Developmental plasticity of lymphocytes
Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or...
Saved in:
| Published in | Current opinion in immunology Vol. 20; no. 2; pp. 139 - 148 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.04.2008
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0952-7915 1879-0372 |
| DOI | 10.1016/j.coi.2008.03.017 |
Cover
| Abstract | Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or erythroid lineages by ectopic cytokine signaling or retroviral expression of the myeloid C/EBPα or erythroid GATA1 transcription factor. Forced C/EBPα expression furthermore induces direct transdifferentiation of immature thymocytes or B cells into macrophages. Notably, conditional inactivation of the B cell commitment factor Pax5 is sufficient to convert mature B cells into functional T cells via dedifferentiation to uncommitted progenitors. Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies. |
|---|---|
| AbstractList | Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or erythroid lineages by ectopic cytokine signaling or retroviral expression of the myeloid C/EBPα or erythroid GATA1 transcription factor. Forced C/EBPα expression furthermore induces direct transdifferentiation of immature thymocytes or B cells into macrophages. Notably, conditional inactivation of the B cell commitment factor Pax5 is sufficient to convert mature B cells into functional T cells via dedifferentiation to uncommitted progenitors. Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies. Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or erythroid lineages by ectopic cytokine signaling or retroviral expression of the myeloid C/EBPalpha or erythroid GATA1 transcription factor. Forced C/EBPalpha expression furthermore induces direct transdifferentiation of immature thymocytes or B cells into macrophages. Notably, conditional inactivation of the B cell commitment factor Pax5 is sufficient to convert mature B cells into functional T cells via dedifferentiation to uncommitted progenitors. Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies. Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or erythroid lineages by ectopic cytokine signaling or retroviral expression of the myeloid C/EBPalpha or erythroid GATA1 transcription factor. Forced C/EBPalpha expression furthermore induces direct transdifferentiation of immature thymocytes or B cells into macrophages. Notably, conditional inactivation of the B cell commitment factor Pax5 is sufficient to convert mature B cells into functional T cells via dedifferentiation to uncommitted progenitors. Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies.Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or erythroid lineages by ectopic cytokine signaling or retroviral expression of the myeloid C/EBPalpha or erythroid GATA1 transcription factor. Forced C/EBPalpha expression furthermore induces direct transdifferentiation of immature thymocytes or B cells into macrophages. Notably, conditional inactivation of the B cell commitment factor Pax5 is sufficient to convert mature B cells into functional T cells via dedifferentiation to uncommitted progenitors. Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies. Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors, lineage-committed precursors and mature lymphocytes. Common lymphoid progenitors and uncommitted pro-T cells can be efficiently diverted into myeloid or erythroid lineages by ectopic cytokine signaling or retroviral expression of the myeloid C/EBP alpha or erythroid GATA1 transcription factor. Forced C/EBP alpha expression furthermore induces direct transdifferentiation of immature thymocytes or B cells into macrophages. Notably, conditional inactivation of the B cell commitment factor Pax5 is sufficient to convert mature B cells into functional T cells via dedifferentiation to uncommitted progenitors. Together these experiments have uncovered an unanticipated developmental plasticity of lymphocytes, which may account for lineage switches observed in human malignancies. |
| Author | Busslinger, Meinrad Cobaleda, César |
| Author_xml | – sequence: 1 givenname: César surname: Cobaleda fullname: Cobaleda, César organization: Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain – sequence: 2 givenname: Meinrad surname: Busslinger fullname: Busslinger, Meinrad email: busslinger@imp.ac.at organization: Research Institute of Molecular Pathology, Vienna Biocenter, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18472258$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFksFu1DAQhi3Uim4LD8AF7QlOSWfsOE6EhIRKW5AqcaB3y3UmwosTBztbKW-Poy0cKrU9-fJ__8jfzCk7GsNIjL1DKBGwPt-VNriSAzQliBJQvWIbbFRbgFD8iG2glbxQLcoTdprSDgCkFPCanWBTKc5ls2Efv9I9-TANNM7Gbydv0uysm5dt6Ld-GaZfwS4zpTfsuDc-0duH94zdXl3eXnwrbn5cf7_4clPYqlFzIXqsOm7RtE0eLnqAtq6UQCN7WdladAqNIsNB2DuShnhPBjtbQc2ptlKcsQ-H2imGP3tKsx5csuS9GSnsk1ZY14JzfDGIbQ1YiTX4_iG4vxuo01N0g4mL_qcgB9QhYGNIKVKv8_fN7MI4R-O8RtCrbL3TWbZeZWsQOsvOJD4i_5c_w3w6MJQl3juKOllHo6XORbKz7nL-OfrzI9p6Nzpr_G9aKO3CPo55Oxp14hr0z_UA1v1Dk3df4WqjfbrgheF_AexuvWA |
