Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
The cannabinoid CB 2 receptor (CB 2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB 2 R, their selectivity, molecular mode of action and pharmacokinetic properties...
Saved in:
| Published in | Nature communications Vol. 8; no. 1; pp. 13958 - 14 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
03.01.2017
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/ncomms13958 |
Cover
| Abstract | The cannabinoid CB
2
receptor (CB
2
R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB
2
R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB
2
R ligands to date. In a collaborative effort between multiple academic and industry laboratories, we identify marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects. We reach a consensus that HU910, HU308 and JWH133 are the recommended selective CB
2
R agonists to study the role of CB
2
R in biological and disease processes. We believe that our unique approach would be highly suitable for the characterization of other therapeutic targets in drug discovery research.
CB
2
receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB
2
receptor agonists and antagonists, recommending three that appear most suitable for
in vitro
and
in vivo
studies. |
|---|---|
| AbstractList | The cannabinoid CB2 receptor (CB2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2 R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB2 R ligands to date. In a collaborative effort between multiple academic and industry laboratories, we identify marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects. We reach a consensus that HU910, HU308 and JWH133 are the recommended selective CB2 R agonists to study the role of CB2 R in biological and disease processes. We believe that our unique approach would be highly suitable for the characterization of other therapeutic targets in drug discovery research. The cannabinoid CB 2 receptor (CB 2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB 2 R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB 2 R ligands to date. In a collaborative effort between multiple academic and industry laboratories, we identify marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects. We reach a consensus that HU910, HU308 and JWH133 are the recommended selective CB 2 R agonists to study the role of CB 2 R in biological and disease processes. We believe that our unique approach would be highly suitable for the characterization of other therapeutic targets in drug discovery research. The cannabinoid CB 2 receptor (CB 2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB 2 R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB 2 R ligands to date. In a collaborative effort between multiple academic and industry laboratories, we identify marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects. We reach a consensus that HU910, HU308 and JWH133 are the recommended selective CB 2 R agonists to study the role of CB 2 R in biological and disease processes. We believe that our unique approach would be highly suitable for the characterization of other therapeutic targets in drug discovery research. CB 2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB 2 receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivo studies. CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivostudies. The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to date. In a collaborative effort between multiple academic and industry laboratories, we identify marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects. We reach a consensus that HU910, HU308 and JWH133 are the recommended selective CB2R agonists to study the role of CB2R in biological and disease processes. We believe that our unique approach would be highly suitable for the characterization of other therapeutic targets in drug discovery research.The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have been poorly characterized. Here we report the most extensive characterization of the molecular pharmacology of the most widely used CB2R ligands to date. In a collaborative effort between multiple academic and industry laboratories, we identify marked differences in the ability of certain agonists to activate distinct signalling pathways and to cause off-target effects. We reach a consensus that HU910, HU308 and JWH133 are the recommended selective CB2R agonists to study the role of CB2R in biological and disease processes. We believe that our unique approach would be highly suitable for the characterization of other therapeutic targets in drug discovery research. |
| ArticleNumber | 13958 |
| Author | de Petrocellis, Luciano Finlay, David Mock, Elliot D. van der Stelt, Mario Stuart, Jordyn de Vries, Henk Fezza, Filomena Soethoudt, Marjolein Gertsch, Jürg Pacher, Pal Connor, Mark Grether, Uwe van Gils, Noortje Glass, Michelle Lichtman, Aron H. Gens, Marianela Dalghi Mastrangelo, Nicolina Baggelaar, Marc P. Di Marzo, Vincenzo Fingerle, Jürgen Chicca, Andrea Alachouzos, Georgios Ullmer, Christoph Xia, Lizi MacDonald, Christa Heitman, Laura H. Maccarrone, Mauro Rothenhäusler, Benno Martella, Andrea Perret, Camille Grim, Travis W. Deng, Hui |
| Author_xml | – sequence: 1 givenname: Marjolein surname: Soethoudt fullname: Soethoudt, Marjolein organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University – sequence: 2 givenname: Uwe surname: Grether fullname: Grether, Uwe organization: Roche Innovation Center Basel, F. Hoffman-La Roche Ltd – sequence: 3 givenname: Jürgen surname: Fingerle fullname: Fingerle, Jürgen organization: Department of Biochemistry, NMI, University Tübingen – sequence: 4 givenname: Travis W. surname: Grim fullname: Grim, Travis W. organization: Department of Pharmacology and Toxicology – sequence: 5 givenname: Filomena surname: Fezza fullname: Fezza, Filomena organization: Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, European Center for Brain Research/IRCCS Santa Lucia Foundation – sequence: 6 givenname: Luciano surname: de Petrocellis fullname: de Petrocellis, Luciano organization: Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R – sequence: 7 givenname: Christoph surname: Ullmer fullname: Ullmer, Christoph organization: Roche Innovation Center Basel, F. Hoffman-La Roche Ltd – sequence: 8 givenname: Benno surname: Rothenhäusler fullname: Rothenhäusler, Benno organization: Roche Innovation Center Basel, F. Hoffman-La Roche Ltd – sequence: 9 givenname: Camille surname: Perret fullname: Perret, Camille organization: Roche Innovation Center Basel, F. Hoffman-La Roche Ltd – sequence: 10 givenname: Noortje surname: van Gils fullname: van Gils, Noortje organization: Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University – sequence: 11 givenname: David surname: Finlay fullname: Finlay, David organization: Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland – sequence: 12 givenname: Christa surname: MacDonald fullname: MacDonald, Christa organization: Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland – sequence: 13 givenname: Andrea surname: Chicca fullname: Chicca, Andrea organization: Institute of Biochemistry and Molecular Medicine, University of Bern – sequence: 14 givenname: Marianela Dalghi surname: Gens fullname: Gens, Marianela Dalghi organization: Institute of Biochemistry and Molecular