Enhanced striatal cholinergic neuronal activity mediates L-DOPA—induced dyskinesia in parkinsonian mice - Ding, Yunmin; Won, Lisa; Britt, Jonathan P.; Lim, Sean Austin O.; McGehee, Daniel S.; Kang, Un Jung; Palmiter, Richard D. (Proceedings of the National Academy of Sciences - PNAS, 2011)
Keywords: 6-Hydroxydopamine; Acetylcholine receptors (muscarinic); Adenosine A2 Receptor Antagonists - chemistry; Aminoacetonitrile - analogs & derivatives; Aminoacetonitrile - pharmacology; Animal models; Animals; antagonists; Aphakia - metabolism; Behavioral neuroscience; Biological Sciences; Cells; Choline O-Acetyltransferase - metabolism; Cholinergic Fibers - metabolism; Cholinergic nerves; Cholinergics; Data processing; Disease Models, Animal; Dopamine; Dopamine - genetics; Dyskinesia; Dyskinesias - metabolism; Excitability; Extracellular signal-regulated kinase; Firing rate; Gene expression; Gene Expression Regulation; Homeodomain Proteins - genetics; Interneurons; Kinases; L-dopa; Lesions; Levodopa; Levodopa - metabolism; Mice; Mice, Transgenic; mitogen-activated protein kinase; Movement disorders; Neostriatum; Neurodegenerative diseases; Neurons; Neurons - metabolism; Parkinson disease; Parkinson Disease - metabolism; Parkinson's disease; Phosphorylation; Proteins; Receptors; Rodents; Signal transduction; spiny neurons; toxicity; Transcription Factors - genetics