Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tu...

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Bibliographic Details
Published in	Genome research Vol. 22; no. 2; pp. 299 - 306
Main Authors	Castellarin, Mauro, Warren, René L., Freeman, J. Douglas, Dreolini, Lisa, Krzywinski, Martin, Strauss, Jaclyn, Barnes, Rebecca, Watson, Peter, Allen-Vercoe, Emma, Moore, Richard A., Holt, Robert A.
Format	Journal Article
Language	English
Published	United States Cold Spring Harbor Laboratory Press 01.02.2012
Subjects	Cell Line, Tumor Cluster Analysis Colorectal Neoplasms - microbiology Fusobacterium Fusobacterium Infections - microbiology Fusobacterium nucleatum Fusobacterium nucleatum - classification Fusobacterium nucleatum - genetics Fusobacterium nucleatum - isolation & purification Genome, Bacterial Humans Intestine, Large - microbiology Metagenome - genetics Phylogeny
Online Access	Get full text
ISSN	1088-9051 1549-5469 1549-5469
DOI	10.1101/gr.126516.111

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Abstract	An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens. F. nucleatum is an invasive anaerobe that has been linked previously to periodontitis and appendicitis, but not to cancer. Fusobacteria are rare constituents of the fecal microbiota, but have been cultured previously from biopsies of inflamed gut mucosa. We obtained a Fusobacterium isolate from a frozen tumor specimen; this showed highest sequence similarity to a known gut mucosa isolate and was confirmed to be invasive. We verified overabundance of Fusobacterium sequences in tumor versus matched normal control tissue by quantitative PCR analysis from a total of 99 subjects ( p = 2.5 × 10 −6 ), and we observed a positive association with lymph node metastasis.
AbstractList	An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens. F. nucleatum is an invasive anaerobe that has been linked previously to periodontitis and appendicitis, but not to cancer. Fusobacteria are rare constituents of the fecal microbiota, but have been cultured previously from biopsies of inflamed gut mucosa. We obtained a Fusobacterium isolate from a frozen tumor specimen; this showed highest sequence similarity to a known gut mucosa isolate and was confirmed to be invasive. We verified overabundance of Fusobacterium sequences in tumor versus matched normal control tissue by quantitative PCR analysis from a total of 99 subjects ( p = 2.5 × 10 −6 ), and we observed a positive association with lymph node metastasis. An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens. F. nucleatum is an invasive anaerobe that has been linked previously to periodontitis and appendicitis, but not to cancer. Fusobacteria are rare constituents of the fecal microbiota, but have been cultured previously from biopsies of inflamed gut mucosa. We obtained a Fusobacterium isolate from a frozen tumor specimen; this showed highest sequence similarity to a known gut mucosa isolate and was confirmed to be invasive. We verified overabundance of Fusobacterium sequences in tumor versus matched normal control tissue by quantitative PCR analysis from a total of 99 subjects (p = 2.5 x 10-6), and we observed a positive association with lymph node metastasis. An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens. F. nucleatum is an invasive anaerobe that has been linked previously to periodontitis and appendicitis, but not to cancer. Fusobacteria are rare constituents of the fecal microbiota, but have been cultured previously from biopsies of inflamed gut mucosa. We obtained a Fusobacterium isolate from a frozen tumor specimen; this showed highest sequence similarity to a known gut mucosa isolate and was confirmed to be invasive. We verified overabundance of Fusobacterium sequences in tumor versus matched normal control tissue by quantitative PCR analysis from a total of 99 subjects (p = 2.5 × 10(-6)), and we observed a positive association with lymph node metastasis. An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens. F. nucleatum is an invasive anaerobe that has been linked previously to periodontitis and appendicitis, but not to cancer. Fusobacteria are rare constituents of the fecal microbiota, but have been cultured previously from biopsies of inflamed gut mucosa. We obtained a Fusobacterium isolate from a frozen tumor specimen; this showed highest sequence similarity to a known gut mucosa isolate and was confirmed to be invasive. We verified overabundance of Fusobacterium sequences in tumor versus matched normal control tissue by quantitative PCR analysis from a total of 99 subjects (p = 2.5 × 10(-6)), and we observed a positive association with lymph node metastasis.An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens. F. nucleatum is an invasive anaerobe that has been linked previously to periodontitis and appendicitis, but not to cancer. Fusobacteria are rare constituents of the fecal microbiota, but have been cultured previously from biopsies of inflamed gut mucosa. We obtained a Fusobacterium isolate from a frozen tumor specimen; this showed highest sequence similarity to a known gut mucosa isolate and was confirmed to be invasive. We verified overabundance of Fusobacterium sequences in tumor versus matched normal control tissue by quantitative PCR analysis from a total of 99 subjects (p = 2.5 × 10(-6)), and we observed a positive association with lymph node metastasis.
Author	Castellarin, Mauro Holt, Robert A. Dreolini, Lisa Moore, Richard A. Watson, Peter Barnes, Rebecca Freeman, J. Douglas Krzywinski, Martin Strauss, Jaclyn Warren, René L. Allen-Vercoe, Emma
AuthorAffiliation	5 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada 3 University of Guelph, Guelph, Ontario N1G 2W1, Canada 4 BC Cancer Agency, Deeley Research Centre, Victoria, British Columbia V8R 6V5, Canada 2 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada 1 BC Cancer Agency, Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
AuthorAffiliation_xml	– name: 5 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada – name: 4 BC Cancer Agency, Deeley Research Centre, Victoria, British Columbia V8R 6V5, Canada – name: 1 BC Cancer Agency, Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada – name: 2 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada – name: 3 University of Guelph, Guelph, Ontario N1G 2W1, Canada
Author_xml	– sequence: 1 givenname: Mauro surname: Castellarin fullname: Castellarin, Mauro – sequence: 2 givenname: René L. surname: Warren fullname: Warren, René L. – sequence: 3 givenname: J. Douglas surname: Freeman fullname: Freeman, J. Douglas – sequence: 4 givenname: Lisa surname: Dreolini fullname: Dreolini, Lisa – sequence: 5 givenname: Martin surname: Krzywinski fullname: Krzywinski, Martin – sequence: 6 givenname: Jaclyn surname: Strauss fullname: Strauss, Jaclyn – sequence: 7 givenname: Rebecca surname: Barnes fullname: Barnes, Rebecca – sequence: 8 givenname: Peter surname: Watson fullname: Watson, Peter – sequence: 9 givenname: Emma surname: Allen-Vercoe fullname: Allen-Vercoe, Emma – sequence: 10 givenname: Richard A. surname: Moore fullname: Moore, Richard A. – sequence: 11 givenname: Robert A. surname: Holt fullname: Holt, Robert A.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22009989$$D View this record in MEDLINE/PubMed
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Snippet	An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue...
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SubjectTerms	Cell Line, Tumor Cluster Analysis Colorectal Neoplasms - microbiology Fusobacterium Fusobacterium Infections - microbiology Fusobacterium nucleatum Fusobacterium nucleatum - classification Fusobacterium nucleatum - genetics Fusobacterium nucleatum - isolation & purification Genome, Bacterial Humans Intestine, Large - microbiology Metagenome - genetics Phylogeny
Title	Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
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