Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin - Chan, Leong-Perng; Chou, Tzung-Han; Ding, Hsiou-Yu; Chen, Pin-Ru; Chiang, Feng-Yu; Kuo, Po-Lin; Liang, Chia-Hua (Biochimica et biophysica acta, 2012)
Keywords: 5-Fluorouracil; Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; antioxidant activity; antioxidants; Apigenin; Apigenin - pharmacology; apoptosis; Apoptosis - drug effects; Blotting, Western; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; caspases; Caspases - genetics; Caspases - metabolism; cell cycle checkpoints; Cell Cycle Checkpoints - drug effects; cell proliferation; Cell Survival - drug effects; cell viability; Cells, Cultured; chemoprevention; Cisplatin; Cisplatin - administration & dosage; death; Death receptor; Drug Synergism; Flow Cytometry; fluorouracil; Fluorouracil - administration & dosage; glutathione; head; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Human head and neck squamous cell carcinoma; Humans; lipid peroxidation; Lipid Peroxidation - drug effects; liver; Liver - cytology; Liver - drug effects; Liver - metabolism; Melanoma - drug therapy; Melanoma - metabolism; Melanoma - pathology; Mice; oxidative stress; protective effect; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; reactive oxygen species; Reactive Oxygen Species - metabolism; Receptors, Tumor Necrosis Factor - genetics; Receptors, Tumor Necrosis Factor - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; signal transduction; Skin Neoplasms - drug therapy; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; synergism; TNF-Related Apoptosis-Inducing Ligand - genetics; TNF-Related Apoptosis-Inducing Ligand - metabolism; tumor necrosis factors; NF-κB; TRAIL-R; 5-Fluorouracil; TNF-R; Apigenin; HNSCC; Death receptor; ROS; Human head and neck squamous cell carcinoma; EGFR; Cisplatin; 5-Fu