Medicine, University of Bern – sequence: 15 givenname: Jordyn surname: Stuart fullname: Stuart, Jordyn organization: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde – sequence: 16 givenname: Henk surname: de Vries fullname: de Vries, Henk organization: Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University – sequence: 17 givenname: Nicolina surname: Mastrangelo fullname: Mastrangelo, Nicolina organization: Department of Medicine, Campus Bio-Medico University of Rome – sequence: 18 givenname: Lizi surname: Xia fullname: Xia, Lizi organization: Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University – sequence: 19 givenname: Georgios surname: Alachouzos fullname: Alachouzos, Georgios organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University – sequence: 20 givenname: Marc P. surname: Baggelaar fullname: Baggelaar, Marc P. organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University – sequence: 21 givenname: Andrea surname: Martella fullname: Martella, Andrea organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University – sequence: 22 givenname: Elliot D. surname: Mock fullname: Mock, Elliot D. organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University – sequence: 23 givenname: Hui surname: Deng fullname: Deng, Hui organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University – sequence: 24 givenname: Laura H. surname: Heitman fullname: Heitman, Laura H. organization: Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University – sequence: 25 givenname: Mark orcidid: 0000-0003-2538-2001 surname: Connor fullname: Connor, Mark organization: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde – sequence: 26 givenname: Vincenzo surname: Di Marzo fullname: Di Marzo, Vincenzo organization: Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R – sequence: 27 givenname: Jürg surname: Gertsch fullname: Gertsch, Jürg organization: Institute of Biochemistry and Molecular Medicine, University of Bern – sequence: 28 givenname: Aron H. surname: Lichtman fullname: Lichtman, Aron H. organization: Department of Pharmacology and Toxicology – sequence: 29 givenname: Mauro orcidid: 0000-0002-3990-2963 surname: Maccarrone fullname: Maccarrone, Mauro organization: European Center for Brain Research/IRCCS Santa Lucia Foundation, Department of Medicine, Campus Bio-Medico University of Rome – sequence: 30 givenname: Pal surname: Pacher fullname: Pacher, Pal email: pacher@mail.nih.gov organization: Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute of Health/NIAAA – sequence: 31 givenname: Michelle surname: Glass fullname: Glass, Michelle email: m.glass@auckland.ac.nz organization: Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland – sequence: 32 givenname: Mario surname: van der Stelt fullname: van der Stelt, Mario email: m.van.der.stelt@chem.leidenuniv.nl organization: Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University |
| BookMark | eNptkktrGzEUhUVJaRI3q_6BgW4KzbR6jqVNITV9BALdtKsuxB3NnanMjORKsiH_vmM7BSfkbiR0vnOuJO4lOQsxICFvGP3AqNAfg4vTlJkwSr8gF5xKVrMlF2cn-3NylfOaziUM01K-IudcU6koZxfk9wpCgNaH6Ltq9ZlXCR1uSkzV6AcIXbVJsfejD8Os7BDGXLUeMnZV9kOA8aDsudj3dYE0YKnAFb_z5f41ednPBrx6WBfk19cvP1ff67sf325XN3e1k9qUmnFFKTdiKbARBlBKkLIzVPVaA-XItcJeQyN007UGe-Wg4UYaqZfAZUPFgtwec7sIa7tJfoJ0byN4eziIabCQincj2k73rZQaWifnQgGMUm163YoGGZv7L8inY9Zm207YOQwlwfgo9LES_B87xJ1VnDVU7QPePQSk-HeLudjJZ4fjCAHjNlumlaJNI6ic0bdP0HXcpvlTD5Rc6qVSeqbYkXIp5pywt84XKD7u-_vRMmr3k2BPJmH2vH_i-f-A5-nrI51nKgyYTu7xDP4Pmk7FCA |
| CitedBy_id | crossref_primary_10_1002_ejoc_201800064 crossref_primary_10_1089_ars_2017_7144 crossref_primary_10_1007_s43440_021_00270_y crossref_primary_10_1016_j_brainres_2020_147135 crossref_primary_10_1016_j_ejmech_2017_11_076 crossref_primary_10_1007_s11357_022_00565_9 crossref_primary_10_1021_acsptsci_9b00049 crossref_primary_10_1038_npp_2017_130 crossref_primary_10_1111_epi_16388 crossref_primary_10_3390_molecules24183338 crossref_primary_10_1042_CS20231156 crossref_primary_10_7554_eLife_55582 crossref_primary_10_15789_1563_0625_SSP_1862 crossref_primary_10_1590_1982_0224_2024_0065 crossref_primary_10_1007_s13337_024_00871_0 crossref_primary_10_1016_j_brainresbull_2017_11_017 crossref_primary_10_1371_journal_pone_0233020 crossref_primary_10_4199_C00151ED1V01Y201702ISP074 crossref_primary_10_3389_fnins_2022_925792 crossref_primary_10_3389_fphar_2019_00350 crossref_primary_10_1038_s41467_022_31357_6 crossref_primary_10_1002_chem_201904584 crossref_primary_10_1124_jpet_117_245522 crossref_primary_10_1038_s42003_023_04868_1 crossref_primary_10_1089_can_2021_0127 crossref_primary_10_3390_ph11020055 crossref_primary_10_36290_far_2024_024 crossref_primary_10_1042_NS20170144 crossref_primary_10_3390_ijms24108508 crossref_primary_10_1002_hep_30916 crossref_primary_10_3389_fnmol_2023_1152167 crossref_primary_10_3390_ijms242316728 crossref_primary_10_1016_j_plipres_2022_101194 crossref_primary_10_1016_j_neubiorev_2022_104860 crossref_primary_10_1038_s41598_021_03896_3 crossref_primary_10_1002_cmdc_201700306 crossref_primary_10_1111_bph_16095 crossref_primary_10_1111_ejn_14330 crossref_primary_10_1021_jacs_0c08926 crossref_primary_10_1016_j_ejmech_2018_09_070 crossref_primary_10_15252_embj_201798697 crossref_primary_10_1016_j_yexcr_2020_111881 crossref_primary_10_1002_bab_1568 crossref_primary_10_1016_j_nbd_2022_105670 crossref_primary_10_1080_13543776_2024_2368745 crossref_primary_10_3390_ijms24032348 crossref_primary_10_1111_andr_12928 crossref_primary_10_1002_glia_24280 crossref_primary_10_1002_glia_24281 crossref_primary_10_1038_s41582_019_0284_z crossref_primary_10_1111_dth_15162 crossref_primary_10_1016_j_biopsych_2022_05_012 crossref_primary_10_14814_phy2_15947 crossref_primary_10_1055_s_0042_1751361 crossref_primary_10_1111_bph_14815 crossref_primary_10_1002_hsr2_1908 crossref_primary_10_1016_j_freeradbiomed_2019_11_027 crossref_primary_10_1080_14728222_2021_1971196 crossref_primary_10_1021_acs_jmedchem_0c00522 crossref_primary_10_3390_ijms21217880 crossref_primary_10_3390_molecules26082126 crossref_primary_10_3390_ijms241914874 crossref_primary_10_3389_fphar_2024_1426446 crossref_primary_10_1002_chem_201805004 crossref_primary_10_1007_s12035_022_02884_6 crossref_primary_10_1021_acs_jcim_2c01503 crossref_primary_10_3389_fnmol_2018_00487 crossref_primary_10_3390_ijms23115908 crossref_primary_10_1089_can_2019_0016 crossref_primary_10_2147_JPR_S351513 crossref_primary_10_1038_s41386_020_0696_x crossref_primary_10_1089_can_2018_0003 crossref_primary_10_1089_can_2022_0133 crossref_primary_10_1021_acs_jmedchem_2c01485 crossref_primary_10_1091_mbc_e17_03_0198 crossref_primary_10_1097_MAO_0000000000003280 crossref_primary_10_1016_j_tips_2022_06_010 crossref_primary_10_3389_fimmu_2019_01027 crossref_primary_10_1016_j_neuroscience_2022_04_011 crossref_primary_10_29328_journal_jnnd_1001049 crossref_primary_10_1523_JNEUROSCI_2256_23_2024 crossref_primary_10_1089_can_2021_0044 crossref_primary_10_3390_cancers13081934 crossref_primary_10_1016_j_ejmech_2024_116298 crossref_primary_10_3389_fphar_2023_1235255 crossref_primary_10_1111_bph_17301 crossref_primary_10_1016_j_bioorg_2023_106377 crossref_primary_10_1016_j_phrs_2021_105729 crossref_primary_10_3389_fphar_2022_826400 crossref_primary_10_3390_molecules24050918 crossref_primary_10_1021_acsptsci_2c00069 crossref_primary_10_1016_j_fct_2023_113799 