Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study
Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm fu...
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Published in | Investigative and clinical urology Vol. 62; no. 3; pp. 354 - 360 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
The Korean Urological Association
01.05.2021
Korean Urological Association 대한비뇨의학회 |
Subjects | |
Online Access | Get full text |
ISSN | 2466-0493 2466-054X 2466-054X |
DOI | 10.4111/icu.20200394 |
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Abstract | Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction.
This study included young healthy men who underwent fertility evaluation; 32 cases were finally included. Men were excluded if they used a PDE5 inhibitor within 2 weeks or if they had insufficient semen volume (≤2 mL), leukocytospermia, or a genitourinary infection. Changes in sperm motility and acrosome reaction were determined after
exposure to the maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg).
Mean age of the participants was 35.4±4.9 years, mean sperm concentration was 68.7±32.4 ×10⁶/mL, and mean sperm motility was 50.38%±8.41%. All three groups (control, sildenafil, tadalafil) experienced trends of decreased average sperm motility over time, but these changes were not significant. There were no significant differences between the three groups in the acrosome reaction after 120 minutes of drug exposure, either. The maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg) did not substantially affect sperm motility or acrosome reaction.
Our results suggest that on-demand use of a PDE5 inhibitor is safe and useful for the male partner of an infertile couple; however, further studies are warranted for daily PDE5 inhibitor use. |
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AbstractList | Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction.
This study included young healthy men who underwent fertility evaluation; 32 cases were finally included. Men were excluded if they used a PDE5 inhibitor within 2 weeks or if they had insufficient semen volume (≤2 mL), leukocytospermia, or a genitourinary infection. Changes in sperm motility and acrosome reaction were determined after
exposure to the maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg).
Mean age of the participants was 35.4±4.9 years, mean sperm concentration was 68.7±32.4 ×10⁶/mL, and mean sperm motility was 50.38%±8.41%. All three groups (control, sildenafil, tadalafil) experienced trends of decreased average sperm motility over time, but these changes were not significant. There were no significant differences between the three groups in the acrosome reaction after 120 minutes of drug exposure, either. The maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg) did not substantially affect sperm motility or acrosome reaction.
Our results suggest that on-demand use of a PDE5 inhibitor is safe and useful for the male partner of an infertile couple; however, further studies are warranted for daily PDE5 inhibitor use. Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction. Materials and Methods: This study included young healthy men who underwent fertility evaluation; 32 cases were finally included. Men were excluded if they used a PDE5 inhibitor within 2 weeks or if they had insufficient semen volume (≤2 mL), leukocytospermia, or a genitourinary infection. Changes in sperm motility and acrosome reaction were determined after in vitro exposure to the maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg). Results: Mean age of the participants was 35.4±4.9 years, mean sperm concentration was 68.7±32.4 ×106/mL, and mean sperm motility was 50.38%±8.41%. All three groups (control, sildenafil, tadalafil) experienced trends of decreased average sperm motility over time, but these changes were not significant. There were no significant differences between the three groups in the acrosome reaction after 120 minutes of drug exposure, either. The maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg) did not substantially affect sperm motility or acrosome reaction. Conclusions: Our results suggest that on-demand use of a PDE5 inhibitor is safe and useful for the male partner of an infertile couple; however, further studies are warranted for daily PDE5 inhibitor use. KCI Citation Count: 0 Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction.PURPOSEPhosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction.This study included young healthy men who underwent fertility evaluation; 32 cases were finally included. Men were excluded if they used a PDE5 inhibitor within 2 weeks or if they had insufficient semen volume (≤2 mL), leukocytospermia, or a genitourinary infection. Changes in sperm motility and acrosome reaction were determined after in vitro exposure to the maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg).MATERIALS AND METHODSThis study included young healthy men who underwent fertility evaluation; 32 cases were finally included. Men were excluded if they used a PDE5 inhibitor within 2 weeks or if they had insufficient semen volume (≤2 mL), leukocytospermia, or a genitourinary infection. Changes in sperm motility and acrosome reaction were determined after in vitro exposure to the maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg).Mean age of the participants was 35.4±4.9 years, mean sperm concentration was 68.7±32.4 ×10⁶/mL, and mean sperm motility was 50.38%±8.41%. All three groups (control, sildenafil, tadalafil) experienced trends of decreased average sperm motility over time, but these changes were not significant. There were no significant differences between the three groups in the acrosome reaction after 120 minutes of drug exposure, either. The maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg) did not substantially affect sperm motility or acrosome reaction.RESULTSMean age of the participants was 35.4±4.9 years, mean sperm concentration was 68.7±32.4 ×10⁶/mL, and mean sperm motility was 50.38%±8.41%. All three groups (control, sildenafil, tadalafil) experienced trends of decreased average sperm motility over time, but these changes were not significant. There were no significant differences between the three groups in the acrosome reaction after 120 minutes of drug exposure, either. The maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg) did not substantially affect sperm motility or acrosome reaction.Our results suggest that on-demand use of a PDE5 inhibitor is safe and useful for the male partner of an infertile couple; however, further studies are warranted for daily PDE5 inhibitor use.CONCLUSIONSOur results suggest that on-demand use of a PDE5 inhibitor is safe and useful for the male partner of an infertile couple; however, further studies are warranted for daily PDE5 inhibitor use. Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction. Materials and Methods: This study included young healthy men who underwent fertility evaluation; 32 cases were finally included. Men were excluded if they used a PDE5 inhibitor within 2 weeks or if they had insufficient semen volume (≤2 mL), leukocytospermia, or a genitourinary infection. Changes in sperm motility and acrosome reaction were determined after in vitro exposure to the maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg). Results: Mean age of the participants was 35.4±4.9 years, mean sperm concentration was 68.7±32.4 ×106/mL, and mean sperm motility was 50.38%±8.41%. All three groups (control, sildenafil, tadalafil) experienced trends of decreased average sperm motility over time, but these changes were not significant. There were no significant differences between the three groups in the acrosome reaction after 120 minutes of drug exposure, either. The maximal semen concentration of oral intake of sildenafil (100 mg) or tadalafil (20 mg) did not substantially affect sperm motility or acrosome reaction. Conclusions: Our results suggest that on-demand use of a PDE5 inhibitor is safe and useful for the male partner of an infertile couple; however, further studies are warranted for daily PDE5 inhibitor use. |
Author | Song, Seung-Hun Kim, Dong Suk Sung, Suye Shin, Dong Hyuk Heo, Yohan Her, Young Sun Eum, Jin Hee Baek, Jung Won Oh, Mi Hee |
AuthorAffiliation | 1 Department of Urology, Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea 2 Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea |
AuthorAffiliation_xml | – name: 2 Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – name: 1 Department of Urology, Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea |
Author_xml | – sequence: 1 givenname: Seung-Hun orcidid: 0000-0003-4649-9129 surname: Song fullname: Song, Seung-Hun organization: Department of Urology, Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 2 givenname: Dong Hyuk orcidid: 0000-0002-9789-237X surname: Shin fullname: Shin, Dong Hyuk organization: Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 3 givenname: Young Sun orcidid: 0000-0003-3678-2801 surname: Her fullname: Her, Young Sun organization: Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 4 givenname: Mi Hee orcidid: 0000-0002-2880-5738 surname: Oh fullname: Oh, Mi Hee organization: Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 5 givenname: Jung Won orcidid: 0000-0003-2686-6358 surname: Baek fullname: Baek, Jung Won organization: Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 6 givenname: Suye orcidid: 0000-0002-4581-3182 surname: Sung fullname: Sung, Suye organization: Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 7 givenname: Jin Hee orcidid: 0000-0002-7875-1870 surname: Eum fullname: Eum, Jin Hee organization: Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 8 givenname: Yohan orcidid: 0000-0003-2341-6319 surname: Heo fullname: Heo, Yohan organization: Department of Urology, Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea – sequence: 9 givenname: Dong Suk orcidid: 0000-0001-7350-0303 surname: Kim fullname: Kim, Dong Suk organization: Department of Urology, Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea |
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CitedBy_id | crossref_primary_10_1016_j_cryobiol_2024_105163 crossref_primary_10_1016_j_cryobiol_2023_05_005 crossref_primary_10_1016_j_fertnstert_2023_10_021 crossref_primary_10_1080_01480545_2021_2018455 crossref_primary_10_1093_sxmrev_qead010 |
Cites_doi | 10.4081/aiua.2015.3.210 10.1016/j.eururo.2007.09.046 10.1016/j.fertnstert.2003.08.032 10.1046/j.0306-5251.2001.00033.x 10.1002/j.1939-4640.1993.tb00402.x 10.1097/01.ju.0000177453.14334.a2 10.1038/sj.ijir.3900551 10.1093/humrep/13.5.1248 10.1038/sj.ijir.3900354 10.1016/j.juro.2007.10.077 10.1111/j.1464-410X.2010.09243.x 10.1111/and.12097 10.1016/j.urology.2017.02.032 10.2119/molmed.2014.00158 10.1038/sj.ijir.3901307 10.1016/j.fertnstert.2006.11.182 10.1095/biolreprod67.2.423 10.1016/j.fertnstert.2006.12.019 10.1038/ijir.2008.29 10.1111/j.1745-7262.2008.00373.x 10.1016/j.fertnstert.2006.11.017 10.1097/01.ju.0000081053.97792.da |
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Snippet | Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5... Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive... |
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StartPage | 354 |
SubjectTerms | Acrosome Reaction - drug effects Adult Cell Culture Techniques erectile dysfunction Humans infertility Male Original Phosphodiesterase 5 Inhibitors - pharmacology phosphodiesterase type 5 inhibitor Semen Analysis Sildenafil Citrate - pharmacology Sperm Count Sperm Motility - drug effects spermatozoa Tadalafil - pharmacology 비뇨기과학 |
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Title | Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/33943054 https://www.proquest.com/docview/2522187700 https://pubmed.ncbi.nlm.nih.gov/PMC8100009 https://doaj.org/article/073bb5efaeb24b6286a08324839a8a20 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002714620 |
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ispartofPNX | Investigative and Clinical Urology, 2021, 62(3), , pp.354-360 |
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