Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia - Sykes, David B.; Kfoury, Youmna S.; Mercier, François E.; Wawer, Mathias J.; Law, Jason M.; Haynes, Mark K.; Lewis, Timothy A.; Schajnovitz, Amir; Jain, Esha; Lee, Dongjun; Meyer, Hanna; Pierce, Kerry A.; et al. (Cell, 2016)
Keywords: acute myeloid leukemia; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - therapeutic use; brequinar; Cell Differentiation; developmental stages; differentiation; dihydroorotate dehydrogenase; enzyme inhibition; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - therapeutic use; gene expression regulation; genes; high-throughput screen; High-Throughput Screening Assays; Homeodomain Proteins - genetics; HoxA9; Humans; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - pathology; leukemia-initiating cell; metabolic inhibitor; Mice; Molecular Targeted Therapy; Myeloid Cells - pathology; myeloid leukemia; Oxidoreductases Acting on CH-CH Group Donors - antagonists & inhibitors; Oxidoreductases Acting on CH-CH Group Donors - metabolism; phenotype; phenotypic screen; Pyrimidines - metabolism; Small Molecule Libraries - chemistry; Small Molecule Libraries - isolation & purification; Small Molecule Libraries - therapeutic use; Xenograft Model Antitumor Assays; high-throughput screen; dihydroorotate dehydrogenase; differentiation; HoxA9; acute myeloid leukemia; leukemia-initiating cell; phenotypic screen; brequinar; metabolic inhibitor