crossref_primary_10_1021_jacs_7b06456 crossref_primary_10_1515_hmbci_2018_0013 crossref_primary_10_3389_fphar_2022_858215 crossref_primary_10_1002_prp2_1157 crossref_primary_10_1016_j_ejmech_2022_114750 crossref_primary_10_1038_nrcardio_2017_130 crossref_primary_10_1038_s41598_019_53579_3 crossref_primary_10_1097_FBP_0000000000000580 crossref_primary_10_1016_j_lfs_2021_120018 crossref_primary_10_1080_17460441_2020_1752178 crossref_primary_10_1016_j_bcp_2018_03_018 crossref_primary_10_1016_j_ejphar_2021_174398 crossref_primary_10_3390_ijms24087601 crossref_primary_10_3390_ijms22094954 crossref_primary_10_3389_fpls_2018_00537 crossref_primary_10_1016_j_bcp_2019_05_022 crossref_primary_10_1016_j_ejmech_2024_116845 crossref_primary_10_1016_j_ejphar_2023_176092 crossref_primary_10_3389_fphar_2022_1039564 crossref_primary_10_1038_s41467_019_13817_8 crossref_primary_10_1080_10799893_2024_2431986 crossref_primary_10_1038_cddis_2017_496 crossref_primary_10_1038_s41598_018_32906_0 crossref_primary_10_1021_acs_joc_0c02698 crossref_primary_10_1038_s41589_020_0528_7 crossref_primary_10_1021_acsptsci_4c00269 crossref_primary_10_1021_jacs_0c05587 crossref_primary_10_1016_j_drudis_2018_01_029 crossref_primary_10_1002_cmdc_202000298 crossref_primary_10_3390_cells13231943 crossref_primary_10_1007_s11892_018_0975_7 crossref_primary_10_1124_pr_118_016790 crossref_primary_10_1016_j_neuropharm_2024_110257 crossref_primary_10_1089_dna_2019_5024 crossref_primary_10_1002_ange_202306176 crossref_primary_10_1016_j_jnutbio_2017_09_019 crossref_primary_10_1152_physiolgenomics_00001_2019 crossref_primary_10_1016_j_jbc_2024_107330 crossref_primary_10_1016_j_neuropharm_2021_108448 crossref_primary_10_1021_acsptsci_4c00014 crossref_primary_10_1182_blood_2020004871 crossref_primary_10_1016_j_bcp_2018_08_046 crossref_primary_10_1124_mol_117_108605 crossref_primary_10_3389_fcimb_2020_588195 crossref_primary_10_1007_s11033_021_06366_1 crossref_primary_10_1021_acsptsci_0c00214 crossref_primary_10_1016_j_isci_2020_101301 crossref_primary_10_1097_j_pain_0000000000002314 crossref_primary_10_1016_j_ejcb_2023_151324 crossref_primary_10_1089_neu_2018_6063 crossref_primary_10_1159_000540751 crossref_primary_10_1002_ardp_202200493 crossref_primary_10_1186_s12950_018_0201_z crossref_primary_10_1038_s41598_023_37702_z crossref_primary_10_12998_wjcc_v11_i12_2670 crossref_primary_10_3389_fphar_2021_702675 crossref_primary_10_1016_j_bbi_2025_03_008 crossref_primary_10_1038_s41467_024_55808_4 crossref_primary_10_1016_j_tips_2020_06_010 crossref_primary_10_1039_C9MD00173E crossref_primary_10_1021_acs_jmedchem_0c00778 crossref_primary_10_1016_j_pnpbp_2020_110054 crossref_primary_10_1021_jacs_7b11281 crossref_primary_10_1016_j_lfs_2021_119407 crossref_primary_10_1016_j_chembiol_2020_10_006 crossref_primary_10_1097_FJC_0000000000000613 crossref_primary_10_1177_2472555217748403 crossref_primary_10_1002_cbic_202300785 crossref_primary_10_1021_acs_jmedchem_3c02423 crossref_primary_10_3389_fneur_2020_00087 crossref_primary_10_1016_j_aca_2022_340012 crossref_primary_10_1016_j_cellsig_2020_109865 crossref_primary_10_1016_j_ejmech_2023_115647 crossref_primary_10_2174_0929867329666220825161603 crossref_primary_10_1016_j_compbiolchem_2022_107723 crossref_primary_10_1007_s10571_019_00719_y crossref_primary_10_1016_j_molmed_2019_11_002 crossref_primary_10_1002_cmdc_202400098 crossref_primary_10_3389_fphar_2019_00418 crossref_primary_10_3390_v13071242 crossref_primary_10_3390_ijms231911447 crossref_primary_10_1093_ecco_jcc_jjx096 crossref_primary_10_1093_ecco_jcc_jjy185 crossref_primary_10_2174_0929867327666200303122734 crossref_primary_10_1038_s41467_023_37112_9 crossref_primary_10_1039_D1SC06659E crossref_primary_10_1016_j_bcp_2018_07_031 crossref_primary_10_1021_acs_biochem_0c00263 crossref_primary_10_1089_can_2016_0037 crossref_primary_10_1016_j_biopha_2021_111283 crossref_primary_10_1186_s41181_024_00319_2 crossref_primary_10_3389_fmolb_2022_841190 crossref_primary_10_1002_1873_3468_12863 crossref_primary_10_3389_fimmu_2017_01487 crossref_primary_10_1002_pmic_201900372 crossref_primary_10_1002_anie_202306176 crossref_primary_10_3390_ijms21249763 crossref_primary_10_1002_glia_23911 crossref_primary_10_1021_jacs_2c13629 crossref_primary_10_3390_ijms242417516 crossref_primary_10_1016_j_biopha_2017_09_085 crossref_primary_10_1016_j_ejphar_2021_174301 crossref_primary_10_1002_jnr_24933 crossref_primary_10_1016_j_bcp_2018_07_041 crossref_primary_10_4155_ppa_2021_0002 crossref_primary_10_17816_RCF623144 crossref_primary_10_1172_JCI175205 crossref_primary_10_1021_acsmedchemlett_7b00129 crossref_primary_10_3390_ijms24044060 crossref_primary_10_1016_j_kint_2018_01_024 crossref_primary_10_1016_j_psychres_2018_03_030 crossref_primary_10_1016_j_plipres_2018_05_002 crossref_primary_10_1186_s12931_022_02253_w crossref_primary_10_1016_j_bcp_2019_08_025 crossref_primary_10_3390_cells10030700 crossref_primary_10_1111_jre_12765 crossref_primary_10_1017_S0007114517002884 crossref_primary_10_3390_molecules29143381 crossref_primary_10_1111_evj_13860 crossref_primary_10_1080_01480545_2019_1680686 crossref_primary_10_1007_s43440_020_00166_3 crossref_primary_10_3390_ijms21176115 crossref_primary_10_1111_bph_14769 crossref_primary_10_3390_ijms21207693 crossref_primary_10_1093_jleuko_qiae246 crossref_primary_10_1016_j_mam_2018_10_001 crossref_primary_10_3390_biom11040582 crossref_primary_10_1021_acscentsci_3c01461 crossref_primary_10_2174_1568026622666220405143003 crossref_primary_10_1016_j_prostaglandins_2019_106351 crossref_primary_10_3389_fphar_2023_1158091 crossref_primary_10_1016_j_neurobiolaging_2019_03_008 crossref_primary_10_1021_acs_jmedchem_9b01280 crossref_primary_10_7717_peerj_12262 crossref_primary_10_1146_annurev_pharmtox_010818_021441 crossref_primary_10_3389_fphys_2019_00361 crossref_primary_10_3390_biomedicines10112986 crossref_primary_10_1016_j_phymed_2019_153160 crossref_primary_10_3390_cells10123396 crossref_primary_10_3389_fphar_2018_01202 crossref_primary_10_1021_acs_molpharmaceut_7b00746 crossref_primary_10_3390_ijms232012144 crossref_primary_10_3390_molecules27010064 crossref_primary_10_1016_j_biopha_2024_116473 crossref_primary_10_1177_1744806917728227 crossref_primary_10_1021_acschemneuro_0c00729 crossref_primary_10_3390_ijms21113809 crossref_primary_10_1038_s41598_020_72553_y crossref_primary_10_1016_j_bcp_2017_10_014 crossref_primary_10_1111_bph_16172 crossref_primary_10_1038_s41598_017_09808_8 crossref_primary_10_1124_pharmrev_122_000600 crossref_primary_10_3389_fnmol_2018_00180 crossref_primary_10_2174_1874467212666190215112036 crossref_primary_10_1152_physrev_00005_2019 crossref_primary_10_1038_s41598_017_17796_y |
