Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study
Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experi...
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| Published in | Medicine (Baltimore) Vol. 101; no. 37; p. e30580 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott Williams & Wilkins
16.09.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1536-5964 0025-7974 1536-5964 |
| DOI | 10.1097/MD.0000000000030580 |
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| Abstract | Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)—located on the gene encoding for pleiotrophin on chromosome 7—that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (
P
= 1.31 × 10
-7
, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (
P
= .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing. |
|---|---|
| AbstractList | Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)-located on the gene encoding for pleiotrophin on chromosome 7-that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)-located on the gene encoding for pleiotrophin on chromosome 7-that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing. Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)—located on the gene encoding for pleiotrophin on chromosome 7—that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain ( P = 1.31 × 10 -7 , FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort ( P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing. Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)—located on the gene encoding for pleiotrophin on chromosome 7—that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain ( P = 1.31 × 10 -7 , FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort ( P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing. |
| Author | Nakagawa-Senda, Hiroko Shimanoe, Chisato Takezaki, Toshiro Otonari, Jun Ozaki, Etsuko Saita, Kosuke Tanaka, Keitaro Ibusuki, Rie Sudo, Yoshika Ito, Hidemi Ikezaki, Hiroaki Uchida, Kanji Kita, Yoshikuni Hishida, Asahi Katsuura-Kamano, Sakurako Sumitani, Masahiko Abe, Hiroaki Oze, Isao Nakamura, Yohko Kusakabe, Miho Tamura, Takashi Matsui, Daisuke Nakamura, Yasuyuki Arisawa, Kokichi Suzuki, Sadao Kuriki, Kiyonori Nishizawa, Daisuke Ikeda, Kazutaka Wakai, Kenji Takeuchi, Kenji Momozawa, Yukihide |
| AuthorAffiliation | Department of Pharmacy, Saga University Hospital, Saga, Japan Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan Division of Cancer Information and Control, Aichi Cancer Center Research Institute |
| AuthorAffiliation_xml | – name: Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan – name: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan – name: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan – name: Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan – name: Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan – name: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan – name: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan – name: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan – name: Faculty of Nursing Science, Tsuruga Nursing University, Tsuruga, Japan – name: Department of Preventive Medicine, Nagoya University, Graduate School of Medicine, Nagoya, Japan – name: Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan – name: Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan – name: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan – name: Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – name: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan – name: Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan – name: Department of Pharmacy, Saga University Hospital, Saga, Japan |
| Author_xml | – sequence: 1 givenname: Kosuke surname: Saita fullname: Saita, Kosuke organization: Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan – sequence: 2 givenname: Masahiko surname: Sumitani fullname: Sumitani, Masahiko organization: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan – sequence: 3 givenname: Daisuke surname: Nishizawa fullname: Nishizawa, Daisuke organization: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan – sequence: 4 givenname: Takashi surname: Tamura fullname: Tamura, Takashi organization: Department of Preventive Medicine, Nagoya University, Graduate School of Medicine, Nagoya, Japan – sequence: 5 givenname: Kazutaka surname: Ikeda fullname: Ikeda, Kazutaka organization: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan – sequence: 6 givenname: Kenji surname: Wakai fullname: Wakai, Kenji