| CitedBy_id | crossref_primary_10_1074_jbc_M110_176289 crossref_primary_10_1182_blood_2008_07_167759 crossref_primary_10_1182_bloodadvances_2020002726 crossref_primary_10_1038_modpathol_2011_102 crossref_primary_10_1101_gad_1727208 crossref_primary_10_1038_bcj_2010_1 crossref_primary_10_1016_j_stemcr_2016_12_015 crossref_primary_10_1038_leu_2014_87 crossref_primary_10_1016_j_bbagrm_2014_07_003 crossref_primary_10_1186_s12943_019_1127_7 crossref_primary_10_1016_j_stem_2008_12_004 crossref_primary_10_1016_j_molimm_2015_10_014 crossref_primary_10_1002_eji_201141519 crossref_primary_10_1177_0300985810363705 crossref_primary_10_1371_journal_pone_0071426 crossref_primary_10_3389_fimmu_2022_849451 crossref_primary_10_1172_JCI44417 crossref_primary_10_1073_pnas_0914496107 crossref_primary_10_1371_journal_pone_0182001 crossref_primary_10_1182_blood_2009_01_198911 crossref_primary_10_1002_ijc_24225 crossref_primary_10_1038_ni_2641 crossref_primary_10_1073_pnas_1406985111 crossref_primary_10_1182_blood_2011_01_332064 crossref_primary_10_1182_blood_2011_01_293050 crossref_primary_10_1016_j_biosystems_2025_105399 crossref_primary_10_1084_jem_20150821 crossref_primary_10_5144_0256_4947_2012_296 crossref_primary_10_1186_1752_0509_5_S2_S7 crossref_primary_10_1155_2012_564381 crossref_primary_10_47102_annals_acadmedsg_V38N10p837 crossref_primary_10_1182_blood_2019001438 crossref_primary_10_1093_toxsci_kfq035 crossref_primary_10_1189_jlb_1RU0916_391RR crossref_primary_10_1016_j_gde_2013_07_003 crossref_primary_10_1042_CBI20100516 crossref_primary_10_2302_kjm_60_47 |
| Cites_doi | 10.1016/j.cell.2005.02.013 10.1016/S0092-8674(00)80453-5 10.1002/eji.200526318 10.1038/384474a0 10.1038/35030112 10.1038/ni1455 10.4049/jimmunol.173.6.3935 10.1016/j.immuni.2007.02.013 10.1038/ni1119 10.1016/S0092-8674(00)81692-X 10.1038/nature06159 10.1084/jem.20021843 10.1038/nature05944 10.1371/journal.pbio.0030082 10.1084/jem.20020784 10.1016/j.immuni.2007.05.009 10.1073/pnas.86.14.5434 10.1182/blood-2007-11-124792 10.1016/j.immuni.2007.05.010 10.1038/ni1437 10.1016/S1074-7613(00)80078-3 10.1016/j.immuni.2006.04.008 10.1016/S0092-8674(04)00419-2 10.1038/ni1454 10.1016/j.cell.2004.05.014 10.1016/j.immuni.2007.05.019 10.1038/ni1453 10.1016/j.immuni.2006.09.011 10.1146/annurev.immunol.24.021605.090742 10.1073/pnas.0510304103 10.1093/emboj/cdg380 10.1016/j.cell.2008.03.028 10.1182/blood-2002-06-1780 10.1126/science.1067518 10.1182/blood.V89.10.3636 10.1038/nri1572 10.1182/blood.V67.1.1.1 10.1016/j.immuni.2007.05.013 10.1146/annurev.genet.38.072902.091907 10.1073/pnas.072087899 10.1084/jem.20021149 10.1016/j.immuni.2007.05.021 10.1084/jem.20052444 10.1016/S1074-7613(03)00242-5 10.1038/sj.emboj.7601199 10.1038/44076 10.1038/sj.emboj.7600421 10.1016/S1074-7613(01)00153-4 10.1038/ni1486 10.1016/j.immuni.2006.01.012 10.1038/nature05934 10.1073/pnas.87.12.4781 |
| ContentType | Journal Article |
| Copyright | 2008 Elsevier Ltd Elsevier Ltd |
| Copyright_xml | – notice: 2008 Elsevier Ltd – notice: Elsevier Ltd |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7U9 H94 7X8 |
| DOI | 10.1016/j.coi.2008.03.017 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Immunology Abstracts Virology and AIDS Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1879-0372 |
| EndPage | 148 |
| ExternalDocumentID | 18472258 10_1016_j_coi_2008_03_017 S0952791508000411 1_s2_0_S0952791508000411 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- --K --M -~X .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABEFU ABFRF ABJNI ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CJTIS CNWQP COF CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDU HMG HMK HMO HVGLF HZ~ IH2 IHE J1W J5H K-O KOM L7B LUGTX M29 M41 MO0 N9A O-L O9- O9~ OAUVE OK0 OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SES SEW SIN SPCBC SSH SSI SSZ T5K TN5 UAP WUQ XPP Z5R ZGI ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AAIAV ABLVK ABYKQ AJBFU EFLBG LCYCR AAYXX ACLOT CITATION ~HD AGRNS CGR CUY CVF ECM EIF NPM 7T5 7U9 H94 7X8 |
| ID | FETCH-LOGICAL-c487t-3f14d2c1a980953f00964731a5f54c63d71a7ea203cbe5ae2fea1dc4062e6c53 |
| IEDL.DBID | .~1 |
| ISSN | 0952-7915 |
| IngestDate | Sun Sep 28 08:19:48 EDT 2025 Mon Sep 29 05:34:25 EDT 2025 Mon Jul 21 06:05:46 EDT 2025 Thu Apr 24 22:53:16 EDT 2025 Wed Oct 01 02:20:04 EDT 2025 Fri Feb 23 02:19:36 EST 2024 Sun Feb 23 10:18:57 EST 2025 Tue Aug 26 20:13:17 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c487t-3f14d2c1a980953f00964731a5f54c63d71a7ea203cbe5ae2fea1dc4062e6c53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-3 |
| PMID | 18472258 |
| PQID | 19601431 |
| PQPubID | 23462 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_71663221 proquest_miscellaneous_19601431 pubmed_primary_18472258 crossref_citationtrail_10_1016_j_coi_2008_03_017 crossref_primary_10_1016_j_coi_2008_03_017 elsevier_sciencedirect_doi_10_1016_j_coi_2008_03_017 elsevier_clinicalkeyesjournals_1_s2_0_S0952791508000411 elsevier_clinicalkey_doi_10_1016_j_coi_2008_03_017 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2008-04-01 |
| PublicationDateYYYYMMDD | 2008-04-01 |
| PublicationDate_xml | – month: 04 year: 2008 text: 2008-04-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Current opinion in immunology |
| PublicationTitleAlternate | Curr Opin Immunol |
| PublicationYear | 2008 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Höflinger, Kesavan, Fuxa, Hutter, Heavey, Radtke, Busslinger (bib20) 2004; 173 Weintraub, Tapscott, Davis, Thayer, Adam, Lassar, Miller (bib36) 1989; 86 Kraus, Alimzhanov, Rajewsky, Rajewsky (bib48) 2004; 117 Weissman (bib1) 2000; 100 Rumfelt, Zhou, Rowley, Shinton, Hardy (bib22) 2006; 203 Horcher, Souabni, Busslinger (bib43) 2001; 14 Förster, Rajewsky (bib46) 1990; 87 Nagai, Garrett, Ohta, Bahrun, Kouro, Akira, Takatsu, Kincade (bib27) 2006; 24 O’Riordan, Grosschedl (bib13) 1999; 11 Delogu, Schebesta, Sun, Aschenbrenner, Perlot, Busslinger (bib8) 2006; 24 Kondo, Scherer, Miyamoto, King, Akashi, Sugamura, Weissman (bib23) 2000; 407 Nutt, Kee (bib12) 2007; 26 Månsson, Hultquist, Luc, Yang, Anderson, Kharazi, Al-Hashmi, Liuba, Thoren, Adolfsson (bib9) 2007; 26 Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M, Warnke R, Jaffe ES Ting, Olson, Barton, Leiden (bib32) 1996; 384 Schebesta, McManus, Salvagiotto, Delogu, Busslinger, Busslinger (bib17) 2007; 27 Tze, Schram, Lam, Hogquist, Hippen, Liu, Shinton, Otipoby, Rodine, Vegoe (bib49) 2005; 3 Adolfsson, Månsson, Buza-Vidas, Hultquist, Liuba, Jensen, Bryder, Yang, Borge, Thoren (bib4) 2005; 121 Shapiro-Shelef, Calame (bib47) 2005; 5 . Zheng, Rudensky (bib41) 2007; 8 Fukuchi, Shibata, Ito, Goto-Koshino, Sotomaru, Kitamura, Nakajima (bib30) 2006; 25 Fuxa, Busslinger (bib16) 2007; 178 Greaves, Chan, Furley, Watt, Molgaard (bib51) 1986; 67 Bhandoola, von Boehmer, Petrie, Zúñiga-Pflücker (bib18) 2007; 26 Balciunaite, Ceredig, Massa, Rolink (bib21) 2005; 35 Hsu, King-Fleischman, Lai, Matsumoto, Weissman, Kondo (bib25) 2006; 103 Amsen, Antov, Jankovic, Sher, Radtke, Souabni, Busslinger, McCright, Gridley, Flavell (bib31) 2007; 27 Taghon, Yui, Rothenberg (bib33) 2007; 8 Laiosa, Stadtfeld, Xie, de Andres-Aguayo, Graf (bib40) 2006; 25 Cobaleda, Jochum, Busslinger (bib3) 2007; 449 Iwasaki-Arai, Iwasaki, Miyamoto, Watanabe, Akashi (bib26) 2003; 197 Ringrose, Paro (bib50) 2004; 38 Laiosa, Stadtfeld, Graf (bib2) 2006; 24 Tagoh, Schebesta, Lefevre, Wilson, Hume, Busslinger, Bonifer (bib45) 2004; 23 2008 Kondo, Weissman, Akashi (bib5) 1997; 91 Cobaleda, Schebesta, Delogu, Busslinger (bib11) 2007; 8 Maier, Ostraat, Gao, Fields, Shinton, Medina, Ikawa, Murre, Singh, Hardy (bib14) 2004; 5 Tanigaki, Honjo (bib19) 2007; 8 Miller, Izon, DeMuth, Gerstein, Bhandoola, Allman (bib10) 2002; 196 Heavey, Charalambous, Cobaleda, Busslinger (bib28) 2003; 22 Migliaccio, Rana, Sanchez, Lorenzini, Centurione, Bianchi, Vannucchi, Migliaccio, Orkin (bib35) 2003; 197 Hardy, Kincade, Dorshkind (bib6) 2007; 26 King, Kondo, Scherer, Weissman (bib24) 2002; 99 Iwasaki, Mizuno, Wells, Cantor, Watanabe, Akashi (bib29) 2003; 19 Wernig, Meissner, Foreman, Brambrink, Ku, Hochedlinger, Bernstein, Jaenisch (bib38) 2007; 448 Akashi, He, Chen, Iwasaki, Niu, Steenhard, Zhang, Haug, Li (bib7) 2003; 101 Williams, Rudensky (bib42) 2007; 8 250–264 Nutt, Heavey, Rolink, Busslinger (bib15) 1999; 401 2008, in press (doi:10.1182) Tsai, Orkin (bib34) 1997; 89 Xie, Ye, Feng, Graf (bib39) 2004; 117 Mikkola, Heavey, Horcher, Busslinger (bib44) 2002; 297 Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, et al. Okita, Ichisaka, Yamanaka (bib37) 2007; 448 Maier (10.1016/j.coi.2008.03.017_bib14) 2004; 5 Höflinger (10.1016/j.coi.2008.03.017_bib20) 2004; 173 Nutt (10.1016/j.coi.2008.03.017_bib12) 2007; 26 Okita (10.1016/j.coi.2008.03.017_bib37_1) 2007; 448 Delogu (10.1016/j.coi.2008.03.017_bib8_1) 2006; 24 Iwasaki-Arai (10.1016/j.coi.2008.03.017_bib26) 2003; 197 Fukuchi (10.1016/j.coi.2008.03.017_bib30) 2006; 25 O’Riordan (10.1016/j.coi.2008.03.017_bib13) 1999; 11 Förster (10.1016/j.coi.2008.03.017_bib46) 1990; 87 Akashi (10.1016/j.coi.2008.03.017_bib7) 2003; 101 Tsai (10.1016/j.coi.2008.03.017_bib34) 1997; 89 Wernig (10.1016/j.coi.2008.03.017_bib38_1) 2007; 448 Tze (10.1016/j.coi.2008.03.017_bib49) 2005; 3 Kondo (10.1016/j.coi.2008.03.017_bib23) 2000; 407 Bhandoola (10.1016/j.coi.2008.03.017_bib18) 2007; 26 Laiosa (10.1016/j.coi.2008.03.017_bib2) 2006; 24 Mikkola (10.1016/j.coi.2008.03.017_bib44) 2002; 297 10.1016/j.coi.2008.03.017_bib52_1 Fuxa (10.1016/j.coi.2008.03.017_bib16) 2007; 178 Taghon (10.1016/j.coi.2008.03.017_bib33_1) 2007; 8 Greaves (10.1016/j.coi.2008.03.017_bib51) 1986; 67 Weintraub (10.1016/j.coi.2008.03.017_bib36) 1989; 86 Amsen (10.1016/j.coi.2008.03.017_bib31) 2007; 27 Månsson (10.1016/j.coi.2008.03.017_bib9_1) 2007; 26 Miller (10.1016/j.coi.2008.03.017_bib10) 2002; 196 Kondo (10.1016/j.coi.2008.03.017_bib5) 