| Cites_doi | 10.1002/cmdc.200900472 10.1111/j.1476-5381.2011.01381.x 10.1016/j.phrs.2013.12.010 10.1517/13543770903436505 10.1016/0003-2697(85)90442-7 10.1124/mol.113.088880 10.1007/3-540-26573-2_10 10.1038/505612a 10.1038/nrn3846 10.1002/anie.201306295 10.1038/nrd3954 10.1002/jps.10332 10.1016/0006-2952(73)90196-2 10.1016/j.lfs.2003.07.005 10.1016/S0968-0896(02)00319-X 10.1038/365061a0 10.1016/j.drudis.2011.09.007 10.1016/j.bmc.2013.03.030 10.1038/nm0915-966 10.1177/1087057112461376 10.1098/rstb.2011.0382 10.1002/jps.22452 10.1038/nrn3811 10.1016/j.bcp.2009.07.024 10.1016/j.bcp.2014.09.020 10.1111/j.1476-5381.2010.00872.x 10.1016/j.chembiol.2007.11.006 10.1194/jlr.D056390 10.1016/j.tetlet.2012.10.080 10.1021/jm050442r 10.1016/j.yjmcc.2008.12.014 10.1074/jbc.M306642200 10.1124/pr.58.3.2 10.1098/rspb.1983.0093 10.1016/j.plipres.2011.01.001 10.1021/jm200916p 10.1111/bph.13226 10.3109/10408444.2012.682115 10.1021/jm970530e 10.1097/AJP.0b013e318219799a 10.1016/j.bmcl.2011.02.078 10.1021/cn200111m 10.1038/sj.bjp.0707531 10.1124/mol.114.094649 10.1021/jm4005626 10.1021/ja01062a046 10.1096/fj.06-7451com 10.1074/jbc.M303994200 10.1053/j.gastro.2004.12.050 10.1189/jlb.0307180 10.1021/jm060920d 10.1038/sj.bjp.0706838 10.1016/j.ejmech.2012.06.043 10.1016/j.freeradbiomed.2009.11.022 10.1002/med.10041 10.1124/dmd.114.057943 10.1038/npp.2010.44 10.1124/pr.54.2.161 10.1016/0003-2697(76)90527-3 10.1111/j.1476-5381.2012.02090.x 10.1111/bph.12329 10.1016/j.bcp.2010.06.007 10.1111/j.1476-5381.2011.01658.x 10.1016/S0026-895X(25)10492-6 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2017 Copyright Nature Publishing Group Jan 2017 Copyright © 2017, The Author(s) 2017 The Author(s) |
| Copyright_xml | – notice: The Author(s) 2017 – notice: Copyright Nature Publishing Group Jan 2017 – notice: Copyright © 2017, The Author(s) 2017 The Author(s) |
| DBID | C6C AAYXX CITATION 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/ncomms13958 |
| DatabaseName | Springer Nature OA Free Journals CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts ProQuest Health & Medical Collection (NC LIVE) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection (subscription) ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts ProQuest SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Proquest Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology Medicine Chemistry |
| EISSN | 2041-1723 |
| EndPage | 14 |
| ExternalDocumentID | oai_doaj_org_article_d8fb448abc4444e3a10089f8b36e11e6 PMC5216056 4291596251 10_1038_ncomms13958 |
| GeographicLocations | Italy Netherlands United States--US Switzerland |
| GeographicLocations_xml | – name: Switzerland – name: Netherlands – name: United States--US – name: Italy |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BAPOH BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EJD EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX CITATION PHGZM PHGZT 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AARCD AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c489t-1250029373e639ae44a44d905f88a02e285ef8a6386db9ef5ca62949487a24603 |
| IEDL.DBID | M48 |
| ISSN | 2041-1723 |
| IngestDate | Wed Aug 27 01:32:09 EDT 2025 Thu Aug 21 14:34:17 EDT 2025 Fri Sep 05 13:56:54 EDT 2025 Wed Aug 13 06:31:19 EDT 2025 Thu Apr 24 23:02:06 EDT 2025 Thu Jul 03 08:36:50 EDT 2025 Fri Feb 21 02:41:43 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c489t-1250029373e639ae44a44d905f88a02e285ef8a6386db9ef5ca62949487a24603 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work These authors jointly supervised this work |
| ORCID | 0000-0002-3990-2963 0000-0003-2538-2001 |
| OpenAccessLink | https://www.proquest.com/docview/1854787558?pq-origsite=%requestingapplication%&accountid=15518 |
| PMID | 28045021 |
| PQID | 1854787558 |
| PQPubID | 546298 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_d8fb448abc4444e3a10089f8b36e11e6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5216056 proquest_miscellaneous_1855066304 proquest_journals_1854787558 crossref_citationtrail_10_1038_ncomms13958 crossref_primary_10_1038_ncomms13958 springer_journals_10_1038_ncomms13958 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-01-03 |
| PublicationDateYYYYMMDD | 2017-01-03 |
| PublicationDate_xml | – month: 01 year: 2017 text: 2017-01-03 day: 03 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationYear | 2017 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Nicolussi (CR32) 2014; 92 Kilkenny (CR69) 2010; 160 Lane, Beukers, Mulder-Krieger, Ijzerman (CR34) 2010; 79 Nicolussi (CR57) 2014; 80 Pacher, Bátkai, Kunos (CR24) 2006; 58 Bradford (CR59) 1976; 72 Mechoulam, Hanus, Pertwee, Howlett (CR13) 2014; 15 Mussinu (CR27) 2003; 11 Mackie (CR16) 2005; 168 CR36 Zamek-Gliszczynski (CR64) 2011; 100 Felder (CR17) 1995; 48 Collins, Tabak (CR25) 2014; 505 LeCluyse, Witek, Andersen, Powers (CR63) 2012; 42 Gashaw, Ellinghaus, Sommer, Asadullah (CR1) 2011; 16 Kusakabe (CR5) 2013; 21 Blankman, Simon, Cravatt (CR38) 2007; 14 Horváth (CR33) 2012; 165 Cheng, Prusoff (CR53) 1973; 22 Kansy, Senner, Gubernator (CR67) 1998; 41 Cawston (CR48) 2013; 170 Van der Wel (CR61) 2015; 56 Han, Thatte, Buzard, Jones (CR21) 2013; 56 Knapman (CR50) 2013; 18 Mukhopadhyay (CR6) 2010; 48 Muegge (CR39) 2003; 23 Howlett (CR18) 2002; 54 Harrison, Traynor (CR46) 2003; 74 Poirier (CR66) 2014; 42 Di Marzo, De Petrocellis (CR37) 2012; 367 Rajesh (CR10) 2007; 82 Black, Leff (CR31) 1983; 220 CR47 Kenakin, Watson, Muniz-Medina, Christopoulos, Novick (CR54) 2012; 3 Julien (CR8) 2005; 128 CR42 Rogers (CR22) 2015; 21 Grimsey, Graham, Dragunow, Glass (CR49) 2010; 80 Banker, Clark, Williams (CR65) 2003; 92 Qi (CR40) 2005; 48 Wilkinson, Price, Kassiou (CR41) 2013; 54 Maccarrone (CR56) 2003; 278 Montecucco (CR12) 2009; 46 Van Der Stelt (CR3) 2011; 54 Murineddu (CR28) 2006; 49 Van der Westhuizen, Breton, Christopoulos, Bouvier (CR30) 2014; 85 Manley (CR23) 2011; 21 Horváth (CR11) 2012; 165 Yao (CR29) 2006; 149 Pacher, Mechoulam (CR2) 2011; 50 Ullmer (CR52) 2012; 167 Maccarrone, Guzmán, Mackie, Doherty, Harkany (CR26) 2014; 15 Okamoto, Morishita, Tsuboi, Tonai, Ueda (CR58) 2004; 279 Guindon, Hohmann (CR4) 2008; 153 Gruden, Barutta, Kunos, Pacher (CR7) 2015; 173 Dhopeshwarkar, Mackie (CR19) 2014; 86 Gattinoni (CR45) 2010; 5 Baggelaar (CR43) 2013; 52 Oddi (CR51) 2012; 165 Thakur, Tichkule, Bajaj, Makriyannis (CR20) 2009; 19 Kenakin, Christopoulos (CR55) 2013; 12 CR68 Munro, Thomas, Abu-Shaar (CR15) 1993; 365 CR60 Ostenfeld (CR35) 2011; 27 Gaoni, Mechoulam (CR14) 1964; 86 Bátkai (CR9) 2007; 21 Smith (CR44) 1985; 150 Di (CR62) 2012; 57 Falenski (CR70) 2010; 35 Y Okamoto (BFncomms13958_CR58) 2004; 279 P Pacher (BFncomms13958_CR2) 2011; 50 M Rajesh (BFncomms13958_CR10) 2007; 82 S Gattinoni (BFncomms13958_CR45) 2010; 5 S Munro (BFncomms13958_CR15) 1993; 365 BFncomms13958_CR47 L Qi (BFncomms13958_CR40) 2005; 48 C Kilkenny (BFncomms13958_CR69) 2010; 160 I Muegge (BFncomms13958_CR39) 2003; 23 C Harrison (BFncomms13958_CR46) 2003; 74 T Van der Wel (BFncomms13958_CR61) 2015; 56 I Gashaw (BFncomms13958_CR1) 2011; 16 B Julien (BFncomms13958_CR8) 2005; 128 AC Howlett (BFncomms13958_CR18) 2002; 54 B Horváth (BFncomms13958_CR11) 2012; 165 Y Gaoni (BFncomms13958_CR14) 1964; 86 BFncomms13958_CR42 C Ullmer (BFncomms13958_CR52) 2012; 167 P Pacher (BFncomms13958_CR24) 2006; 58 T Kenakin (BFncomms13958_CR54) 2012; 3 MP Baggelaar (BFncomms13958_CR43) 2013; 52 JR Lane (BFncomms13958_CR34) 2010; 79 S Nicolussi (BFncomms13958_CR32) 2014; 92 M Maccarrone (BFncomms13958_CR56) 2003; 278 GA Thakur (BFncomms13958_CR20) 2009; 19 G Murineddu (BFncomms13958_CR28) 2006; 49 NL Grimsey (BFncomms13958_CR49) 2010; 80 J-M Mussinu (BFncomms13958_CR27) 2003; 11 G Gruden (BFncomms13958_CR7) 2015; 173 B Horváth (BFncomms13958_CR33) 2012; 165 BFncomms13958_CR68 FS Collins (BFncomms13958_CR25) 2014; 505 MJ Banker (BFncomms13958_CR65) 2003; 92 A Dhopeshwarkar (BFncomms13958_CR19) 2014; 86 CC Felder (BFncomms13958_CR17) 1995; 48 