Population-specific brain [18F]-FDG PET templates of Chinese subjects for statistical parametric mapping

• Published in: Scientific data Vol. 8; no. 1; pp. 1 - 7
• Main Authors: Wang, Hongkai, Tian, Yang, Liu, Yang, Chen, Zhaofeng, Zhai, Haoyu, Zhuang, Mingrui, Zhang, Nan, Jiang, Yuanfang, Gao, Ya, Feng, Hongbo, Zhang, Yanjun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.11.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/700/1421/1771; 692/700/1421/65; Brain mapping; Computational neuroscience; Data Descriptor; Humanities and Social Sciences; Metabolism; Morphometry; multidisciplinary; Positron emission tomography; Science; Science (multidisciplinary); Statistics; Tomography
• ISSN: 2052-4463; 2052-4463
• DOI: 10.1038/s41597-021-01089-1

Statistical Parametric Mapping (SPM) is a computational approach for analysing functional brain images like Positron Emission Tomography (PET). When performing SPM analysis for different patient populations, brain PET template images representing population-specific brain morphometry and metabolism features are helpful. However, most currently available brain PET templates were constructed using the Caucasian data. To enrich the family of publicly available brain PET templates, we created Chinese-specific template images based on 116 [ 18 F]-fluorodeoxyglucose ([ 18 F]-FDG) PET images of normal participants. These images were warped into a common averaged space, in which the mean and standard deviation templates were both computed. We also developed the SPM analysis programmes to facilitate easy use of the templates. Our templates were validated through the SPM analysis of Alzheimer’s and Parkinson’s patient images. The resultant SPM t-maps accurately depicted the disease-related brain regions with abnormal [ 18 F]-FDG uptake, proving the templates’ effectiveness in brain function impairment analysis. Measurement(s) brain metabolism measurement Technology Type(s) FDG-Positron Emission Tomography Factor Type(s) age • sex Sample Characteristic - Organism Homo sapiens Sample Characteristic - Location China Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.16382418