Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults
Context:Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are assoc...
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| Published in | The journal of clinical endocrinology and metabolism Vol. 99; no. 6; pp. E1055 - E1060 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.06.2014
Copyright by The Endocrine Society Endocrine Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-972X 1945-7197 1945-7197 |
| DOI | 10.1210/jc.2013-3669 |
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| Abstract | Context:Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.Objectives:The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP).Design/Subjects/Setting:This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.Results:Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.Conclusion:Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity. |
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| AbstractList | Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.
The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP). DESIGN/SUBJECTS/SETTING: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.
Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.
Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity. CONTEXT:Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known. OBJECTIVES:The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP). DESIGN/SUBJECTS/SETTING:This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP. RESULTS:Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity. CONCLUSION:Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity. Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.CONTEXTEarly-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP). DESIGN/SUBJECTS/SETTING: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.OBJECTIVESThe objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP). DESIGN/SUBJECTS/SETTING: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.RESULTSCirculating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity.CONCLUSIONEarly-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity. Context:Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.Objectives:The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP).Design/Subjects/Setting:This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.Results:Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.Conclusion:Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity. |
| Author | Zaichenko, Lesya Crowell, Judith A. Joung, Kyoung Eun Thakkar, Bindiya Davis, Cynthia R. Park, Kyung-Hee Warner, Dorothy Brinkoetter, Mary Sahin-Efe, Ayse Mantzoros, Christos S. Usher, Nicole |
| AuthorAffiliation | Division of Newborn Medicine (K.E.J.), Boston Childrenʼs Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Beth Israel Deaconess Medical Center, and Harvard Medical School (K.E.J., C.S.M.), Boston, Massachusetts 02215; Department of Family Medicine (K.-H.P.), Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do 431–070, Korea; Section of Endocrinology (L.Z., A.S.-E., B.T., M.B., C.S.M.), Division of Endocrinology, Boston Veterans Affairs Healthcare System, Jamaica Plain, Massachusetts 02130; Section of Endocrinology, Diabetes, and Nutrition (A.S.-E., B.T., C.S.M.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118; Judge Baker Childrenʼs Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120; and Department of Psychiatry and Behavioral Sciences (J.A.C.), Stony Brook University School of Medicine, Stony Brook, New York 11794 |
| AuthorAffiliation_xml | – name: Division of Newborn Medicine (K.E.J.), Boston Childrenʼs Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Beth Israel Deaconess Medical Center, and Harvard Medical School (K.E.J., C.S.M.), Boston, Massachusetts 02215; Department of Family Medicine (K.-H.P.), Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do 431–070, Korea; Section of Endocrinology (L.Z., A.S.-E., B.T., M.B., C.S.M.), Division of Endocrinology, Boston Veterans Affairs Healthcare System, Jamaica Plain, Massachusetts 02130; Section of Endocrinology, Diabetes, and Nutrition (A.S.-E., B.T., C.S.M.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118; Judge Baker Childrenʼs Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120; and Department of Psychiatry and Behavioral Sciences (J.A.C.), Stony Brook University School of Medicine, Stony Brook, New York 11794 |
| Author_xml | – sequence: 1 givenname: Kyoung Eun surname: Joung fullname: Joung, Kyoung Eun organization: 1Division of Newborn Medicine (K.E.J.), Boston, Massachusetts 02215 – sequence: 2 givenname: Kyung-Hee surname: Park fullname: Park, Kyung-Hee organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 – sequence: 3 givenname: Lesya surname: Zaichenko fullname: Zaichenko, Lesya organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 – sequence: 4 givenname: Ayse surname: Sahin-Efe fullname: Sahin-Efe, Ayse organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 – sequence: 5 givenname: Bindiya surname: Thakkar fullname: Thakkar, Bindiya organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 – sequence: 6 givenname: Mary surname: Brinkoetter fullname: Brinkoetter, Mary organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 – sequence: 7 givenname: Nicole surname: Usher fullname: Usher, Nicole organization: 7Judge Baker Children's Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120 – sequence: 8 givenname: Dorothy surname: Warner fullname: Warner, Dorothy organization: 7Judge Baker Children's Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120 – sequence: 9 givenname: Cynthia R. surname: Davis fullname: Davis, Cynthia R. organization: 7Judge Baker Children's Center (N.U., D.W., C.R.D., J.A.C.), Boston, Massachusetts 02120 – sequence: 10 givenname: Judith A. surname: Crowell fullname: Crowell, Judith A. organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 – sequence: 11 givenname: Christos S. surname: Mantzoros fullname: Mantzoros, Christos S. email: cmantzor@bidmc.harvard.edu organization: 2Boston Children's Hospital, Boston, Division of Endocrinology and Metabolism (K.E.J., K.-H.P., L.Z., A.S.-E., B.T., M.B., C.S.M.), Boston, Massachusetts 02215 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24650014$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adiponectin Adiponectin - blood Adult Body mass index C-reactive protein C-Reactive Protein - analysis Child Child Abuse - psychology Child Abuse - statistics & numerical data Cross-Sectional Studies Diabetes mellitus (non-insulin dependent) Female Fibronectins - blood Humans JCEM Online: Brief Reports Leptin Leptin - blood Life Change Events Male Metabolic syndrome Metabolism Middle Aged Physical activity Stress, Psychological - blood Stress, Psychological - epidemiology |
| Title | Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults |
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