Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial
Eur J Clin Invest 2010; 40 (2): 148–154 Objective The aim of this study was to investigate the effect of alpha‐lipoic acid (ALA) treatment on endothelium‐dependent and ‐independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. Research design and m...
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| Published in | European journal of clinical investigation Vol. 40; no. 2; pp. 148 - 154 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2010
Wiley-Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0014-2972 1365-2362 1365-2362 |
| DOI | 10.1111/j.1365-2362.2009.02236.x |
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| Abstract | Eur J Clin Invest 2010; 40 (2): 148–154
Objective The aim of this study was to investigate the effect of alpha‐lipoic acid (ALA) treatment on endothelium‐dependent and ‐independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus.
Research design and methods A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double‐blinded, parallel group study. FBF responses to intra‐arterial acetylcholine (ACh) and glycerol trinitrate (GTN) were measured before and after 21 days of intravenous treatment with 600 mg alpha‐lipoic acid or placebo.
Results FBF responses were comparable at baseline. After treatment, FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo. By contrast, ALA treatment increased endothelium‐dependent vasodilatation to ACh (P < 0·05) but not to GTN compared with baseline.
Conclusions Intravenous ALA treatment improves endothelium‐dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established. |
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| AbstractList | The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus.OBJECTIVEThe aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus.A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double-blinded, parallel group study. FBF responses to intra-arterial acetylcholine (ACh) and glycerol trinitrate (GTN) were measured before and after 21 days of intravenous treatment with 600 mg alpha-lipoic acid or placebo.RESEARCH DESIGN AND METHODSA total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double-blinded, parallel group study. FBF responses to intra-arterial acetylcholine (ACh) and glycerol trinitrate (GTN) were measured before and after 21 days of intravenous treatment with 600 mg alpha-lipoic acid or placebo.FBF responses were comparable at baseline. After treatment, FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo. By contrast, ALA treatment increased endothelium-dependent vasodilatation to ACh (P < 0.05) but not to GTN compared with baseline.RESULTSFBF responses were comparable at baseline. After treatment, FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo. By contrast, ALA treatment increased endothelium-dependent vasodilatation to ACh (P < 0.05) but not to GTN compared with baseline.Intravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established.CONCLUSIONSIntravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established. The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double-blinded, parallel group study. FBF responses to intra-arterial acetylcholine (ACh) and glycerol trinitrate (GTN) were measured before and after 21 days of intravenous treatment with 600 mg alpha-lipoic acid or placebo. FBF responses were comparable at baseline. After treatment, FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo. By contrast, ALA treatment increased endothelium-dependent vasodilatation to ACh (P < 0.05) but not to GTN compared with baseline. Intravenous ALA treatment improves endothelium-dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established. Eur J Clin Invest 2010; 40 (2): 148–154 Objective The aim of this study was to investigate the effect of alpha‐lipoic acid (ALA) treatment on endothelium‐dependent and ‐independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. Research design and methods A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double‐blinded, parallel group study. FBF responses to intra‐arterial acetylcholine (ACh) and glycerol trinitrate (GTN) were measured before and after 21 days of intravenous treatment with 600 mg alpha‐lipoic acid or placebo. Results FBF responses were comparable at baseline. After treatment, FBF reactivity to ACh and GTN was unchanged in subjects receiving placebo. By contrast, ALA treatment increased endothelium‐dependent vasodilatation to ACh (P < 0·05) but not to GTN compared with baseline. Conclusions Intravenous ALA treatment improves endothelium‐dependent vasodilatation in patients with type 2 diabetes, in the absence of effects on forearm vasomotor function. If this salutary action translates into vascular risk reduction remains to be established. |
| Author | Heinisch, B. B. Schaller, G. Pleiner, J. Wolzt, M. Mittermayer, F. Francesconi, M. Gouya, G. |
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| Keywords | Endocrinopathy Type 2 diabetes Human Lipoic acid Endothelial cell alpha-lipoic acid forearm blood flow Glycerol Metabolic diseases Patient Blood flow Endothelium Medicine Improvement Randomization Forearm glycerol trinitrate Blood vessel Placebo Neurotransmitter Clinical trial Acetylcholine Circulatory system Hemodynamics |
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Objective The aim of this study was to investigate the effect of alpha‐lipoic acid (ALA) treatment on... The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by... |
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| SubjectTerms | Acetylcholine Acetylcholine - pharmacology alpha-lipoic acid Antioxidants - pharmacology Antioxidants - therapeutic use Biological and medical sciences Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Forearm - blood supply Forearm - physiopathology forearm blood flow General aspects glycerol trinitrate Humans Male Medical sciences Middle Aged Nitroglycerin - pharmacology Regional Blood Flow - drug effects Thioctic Acid - pharmacology Thioctic Acid - therapeutic use type 2 diabetes Vasodilation - drug effects Vasodilator Agents - pharmacology |
| Title | Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial |
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