Mitochondria in Ischemic Stroke: New Insight and Implications

Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement...

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Published inAging and disease Vol. 9; no. 5; pp. 924 - 937
Main Authors Liu, Fan, Lu, Jianfei, Manaenko, Anatol, Tang, Junjia, Hu, Qin
Format Journal Article
LanguageEnglish
Published United States JKL International 01.10.2018
JKL International LLC
Subjects
Care and treatment
Complications and side effects
Development and progression
Health aspects
Mitochondria
Physiological aspects
Review
Stroke
mitochondrial transfer
mitochondrial quality control
mitophagy
Ischemic stroke
neuroprotection
Online AccessGet full text
ISSN2152-5250
2152-5250
DOI10.14336/AD.2017.1126

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Abstract Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.
AbstractList Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies. Key words: Ischemic stroke, mitochondrial quality control, mitophagy, mitochondrial transfer, neuroprotection
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.
Audience Academic
Author Lu, Jianfei
Manaenko, Anatol
Liu, Fan
Tang, Junjia
Hu, Qin
AuthorAffiliation 1 Discipline of Neuroscience, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3 Department of neurosurgery, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
2 Departments of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany
AuthorAffiliation_xml – name: 2 Departments of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany
– name: 3 Department of neurosurgery, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
– name: 1 Discipline of Neuroscience, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Author_xml – sequence: 1
  givenname: Fan
  surname: Liu
  fullname: Liu, Fan
– sequence: 2
  givenname: Jianfei
  surname: Lu
  fullname: Lu, Jianfei
– sequence: 3
  givenname: Anatol
  surname: Manaenko
  fullname: Manaenko, Anatol
– sequence: 4
  givenname: Junjia
  surname: Tang
  fullname: Tang, Junjia
– sequence: 5
  givenname: Qin
  surname: Hu
  fullname: Hu, Qin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30271667$$D View this record in MEDLINE/PubMed
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IsDoiOpenAccess true
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Issue 5
Keywords mitochondrial transfer
mitochondrial quality control
mitophagy
Ischemic stroke
neuroprotection
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
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Snippet Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of...
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SubjectTerms Care and treatment
Complications and side effects
Development and progression
Health aspects
Mitochondria
Physiological aspects
Review
Stroke
Title Mitochondria in Ischemic Stroke: New Insight and Implications
URI https://www.ncbi.nlm.nih.gov/pubmed/30271667
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