and treatment response prediction.
Author Cho, Young-Seok
Oh, Chang Kyo
Author_xml – sequence: 1
  givenname: Chang Kyo
  orcidid: 0000-0002-3401-1133
  surname: Oh
  fullname: Oh, Chang Kyo
– sequence: 2
  givenname: Young-Seok
  orcidid: 0000-0003-1537-3427
  surname: Cho
  fullname: Cho, Young-Seok
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38295766$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003074747$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp1kt9rFDEQx4NU7Fn76Kvsowh75sfm15OUYvWgoEh9Dkl29hpvLzmTvUL_--b2arGCD2Eg8_l-Z4aZ1-gkpggIvSV4ySmRH0NeUkzZEmNC-Au0oFSplmguTtCCcK1aTTA-ReelBIe7TnZEM_YKnTJFNZdCLNDqu51u0xoilFAaG_vGhbS1eQO5NGlofBpTBj_ZsfE2esiNu29gFw6KKfjGjhNkO4UU36CXgx0LnD_GM_Tz6vPN5df2-tuX1eXFdes7padWCK2E4kID1Y5wT7UilkpdXy87aqEfeG977SWmClSHsZO977ikyuKqYGfow9E35sFsfDDJhjmuk9lkc_HjZmUIlkwSrSq8OsJ9sr_MLoc62v2smD9SXhub6xwjGAmeMd0JcJR2innlLPYDA6BeOOdE9fp09Nrt3RZ6D3HKdnxm-jwTw21t6s6Q2o7mhFeH948OOf3eQ5nMNhQP42gjpH0xVFOBpZDsgL77u9hTlT-bq0B7BHxOpWQYnhCCzeE4TMjmcBxmPo7Ks394H6Z5cbXXMP5H9QDLQ7x8
CitedBy_id crossref_primary_10_1002_ueg2_70013
crossref_primary_10_1111_jgh_16833
crossref_primary_10_1016_j_bbadis_2024_167578
crossref_primary_10_3390_cancers16213649
Cites_doi 10.1002/cam4.2475
10.1186/1471-2407-13-196
10.1016/j.lfs.2020.118226
10.21873/anticanres.11341
10.3748/wjg.v13.i10.1528
10.3390/ijms232113431
10.1016/s0304-3835(01)00839-4
10.1158/1078-0432.1203.11.3
10.1016/j.prp.2020.153130
10.1038/s41571-018-0036-9
10.1111/cas.12166
10.1515/med-2020-0012
10.1101/gad.12.5.599
10.1373/clinchem.2008.122937
10.1158/1940-6207.capr-12-0501
10.1136/gutjnl-2019-318903
10.1371/journal.pone.0045357
10.1093/jnci/djt322
10.1001/jama.299.4.425
10.1038/s41598-023-31449-3
10.1002/ijc.26484
10.3748/wjg.v20.i20.6329
10.1371/journal.pone.0180809
10.1002/ijc.23470
10.1186/s12885-015-1674-2
10.3233/cbm-150563
10.1053/j.gastro.2008.07.078
10.1016/j.biocel.2012.05.002
10.3390/ijms161226180
10.3390/ijms241310622
10.1002/cncr.25737
10.1016/j.jmoldx.2016.02.005
10.1158/1055-9965.epi-13-0512
10.1038/79120
10.1093/carcin/bgu055
10.1373/clinchem.2007.095992
10.1186/1471-2407-14-531
10.1038/s41575-019-0230-y
10.1016/j.cell.2007.11.005
10.1111/his.12534
10.1371/journal.pone.0108265
10.1371/journal.pone.0003759
10.1111/j.1572-0241.2005.50412.x
10.1158/0008-5472.can-11-1021
10.1053/j.gastro.2006.08.034
10.1038/s41598-017-03321-8
10.3748/wjg.v13.i6.950
10.1016/j.humpath.2011.07.009
10.1016/j.cgh.2020.02.043
10.1093/jnci/dju195
10.1038/sj.onc.1206928
10.1371/journal.pone.0009061
10.1038/nrc2876
10.1038/cdd.2013.125
10.1093/jnci/djp131
10.2217/epi-2016-0146
10.1186/s12935-023-02867-0
10.1007/s00432-009-0688-z
10.1093/jnci/djt101
10.1158/1078-0432.ccr-12-3518
10.1155/2019/5232780
10.2147/cmar.s300861
10.25011/cim.v34i1.15105
10.1007/s00535-011-0456-0
10.1158/1078-0432.ccr-07-1011
10.1186/1471-2407-14-245
10.1371/currents.rrn1220
10.2217/epi.15.39
10.3389/fmed.2022.915226
10.1053/j.gastro.2022.06.089
