Effects of Central Obesity on Esophageal Epithelial Barrier Function
We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER). Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome den...
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| Published in | The American journal of gastroenterology Vol. 116; no. 7; pp. 1537 - 1541 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer
01.07.2021
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9270 1572-0241 1572-0241 |
| DOI | 10.14309/ajg.0000000000001196 |
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| Abstract | We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).
Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.
The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.
Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury. |
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| AbstractList | We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).
Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.
The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.
Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury. We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).INTRODUCTIONWe assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.METHODSThirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.RESULTSThe Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.DISCUSSIONCentral obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury. INTRODUCTION:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).METHODS:Thirty-eight participants were divided into 4 groups: Obesity−/GER–, Obesity+/GER−, Obesity−/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.RESULTS:The Obesity+/GER− group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity−/GER + and Obesity+/GER+ patients.DISCUSSION:Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury. |
| Author | Gibbens, Ying Y. Iyer, Prasad G. Blevins, Christopher H. Katzka, David A. Johnson, Michele L. Lansing, Ramona |
| AuthorAffiliation | Division of Gastroenterology, Billings Clinic, Billings, Montana, USA Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA |
| AuthorAffiliation_xml | – name: Division of Gastroenterology, Billings Clinic, Billings, Montana, USA – name: Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA – name: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA – name: 1 Department of Medicine, Mayo Clinic, Rochester, Minnesota – name: 3 Division of Gastroenterology, Billings Clinic, Billings, Montana – name: 2 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota |
| Author_xml | – sequence: 1 givenname: Ying Y. surname: Gibbens fullname: Gibbens, Ying Y. organization: Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA – sequence: 2 givenname: Ramona surname: Lansing fullname: Lansing, Ramona organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA – sequence: 3 givenname: Michele L. surname: Johnson fullname: Johnson, Michele L. organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA – sequence: 4 givenname: Christopher H. surname: Blevins fullname: Blevins, Christopher H. organization: Division of Gastroenterology, Billings Clinic, Billings, Montana, USA – sequence: 5 givenname: David A. surname: Katzka fullname: Katzka, David A. organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA – sequence: 6 givenname: Prasad G. surname: Iyer fullname: Iyer, Prasad G. organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA |
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| Cites_doi | 10.1111/nmo.13403 10.1111/j.1365-2036.2006.03237.x 10.1016/j.cgh.2013.05.009 10.1111/bjd.15721 10.1097/MOG.0b013e328347bac4 10.1001/jama.2016.5657 10.1111/j.1572-0241.2005.40978.x 10.1111/j.1572-0241.2005.40476.x 10.1016/j.cgh.2006.08.006 10.1038/ajg.2010.476 10.1097/MEG.0b013e3282f1cc39 10.1177/2050640615598426 10.1038/nri1937 10.1111/j.1572-0241.2007.01688.x |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Both David Katzka and Prasad Iyer are co-senior authors Guarantor of the article: Prasad G. Iyer, M.D., M.S. Ying Y Gibbens was responsible for the data acquisition, data analysis, drafting the manuscript and statistical analysis. Ramona Lansing and Michele L Johnson was responsible for administrative, technical and material support. Christopher H Blevins was responsible for the study concept, study design, and data acquisition. David A Katzka was responsible for critical review of manuscript for important intellectual content. Prasad G Iyer was responsible for the study concept, study design, critical revision of the manuscript for important intellectual content, obtained funding support and provided study supervision. Specific author contributions |
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| References_xml | – volume: 30 start-page: e13403 issue: 10 year: 2018 ident: R10-20250804 article-title: Obesity and GERD impair esophageal epithelial permeability through 2 distinct mechanisms publication-title: Neurogastroenterol Motil doi: 10.1111/nmo.13403 – volume: 25 start-page: 629 issue: 5 year: 2007 ident: R5-20250804 article-title: Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gastro-oesophageal reflux disease publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2006.03237.x – volume: 11 start-page: 1 issue: 11 year: 2013 ident: R8-20250804 article-title: Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: A systematic review and meta-analysis publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2013.05.009 – volume: 177 start-page: 1612 issue: 6 year: 2017 ident: R11-20250804 article-title: Inhibition of p38MAPK signalling prevents epidermal blistering and alterations of desmosome structure induced by pemphigus autoantibodies in human epidermis publication-title: Br J Dermatol doi: 10.1111/bjd.15721 – volume: 27 start-page: 374 issue: 4 year: 2011 ident: R12-20250804 article-title: Endomicroscopy in the evaluation of Barrett's esophagus publication-title: Curr Opin Gastroenterol doi: 10.1097/MOG.0b013e328347bac4 – volume: 315 start-page: 2104 issue: 19 year: 2016 ident: R14-20250804 article-title: Association of acute gastroesophageal reflux disease with esophageal histologic changes publication-title: JAMA doi: 10.1001/jama.2016.5657 – volume: 100 start-page: 543 issue: 3 year: 2005 ident: R2-20250804 article-title: Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2005.40978.x – volume: 100 start-page: 537 issue: 3 year: 2005 ident: R7-20250804 article-title: Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2005.40476.x – volume: 5 start-page: 4 issue: 1 year: 2007 ident: R3-20250804 article-title: Microscopic esophageal mucosal injury in nonerosive reflux disease publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2006.08.006 – volume: 106 start-page: 844 issue: 5 year: 2011 ident: R4-20250804 article-title: Refractory heartburn: Comparison of intercellular space diameter in documented GERD vs. Functional heartburn publication-title: Am J Gastroenterol doi: 10.1038/ajg.2010.476 – volume: 20 issue: 3 year: 2008 ident: R15-20250804 article-title: Refractory gastrooesophageal reflux disease publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0b013e3282f1cc39 – volume: 4 start-page: 177 issue: 2 year: 2016 ident: R9-20250804 article-title: Influence of reflux and central obesity on intercellular space diameter of esophageal squamous epithelium publication-title: United Eur Gastroenterol J doi: 10.1177/2050640615598426 – volume: 6 start-page: 772 issue: 10 year: 2006 ident: R13-20250804 article-title: Adipocytokines: Mediators linking adipose tissue, inflammation and immunity publication-title: Nat Rev Immunol doi: 10.1038/nri1937 – volume: 103 start-page: 1021 issue: 4 year: 2008 ident: R6-20250804 article-title: Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2007.01688.x – volume: 30 start-page: 1 issue: 2 year: 2017 ident: R1-20250804 article-title: The natural history of gastro-esophageal reflux disease: A comprehensive review publication-title: Dis Esophagus |
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| Snippet | We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).
Thirty-eight participants... INTRODUCTION:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux... We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).INTRODUCTIONWe assessed if... |
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| SubjectTerms | Acids Adult Aged Cancer Cytokines Desmosomes - ultrastructure Disease Endoscopy Esophageal Mucosa - metabolism Esophageal Mucosa - pathology Esophageal Mucosa - ultrastructure Esophagus Extracellular Space Female Gastroenterology Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - metabolism Gastroesophageal Reflux - pathology Humans Male Middle Aged Obesity Obesity, Abdominal - complications Obesity, Abdominal - metabolism Obesity, Abdominal - pathology Permeability Regression analysis Transmission electron microscopy |
| Title | Effects of Central Obesity on Esophageal Epithelial Barrier Function |
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