The safety and tolerability of spironolactone in patients with mild to moderate chronic kidney disease - Edwards, Nicola C.; Steeds, Richard P.; Chue, Colin D.; Stewart, Paul M.; Ferro, Charles J.; Townend, Jonathan N. (British journal of clinical pharmacology, 2012)
Keywords: Adult; Aged; aldosterone; Angiotensin II Type 1 Receptor Blockers - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biological and medical sciences; Blood Pressure - drug effects; chronic kidney disease; Dose-Response Relationship, Drug; Drug Interactions; Drug Safety; Female; Follow-Up Studies; Glomerular Filtration Rate - drug effects; Humans; Hyperkalemia - chemically induced; Kidneys; Male; Medical sciences; Middle Aged; Mineralocorticoid Receptor Antagonists - adverse effects; Mineralocorticoid Receptor Antagonists - therapeutic use; mineralocorticoid receptor blockade; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Pharmacology. Drug treatments; potassium; Potassium - blood; Regression Analysis; Renal failure; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - drug therapy; Severity of Illness Index; Spironolactone - adverse effects; Spironolactone - therapeutic use; Urinary system involvement in other diseases. Miscellaneous; Kidney disease; Human; Urinary system disease; Potassium sparing diuretic; Steroid hormone; Mineralocorticoid; Toxicity; mineralocorticoid receptor blockade; Chronic kidney disease; Aldosterone; Inorganic element; Aldosterone antagonist; Spironolactone; Mineralocorticoid receptor; Adrenal hormone; Renal failure; Safety; Potassium