10.1056/nejmoa1311194
10.3892/or.2011.1547
10.1016/s0092-8674(04)00045-5
10.3390/cancers14010065
10.1016/j.canlet.2021.01.009
10.1002/jcla.23601
10.5217/ir.2017.15.4.495
10.1016/j.clinbiochem.2022.01.003
10.1136/gut.2008.167817
10.1245/s10434-012-2410-7
10.1002/ijc.27505
10.1038/nrg3173
10.1007/s10620-008-0601-7
10.1158/1078-0432.ccr-06-1264
10.1089/gtmb.2018.0308
10.3390/ijms241311023
10.1038/bjc.2017.12
10.1186/s12943-019-1014-2
10.1186/s13148-019-0757-3
10.1371/journal.pone.0092921
10.1371/journal.pone.0099233
10.1053/j.gastro.2019.10.005
10.1038/ncomms13875
10.1016/s0016-5085(01)81443-8
10.1177/1756283x16671287
10.1002/ijc.11117
10.1002/ijc.10526
10.1093/nar/gkr254
10.1136/gut.2011.239236
10.1158/0008-5472.can-18-3880
10.1158/1055-9965.epi-07-0518
10.1007/s13277-012-0554-5
10.1002/ijc.25007
10.1016/j.molonc.2014.01.011
10.1002/ijc.30625
10.1155/2018/6437104
10.1016/j.ejso.2013.02.023
10.1371/journal.pone.0066587
10.1007/s13277-015-3967-0
10.1158/1078-0432.ccr-09-0055
10.1186/1559-0275-11-24
10.1016/j.ebiom.2016.10.026
10.1186/s13045-018-0656-7
10.1093/jnci/djn359
10.1158/1078-0432.ccr-12-3734
10.1158/1055-9965.epi-11-0035
10.1016/j.cancergencyto.2010.05.018
10.1080/2162402x.2016.1257454
10.1158/1940-6207.capr-11-0315
10.1016/j.jmoldx.2013.03.004
10.1177/1533033818791794
10.1053/j.gastro.2023.05.037
10.2217/epi-2021-0277
10.1038/nrg3074
10.1111/j.1349-7006.2010.01776.x
10.3892/ol.2014.2413
10.1038/nrg2540
10.1200/jco.2001.19.2.299
10.1080/15592294.2017.1356957
10.1159/000500639
10.1016/j.molonc.2013.09.001
10.1158/0008-5472.can-13-1400
10.1007/s00432-014-1766-4
10.1158/1078-0432.ccr-10-2509
10.1158/1940-6207.capr-10-0036
10.3390/cancers11081111
10.1101/cshperspect.a019521
10.3390/cells12071081
10.1038/nbt.1559
10.1371/journal.pone.0088745
10.1038/ajg.2011.6
10.1186/s40364-021-00272-1
10.1093/annonc/mdx248
10.1053/j.gastro.2015.07.011
10.1371/journal.pone.0000399
10.1245/s10434-009-0901-y
10.1093/jnci/dji204
10.1155/2009/921907
10.1016/j.trsl.2014.11.001
10.1158/1078-0432.ccr-09-0111
10.1038/nrc1840
10.3892/ol.2014.2815
10.1093/jnci/djp265
10.1080/07853890.2020.1828617
10.1007/dcr.0b013e3181a79533
10.1186/s12885-015-1123-2
ContentType Journal Article
Copyright Copyright 2024. Korean Association for the Study of Intestinal Diseases. 2024
Copyright_xml – notice: Copyright 2024. Korean Association for the Study of Intestinal Diseases. 2024
DBID AAYXX
CITATION
NPM
7X8
5PM
DOA
ACYCR
DOI 10.5217/ir.2023.00115
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
Korean Citation Index
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList

CrossRef
MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2288-1956
EndPage 151
ExternalDocumentID oai_kci_go_kr_ARTI_10737198
oai_doaj_org_article_7ec33946eb22483c8ba0cf3ee2c6bbb6
PMC11079515
38295766
10_5217_ir_2023_00115
Genre Journal Article
Review
GroupedDBID 5-W
53G
8JR
8XY
AAYXX
ABDBF
ACUHS
ADBBV
AEGXH
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EF.