ET Van der Westhuizen (BFncomms13958_CR30) 2014; 85 V Di Marzo (BFncomms13958_CR37) 2012; 367 KW Falenski (BFncomms13958_CR70) 2010; 35 S Bátkai (BFncomms13958_CR9) 2007; 21 F Montecucco (BFncomms13958_CR12) 2009; 46 JW Black (BFncomms13958_CR31) 1983; 220 R Mechoulam (BFncomms13958_CR13) 2014; 15 EE Cawston (BFncomms13958_CR48) 2013; 170 K Mackie (BFncomms13958_CR16) 2005; 168 PK Smith (BFncomms13958_CR44) 1985; 150 M Maccarrone (BFncomms13958_CR26) 2014; 15 BFncomms13958_CR60 BB Yao (BFncomms13958_CR29) 2006; 149 SM Wilkinson (BFncomms13958_CR41) 2013; 54 T Kenakin (BFncomms13958_CR55) 2013; 12 M Kansy (BFncomms13958_CR67) 1998; 41 S Han (BFncomms13958_CR21) 2013; 56 M Van Der Stelt (BFncomms13958_CR3) 2011; 54 MM Bradford (BFncomms13958_CR59) 1976; 72 BFncomms13958_CR36 PJ Manley (BFncomms13958_CR23) 2011; 21 MJ Zamek-Gliszczynski (BFncomms13958_CR64) 2011; 100 A Knapman (BFncomms13958_CR50) 2013; 18 EL LeCluyse (BFncomms13958_CR63) 2012; 42 S Nicolussi (BFncomms13958_CR57) 2014; 80 JL Blankman (BFncomms13958_CR38) 2007; 14 J Guindon (BFncomms13958_CR4) 2008; 153 T Ostenfeld (BFncomms13958_CR35) 2011; 27 K Kusakabe (BFncomms13958_CR5) 2013; 21 A Poirier (BFncomms13958_CR66) 2014; 42 S Oddi (BFncomms13958_CR51) 2012; 165 P Mukhopadhyay (BFncomms13958_CR6) 2010; 48 L Di (BFncomms13958_CR62) 2012; 57 N Rogers (BFncomms13958_CR22) 2015; 21 Y Cheng (BFncomms13958_CR53) 1973; 22 |
| References_xml | – volume: 5 start-page: 357 year: 2010 end-page: 360 ident: CR45 article-title: Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system publication-title: ChemMedChem. doi: 10.1002/cmdc.200900472 – volume: 165 start-page: 2462 year: 2012 end-page: 2478 ident: CR33 article-title: A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01381.x – volume: 80 start-page: 52 year: 2014 end-page: 65 ident: CR57 article-title: Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2013.12.010 – volume: 19 start-page: 1647 year: 2009 end-page: 1673 ident: CR20 article-title: Latest advances in cannabinoid receptor agonists publication-title: Expert Opin. Ther. Pat. doi: 10.1517/13543770903436505 – volume: 150 start-page: 76 year: 1985 end-page: 85 ident: CR44 article-title: Measurement of protein using bicinchoninic acid publication-title: Anal. Biochem. doi: 10.1016/0003-2697(85)90442-7 – ident: CR68 – volume: 85 start-page: 492 year: 2014 end-page: 509 ident: CR30 article-title: Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy publication-title: Mol. Pharmacol. doi: 10.1124/mol.113.088880 – volume: 168 start-page: 299 year: 2005 end-page: 325 ident: CR16 article-title: Distribution of cannabinoid receptors in the central and peripheral nervous system publication-title: Handb. Exp. Pharmacol. doi: 10.1007/3-540-26573-2_10 – volume: 505 start-page: 612 year: 2014 end-page: 613 ident: CR25 article-title: Policy: NIH plans to enhance reproducibility publication-title: Nature doi: 10.1038/505612a – volume: 15 start-page: 786 year: 2014 end-page: 801 ident: CR26 article-title: Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3846 – volume: 52 start-page: 12081 year: 2013 end-page: 12085 ident: CR43 article-title: Development of an activity-based probe and design reveal highly selective inhibitors for diacylglycerol lipase-α in brain publication-title: Angew. Chemie—Int. Ed. doi: 10.1002/anie.201306295 – volume: 12 start-page: 205 year: 2013 end-page: 216 ident: CR55 article-title: Signalling bias in new drug discovery: detection, quantification and therapeutic impact publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3954 – volume: 92 start-page: 967 year: 2003 end-page: 974 ident: CR65 article-title: Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding publication-title: J. Pharm. Sci. doi: 10.1002/jps.10332 – volume: 22 start-page: 3099 year: 1973 end-page: 3108 ident: CR53 article-title: Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(73)90196-2 – volume: 74 start-page: 489 year: 2003 end-page: 508 ident: CR46 article-title: The [35S]GTPgammaS binding assay: approaches and applications in pharmacology publication-title: Life Sci. doi: 10.1016/j.lfs.2003.07.005 – ident: CR42 – volume: 11 start-page: 251 year: 2003 end-page: 263 ident: CR27 article-title: Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(02)00319-X – volume: 365 start-page: 61 year: 1993 end-page: 65 ident: CR15 article-title: Molecular characterization of a peripheral receptor for cannabinoids publication-title: Nature doi: 10.1038/365061a0 – volume: 16 start-page: 1037 year: 2011 end-page: 1043 ident: CR1 article-title: What makes a good drug target? publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2011.09.007 – volume: 21 start-page: 3154 year: 2013 end-page: 3163 ident: CR5 article-title: Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2013.03.030 – volume: 21 start-page: 966 year: 2015 end-page: 967 ident: CR22 article-title: Cannabinoid receptor with an ‘identity crisis’ gets a second look publication-title: Nat. Med. doi: 10.1038/nm0915-966 – volume: 18 start-page: 269 year: 2013 end-page: 276 ident: CR50 article-title: A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells publication-title: J. Biomol. Screen. doi: 10.1177/1087057112461376 – volume: 367 start-page: 3216 year: 2012 end-page: 3228 ident: CR37 article-title: Why do cannabinoid receptors have more than one endogenous ligand? publication-title: Philos. Trans. R. Soc. Lond. B. Biol. Sci. doi: 10.1098/rstb.2011.0382 – volume: 100 start-page: 2498 year: 2011 end-page: 2507 ident: CR64 article-title: Validation of 96-well equilibrium dialysis with non-radiolabeled drug for definitive measurement of protein binding and application to clinical development of highly-bound drugs publication-title: J. Pharm. Sci. doi: 10.1002/jps.22452 – volume: 15 start-page: 757 year: 2014 end-page: 764 ident: CR13 article-title: Early phytocannabinoid chemistry to endocannabinoids and beyond publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3811 – volume: 79 start-page: 48 year: 2010 end-page: 56 ident: CR34 article-title: The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2009.07.024 – volume: 92 start-page: 669 year: 2014 end-page: 689 ident: CR32 article-title: Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2014.09.020 – ident: CR60 – ident: CR36 – volume: 160 start-page: 1577 year: 2010 end-page: 1579 ident: CR69 article-title: Animal research: reporting experiments: the ARRIVE guidelines publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2010.00872.x – volume: 14 start-page: 1347 year: 2007 end-page: 1356 ident: CR38 article-title: A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2007.11.006 – volume: 56 start-page: 927 year: 2015 end-page: 935 ident: CR61 article-title: A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α publication-title: J. Lipid Res. doi: 10.1194/jlr.D056390 – volume: 54 start-page: 52 year: 2013 end-page: 54 ident: CR41 article-title: Improved accessibility to the desoxy analogues of Δ9- tetrahydrocannabinol and cannabidiol publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2012.10.080 – volume: 48 start-page: 7389 year: 2005 end-page: 7399 ident: CR40 article-title: Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol publication-title: J. Med. Chem. doi: 10.1021/jm050442r – volume: 46 start-page: 612 