Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate - Joerger, Markus; Ferreri, Andrés J. M.; Krähenbühl, Stephan; Schellens, Jan H. M.; Cerny, Thomas; Zucca, Emanuele; Huitema, Alwin D. R. (British journal of clinical pharmacology, 2012)
Keywords: Adaptations; Algorithms; Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - pharmacokinetics; Area Under Curve; Bayes Theorem; Bayesian estimate; Biological and medical sciences; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Central nervous system; CNS lymphoma; Data processing; Dose-Response Relationship, Drug; Drugs; Female; Hematologic and hematopoietic diseases; high dose chemotherapy; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma; Lymphoma - drug therapy; Lymphoma - metabolism; Male; Medical sciences; Metabolic Clearance Rate; Methotrexate; Methotrexate - administration & dosage; Methotrexate - pharmacokinetics; Pharmacokinetics; Pharmacology. Drug treatments; therapeutic drug monitoring; Treatment Outcome; Antineoplastic agent; Targeting; Central nervous system; Posology; Antifolate; Therapeutic drug monitoring; Target; high dose chemotherapy; CNS lymphoma; Lymphoproliferative syndrome; Methotrexate; High dose; Human; Nervous system diseases; Statistical analysis; Bayesian estimate; Malignant hemopathy; Lymphoid neoplasm; Non Hodgkin lymphoma; Algorithm; Cerebral disorder; Primary cerebral lymphoma; Chemotherapy; Treatment; Antimetabolic; Central nervous system disease; Diffuse large B cell lymphoma; Cancer