GROUPED_DOAJ
GX1
HYE
HZB
KQ8
M48
OK1
PGMZT
RPM
M~E
NPM
7X8
5PM
ACYCR
ADRAZ
IPNFZ
RIG
ID FETCH-LOGICAL-c489t-669868569e29b15c2981a279a27d742aedf5dad9c7028e8400b7dc45728a09b13
IEDL.DBID M48
ISSN 1598-9100
IngestDate Sun Jul 20 03:11:08 EDT 2025
Wed Aug 27 01:16:06 EDT 2025
Thu Aug 21 18:35:56 EDT 2025
Fri Jul 11 06:11:30 EDT 2025
Wed Feb 19 02:13:37 EST 2025
Tue Jul 01 02:11:39 EDT 2025
Thu Apr 24 23:05:58 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Biomarkers
Prognosis
Colorectal neoplasms
Diagnosis
Epigenetic
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c489t-669868569e29b15c2981a279a27d742aedf5dad9c7028e8400b7dc45728a09b13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0002-3401-1133
0000-0003-1537-3427
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.5217/ir.2023.00115
PMID 38295766
PQID 2926076735
PQPubID 23479
PageCount 21
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_10737198
doaj_primary_oai_doaj_org_article_7ec33946eb22483c8ba0cf3ee2c6bbb6
pubmedcentral_primary_oai_pubmedcentral_nih_gov_11079515
proquest_miscellaneous_2926076735
pubmed_primary_38295766
crossref_primary_10_5217_ir_2023_00115
crossref_citationtrail_10_5217_ir_2023_00115
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-04-01
PublicationDateYYYYMMDD 2024-04-01
PublicationDate_xml – month: 04
  year: 2024
  text: 2024-04-01
  day: 01
PublicationDecade 2020
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Intestinal research
PublicationTitleAlternate Intest Res
PublicationYear 2024
Publisher Korean Association for the Study of Intestinal Diseases
대한장연구학회
Publisher_xml – name: Korean Association for the Study of Intestinal Diseases
– name: 대한장연구학회
References ref57
ref56
Tao (ref155) 2015
ref58
ref53
ref52
ref55
ref168
ref54
Ahmed (ref137) 2009
Liu (ref122) 2018
ref51
ref50
ref46
ref45
ref48
ref47
ref42
ref41
ref44
ref43
ref49
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref100
ref101
ref40
ref35
ref37
ref36
ref31
ref148
ref30
ref149
ref33
ref146
ref32
ref147
ref39
ref38
Ren (ref167) 2015
ref156
ref154
ref151
ref152
ref150
ref24
ref23
ref26
ref25
ref20
ref159
ref22
ref157
ref21
ref158
Nagasaka (ref59) 2003
ref28
ref27
ref29
ref166
ref164
ref165
Zhao (ref153) 2015
ref162
Zheng (ref163) 2014
ref161
ref13
ref12
ref15
ref128
ref14
ref129
ref97
ref126
ref96
ref127
ref11
ref99
ref124
ref10
ref98
ref125
ref17
ref16
Chang (ref80) 2010
ref19
ref18
ref93
ref133
ref92
ref134
ref95
ref131
ref94
ref132
ref130
ref91
ref90
ref89
ref139
ref86
ref85
ref138
ref88
ref135
ref87
ref136
Zou (ref34) 2002
ref82
ref144
ref81
ref145
ref84
ref142
ref83
ref143
ref140
ref141
ref79
ref108
ref78
ref109
ref106
ref107
ref75
ref104
ref74
ref77
ref102
ref76
ref103
ref2
ref1
Liu (ref65) 2016
ref71
ref111
ref70
ref112
ref73
ref72
ref110
ref68
ref119
ref67
ref117
ref69
ref118
ref64
ref115
ref63
ref116
ref66
ref113
ref114
Michael (ref105) 2003
ref60
ref123
Shi (ref160) 2015
ref62
ref120
ref61
ref121
References_xml – ident: ref29
  doi: 10.1002/cam4.2475
– ident: ref151
  doi: 10.1186/1471-2407-13-196
– ident: ref131
  doi: 10.1016/j.lfs.2020.118226