organization: Department of Preventive Medicine, Nagoya University, Graduate School of Medicine, Nagoya, Japan – sequence: 7 givenname: Yoshika surname: Sudo fullname: Sudo, Yoshika organization: Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan – sequence: 8 givenname: Hiroaki surname: Abe fullname: Abe, Hiroaki organization: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan – sequence: 9 givenname: Jun surname: Otonari fullname: Otonari, Jun organization: Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 10 givenname: Hiroaki surname: Ikezaki fullname: Ikezaki, Hiroaki organization: Department of Comprehensive General Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 11 givenname: Kenji surname: Takeuchi fullname: Takeuchi, Kenji organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan – sequence: 12 givenname: Asahi surname: Hishida fullname: Hishida, Asahi organization: Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan – sequence: 13 givenname: Keitaro surname: Tanaka fullname: Tanaka, Keitaro organization: Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan – sequence: 14 givenname: Chisato surname: Shimanoe fullname: Shimanoe, Chisato organization: Department of Pharmacy, Saga University Hospital, Saga, Japan – sequence: 15 givenname: Toshiro surname: Takezaki fullname: Takezaki, Toshiro organization: Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 16 givenname: Rie surname: Ibusuki fullname: Ibusuki, Rie organization: Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 17 givenname: Isao surname: Oze fullname: Oze, Isao organization: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan – sequence: 18 givenname: Hidemi surname: Ito fullname: Ito, Hidemi organization: Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan – sequence: 19 givenname: Etsuko surname: Ozaki fullname: Ozaki, Etsuko organization: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan – sequence: 20 givenname: Daisuke surname: Matsui fullname: Matsui, Daisuke organization: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan – sequence: 21 givenname: Yohko surname: Nakamura fullname: Nakamura, Yohko organization: Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan – sequence: 22 givenname: Miho surname: Kusakabe fullname: Kusakabe, Miho organization: Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan – sequence: 23 givenname: Sadao surname: Suzuki fullname: Suzuki, Sadao organization: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan – sequence: 24 givenname: Hiroko surname: Nakagawa-Senda fullname: Nakagawa-Senda, Hiroko organization: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan – sequence: 25 givenname: Kokichi surname: Arisawa fullname: Arisawa, Kokichi organization: Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan – sequence: 26 givenname: Sakurako surname: Katsuura-Kamano fullname: Katsuura-Kamano, Sakurako organization: Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan – sequence: 27 givenname: Kiyonori surname: Kuriki fullname: Kuriki, Kiyonori organization: Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan – sequence: 28 givenname: Yoshikuni surname: Kita fullname: Kita, Yoshikuni organization: Faculty of Nursing Science, Tsuruga Nursing University, Tsuruga, Japan – sequence: 29 givenname: Yasuyuki surname: Nakamura fullname: Nakamura, Yasuyuki organization: Department of Public Health, Shiga University of Medical Science, Otsu, Japan – sequence: 30 givenname: Yukihide surname: Momozawa fullname: Momozawa, Yukihide organization: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan – sequence: 31 givenname: Kanji surname: Uchida fullname: Uchida, Kanji organization: Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo, Japan |
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| Cites_doi | 10.1369/jhc.4A6574.2005 10.1080/08977190801987711 10.1038/ng1847 10.1038/s41598-018-19914-w 10.1007/BF01117507 10.1016/S0304-3959(00)00361-4 10.1038/nature19057 10.1016/S0140-6736(12)61729-2 10.1046/j.1460-9568.1998.00039.x 10.3109/08977194.2012.693920 10.2217/bmm-2017-0427 10.1016/j.neuron.2012.02.008 10.1074/jbc.M116.773713 10.1016/j.jbiomech.2019.109573 10.1038/nature12873 10.1016/j.biochi.2008.04.010 10.1093/bioinformatics/btn653 10.1111/j.2517-6161.1995.tb02031.x 10.1086/519795 10.1016/j.pbb.2013.07.013 10.1093/bioinformatics/bth457 10.1186/s12974-017-0823-8 10.1002/cpt.590 10.1016/j.advms.2015.05.003 10.1016/j.ymgme.2011.01.017 10.1016/j.neures.2012.09.001 10.1080/08977190902906859 10.1016/j.neulet.2017.10.038 10.1038/oby.2009.141 10.1016/j.ejphar.2010.08.029 10.1093/nar/gkp290 10.1186/1471-2458-11-770 10.1038/ki.2011.305 |
