Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R - Atsmon, Jacob; Brill-Almon, Einat; Nadri-Shay, Carmit; Chertkoff, Raul; Alon, Sari; Shaikevich, Dimitri; Volokhov, Inna; Haim, Kirsten Y.; Bartfeld, Daniel; Shulman, Avidor; Ruderfer, Ilya; Ben-Moshe, Tehila; et al. (Toxicology and applied pharmacology, 2015)
Keywords: 60 APPLIED LIFE SCIENCES; Acetylcholinesterase - administration & dosage; Acetylcholinesterase - adverse effects; Acetylcholinesterase - chemistry; Acetylcholinesterase - pharmacokinetics; Acetylcholinesterase - pharmacology; AChE-R; Adult; AFFINITY; Animals; Antidotes - administration & dosage; Antidotes - adverse effects; Antidotes - chemistry; Antidotes - pharmacokinetics; Antidotes - pharmacology; CHEMICAL WARFARE AGENTS; Chemistry, Pharmaceutical; DIAGRAMS; Disease Models, Animal; EVALUATION; Female; First-in-human; GPI-Linked Proteins - administration & dosage; GPI-Linked Proteins - adverse effects; GPI-Linked Proteins - chemistry; GPI-Linked Proteins - pharmacokinetics; GPI-Linked Proteins - pharmacology; HALF-LIFE; HUMAN POPULATIONS; Humans; Injections, Intravenous; Israel; LETHAL DOSES; Male; MICE; Mice, Inbred BALB C; Middle Aged; Organophosphate Poisoning - drug therapy; Organophosphate Poisoning - prevention & control; Organophosphorous; PESTICIDES; PLANTS; POISONING; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - adverse effects; Polyethylene Glycols - chemistry; Polyethylene Glycols - pharmacokinetics; Polyethylene Glycols - pharmacology; Preclinical; PREVENTIVE MEDICINE; Prophylaxis; Recombinant Proteins; SAFETY; SWINE; Swine, Miniature; TOXICITY; TOXINS; Young Adult; Israel; AChE; OP; Vz; Prophylaxis; CL; IV; First-in-human; AUC; AChE-R; kel; PEG; t; BuChE; pr-AChE-R; Organophosphorous; Preclinical; DEPQ