– ident: ref63
  doi: 10.21873/anticanres.11341
– ident: ref78
  doi: 10.3748/wjg.v13.i10.1528
– ident: ref147
  doi: 10.3390/ijms232113431
– ident: ref43
  doi: 10.1016/s0304-3835(01)00839-4
– ident: ref79
  doi: 10.1158/1078-0432.1203.11.3
– ident: ref120
  doi: 10.1016/j.prp.2020.153130
– start-page: 2258
  volume-title: Circulating lncRNAs associated with occurrence of colorectal cancer progression
  year: 2015
  ident: ref160
– ident: ref128
  doi: 10.1038/s41571-018-0036-9
– ident: ref99
  doi: 10.1111/cas.12166
– ident: ref165
  doi: 10.1515/med-2020-0012
– ident: ref11
  doi: 10.1101/gad.12.5.599
– ident: ref82
  doi: 10.1373/clinchem.2008.122937
– ident: ref86
  doi: 10.1158/1940-6207.capr-12-0501
– ident: ref156
  doi: 10.1136/gutjnl-2019-318903
– ident: ref50
  doi: 10.1371/journal.pone.0045357
– ident: ref67
  doi: 10.1093/jnci/djt322
– ident: ref108
  doi: 10.1001/jama.299.4.425
– ident: ref123
  doi: 10.1038/s41598-023-31449-3
– ident: ref26
  doi: 10.1002/ijc.26484
– ident: ref87
  doi: 10.3748/wjg.v20.i20.6329
– ident: ref28
  doi: 10.1371/journal.pone.0180809
– ident: ref5
  doi: 10.1002/ijc.23470
– ident: ref31
  doi: 10.1186/s12885-015-1674-2
– ident: ref141
  doi: 10.3233/cbm-150563
– ident: ref9
  doi: 10.1053/j.gastro.2008.07.078
– ident: ref10
  doi: 10.1016/j.biocel.2012.05.002
– ident: ref95
  doi: 10.3390/ijms161226180
– ident: ref134
  doi: 10.3390/ijms241310622
– ident: ref52
  doi: 10.1002/cncr.25737
– ident: ref7
  doi: 10.1016/j.jmoldx.2016.02.005
– ident: ref145
  doi: 10.1158/1055-9965.epi-13-0512
– ident: ref4
  doi: 10.1038/79120
– ident: ref150
  doi: 10.1093/carcin/bgu055
– ident: ref39
  doi: 10.1373/clinchem.2007.095992
– ident: ref98
  doi: 10.1186/1471-2407-14-531
– start-page: 14131
  volume-title: Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma
  year: 2015
  ident: ref153
– ident: ref121
  doi: 10.1038/s41575-019-0230-y
– ident: ref90
  doi: 10.1016/j.cell.2007.11.005
– ident: ref102
  doi: 10.1111/his.12534
– ident: ref101
  doi: 10.1371/journal.pone.0108265
– ident: ref21
  doi: 10.1371/journal.pone.0003759
– ident: ref36
  doi: 10.1111/j.1572-0241.2005.50412.x
– start-page: 11458
  volume-title: Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer
  year: 2015
  ident: ref167
– ident: ref149
  doi: 10.1158/0008-5472.can-11-1021
– ident: ref33
  doi: 10.1053/j.gastro.2006.08.034
– ident: ref6
  doi: 10.1038/s41598-017-03321-8
– ident: ref83
  doi: 10.3748/wjg.v13.i6.950
– ident: ref91
  doi: 10.1016/j.humpath.2011.07.009
– ident: ref142
  doi: 10.1016/j.cgh.2020.02.043
– ident: ref3
  doi: 10.1093/jnci/dju195
– ident: ref162
  doi: 10.1038/sj.onc.1206928
– ident: ref20
  doi: 10.1371/journal.pone.0009061
– ident: ref8
  doi: 10.1038/nrc2876
– ident: ref113
  doi: 10.1038/cdd.2013.125
– ident: ref72
  doi: 10.1093/jnci/djp131
– ident: ref19
  doi: 10.2217/epi-2016-0146
– ident: ref148
  doi: 10.1186/s12935-023-02867-0
– ident: ref47
  doi: 10.1007/s00432-009-0688-z
– ident: ref109
  doi: 10.1093/jnci/djt101
– ident: ref60
  doi: 10.1158/1078-0432.ccr-12-3518
– ident: ref30
  doi: 10.1155/2019/5232780
– ident: ref74
  doi: 10.2147/cmar.s300861
– ident: ref22
  doi: 10.25011/cim.v34i1.15105
– ident: ref136
  doi: 10.1007/s00535-011-0456-0
– ident: ref48
  doi: 10.1158/1078-0432.ccr-07-1011
– ident: ref55
  doi: 10.1186/1471-2407-14-245
– ident: ref71
  doi: 10.1371/currents.rrn1220
– ident: ref89
  doi: 10.2217/epi.15.39
– ident: ref126
  doi: 10.3389/fmed.2022.915226
– ident: ref127
  doi: 10.1053/j.gastro.2022.06.089
– ident: ref73
  doi: 10.1056/nejmoa1311194
– ident: ref96
  doi: 10.3892/or.2011.1547
– ident: ref103
  doi: 10.1016/s0092-8674(04)00045-5
– ident: ref143
  doi: 10.3390/cancers14010065
– ident: ref146
  doi: 10.1016/j.canlet.2021.01.009
– ident: ref161
  doi: 10.1002/jcla.23601
– ident: ref75
  doi: 10.5217/ir.2017.15.4.495
– ident: ref154
  doi: 10.1016/j.clinbiochem.2022.01.003
– start-page: 882
  volume-title: Reduced accumulation of specific microRNAs in colorectal neoplasia
  year: 2003
  ident: ref105
– ident: ref114
  doi: 10.1136/gut.2008.167817
– ident: ref53
  doi: 10.1245/s10434-012-2410-7
– ident: ref56
  doi: 10.1002/ijc.27505
– ident: ref15
  doi: 10.1038/nrg3173
– ident: ref93
  doi: 10.1007/s10620-008-0601-7
– ident: ref35
  doi: 10.1158/1078-0432.ccr-06-1264
– ident: ref164
  doi: 10.1089/gtmb.2018.0308
– ident: ref112
  doi: 10.3390/ijms241311023
– start-page: 281
  volume-title: Diagnostic microRNA markers for screening sporadic human colon cancer and active ulcerative colitis in stool and tissue
  year: 2009
  ident: ref137
– ident: ref119
  doi: 10.1038/bjc.2017.12
– ident: ref168
  doi: 10.1186/s12943-019-1014-2
– ident: ref32
  doi: 10.1186/s13148-019-0757-3
– ident: ref130
  doi: 10.1371/journal.pone.0092921
– ident: ref77
  doi: 10.1371/journal.pone.0099233
– ident: ref140
  doi: 10.1053/j.gastro.2019.10.005
– ident: ref158
  doi: 10.1038/ncomms13875
– ident: ref37
  doi: 10.1016/s0016-5085(01)81443-8
– ident: ref13
  doi: 10.1177/1756283x16671287
– ident: ref44
  doi: 10.1002/ijc.11117
– ident: ref45
  doi: 10.1002/ijc.10526
– ident: ref107
  doi: 10.1093/nar/gkr254
– start-page: 1185
  volume-title: Serum microRNA signatures and metabolomics have high diagnostic value in colorectal cancer using two novel methods
  year: 2018
  ident: ref122
– ident: ref135
  doi: 10.1136/gut.2011.239236
– ident: ref157
  doi: 10.1158/0008-5472.can-18-3880
– ident: ref70
  doi: 10.1158/1055-9965.epi-07-0518
– ident: ref94
  doi: 10.1007/s13277-012-0554-5
– ident: ref115
  doi: 10.1002/ijc.25007
– ident: ref64
  doi: 10.1016/j.molonc.2014.01.011
– ident: ref57
  doi: 10.1002/ijc.30625
– ident: ref18
  doi: 10.1155/2018/6437104
– ident: ref97
  doi: 10.1016/j.ejso.2013.02.023
– ident: ref46
  doi: 10.1371/journal.pone.0066587
– ident: ref124
  doi: 10.1007/s13277-015-3967-0
– ident: ref81
  doi: 10.1158/1078-0432.ccr-09-0055
– ident: ref92
  doi: 10.1186/1559-0275-11-24
– ident: ref166
  doi: 10.1016/j.ebiom.2016.10.026
– ident: ref159
  doi: 10.1186/s13045-018-0656-7
– ident: ref51
  doi: 10.1093/jnci/djn359
– ident: ref61
  doi: 10.1158/1078-0432.ccr-12-3734
– start-page: 3174