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| References | Fernández-Calle (R25-20250504) 2017; 14 Lauri (R22-20250504) 1998; 10 Ezquerra (R32-20250504) 2008; 26 Vicente-Rodríguez (R34-20250504) 2013; 110 Goldberg (R3-20250504) 2011; 11 Gramage (R23-20250504) 2010; 647 Smith (R18-20250504) 2013; 14 Shen (R30-20250504) 2017; 292 Xu (R7-20250504) 2009; 37 Laramie (R36-20250504) 2009; 17 Palmieri (R33-20250504) 2015; 60 Diaz (R11-20250504) 2018; 12 Barrett (R16-20250504) 2005; 21 Silver (R29-20250504) 2012; 30 von Hehn (R5-20250504) 2012; 73 Benjamini (R17-20250504) 1995; 57 Mencej-Bedrač (R35-20250504) 2011; 103 Blondet (R31-20250504) 2005; 53 Lek (R6-20250504) 2016; 536 Sumitani (R13-20250504) 2020; 100 Mäntyselkä (R2-20250504) 2001; 89 Okada (R12-20250504) 2014; 506 Vos (R1-20250504) 2012; 380 Chua (R10-20250504) 2017; 101 Nakagawa-Senda (R19-20250504) 2018; 8 Yokoi (R28-20250504) 2012; 81 Achour (R27-20250504) 2008; 90 del Olmo (R21-20250504) 2009; 27 Chelala (R8-20250504) 2009; 25 Purcell (R14-20250504) 2007; 81 Price (R15-20250504) 2006; 38 Fernández-Calle (R24-20250504) 2018; 662 Urban (R9-20250504) 2020; 102 Rauvala (R20-20250504) 1989; 9 Miao (R26-20250504) 2012; 74 |
| References_xml | – volume: 53 start-page: 971 year: 2005 ident: R31-20250504 article-title: Pleiotrophin cellular localization in nerve regeneration after peripheral nerve injury. publication-title: J Histochem Cytochem doi: 10.1369/jhc.4A6574.2005 – volume: 26 start-page: 44 year: 2008 ident: R32-20250504 article-title: Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain. publication-title: Growth Factors doi: 10.1080/08977190801987711 – volume: 38 start-page: 904 year: 2006 ident: R15-20250504 article-title: Principal components analysis corrects for stratification in genome-wide association studies. publication-title: Nat Genet doi: 10.1038/ng1847 – volume: 8 start-page: 1493 year: 2018 ident: R19-20250504 article-title: A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: the J-MICC Study. publication-title: Sci Rep doi: 10.1038/s41598-018-19914-w – volume: 9 start-page: 1 year: 1989 ident: R20-20250504 article-title: Extracellular adhesive molecules in neurite growth. publication-title: Biosci Rep doi: 10.1007/BF01117507 – volume: 89 start-page: 175 year: 2001 ident: R2-20250504 article-title: Pain as a reason to visit the doctor: a study in Finnish primary health care. publication-title: Pain doi: 10.1016/S0304-3959(00)00361-4 – volume: 536 start-page: 285 year: 2016 ident: R6-20250504 article-title: Analysis of protein-coding genetic variation in 60,706 humans. publication-title: Nature doi: 10.1038/nature19057 – volume: 380 start-page: 2163 year: 2012 ident: R1-20250504 article-title: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. publication-title: Lancet doi: 10.1016/S0140-6736(12)61729-2 – volume: 10 start-page: 188 year: 1998 ident: R22-20250504 article-title: Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slices. publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.1998.00039.x – volume: 30 start-page: 258 year: 2012 ident: R29-20250504 article-title: Expression of pleiotrophin, an important regulator of cell migration, is inhibited in intestinal epithelial cells by treatment with non-steroidal anti-inflammatory drugs. publication-title: Growth Factors doi: 10.3109/08977194.2012.693920 – volume: 12 start-page: 907 year: 2018 ident: R11-20250504 article-title: Predictive biomarkers of chemotherapy-induced peripheral neuropathy: a review. publication-title: Biomark Med doi: 10.2217/bmm-2017-0427 – volume: 73 start-page: 638 year: 2012 ident: R5-20250504 article-title: Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. publication-title: Neuron doi: 10.1016/j.neuron.2012.02.008 – volume: 292 start-page: 18848 year: 2017 ident: R30-20250504 article-title: Pleiotrophin, a multifunctional cytokine and growth factor, induces leukocyte responses through the integrin Mac-1. publication-title: J Biol Chem doi: 10.1074/jbc.M116.773713 – volume: 102 start-page: 109573 year: 2020 ident: R9-20250504 article-title: Current perspectives on the role of biomechanical loading and genetics in development of disc degeneration and low back pain; a narrative review. publication-title: J Biomech doi: 10.1016/j.jbiomech.2019.109573 – volume: 506 start-page: 376 year: 2014 ident: R12-20250504 article-title: Genetics of rheumatoid