Effects of Central Obesity on Esophageal Epithelial Barrier Function

We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER). Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome den...

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Bibliographic Details
Published inThe American journal of gastroenterology Vol. 116; no. 7; pp. 1537 - 1541
Main Authors Gibbens, Ying Y., Lansing, Ramona, Johnson, Michele L., Blevins, Christopher H., Katzka, David A., Iyer, Prasad G.
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer 01.07.2021
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subjects
Acids
Adult
Aged
Cancer
Cytokines
Desmosomes - ultrastructure
Disease
Endoscopy
Esophageal Mucosa - metabolism
Esophageal Mucosa - pathology
Esophageal Mucosa - ultrastructure
Esophagus
Extracellular Space
Female
Gastroenterology
Gastroesophageal reflux
Gastroesophageal Reflux - complications
Gastroesophageal Reflux - metabolism
Gastroesophageal Reflux - pathology
Humans
Male
Middle Aged
Obesity
Obesity, Abdominal - complications
Obesity, Abdominal - metabolism
Obesity, Abdominal - pathology
Permeability
Regression analysis
Transmission electron microscopy
Online AccessGet full text
ISSN0002-9270
1572-0241
1572-0241
DOI10.14309/ajg.0000000000001196

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Summary:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER). Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured. The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients. Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.
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Both David Katzka and Prasad Iyer are co-senior authors
Guarantor of the article: Prasad G. Iyer, M.D., M.S.
Ying Y Gibbens was responsible for the data acquisition, data analysis, drafting the manuscript and statistical analysis. Ramona Lansing and Michele L Johnson was responsible for administrative, technical and material support. Christopher H Blevins was responsible for the study concept, study design, and data acquisition. David A Katzka was responsible for critical review of manuscript for important intellectual content. Prasad G Iyer was responsible for the study concept, study design, critical revision of the manuscript for important intellectual content, obtained funding support and provided study supervision.
Specific author contributions
ISSN:0002-9270
1572-0241
1572-0241
DOI:10.14309/ajg.0000000000001196