year: 2009 end-page: 620 ident: CR12 article-title: CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2008.12.014 – volume: 279 start-page: 5298 year: 2004 end-page: 5305 ident: CR58 article-title: Molecular characterization of a phospholipase D generating anandamide and its congeners publication-title: J. Biol. Chem. doi: 10.1074/jbc.M306642200 – ident: CR47 – volume: 58 start-page: 389 year: 2006 end-page: 462 ident: CR24 article-title: The endocannabinoid system as an emerging target of pharmacotherapy publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.3.2 – volume: 220 start-page: 141 year: 1983 end-page: 162 ident: CR31 article-title: Operational models of pharmacological agonism publication-title: Proc. R. Soc. Lond. B. Biol. Sci doi: 10.1098/rspb.1983.0093 – volume: 50 start-page: 193 year: 2011 end-page: 211 ident: CR2 article-title: Is lipid signaling through cannabinoid 2 receptors part of a protective system? publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2011.01.001 – volume: 54 start-page: 7350 year: 2011 end-page: 7362 ident: CR3 article-title: Discovery and optimization of 1-(4-(Pyridin-2-yl)benzyl)imidazolidine-2,4- dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists publication-title: J. Med. Chem. doi: 10.1021/jm200916p – volume: 173 start-page: 1116 year: 2015 end-page: 1127 ident: CR7 article-title: Role of the endocannabinoid system in diabetes and diabetic complications publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13226 – volume: 42 start-page: 501 year: 2012 end-page: 548 ident: CR63 article-title: Organotypic liver culture models: meeting current challenges in toxicity testing publication-title: Crit. Rev. Toxicol. doi: 10.3109/10408444.2012.682115 – volume: 41 start-page: 1007 year: 1998 end-page: 1010 ident: CR67 article-title: Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes publication-title: J. Med. Chem. doi: 10.1021/jm970530e – volume: 27 start-page: 668 year: 2011 end-page: 676 ident: CR35 article-title: A randomized, controlled study to investigate the analgesic efficacy of single doses of the cannabinoid receptor-2 agonist GW842166, ibuprofen or placebo in patients with acute pain following third molar tooth extraction publication-title: Clin. J. Pain doi: 10.1097/AJP.0b013e318219799a – volume: 21 start-page: 2359 year: 2011 end-page: 2364 ident: CR23 article-title: Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on efficacy in a rodent model of analgesia publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2011.02.078 – volume: 3 start-page: 193 year: 2012 end-page: 203 ident: CR54 article-title: A simple method for quantifying functional selectivity and agonist bias publication-title: ACS Chem. Neurosci doi: 10.1021/cn200111m – volume: 153 start-page: 319 year: 2008 end-page: 334 ident: CR4 article-title: Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0707531 – volume: 86 start-page: 430 year: 2014 end-page: 437 ident: CR19 article-title: CB2 Cannabinoid receptors as a therapeutic target-what does the future hold? publication-title: Mol. Pharmacol. doi: 10.1124/mol.114.094649 – volume: 56 start-page: 8224 year: 2013 end-page: 8256 ident: CR21 article-title: Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists publication-title: J. Med. Chem. doi: 10.1021/jm4005626 – volume: 86 start-page: 1646 year: 1964 end-page: 1647 ident: CR14 article-title: Isolation, structure, and partial synthesis of an active constituent of hashish publication-title: J. Am. Chem. Soc. doi: 10.1021/ja01062a046 – volume: 21 start-page: 1788 year: 2007 end-page: 1800 ident: CR9 article-title: Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury publication-title: FASEB J. doi: 10.1096/fj.06-7451com – volume: 278 start-page: 33896 year: 2003 end-page: 33903 ident: CR56 article-title: The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M303994200 – volume: 48 start-page: 443 year: 1995 end-page: 450 ident: CR17 article-title: Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors publication-title: Mol. Pharmacol. – volume: 128 start-page: 742 year: 2005 end-page: 755 ident: CR8 article-title: Antifibrogenic role of the cannabinoid receptor CB2 in the liver publication-title: Gastroenterology doi: 10.1053/j.gastro.2004.12.050 – volume: 82 start-page: 1382 year: 2007 end-page: 1389 ident: CR10 article-title: Pivotal advance: Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0307180 – volume: 49 start-page: 7502 year: 2006 end-page: 7512 ident: CR28 article-title: Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2′,4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide publication-title: J. Med. Chem. doi: 10.1021/jm060920d – volume: 149 start-page: 145 year: 2006 end-page: 154 ident: CR29 article-title: pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor? publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0706838 – volume: 57 start-page: 441 year: 2012 end-page: 448 ident: CR62 article-title: Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2012.06.043 – volume: 48 start-page: 457 year: 2010 end-page: 467 ident: CR6 article-title: Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.11.022 – volume: 23 start-page: 302 year: 2003 end-page: 321 ident: CR39 article-title: Selection criteria for drug-like compounds publication-title: Med. Res. Rev. doi: 10.1002/med.10041 – volume: 42 start-page: 1411 year: 2014 end-page: 1422 ident: CR66 article-title: Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.114.057943 – volume: 35 start-page: 1775 year: 2010 end-page: 1787 ident: CR70 article-title: FAAH−/− mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.44 – volume: 54 start-page: 161 year: 2002 end-page: 202 ident: CR18 article-title: International Union of Pharmacology. XXVII. Classification of cannabinoid receptors publication-title: Pharmacol. Rev. doi: 10.1124/pr.54.2.161 – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: CR59 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90527-3 – volume: 165 start-page: 2462 year: 2012 end-page: 2478 ident: CR11 article-title: A new cannabinoid CB 2receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01381.x – volume: 167 start-page: 1448 year: 2012 end-page: 1466 ident: CR52 article-title: Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7 publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2012.02090.x – volume: 170 start-page: 893 year: 2013 end-page: 907 ident: CR48 article-title: Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action publication-title: Br. J. Pharmacol. doi: 10.1111/bph.12329 – volume: 80 start-page: 1050 year: 2010 end-page: 1062 ident: CR49 article-title: Cannabinoid receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2010.06.007 – volume: 165 start-page: 2635 year: 2012 end-page: 2651 ident: CR51 article-title: Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01658.x – volume: 74 start-page: 489 year: 2003 ident: BFncomms13958_CR46 publication-title: Life Sci. doi: 10.1016/j.lfs.2003.07.005 – volume: 279 start-page: 5298 year: 2004 ident: BFncomms13958_CR58 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M306642200 – volume: 35 start-page: 1775 year: 2010 ident: BFncomms13958_CR70 publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.44 – ident: BFncomms13958_CR68 – volume: 15 start-page: 757 year: 