arthritis contributes to biology and drug discovery. publication-title: Nature doi: 10.1038/nature12873 – volume: 90 start-page: 1791 year: 2008 ident: R27-20250504 article-title: Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells. publication-title: Biochimie doi: 10.1016/j.biochi.2008.04.010 – volume: 25 start-page: 655 year: 2009 ident: R8-20250504 article-title: SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn653 – volume: 57 start-page: 289 year: 1995 ident: R17-20250504 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing. publication-title: J R Stat Soc Ser B Methodol doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 81 start-page: 559 year: 2007 ident: R14-20250504 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses. publication-title: Am J Hum Genet doi: 10.1086/519795 – volume: 110 start-page: 185 year: 2013 ident: R34-20250504 article-title: Genetic inactivation of pleiotrophin but not midkine potentiates clonidine-induced alpha-2 adrenergic-mediated analgesia. publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2013.07.013 – volume: 21 start-page: 263 year: 2005 ident: R16-20250504 article-title: Haploview: analysis and visualization of LD and haplotype maps. publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 100 start-page: 1 year: 2020 ident: R13-20250504 article-title: Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management. publication-title: J Neurosci Res – volume: 14 start-page: T91e1 issue: 12 Suppl year: 2013 ident: R18-20250504 article-title: Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. publication-title: J Pain – volume: 14 start-page: 46 year: 2017 ident: R25-20250504 article-title: Pleiotrophin regulates microglia-mediated neuroinflammation. publication-title: J Neuroinflammation doi: 10.1186/s12974-017-0823-8 – volume: 101 start-page: 450 year: 2017 ident: R10-20250504 article-title: Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy. publication-title: Clin Pharmacol Ther doi: 10.1002/cpt.590 – volume: 60 start-page: 287 year: 2015 ident: R33-20250504 article-title: Effects of Pleiotrophin on endothelial and inflammatory cells: pro-angiogenic and anti-inflammatory properties and potential role for vascular bio-prosthesis endothelialization. publication-title: Adv Med Sci doi: 10.1016/j.advms.2015.05.003 – volume: 103 start-page: 76 year: 2011 ident: R35-20250504 article-title: -1227C>T polymorphism in the pleiotrophin gene promoter influences bone mineral density in postmenopausal women. publication-title: Mol Genet Metab doi: 10.1016/j.ymgme.2011.01.017 – volume: 74 start-page: 269 year: 2012 ident: R26-20250504 article-title: Pleiotrophin promotes microglia proliferation and secretion of neurotrophic factors by activating extracellular signal-regulated kinase 1/2 pathway. publication-title: Neurosci Res doi: 10.1016/j.neures.2012.09.001 – volume: 27 start-page: 189 year: 2009 ident: R21-20250504 article-title: Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memory. publication-title: Growth Factors doi: 10.1080/08977190902906859 – volume: 662 start-page: 213 year: 2018 ident: R24-20250504 article-title: Endogenous pleiotrophin and midkine regulate LPS-induced glial responses. publication-title: Neurosci Lett doi: 10.1016/j.neulet.2017.10.038 – volume: 17 start-page: 2182 year: 2009 ident: R36-20250504 article-title: Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study. publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2009.141 – volume: 647 start-page: 97 year: 2010 ident: R23-20250504 article-title: Genetic deletion of pleiotrophin leads to disruption of spinal nociceptive transmission: evidence for pleiotrophin modulation of morphine-induced analgesia. publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2010.08.029 – volume: 37 start-page: W600 year: 2009 ident: R7-20250504 article-title: SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. publication-title: Nucleic Acids Res doi: 10.1093/nar/gkp290 – volume: 11 start-page: 770 year: 2011 ident: R3-20250504 article-title: Pain as a global public health priority. publication-title: BMC Public Health doi: 10.1186/1471-2458-11-770 – volume: 81 start-page: 160 year: 2012 ident: R28-20250504 article-title: Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis. publication-title: Kidney Int doi: 10.1038/ki.2011.305 |
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| Title | Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study |
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