Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects - Goyal, Navin; Skrdla, Pete; Schroyer, Rosemary; Kumar, Subramanya; Fernando, Disala; Oughton, Anna; Norton, Nicola; Sprecher, Dennis L.; Cheriyan, Joseph (American journal of cardiovascular drugs : drugs, devices, and other interventions, 2019)
Keywords: Administration, Oral; Adult; Aged; Area Under Curve; Benzimidazoles - adverse effects; Benzimidazoles - pharmacokinetics; Benzimidazoles - therapeutic use; Bioavailability; Calibration; Cardiology; Case-Control Studies; Double-Blind Method; Drug Administration Schedule; Drug dosages; Edema; Female; Food; Food-Drug Interactions; Half-Life; Heart failure; Heart Failure - drug therapy; Humans; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Plasma; Regulatory approval; Spiro Compounds - adverse effects; Spiro Compounds - pharmacokinetics; Spiro Compounds - therapeutic use; TRPV Cation Channels - antagonists & inhibitors; United Kingdom--UK; United States--US