2014 ident: BFncomms13958_CR13 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3811 – volume: 160 start-page: 1577 year: 2010 ident: BFncomms13958_CR69 publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2010.00872.x – volume: 170 start-page: 893 year: 2013 ident: BFncomms13958_CR48 publication-title: Br. J. Pharmacol. doi: 10.1111/bph.12329 – volume: 56 start-page: 927 year: 2015 ident: BFncomms13958_CR61 publication-title: J. Lipid Res. doi: 10.1194/jlr.D056390 – volume: 21 start-page: 3154 year: 2013 ident: BFncomms13958_CR5 publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2013.03.030 – volume: 15 start-page: 786 year: 2014 ident: BFncomms13958_CR26 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3846 – volume: 54 start-page: 7350 year: 2011 ident: BFncomms13958_CR3 publication-title: J. Med. Chem. doi: 10.1021/jm200916p – volume: 54 start-page: 161 year: 2002 ident: BFncomms13958_CR18 publication-title: Pharmacol. Rev. doi: 10.1124/pr.54.2.161 – volume: 92 start-page: 669 year: 2014 ident: BFncomms13958_CR32 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2014.09.020 – volume: 42 start-page: 501 year: 2012 ident: BFncomms13958_CR63 publication-title: Crit. Rev. Toxicol. doi: 10.3109/10408444.2012.682115 – volume: 165 start-page: 2635 year: 2012 ident: BFncomms13958_CR51 publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01658.x – volume: 173 start-page: 1116 year: 2015 ident: BFncomms13958_CR7 publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13226 – volume: 41 start-page: 1007 year: 1998 ident: BFncomms13958_CR67 publication-title: J. Med. Chem. doi: 10.1021/jm970530e – volume: 367 start-page: 3216 year: 2012 ident: BFncomms13958_CR37 publication-title: Philos. Trans. R. Soc. Lond. B. Biol. Sci. doi: 10.1098/rstb.2011.0382 – volume: 3 start-page: 193 year: 2012 ident: BFncomms13958_CR54 publication-title: ACS Chem. Neurosci doi: 10.1021/cn200111m – volume: 168 start-page: 299 year: 2005 ident: BFncomms13958_CR16 publication-title: Handb. Exp. Pharmacol. doi: 10.1007/3-540-26573-2_10 – volume: 52 start-page: 12081 year: 2013 ident: BFncomms13958_CR43 publication-title: Angew. Chemie—Int. Ed. doi: 10.1002/anie.201306295 – volume: 12 start-page: 205 year: 2013 ident: BFncomms13958_CR55 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3954 – volume: 149 start-page: 145 year: 2006 ident: BFncomms13958_CR29 publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0706838 – volume: 80 start-page: 1050 year: 2010 ident: BFncomms13958_CR49 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2010.06.007 – volume: 85 start-page: 492 year: 2014 ident: BFncomms13958_CR30 publication-title: Mol. Pharmacol. doi: 10.1124/mol.113.088880 – volume: 54 start-page: 52 year: 2013 ident: BFncomms13958_CR41 publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2012.10.080 – volume: 48 start-page: 7389 year: 2005 ident: BFncomms13958_CR40 publication-title: J. Med. Chem. doi: 10.1021/jm050442r – volume: 16 start-page: 1037 year: 2011 ident: BFncomms13958_CR1 publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2011.09.007 – volume: 21 start-page: 1788 year: 2007 ident: BFncomms13958_CR9 publication-title: FASEB J. doi: 10.1096/fj.06-7451com – volume: 278 start-page: 33896 year: 2003 ident: BFncomms13958_CR56 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M303994200 – volume: 86 start-page: 1646 year: 1964 ident: BFncomms13958_CR14 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja01062a046 – volume: 21 start-page: 966 year: 2015 ident: BFncomms13958_CR22 publication-title: Nat. Med. doi: 10.1038/nm0915-966 – volume: 100 start-page: 2498 year: 2011 ident: BFncomms13958_CR64 publication-title: J. Pharm. Sci. doi: 10.1002/jps.22452 – volume: 50 start-page: 193 year: 2011 ident: BFncomms13958_CR2 publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2011.01.001 – volume: 82 start-page: 1382 year: 2007 ident: BFncomms13958_CR10 publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0307180 – volume: 21 start-page: 2359 year: 2011 ident: BFncomms13958_CR23 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2011.02.078 – volume: 58 start-page: 389 year: 2006 ident: BFncomms13958_CR24 publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.3.2 – volume: 48 start-page: 457 year: 2010 ident: BFncomms13958_CR6 publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2009.11.022 – volume: 46 start-page: 612 year: 2009 ident: BFncomms13958_CR12 publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2008.12.014 – volume: 167 start-page: 1448 year: 2012 ident: BFncomms13958_CR52 publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2012.02090.x – volume: 5 start-page: 357 year: 2010 ident: BFncomms13958_CR45 publication-title: ChemMedChem. doi: 10.1002/cmdc.200900472 – volume: 128 start-page: 742 year: 2005 ident: BFncomms13958_CR8 publication-title: Gastroenterology doi: 10.1053/j.gastro.2004.12.050 – ident: BFncomms13958_CR42 – volume: 150 start-page: 76 year: 1985 ident: BFncomms13958_CR44 publication-title: Anal. Biochem. doi: 10.1016/0003-2697(85)90442-7 – volume: 23 start-page: 302 year: 2003 ident: BFncomms13958_CR39 publication-title: Med. Res. Rev. doi: 10.1002/med.10041 – volume: 79 start-page: 48 year: 2010 ident: BFncomms13958_CR34 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2009.07.024 – volume: 165 start-page: 2462 year: 2012 ident: BFncomms13958_CR11 publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01381.x – volume: 22 start-page: 3099 year: 1973 ident: BFncomms13958_CR53 publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(73)90196-2 – volume: 56 start-page: 8224 year: 2013 ident: BFncomms13958_CR21 publication-title: J. Med. Chem. doi: 10.1021/jm4005626 – volume: 365 start-page: 61 year: 1993 ident: BFncomms13958_CR15 publication-title: Nature doi: 10.1038/365061a0 – volume: 11 start-page: 251 year: 2003 ident: BFncomms13958_CR27 publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(02)00319-X – volume: 220 start-page: 141 year: 1983 ident: BFncomms13958_CR31 publication-title: Proc. R. Soc. Lond. B. Biol. Sci doi: 10.1098/rspb.1983.0093 – volume: 92 start-page: 967 year: 2003 ident: BFncomms13958_CR65 publication-title: J. Pharm. Sci. doi: 10.1002/jps.10332 – volume: 14 start-page: 1347 year: 2007 ident: BFncomms13958_CR38 publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2007.11.006 – volume: 18 start-page: 269 year: 2013 ident: BFncomms13958_CR50 publication-title: J. Biomol. Screen. doi: 10.1177/1087057112461376 – volume: 80 start-page: 52 year: 2014 ident: BFncomms13958_CR57 publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2013.12.010 – ident: BFncomms13958_CR36 – volume: 57 start-page: 441 year: 2012 ident: BFncomms13958_CR62 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2012.06.043 – volume: 86 start-page: 430 year: 2014 ident: BFncomms13958_CR19 publication-title: Mol. Pharmacol. doi: 10.1124/mol.114.094649 – volume: 19 start-page: 1647 year: 2009 ident: BFncomms13958_CR20 publication-title: Expert Opin. Ther. Pat. doi: 10.1517/13543770903436505 – volume: 49 start-page: 7502 year: 2006 ident: BFncomms13958_CR28 publication-title: J. Med. Chem. doi: 10.1021/jm060920d – volume: 27 start-page: 668 year: 2011 ident: BFncomms13958_CR35 publication-title: Clin. J. Pain doi: 10.1097/AJP.0b013e318219799a – volume: 42 start-page: 1411 year: 2014 ident: BFncomms13958_CR66 publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.114.057943 – volume: 165 start-page: 2462 year: 2012 ident: BFncomms13958_CR33 publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01381.x – volume: 72 start-page: 248 year: 1976 ident: BFncomms13958_CR59 publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90527-3 – ident: BFncomms13958_CR60 – volume: 505 start-page: 612 year: 2014 ident: BFncomms13958_CR25 publication-title: Nature doi: 10.1038/505612a – ident: BFncomms13958_CR47 – volume: 48 start-page: 443 year: 1995 ident: BFncomms13958_CR17 publication-title: Mol. Pharmacol. doi: 10.1016/S0026-895X(25)10492-6 – volume: 153 start-page: 319 year: 2008 ident: BFncomms13958_CR4 publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0707531 |
