Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia
Neuregulin-1 (Nrg-1)11Italic abbreviation “Nrg-1” represent gene, “NRG-1” represent protein. gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treat...
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| Published in | Neuroscience letters Vol. 438; no. 1; pp. 1 - 5 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
13.06.2008
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-3940 1872-7972 |
| DOI | 10.1016/j.neulet.2007.09.051 |
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| Abstract | Neuregulin-1 (Nrg-1)11Italic abbreviation “Nrg-1” represent gene, “NRG-1” represent protein. gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. |
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| AbstractList | Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker.Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. Neuregulin-1 (Nrg-1)11Italic abbreviation “Nrg-1” represent gene, “NRG-1” represent protein. gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. Neuregulin-1 (Nrg-1) super(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti- psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi- quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F = 6.722, P = 0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. |
| Author | Li, Wen-Qiang Ouyang, Xuan Xu, Lin Lv, Lu-Xian Zhang, Hong-Xing Zhao, Jing-Ping Yuan, Zhi-Qing Huang, Jin-Song |
| Author_xml | – sequence: 1 givenname: Hong-Xing surname: Zhang fullname: Zhang, Hong-Xing organization: Institute of Mental Health of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha 410011, China – sequence: 2 givenname: Jing-Ping surname: Zhao fullname: Zhao, Jing-Ping email: zhaojingpinghunan@yahoo.com.cn organization: Institute of Mental Health of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha 410011, China – sequence: 3 givenname: Lu-Xian surname: Lv fullname: Lv, Lu-Xian email: lvx928@126.com organization: Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical College, 388# Jianshe Middle Road, Xinxiang 453002, China – sequence: 4 givenname: Wen-Qiang surname: Li fullname: Li, Wen-Qiang organization: Department of Psychiatry of the Second Affiliated Hospital of Xinxiang Medical College, 388# Jianshe Middle Road, Xinxiang 453002, China – sequence: 5 givenname: Lin surname: Xu fullname: Xu, Lin organization: Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China – sequence: 6 givenname: Xuan surname: Ouyang fullname: Ouyang, Xuan organization: Institute of Mental Health of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha 410011, China – sequence: 7 givenname: Zhi-Qing surname: Yuan fullname: Yuan, Zhi-Qing organization: Department of Pathology of Xinxiang Medical College, Xinxiang 453002, China – sequence: 8 givenname: Jin-Song surname: Huang fullname: Huang, Jin-Song organization: Institute of Mental Health of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha 410011, China |
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| Keywords | Schizophrenia Neuregulin-1 (NRG-1) mRNA Psychosis Neuregulin |
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| Snippet | Neuregulin-1 (Nrg-1)11Italic abbreviation “Nrg-1” represent gene, “NRG-1” represent protein. gene has been considered as a schizophrenia susceptibility gene.... Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia,... Neuregulin-1 (Nrg-1) super(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with... |
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| SubjectTerms | Adolescent Adult Adult and adolescent clinical studies Antipsychotic Agents - pharmacology Biological and medical sciences Brain Chemistry - genetics DNA Mutational Analysis Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression - genetics Genetic Markers - drug effects Genetic Markers - genetics Genetic Predisposition to Disease - genetics Genetic Testing Humans Lymphocytes - chemistry Lymphocytes - metabolism Male Medical sciences mRNA Nerve Tissue Proteins - genetics Neuregulin-1 Neuregulin-1 (NRG-1) Predictive Value of Tests Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses RNA, Messenger - analysis RNA, Messenger - metabolism Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy Schizophrenia - genetics Vertebrates: nervous system and sense organs |
| Title | Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia |
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