  volume-title: High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer
  year: 2014
  ident: ref163
– ident: ref106
  doi: 10.1158/1055-9965.epi-11-0035
– ident: ref27
  doi: 10.1016/j.cancergencyto.2010.05.018
– ident: ref62
  doi: 10.1080/2162402x.2016.1257454
– ident: ref84
  doi: 10.1158/1940-6207.capr-11-0315
– ident: ref24
  doi: 10.1016/j.jmoldx.2013.03.004
– ident: ref17
  doi: 10.1177/1533033818791794
– ident: ref144
  doi: 10.1053/j.gastro.2023.05.037
– ident: ref117
  doi: 10.2217/epi-2021-0277
– ident: ref16
  doi: 10.1038/nrg3074
– ident: ref54
  doi: 10.1111/j.1349-7006.2010.01776.x
– ident: ref76
  doi: 10.3892/ol.2014.2413
– ident: ref88
  doi: 10.1038/nrg2540
– start-page: 5306
  volume-title: Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases
  year: 2003
  ident: ref59
– ident: ref42
  doi: 10.1200/jco.2001.19.2.299
– ident: ref23
  doi: 10.1080/15592294.2017.1356957
– ident: ref139
  doi: 10.1159/000500639
– ident: ref133
  doi: 10.1016/j.molonc.2013.09.001
– ident: ref14
  doi: 10.1158/0008-5472.can-13-1400
– ident: ref66
  doi: 10.1007/s00432-014-1766-4
– ident: ref58
  doi: 10.1158/1078-0432.ccr-10-2509
– ident: ref138
  doi: 10.1158/1940-6207.capr-10-0036
– ident: ref118
  doi: 10.3390/cancers11081111
– start-page: 2098
  volume-title: Methylation of serum SST gene is an independent prognostic marker in colorectal cancer
  year: 2016
  ident: ref65
– ident: ref12
  doi: 10.1101/cshperspect.a019521
– ident: ref129
  doi: 10.3390/cells12071081
– ident: ref40
  doi: 10.1038/nbt.1559
– ident: ref116
  doi: 10.1371/journal.pone.0088745
– ident: ref38
  doi: 10.1038/ajg.2011.6
– ident: ref111
  doi: 10.1186/s40364-021-00272-1
– ident: ref152
  doi: 10.1093/annonc/mdx248
– ident: ref1
  doi: 10.1053/j.gastro.2015.07.011
– ident: ref2
  doi: 10.1371/journal.pone.0000399
– ident: ref49
  doi: 10.1245/s10434-009-0901-y
– ident: ref69
  doi: 10.1093/jnci/dji204
– start-page: 188
  volume-title: Detection of aberrant p16 methylation in the serum of colorectal cancer patients
  year: 2002
  ident: ref34
– ident: ref132
  doi: 10.1155/2009/921907
– start-page: 720
  volume-title: Detection of colorectal neoplasm using promoter methylation of ITGA4, SFRP2, and p16 in stool samples: a preliminary report in Korean patients
  year: 2010
  ident: ref80
– ident: ref100
  doi: 10.1016/j.trsl.2014.11.001
– ident: ref25
  doi: 10.1158/1078-0432.ccr-09-0111
– ident: ref104
  doi: 10.1038/nrc1840
– ident: ref41
  doi: 10.3892/ol.2014.2815
– ident: ref85
  doi: 10.1093/jnci/djp265
– ident: ref110
  doi: 10.1080/07853890.2020.1828617
– ident: ref68
  doi: 10.1007/dcr.0b013e3181a79533
– ident: ref125
  doi: 10.1186/s12885-015-1123-2
– start-page: 21854
  volume-title: Clinical significance of urothelial carcinoma associated 1 in colon cancer
  year: 2015
  ident: ref155
SSID ssib044741933
ssj0000607986
Score 2.308158
SecondaryResourceType review_article
Snippet Colorectal cancer (CRC) ranks third in cancer incidence and stands as the second leading cause of cancer-related deaths globally. CRC tumorigenesis results...
SourceID nrf
doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 131
SubjectTerms biomarkers
colorectal neoplasms
diagnosis
epigenetic
prognosis
Review
내과학
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQiNfyqIxAnIjq-O1jQVQtEogDlXqz_EqJipIquz3w75lx0tUuAnHhEEVK7NjzsGdGnnxDyJvEREwxpUZDi0a6rBprc2y6nITqXMhtLZ3w-Ys-PZefLtTFTqkvzAmb4YFnxh2ZkoRwEj4FxsaKZGNgqROl8KRjjBVsmzm2E0yBJkkJhtItjsy8JzPjatlHMN-4whmbATfBepmjHoFBuainEmrPQFUcfzA7w9T9yQX9PZNyxzSd3Cf3Fp-SHs-0PCB3yvCQnH0F3268xK2sX9MwZIp_2mMyzrSmY0cRrRp3O-iYUPITjT9puUZwTvyvkdZj9Cq2R-T85OO3D6fNUjehSdK6TaM1kGqVdoW72KrEnW0DNw6uDJFwKLlTOWSXDDgXBSI8Fk1OUhluA4Me4jE5GMahPCU0SBeBuiS1BKY6EKPhXVuUFrl1WbAVeXfLLJ8WUHGsbfHDQ3CBvPX95JG3NXdOrcjbbfPrGU3jbw3fI-e3jRAEuz4A1fCLavh_qcaKvAa5-avU1_54vxz91eQhVDiDcY0wrbMr8upWrh6WFp6XhKGMN2vPHQR7RhsB03kyy3k7IWG5g1ANxrB7GrA34_03Q_-9wndjxA1-rXr2P2h8Tu4C15ZcohfkYDPdlJfgJm3iYV0RvwAL5Q40
  priority: 102
  providerName: Directory of Open Access Journals
Title Pathogenesis and biomarkers of colorectal cancer by epigenetic alteration
URI https://www.ncbi.nlm.nih.gov/pubmed/38295766
https://www.proquest.com/docview/2926076735
https://pubmed.ncbi.nlm.nih.gov/PMC11079515
https://doaj.org/article/7ec33946eb22483c8ba0cf3ee2c6bbb6
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003074747
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Intestinal research, 2024, 22(2), , pp.131-151
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEF5BuXBBIF4ppVoE4oSL7X2fEKBWLRKIA5F6W-3LwWplFyeV6KW_nZm1mxIoEockirMbr2dmd77xjr8h5FUomQ8-hEJCi4KbKAqtoy-aGJhojItVLp3w-Ys8nPNPx-L4mlJoEuDyxtAO60nNh9O9nz8u3sGEB_y6B85HvW2R17NmeVNB3CZ38lYRZvFdI33OwXOaCdmMi3SpTK4DCf4cp3xZjgycf__jhsfKxP7gh7qhuQmT_pla-ZuvOrhP7k0gk74freIBuZW6h-ToK4C9foFrW7ukrosUH73H7JxhSfuGIn01Ln_QMaApDNRf0HSGbJ34oCPN--pZj4_I_GD_28fDYiqkUASuzaqQEi5VC2lSbXwlQm105Wpl4BUhNHYpNiK6aIICtJEg5Cu9ioELVWtXQg_2mGx1fZeeEuq48XB1gUsOQjWgV1U3VRKSxcpEVs7Imyth2TCxjGOxi1ML0QbK1raDRdnmZDoxI6_Xzc9Geo1_NfyAkl83QlbsfKAfFnaaZFalwJjhYHYATDQL2rsyNCylOkjvvZyRl6A3exLa3B8_F709GSzEDkdwXsVUZfSMvLjSq4W5hhsorkv9-dLWBqI_JRWD4TwZ9bweENO1gdgNzqE3LGBjxJu_dO33zOeNITgAXbH9v8J4Ru7ClymBaIdsrYbz9Byw0crv5nsKu9n28f1y_xeAQAu5
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pathogenesis+and+biomarkers+of+colorectal+cancer+by+epigenetic+alteration&rft.jtitle=Intestinal+research&rft.au=Oh%2C+Chang+Kyo&rft.au=Cho%2C+Young-Seok&rft.date=2024-04-01&rft.issn=1598-9100&rft.volume=22&rft.issue=2&rft.spage=131&rft_id=info:doi/10.5217%2Fir.2023.00115&rft_id=info%3Apmid%2F38295766&rft.externalDocID=38295766
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1598-9100&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1598-9100&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1598-9100&client=summon