| SSID | ssj0000391844 |
| Score | 2.6237464 |
| Snippet | The cannabinoid CB
2
receptor (CB
2
R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although... The cannabinoid CB 2 receptor (CB 2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although... The cannabinoid CB2 receptor (CB2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous... The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous... CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of... |
| SourceID | doaj pubmedcentral proquest crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 13958 |
| SubjectTerms | 631/154/309/436/2387 631/154/556 631/92/436/2387 96 96/106 96/109 96/47 96/95 Biochemistry Chemistry Diabetic neuropathy Health sciences Humanities and Social Sciences Laboratories Ligands Medicine Mode of action multidisciplinary Pharmacokinetics Pharmacology Physiology Proteins Science Science (multidisciplinary) Signal transduction Tetrahydrocannabinol THC |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4iCF7EJ64vIqwXodht0m5y1EURQU8uCB7KpEl0QbOLrgf_vTNpd-mq4MUe26FpMpPkm87kG8a6vi9cz1CEUdk0kVZmCRTOJjKTCJ8NFLmhXwO3d8X1UN485A-tUl-UE1bTA9cDd2aVN-hCgKkkXk4AsdFor4woXK_nItl2qtOWMxXXYKHRdZHNgbxUqLOACnx9R7xDxd1bW1Bk6l-Al9-TI79FSOPGc7XO1hrEyM_rL91gSy5sspW6huTnFnscQAiA_u14ZPngIuO4hLkJetL8ZfQEwfK6Kje-mhNbE1obNyPcuiyn1A2IlNyc5MbeJ3VeOKfDDlRTYpsNry7vB9dJUzEhqaTS0wTRCoXZBCoAkQc4KUFKq9PcKwVp5jKVO68A51xhjXY-r6DINDHE9AGVk4odthzGwe0yDh4dPYILlQKpC6ut6YkqN5kyEp3CqsNOZ4NYVg2dOFW1eCljWFuosjXiHdadC09qFo3fxS5IG3MRor6ON9AgysYgyr8MosMOZrosm_n4XiIqIRainNo4nj_GmUThEQhu_BFlcgJgqeyw_oINLHzQ4pMweo6c3IiC0DHExk9m1tJq_GdP9_6jp_tsNSOQEZPiDtjy9O3DHSJEmpqjOBu-AB24EdE priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fa9RAEB7aK7a-iJ4Wo1VWqC9CaC7ZzW0eRLyjpQg9RCwUfAi72d32oG6u7fXB_96Zzea8q2Iek4FNMvvjm53Z7wM4dOPCjjRlGKXJUm54nqrSmpTnHOGzVqXQtDVwNitPz_mXC3GxBbP-LAyVVfZzYpioTdvQHvkRrivEIyOE_LS4SUk1irKrvYSGitIK5mOgGNuGHZySRTaAncnx7Ou31a4L8aFLzuNBvayQRx4b-XmHOIhE39eWpsDgvwE7HxZNPsichgXp5Ck8iUiSfe5c_wy2rB_Co05b8tcQ9qa9lNsQds9iBv05_Jgq7xWGw-3csOkkZzjj2QUG3ux6fqm8YZ2IN7bIiNwJOyfTc1zpDKNKDxUYvBnZtc6lXRk5o7MRJEHxAs5Pjr9PT9MosJA2XFbLlH5Rhus9-guBirKcK85NlQknpcpym0thnVQ4REujK-tEo8q8IkKZsUJfZsU-DHzr7UtgymFcSOiikYpXpamMHhWN0LnUHGPIJoEP_b-tm8g-TiIY13XIgheyXnNEAocr40VHuvFvswk5aWVCTNnhRnt7WceBVxvpNIagSjccL1soYjOqnNRFaUcjWyZw0Lu4jsP3rv7T2RJ4t3qMTqNsivK2vQ82gvBaxhMYb3SNjRfafOLnV4HCG0ETxpHY-Pu-E601_veXvvr_S76GxzmhjVAddwCD5e29fYNYaanfxgHwG0cWFvc priority: 102 providerName: ProQuest – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9wwELYKFRIXRB-IBVq5Er1UisjGj3WOEBWhSnAqElIP0Ti2YSVwVuxy4N8z42RXG8qB3JJM4sQe2994xt8wdhwmwo8teRiNyzPpZJGB9i6ThUT4bEErS0sDl1f64lr-uVE3Pc_2vA-r7Cgt0zC9jA47iXj2MEe4oswG-2gmQpE6V7paLagQ1bmRst-Dlwuz_sxg1knk_ANE-Toe8pVTNM0157tspweJ_LT7rE_sg4-f2VaXNvL5C_tXQYyAJm07dbw6KziOWn6GxjO_n95CdLxLxI2v5kTQhArG7RRnK8cpWgMSCzcnuTaErAsF57S_gdJIfGXX57__VhdZnyQha6QpFxkCFPKsCaxzBBvgpQQpXZmrYAzkhS-M8sEAdjPtbOmDakAXJZHCTADbIxd7bDO20e8zDgFtO0IIjQFZalc6OxaNsoWxEu3AZsR-LSuxbnoGcUpkcV8nT7Yw9VqNj9jxSnjWEWe8LXZGrbESIbbrdKF9vK371q-dCRbNSLCNxMMLIEaiMhgrtB-PvR6xo2Vb1n0XnNcIRIh4SFEZP1a3sfOQRwSib5-SjCLMlcsRmwx0YPBBwztxepdouBH4oC2Ihf9casta4f__6cE75Q7ZdkHQIYW6HbHNxeOT_4bAZ2G_J4V_ATo-Bfc priority: 102 providerName: Springer Nature |
| Title | Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| URI | https://link.springer.com/article/10.1038/ncomms13958 https://www.proquest.com/docview/1854787558 https://www.proquest.com/docview/1855066304 https://pubmed.ncbi.nlm.nih.gov/PMC5216056 https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6 |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9swED_6wWAvZZ8sbRc06F4G3mxZtuWHMRLTtARWxrZAYA9GsuQukNltmsL63-9OtkOd9aF5SMC-WMmdzvqd7_Q7gJMyCW2gKcMoje8JI7inYms8wQXCZ63iSNOjga8X8flMTOfRfAe6ZpytAm8eDO2on9Rstfz49_ruCzr852bLuPxUoW3-3CCUieQu7LtEEdXwtTjf3ZLDFCMZyjBzXwQeLtphu1dv6_u91cmR-PeQ53bd5Fby1K1Jk2dw0IJJNmqs_xx2bPUCnjTtJe9ewq9MVZXC0LdeGJaNOcO7m73CIJstF5eqMqxp2I2XZkTkhApheoGrmmFU1aEcWzcjubosvaZknNE-CGo38Qpmk9Of2bnXNlPwCiHTtYdAhjJwIdoGQYmyQighTOpHpZTK55bLyJZSoTvGRqe2jAoV85TIYxKFdvPD17BX1ZV9A0yVGAMSkiikEmlsUqODsIg0l1pgvFgM4EOnxLxomcap4cUydxnvUOb3ND6Ak43wVUOw8bDYmKyxESFWbHegXl3mrZPlRpYaw02lC4EvGypiLkpLqcPYBoGNB3Dc2TLvZlqOgIUIiiIa493mNDoZZU5UZetbJxMRNvPFAJLeHOj9oP6ZavHb0XUjQMKYEQd_382We4P__08PH6eQI3jKCWG4irhj2Fuvbu1bxEdrPYTdZJ7gu5ycDWF_NJr-mOLn-PTi23c8msXZ0D15GDof-QcikRe3 |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Rb9MwED6NTjBeEBQQhQFG2l6QoqWOkzoPE6JlU8fWCqFNmsRDsGNnVNqSbu2E9uf4bdw5TmkH4m19bE6xnTv77nz29wFsFb3IdjVVGKUJA2EED1RiTSC4wPBZqyTWtDUwGifDE_H5ND5dg1_NXRg6VtmsiW6hNlVOe-Q76FcIRyaO5YfpZUCsUVRdbSg0lKdWMLsOYsxf7Di0Nz8xhZvtHnxCfW9zvr93PBgGnmUgyIVM5wF6eCpNRdhp9NbKCqGEMGkYF1KqkFsuY1tIhXaaGJ3aIs5VwlNCVekpHFAY4XvvwbqgDZQWrPf3xl--LnZ5CH9dCuEvBoaR3ClxUBczjLuIZH7JFTrGgJUw9_YhzVuVWucA9x_DIx-5so-1qT2BNVu24X7NZXnTho1BQx3XhgcjX7F_Ct8GqiwVpt_VxLBBnzNcYe0UE312PjlTpWE1aTi2yAhMCicD0xP0rIbRyRLlEMMZyVVFEdTH1hndxSDKi2dwcief-jm0yqq0L4CpAvNQimZyqUSamNTobpTHmkstMGfNO_C--bZZ7tHOiXTjPHNV90hmS4rowNZCeFqDfPxbrE9KWogQMrf7o7o6y_xEz4wsNKa8SucCfzZShJ6UFlJHie12bdKBzUbFmV8uZtkf4-7Au8VjVBpVb1Rpq2snE1N8GIoO9FZMY6VDq0_KyQ8HGY5BGuat2Ph2Y0RLjf890pf_7-Rb2Bgej46yo4Px4St4yCnScSfzNqE1v7q2rzFOm-s3fjIw-H7X8-83ivxRoA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Rb9MwED6NIQYvCAoTgQ2MtL0gRU0dJ3EeENo6qo2xiQcmVeIh2LE9Ko2krJ3Q_hq_jjsnKe1AvK2PzSm2c3e-O9_5PoAdl8V2oCnDKE0UCiN4qFJrQsEFus9apYmmo4GT0_TwTHwYJ-M1-NXdhaGyym5P9Bu1qUs6I--jXaE-Mkki-64ti_h0MHo3_RESghRlWjs4jUZEju31TwzfZm-PDpDXu5yP3n8eHoYtwkBYCpnPQ7TulJaKccJoqZUVQglh8ihxUqqIWy4T66RCGU2Nzq1LSpXynDqqZAoXE8X43jtwN4uFINiIbJwtzneo87oUor0SGMWyX-Fyvs_Q4yJ4-SUj6LECVhzcm-WZN3K03vSNHsHD1mdle42QPYY1W_XgXoNied2D-8MONK4HGydtrv4JfBmqqlIYeNcTw4b7nOHeaqcY4rOLybmqDGvgwnFERm2kUA2YnqBNNYxqSpTvFc6IrnYubArWGd3CILCLp3B2Kx96E9arurLPgCmHESj5MaVUIk9NbvQgLhPNpRYYrZYBvOm-bVG2fc4JbuOi8Pn2WBZLjAhgZ0E8bdp7_Jtsn5i0IKGe3P6P-vK8aFW8MNJpDHaVLgX-bKyob1LupI5TOxjYNICtjsVFu1HMij9iHcDrxWNkGuVtVGXrK0-TkGcYiQCyFdFYmdDqk2ryzTcLR_cMI1YcfLcToqXB_17p8_9P8hVsoNYVH49Oj1_AA04uji_J24L1-eWV3UYHba5fek1g8PW2Ve83WfVPPA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cannabinoid+CB2+receptor+ligand+profiling+reveals+biased+signalling+and+off-target+activity&rft.jtitle=Nature+communications&rft.au=Soethoudt%2C+Marjolein&rft.au=Grether%2C+Uwe&rft.au=Fingerle%2C+J%C3%BCrgen&rft.au=Grim%2C+Travis+W.&rft.date=2017-01-03&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=8&rft.issue=1&rft_id=info:doi/10.1038%2Fncomms13958&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_ncomms13958 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |