Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production
Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leuk...
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| Published in | The American journal of clinical nutrition Vol. 65; no. 4; pp. 1011 - 1017 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
Elsevier Inc
01.04.1997
American Society for Clinical Nutrition American Society for Clinical Nutrition, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9165 1938-3207 |
| DOI | 10.1093/ajcn/65.4.1011 |
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| Abstract | Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEF), and forced expiratory flow 25–75% (FEF 25–75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n-3 PUFA ingestion, may predict respiratory benefit. |
|---|---|
| AbstractList | Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEP), and forced expiratory flow 25-75% (FEF25-75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes 1, induced by n-3 PUFA ingestion, may predict respiratory benefit Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEF), and forced expiratory flow 25-75% (FEF 25-75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n-3 PUFA ingestion, may predict respiratory benefit.Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEF), and forced expiratory flow 25-75% (FEF 25-75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n-3 PUFA ingestion, may predict respiratory benefit. Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEP), and forced expiratory flow 25-75% (FEF25-75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n-3 PUFA ingestion, may predict respiratory benefit. Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5:1 were ingested sequentially for 1 mo each; patient respiratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEV1), peak expiratory flow (PEF), and forced expiratory flow 25–75% (FEF 25–75) were measured along with weekly 24-h urinary leukotriene concentrations. With low n-3 PUFA ingestion, methacholine-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion predicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD20) in FEV1, FVC, PEF, and FEF25-75 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respiratory capacity. Five-series leukotriene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n-3 PUFA ingestion, may predict respiratory benefit. Broughton et al examined if asthma may respond to dietary modification. A study determined the effectiveness of n-3 polyunsaturated fatty acid ingestion in ameliorating methacholine-induced respiratory distress in an asthmatic population. |
| Author | Johnson, CS Liebman, M Pace, BK Kleppinger, KM Broughton, KS |
| Author_xml | – sequence: 1 givenname: KS surname: Broughton fullname: Broughton, KS email: BROUGHTO@UWYO.EDU organization: Nutrition/Department of Family and Consumer Science, University of Wyoming, Laramie 82071, USA – sequence: 2 givenname: CS surname: Johnson fullname: Johnson, CS organization: Nutrition/Department of Family and Consumer Science, University of Wyoming, Laramie 82071, USA – sequence: 3 givenname: BK surname: Pace fullname: Pace, BK organization: Nutrition/Department of Family and Consumer Science, University of Wyoming, Laramie 82071, USA – sequence: 4 givenname: M surname: Liebman fullname: Liebman, M organization: Nutrition/Department of Family and Consumer Science, University of Wyoming, Laramie 82071, USA – sequence: 5 givenname: KM surname: Kleppinger fullname: Kleppinger, KM organization: Nutrition/Department of Family and Consumer Science, University of Wyoming, Laramie 82071, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2633136$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/9094887$$D View this record in MEDLINE/PubMed |
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| Copyright | 1997 American Society for Nutrition. 1997 INIST-CNRS Copyright American Society for Clinical Nutrition, Inc. Apr 1997 |
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| Keywords | Human Respiratory disease Arachidonic acid derivatives Methacholine chloride Maximum expiratory flow rate Lipids n-3 fatty acid Fish oil Feeding Asthma Leukotriene n-6 fatty acid Diet therapy Diet Eicosanoid Unsaturated fatty acid Obstructive pulmonary disease |
| Language | English |
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| PublicationTitle | The American journal of clinical nutrition |
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| Snippet | Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated... Broughton et al examined if asthma may respond to dietary modification. A study determined the effectiveness of n-3 polyunsaturated fatty acid ingestion in... |
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| SubjectTerms | ACEITES DE PESCADO ACIDE GRAS POLYINSATURE ACIDOS GRASOS POLIINSATURADOS administration & dosage Adult ADULTE ADULTOS ADULTS ASMA ASTHMA Asthma - diet therapy Asthma - metabolism Asthma - physiopathology ASTHME Biological and medical sciences Biomarkers Biomarkers - urine Bronchial Provocation Tests Chronic obstructive pulmonary disease, asthma COMPLEMENT ALIMENTAIRE Diet diet therapy dietary supplements Dose-Response Relationship, Drug drug effects DRUG THERAPY EFFICACY EICOSANOIDE EICOSANOIDES EICOSANOIDS EXCRECION EXCRETION Fatty Acids, Omega-3 Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - therapeutic use FISH OILS FORCED EXPIRATORY FLOW Forced Expiratory Volume Forced Expiratory Volume - drug effects Forced Expiratory Volume - physiology FORCED VITAL CAPACITY FORECASTING HUILE DE POISSON Humans leukotrienes Leukotrienes - metabolism Leukotrienes - urine LUNG FUNCTION Medical sciences metabolism METHACHOLINE Methacholine Chloride Methacholine Chloride - pharmacology OMEGA-3 FATTY ACIDS OMEGA-6 FATTY ACIDS ORINA PEAK EXPIRATORY FLOW pharmacology physiology physiopathology Pneumology POLYUNSATURATED FATTY ACIDS prediction Predictive Value of Tests RATIOS RESPIRATION Respiration - drug effects Respiration - physiology Respiratory system RESPONSES SINTOMAS SUPLEMENTOS SUPPLEMENTS SYMPTOME SYMPTOMS TECHNIQUE DE PREVISION TECNICAS DE PREDICCION TERAPEUTICA MEDICAMENTOSA therapeutic use THERAPEUTIQUE MEDICAMENTEUSE Time Factors URINE Vital Capacity Vital Capacity - drug effects Vital Capacity - physiology VOLUME VOLUMEN WYOMING YOUNG ADULTS |
| Title | Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production |
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