1997; 91 Schebesta (10.1016/j.coi.2008.03.017_bib17_1) 2007; 27 Balciunaite (10.1016/j.coi.2008.03.017_bib21) 2005; 35 Nutt (10.1016/j.coi.2008.03.017_bib15) 1999; 401 King (10.1016/j.coi.2008.03.017_bib24) 2002; 99 Hardy (10.1016/j.coi.2008.03.017_bib6) 2007; 26 Laiosa (10.1016/j.coi.2008.03.017_bib40_1) 2006; 25 Williams (10.1016/j.coi.2008.03.017_bib42_1) 2007; 8 Weissman (10.1016/j.coi.2008.03.017_bib1) 2000; 100 Xie (10.1016/j.coi.2008.03.017_bib39) 2004; 117 Shapiro-Shelef (10.1016/j.coi.2008.03.017_bib47) 2005; 5 Cobaleda (10.1016/j.coi.2008.03.017_bib11) 2007; 8 Kraus (10.1016/j.coi.2008.03.017_bib48) 2004; 117 Hsu (10.1016/j.coi.2008.03.017_bib25_1) 2006; 103 Nagai (10.1016/j.coi.2008.03.017_bib27_1) 2006; 24 Adolfsson (10.1016/j.coi.2008.03.017_bib4) 2005; 121 Cobaleda (10.1016/j.coi.2008.03.017_bib3_1) 2007; 449 Ringrose (10.1016/j.coi.2008.03.017_bib50) 2004; 38 10.1016/j.coi.2008.03.017_bib53_1 Tanigaki (10.1016/j.coi.2008.03.017_bib19) 2007; 8 Rumfelt (10.1016/j.coi.2008.03.017_bib22) 2006; 203 Iwasaki (10.1016/j.coi.2008.03.017_bib29) 2003; 19 Migliaccio (10.1016/j.coi.2008.03.017_bib35) 2003; 197 Zheng (10.1016/j.coi.2008.03.017_bib41) 2007; 8 Ting (10.1016/j.coi.2008.03.017_bib32) 1996; 384 Heavey (10.1016/j.coi.2008.03.017_bib28) 2003; 22 Horcher (10.1016/j.coi.2008.03.017_bib43) 2001; 14 Tagoh (10.1016/j.coi.2008.03.017_bib45) 2004; 23 |
| References_xml | – volume: 38 start-page: 413 year: 2004 end-page: 443 ident: bib50 article-title: Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins publication-title: Annu Rev Genet – volume: 27 start-page: 49 year: 2007 end-page: 63 ident: bib17 article-title: Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration and immune function publication-title: Immunity – volume: 178 start-page: 8222 year: 2007 end-page: 8228 ident: bib16 article-title: Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of publication-title: J Immunol – volume: 8 start-page: 845 year: 2007 end-page: 855 ident: bib33 article-title: Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3 publication-title: Nat Immunol – volume: 448 start-page: 318 year: 2007 end-page: 324 ident: bib38 publication-title: Nature – volume: 117 start-page: 663 year: 2004 end-page: 676 ident: bib39 article-title: Stepwise reprogramming of B cells into macrophages publication-title: Cell – volume: 86 start-page: 5434 year: 1989 end-page: 5438 ident: bib36 article-title: Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD publication-title: Proc Natl Acad Sci U S A – volume: 26 start-page: 715 year: 2007 end-page: 725 ident: bib12 article-title: The transcriptional regulation of B cell lineage commitment publication-title: Immunity – volume: 8 start-page: 463 year: 2007 end-page: 470 ident: bib11 article-title: Pax5: the guardian of B cell identity and function publication-title: Nat Immunol – volume: 103 start-page: 672 year: 2006 end-page: 677 ident: bib25 article-title: Antagonistic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors publication-title: Proc Natl Acad Sci U S A – volume: 26 start-page: 703 year: 2007 end-page: 714 ident: bib6 article-title: The protean nature of cells in the B lymphocyte lineage publication-title: Immunity – volume: 25 start-page: 731 year: 2006 end-page: 744 ident: bib40 article-title: Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBPα and PU.1 transcription factors publication-title: Immunity – volume: 99 start-page: 4508 year: 2002 end-page: 4513 ident: bib24 article-title: Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling publication-title: Proc Natl Acad Sci U S A – volume: 89 start-page: 3636 year: 1997 end-page: 3643 ident: bib34 article-title: Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation publication-title: Blood – volume: 407 start-page: 383 year: 2000 end-page: 386 ident: bib23 article-title: Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines publication-title: Nature – reference: 2008, – volume: 8 start-page: 451 year: 2007 end-page: 456 ident: bib19 article-title: Regulation of lymphocyte development by Notch signaling publication-title: Nat Immunol – volume: 26 start-page: 678 year: 2007 end-page: 689 ident: bib18 article-title: Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from publication-title: Immunity – volume: 11 start-page: 21 year: 1999 end-page: 31 ident: bib13 article-title: Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A publication-title: Immunity – volume: 448 start-page: 313 year: 2007 end-page: 317 ident: bib37 article-title: Generation of germline-competent induced pluripotent stem cells publication-title: Nature – volume: 25 start-page: 3398 year: 2006 end-page: 3410 ident: bib30 article-title: Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBPα publication-title: EMBO J – volume: 26 start-page: 407 year: 2007 end-page: 419 ident: bib9 article-title: Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors publication-title: Immunity – reference: :250–264 – volume: 67 start-page: 1 year: 1986 end-page: 11 ident: bib51 article-title: Lineage promiscuity in hemopoietic differentiation and leukemia publication-title: Blood – reference: 2008, in press (doi:10.1182) – reference: Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, et al.: – volume: 173 start-page: 3935 year: 2004 end-page: 3944 ident: bib20 article-title: Analysis of Notch1 function by in vitro T cell differentiation of publication-title: J Immunol – volume: 91 start-page: 661 year: 1997 end-page: 672 ident: bib5 article-title: Identification of clonogenic common lymphoid progenitors in mouse bone marrow publication-title: Cell – reference: Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M, Warnke R, Jaffe ES: – volume: 35 start-page: 2019 year: 2005 end-page: 2030 ident: bib21 article-title: A B220 publication-title: Eur J Immunol – volume: 19 start-page: 451 year: 2003 end-page: 462 ident: bib29 article-title: GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages publication-title: Immunity – reference: . – volume: 24 start-page: 269 year: 2006 end-page: 281 ident: bib8 article-title: Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells publication-title: Immunity – volume: 384 start-page: 474 year: 1996 end-page: 478 ident: bib32 article-title: Transcription factor GATA-3 is required for development of the T-cell lineage publication-title: Nature – volume: 197 start-page: 281 year: 2003 end-page: 296 ident: bib35 article-title: GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1 publication-title: J Exp Med – volume: 8 start-page: 277 year: 2007 end-page: 284 ident: bib42 article-title: Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 publication-title: Nat Immunol – volume: 5 start-page: 1069 year: 2004 end-page: 1077 ident: bib14 article-title: Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with publication-title: Nat Immunol – volume: 297 start-page: 110 year: 2002 end-page: 113 ident: bib44 article-title: Reversion of B cell commitment upon loss of publication-title: Science – volume: 449 start-page: 473 year: 2007 end-page: 477 ident: bib3 article-title: Conversion of mature B cells into T cells by dedifferentation to uncommitted progenitors publication-title: Nature – volume: 87 start-page: 4781 year: 1990 end-page: 4784 ident: bib46 article-title: The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow publication-title: Proc Natl Acad Sci U S A – volume: 101 start-page: 383 year: 2003 end-page: 389 ident: bib7 article-title: Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis publication-title: Blood – volume: 27 start-page: 89 year: 2007 end-page: 99 ident: bib31 article-title: Direct regulation of publication-title: Immunity – volume: 5 start-page: 230 year: 2005 end-page: 242 ident: bib47 article-title: Regulation of plasma-cell development publication-title: Nat Rev Immunol – volume: 401 start-page: 556 year: 1999 end-page: 562 ident: bib15 article-title: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 publication-title: Nature – volume: 121 start-page: 295 year: 2005 end-page: 306 ident: bib4 article-title: Identification of Flt3 publication-title: Cell – volume: 8 start-page: 457 year: 2007 end-page: 462 ident: bib41 article-title: Foxp3 in control of the regulatory T cell lineage publication-title: Nat Immunol – volume: 197 start-page: 1311 year: 2003 end-page: 1322 ident: bib26 article-title: Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion publication-title: J Exp Med – volume: 22 start-page: 3887 year: 2003 end-page: 3897 ident: bib28 article-title: Myeloid lineage switch of publication-title: EMBO J – volume: 196 start-page: 705 year: 2002 end-page: 711 ident: bib10 article-title: The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7 publication-title: J Exp Med – volume: 3 start-page: 463 year: 2005 end-page: 475 ident: bib49 article-title: Basal immunoglobulin signaling actively maintains developmental stage in immature B cells publication-title: PLoS Biol – volume: 24 start-page: 705 year: 2006 end-page: 738 ident: bib2 article-title: Determinants of lymphoid-myeloid lineage diversification publication-title: Annu Rev Immunol – volume: 203 start-page: 675 year: 2006 end-page: 687 ident: bib22 article-title: Lineage specification and plasticity in CD19 publication-title: J Exp Med – volume: 23 start-page: 4275 year: 2004 end-page: 4285 ident: bib45 article-title: Epigenetic silencing of the publication-title: EMBO J – volume: 24 start-page: 801 year: 2006 end-page: 812 ident: bib27 article-title: Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment publication-title: Immunity – volume: 117 start-page: 787 year: 2004 end-page: 800 ident: bib48 article-title: Survival of resting mature B lymphocytes depends on BCR signaling via the Igα/β heterodimer publication-title: Cell – volume: 100 start-page: 157 year: 2000 end-page: 168 ident: bib1 article-title: Stem cells: units of development, units of regeneration, and units of evolution publication-title: Cell – volume: 14 start-page: 779 year: 2001 end-page: 790 ident: bib43 article-title: Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis publication-title: Immunity – volume: 121 start-page: 295 year: 2005 ident: 10.1016/j.coi.2008.03.017_bib4 article-title: Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: a revised road map for adult blood lineage commitment publication-title: Cell doi: 10.1016/j.cell.2005.02.013 – volume: 91 start-page: 661 year: 1997 ident: 10.1016/j.coi.2008.03.017_bib5 article-title: Identification of clonogenic common lymphoid progenitors in mouse bone marrow publication-title: Cell doi: 10.1016/S0092-8674(00)80453-5 – volume: 35 start-page: 2019 year: 2005 ident: 10.1016/j.coi.2008.03.017_bib21 article-title: A B220+ CD117+ CD19− hematopoietic progenitor with potent lymphoid and myeloid developmental potential publication-title: Eur J Immunol doi: 10.1002/eji.200526318 – volume: 384 start-page: 474 year: 1996 ident: 10.1016/j.coi.2008.03.017_bib32 article-title: Transcription factor GATA-3 is required for development of the T-cell lineage publication-title: Nature doi: 10.1038/384474a0 – volume: 407 start-page: 383 year: 2000 ident: 10.1016/j.coi.2008.03.017_bib23 article-title: Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines publication-title: Nature doi: 10.1038/35030112 – volume: 8 start-page: 457 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib41 article-title: Foxp3 in control of the regulatory T cell lineage publication-title: Nat Immunol doi: 10.1038/ni1455 – volume: 173 start-page: 3935 year: 2004 ident: 10.1016/j.coi.2008.03.017_bib20 article-title: Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors publication-title: J Immunol doi: 10.4049/jimmunol.173.6.3935 – volume: 26 start-page: 407 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib9_1 article-title: Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors publication-title: Immunity doi: 10.1016/j.immuni.2007.02.013 – volume: 5 start-page: 1069 year: 2004 ident: 10.1016/j.coi.2008.03.017_bib14 article-title: Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription publication-title: Nat Immunol doi: 10.1038/ni1119 – volume: 100 start-page: 157 year: 2000 ident: 10.1016/j.coi.2008.03.017_bib1 article-title: Stem cells: units of development, units of regeneration, and units of evolution publication-title: Cell doi: 10.1016/S0092-8674(00)81692-X – volume: 449 start-page: 473 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib3_1 article-title: Conversion of mature B cells into T cells by dedifferentation to uncommitted progenitors publication-title: Nature doi: 10.1038/nature06159 – volume: 197 start-page: 1311 year: 2003 ident: 10.1016/j.coi.2008.03.017_bib26 article-title: Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion publication-title: J Exp Med doi: 10.1084/jem.20021843 – volume: 448 start-page: 318 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib38_1 article-title: In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state publication-title: Nature doi: 10.1038/nature05944 – volume: 3 start-page: 463 year: 2005 ident: 10.1016/j.coi.2008.03.017_bib49 article-title: Basal immunoglobulin signaling actively maintains developmental stage in immature B cells publication-title: PLoS Biol doi: 10.1371/journal.pbio.0030082 – volume: 196 start-page: 705 year: 2002 ident: 10.1016/j.coi.2008.03.017_bib10 article-title: The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7 publication-title: J Exp Med doi: 10.1084/jem.20020784 – volume: 26 start-page: 678 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib18 article-title: Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from publication-title: Immunity doi: 10.1016/j.immuni.2007.05.009 – volume: 86 start-page: 5434 year: 1989 ident: 10.1016/j.coi.2008.03.017_bib36 article-title: Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.86.14.5434 – ident: 10.1016/j.coi.2008.03.017_bib52_1 doi: 10.1182/blood-2007-11-124792 – volume: 26 start-page: 715 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib12 article-title: The transcriptional regulation of B cell lineage commitment publication-title: Immunity doi: 10.1016/j.immuni.2007.05.010 – volume: 8 start-page: 277 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib42_1 article-title: Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 publication-title: Nat Immunol doi: 10.1038/ni1437 – volume: 11 start-page: 21 year: 1999 ident: 10.1016/j.coi.2008.03.017_bib13 article-title: Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A publication-title: Immunity doi: 10.1016/S1074-7613(00)80078-3 – volume: 24 start-page: 801 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib27_1 article-title: Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment publication-title: Immunity doi: 10.1016/j.immuni.2006.04.008 – volume: 117 start-page: 663 year: 2004 ident: 10.1016/j.coi.2008.03.017_bib39 article-title: Stepwise reprogramming of B cells into macrophages publication-title: Cell doi: 10.1016/S0092-8674(04)00419-2 – volume: 8 start-page: 463 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib11 article-title: Pax5: the guardian of B cell identity and function publication-title: Nat Immunol doi: 10.1038/ni1454 – volume: 117 start-page: 787 year: 2004 ident: 10.1016/j.coi.2008.03.017_bib48 article-title: Survival of resting mature B lymphocytes depends on BCR signaling via the Igα/β heterodimer publication-title: Cell doi: 10.1016/j.cell.2004.05.014 – volume: 27 start-page: 49 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib17_1 article-title: Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration and immune function publication-title: Immunity doi: 10.1016/j.immuni.2007.05.019 – volume: 8 start-page: 451 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib19 article-title: Regulation of lymphocyte development by Notch signaling publication-title: Nat Immunol doi: 10.1038/ni1453 – volume: 25 start-page: 731 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib40_1 article-title: Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBPα and PU.1 transcription factors publication-title: Immunity doi: 10.1016/j.immuni.2006.09.011 – volume: 24 start-page: 705 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib2 article-title: Determinants of lymphoid-myeloid lineage diversification publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.24.021605.090742 – volume: 103 start-page: 672 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib25_1 article-title: Antagonistic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0510304103 – volume: 22 start-page: 3887 year: 2003 ident: 10.1016/j.coi.2008.03.017_bib28 article-title: Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPα and GATA factors publication-title: EMBO J doi: 10.1093/emboj/cdg380 – ident: 10.1016/j.coi.2008.03.017_bib53_1 doi: 10.1016/j.cell.2008.03.028 – volume: 101 start-page: 383 year: 2003 ident: 10.1016/j.coi.2008.03.017_bib7 article-title: Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis publication-title: Blood doi: 10.1182/blood-2002-06-1780 – volume: 297 start-page: 110 year: 2002 ident: 10.1016/j.coi.2008.03.017_bib44 article-title: Reversion of B cell commitment upon loss of Pax5 expression publication-title: Science doi: 10.1126/science.1067518 – volume: 89 start-page: 3636 year: 1997 ident: 10.1016/j.coi.2008.03.017_bib34 article-title: Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation publication-title: Blood doi: 10.1182/blood.V89.10.3636 – volume: 5 start-page: 230 year: 2005 ident: 10.1016/j.coi.2008.03.017_bib47 article-title: Regulation of plasma-cell development publication-title: Nat Rev Immunol doi: 10.1038/nri1572 – volume: 67 start-page: 1 year: 1986 ident: 10.1016/j.coi.2008.03.017_bib51 article-title: Lineage promiscuity in hemopoietic differentiation and leukemia publication-title: Blood doi: 10.1182/blood.V67.1.1.1 – volume: 26 start-page: 703 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib6 article-title: The protean nature of cells in the B lymphocyte lineage publication-title: Immunity doi: 10.1016/j.immuni.2007.05.013 – volume: 38 start-page: 413 year: 2004 ident: 10.1016/j.coi.2008.03.017_bib50 article-title: Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins publication-title: Annu Rev Genet doi: 10.1146/annurev.genet.38.072902.091907 – volume: 99 start-page: 4508 year: 2002 ident: 10.1016/j.coi.2008.03.017_bib24 article-title: Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.072087899 – volume: 197 start-page: 281 year: 2003 ident: 10.1016/j.coi.2008.03.017_bib35 article-title: GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant publication-title: J Exp Med doi: 10.1084/jem.20021149 – volume: 27 start-page: 89 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib31 article-title: Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch publication-title: Immunity doi: 10.1016/j.immuni.2007.05.021 – volume: 203 start-page: 675 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib22 article-title: Lineage specification and plasticity in CD19− early B cell precursors publication-title: J Exp Med doi: 10.1084/jem.20052444 – volume: 19 start-page: 451 year: 2003 ident: 10.1016/j.coi.2008.03.017_bib29 article-title: GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages publication-title: Immunity doi: 10.1016/S1074-7613(03)00242-5 – volume: 25 start-page: 3398 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib30 article-title: Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBPα publication-title: EMBO J doi: 10.1038/sj.emboj.7601199 – volume: 401 start-page: 556 year: 1999 ident: 10.1016/j.coi.2008.03.017_bib15 article-title: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 publication-title: Nature doi: 10.1038/44076 – volume: 23 start-page: 4275 year: 2004 ident: 10.1016/j.coi.2008.03.017_bib45 article-title: Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible publication-title: EMBO J doi: 10.1038/sj.emboj.7600421 – volume: 14 start-page: 779 year: 2001 ident: 10.1016/j.coi.2008.03.017_bib43 article-title: Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis publication-title: Immunity doi: 10.1016/S1074-7613(01)00153-4 – volume: 8 start-page: 845 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib33_1 article-title: Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3 publication-title: Nat Immunol doi: 10.1038/ni1486 – volume: 24 start-page: 269 year: 2006 ident: 10.1016/j.coi.2008.03.017_bib8_1 article-title: Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells publication-title: Immunity doi: 10.1016/j.immuni.2006.01.012 – volume: 178 start-page: 8222 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib16 article-title: Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function publication-title: J Immunol – volume: 448 start-page: 313 year: 2007 ident: 10.1016/j.coi.2008.03.017_bib37_1 article-title: Generation of germline-competent induced pluripotent stem cells publication-title: Nature doi: 10.1038/nature05934 – volume: 87 start-page: 4781 year: 1990 ident: 10.1016/j.coi.2008.03.017_bib46 article-title: The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.87.12.4781 |
| SSID | ssj0005530 |
| Score | 2.111952 |
| SecondaryResourceType | review_article |
| Snippet | Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors,... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 139 |
| SubjectTerms | Allergy and Immunology Cell Dedifferentiation Cell Differentiation Cell Lineage Cytokines - physiology Hematologic Neoplasms - genetics Humans Precursor Cells, B-Lymphoid - cytology Precursor Cells, B-Lymphoid - immunology Precursor Cells, B-Lymphoid - metabolism Precursor Cells, T-Lymphoid - cytology Precursor Cells, T-Lymphoid - immunology Precursor Cells, T-Lymphoid - metabolism Signal Transduction Transcription Factors - metabolism |
| Title | Developmental plasticity of lymphocytes |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0952791508000411 https://www.clinicalkey.es/playcontent/1-s2.0-S0952791508000411 https://dx.doi.org/10.1016/j.coi.2008.03.017 https://www.ncbi.nlm.nih.gov/pubmed/18472258 https://www.proquest.com/docview/19601431 https://www.proquest.com/docview/71663221 |
| Volume | 20 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier ScienceDirect customDbUrl: eissn: 1879-0372 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0005530 issn: 0952-7915 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1879-0372 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0005530 issn: 0952-7915 databaseCode: ACRLP dateStart: 19950201 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection customDbUrl: eissn: 1879-0372 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0005530 issn: 0952-7915 databaseCode: AIKHN dateStart: 19950201 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1879-0372 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0005530 issn: 0952-7915 databaseCode: AKRWK dateStart: 19880901 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSxxBEC5ESfAS1CS6vrIHIRAYd_o1j6NIZDXoRQPemp7qbtggO0t2PezF3271TM-6IT7A61BFNzXVVV_RX1cBHCHDXDhrE6kEJpJyXmIE94kteJlVHq1srgsur7Lhb3lxq25X4LR7CxNolTH2tzG9idbxyyBaczAZjQbXBA54XoZ-5gGYNO97Q_cv8unjhyWah2rmjQTh0JpRdTebDccL61GkU4rjtJlZ9mxuegl7NjnobAM-RfDYP2n3twkrbrwFH9pxkvMt-HgZL8o_w_clMhBpTAgjB_r0bN6vff9uTr-wxjmhzC9wc_bz5nSYxJkICVJpMUuEZ9JyZKYsQqc4H0oQmQtmlFcSM2FzZnJneCqwcso47p1hFiltc5ehEl9hdVyP3Q70MfXcssJWORbSFqpCg0aWVEBI78si70HaGUNj7Bcexlbc6Y4Y9keT_eIcS6HJfj34sVCZtM0yXhPmnYV19wqU4pamUP6aUv6ckpvGkzfVTE-5TvV_3tEDudD8x8HeWvBb9_M1Hbxwm2LGrr6nhaj2I7DJXpagUjSjeEkS263XPBmlCD06VbH7vk3twXpLWwkEon1Ynf29dweEjWbVYeP8h7B2cv5rePUIHQcLEw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxsxEB6CQ5teSps2qdNHfCgEChuvXvs4htDgNLEvdSA3oR1J4BC8JnYO_vcZ7WqTluYBvS4zSMxKM98wn2YAviPDXDhrE6kEJpJiXmIE94kteJlVHq1sygXjSTa6kL8u1eUGHHdvYQKtMvr-1qc33jp-GUZrDhez2fA3gQOel6GfeQAm4X3vplTkk3uweXR6Npo8MD1UM3IkyIfujKorbjY0L6xnkVEpDtNmbNmj4ekp-NmEoZN38Dbix8FRu8X3sOHm2_CqnSi53obX41gr_wAHf_CBSGNBMDkwqFfrQe0H12v6izWuCWh-hOnJz-nxKIljERKk7GKVCM-k5chMWYRmcT5kITIXzCivJGbC5szkzvBUYOWUcdw7wyxS5OYuQyV2oDev5-4TDDD13LLCVjkW0haqQoNGlpRDSO_LIu9D2hlDY2wZHiZXXOuOG3alyX5xlKXQZL8-_LhXWbT9Mp4T5p2FdfcQlFyXJm_-nFL-mJJbxsu31EwvuU71PwekD_Je868z9tKC-93P13T3QkHFzF19SwtR-kd4kz0tQdloRi6TJHbbU_NglCK06VTF3v9tah-2RtPxuT4_nZx9hjctiyXwib5Ab3Vz674SVFpV3-JVuAMueQ2- |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Developmental+plasticity+of+lymphocytes&rft.jtitle=Current+opinion+in+immunology&rft.au=Cobaleda%2C+C%C3%A9sar&rft.au=Busslinger%2C+Meinrad&rft.date=2008-04-01&rft.issn=0952-7915&rft.volume=20&rft.issue=2&rft.spage=139&rft.epage=148&rft_id=info:doi/10.1016%2Fj.coi.2008.03.017&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_coi_2008_03_017 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F09527915%2FS0952791508X00032%2Fcov150h.gif |