Methane and Hydrogen Positivity on Breath Test Is Associated With Greater Body Mass Index and Body Fat
Context:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects.Objective:The objective of the study was...
Saved in:
| Published in | The journal of clinical endocrinology and metabolism Vol. 98; no. 4; pp. E698 - E702 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
01.04.2013
Copyright by The Endocrine Society Endocrine Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-972X 1945-7197 1945-7197 |
| DOI | 10.1210/jc.2012-3144 |
Cover
| Abstract | Context:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects.Objective:The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort.Design and Subjects:This was a prospective study (n = 792) of consecutive subjects presenting for breath testing.Setting:The study was conducted at a tertiary care center.Outcome Measurements:BMI and percent body fat were measured.Results:Subjects were classified into 4 groups based on breath testing: normal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen ≥20 ppm); methane positive only (M+) (methane ≥3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane ≥3 ppm and hydrogen ≥20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N: 24.1 ± 5.2 kg/m2; H+: 24.2 ± 4.5 kg/m2; M+: 24.0 ± 3.75 kg/m2; M+/H+: 26.5 ± 7.1 kg/m2, P < .02) and also had significantly higher percent body fat (N: 28.3 ± 10.0%; H+: 27.5 ± 9.0%; M+: 28.0 ± 8.9%; M+/H+; 34.1 ± 10.9%, P < .001).Conclusions:The presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain. |
|---|---|
| AbstractList | Context:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects.Objective:The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort.Design and Subjects:This was a prospective study (n = 792) of consecutive subjects presenting for breath testing.Setting:The study was conducted at a tertiary care center.Outcome Measurements:BMI and percent body fat were measured.Results:Subjects were classified into 4 groups based on breath testing: normal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen ≥20 ppm); methane positive only (M+) (methane ≥3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane ≥3 ppm and hydrogen ≥20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N: 24.1 ± 5.2 kg/m2; H+: 24.2 ± 4.5 kg/m2; M+: 24.0 ± 3.75 kg/m2; M+/H+: 26.5 ± 7.1 kg/m2, P < .02) and also had significantly higher percent body fat (N: 28.3 ± 10.0%; H+: 27.5 ± 9.0%; M+: 28.0 ± 8.9%; M+/H+; 34.1 ± 10.9%, P < .001).Conclusions:The presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain. Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects.CONTEXTColonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects.The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort.OBJECTIVEThe objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort.This was a prospective study (n = 792) of consecutive subjects presenting for breath testing.DESIGN AND SUBJECTSThis was a prospective study (n = 792) of consecutive subjects presenting for breath testing.The study was conducted at a tertiary care center.SETTINGThe study was conducted at a tertiary care center.BMI and percent body fat were measured.OUTCOME MEASUREMENTSBMI and percent body fat were measured.Subjects were classified into 4 groups based on breath testing: normal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen ≥20 ppm); methane positive only (M+) (methane ≥3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane ≥3 ppm and hydrogen ≥20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N: 24.1 ± 5.2 kg/m(2); H+: 24.2 ± 4.5 kg/m(2); M+: 24.0 ± 3.75 kg/m(2); M+/H+: 26.5 ± 7.1 kg/m(2), P < .02) and also had significantly higher percent body fat (N: 28.3 ± 10.0%; H+: 27.5 ± 9.0%; M+: 28.0 ± 8.9%; M+/H+; 34.1 ± 10.9%, P < .001).RESULTSSubjects were classified into 4 groups based on breath testing: normal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen ≥20 ppm); methane positive only (M+) (methane ≥3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane ≥3 ppm and hydrogen ≥20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N: 24.1 ± 5.2 kg/m(2); H+: 24.2 ± 4.5 kg/m(2); M+: 24.0 ± 3.75 kg/m(2); M+/H+: 26.5 ± 7.1 kg/m(2), P < .02) and also had significantly higher percent body fat (N: 28.3 ± 10.0%; H+: 27.5 ± 9.0%; M+: 28.0 ± 8.9%; M+/H+; 34.1 ± 10.9%, P < .001).The presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain.CONCLUSIONSThe presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain. Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects. The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort. This was a prospective study (n = 792) of consecutive subjects presenting for breath testing. The study was conducted at a tertiary care center. BMI and percent body fat were measured. Subjects were classified into 4 groups based on breath testing: normal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen ≥20 ppm); methane positive only (M+) (methane ≥3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane ≥3 ppm and hydrogen ≥20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N: 24.1 ± 5.2 kg/m(2); H+: 24.2 ± 4.5 kg/m(2); M+: 24.0 ± 3.75 kg/m(2); M+/H+: 26.5 ± 7.1 kg/m(2), P < .02) and also had significantly higher percent body fat (N: 28.3 ± 10.0%; H+: 27.5 ± 9.0%; M+: 28.0 ± 8.9%; M+/H+; 34.1 ± 10.9%, P < .001). The presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain. CONTEXT:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects. OBJECTIVE:The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort. DESIGN AND SUBJECTS:This was a prospective study (n = 792) of consecutive subjects presenting for breath testing. SETTING:The study was conducted at a tertiary care center. OUTCOME MEASUREMENTS:BMI and percent body fat were measured. RESULTS:Subjects were classified into 4 groups based on breath testingnormal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen ≥20 ppm); methane positive only (M+) (methane ≥3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane ≥3 ppm and hydrogen ≥20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N24.1 ± 5.2 kg/m; H+24.2 ± 4.5 kg/m; M+24.0 ± 3.75 kg/m; M+/H+26.5 ± 7.1 kg/m, P < .02) and also had significantly higher percent body fat (N28.3 ± 10.0%; H+27.5 ± 9.0%; M+28.0 ± 8.9%; M+/H+; 34.1 ± 10.9%, P < .001). CONCLUSIONS:The presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain. Context:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and breath methane is associated with a greater body mass index (BMI) among obese human subjects.Objective:The objective of the study was to characterize the relationship between methane and hydrogen on breath test (as a surrogate for colonization with the hydrogen requiring methanogen, Methanobrevibacter smithii), body weight, and percent body fat in a general population cohort.Design and Subjects:This was a prospective study (n = 792) of consecutive subjects presenting for breath testing.Setting:The study was conducted at a tertiary care center.Outcome Measurements:BMI and percent body fat were measured.Results:Subjects were classified into 4 groups based on breath testing: normal (N) (methane <3 ppm and hydrogen <20 ppm at or before 90 minutes); hydrogen positive only (H+) [methane <3 ppm and hydrogen greater than or equal to 20 ppm); methane positive only (M+) (methane greater than or equal to 3 ppm and hydrogen <20 ppm), or methane and hydrogen positive (M+/H+) (methane greater than or equal to 3 ppm and hydrogen greater than or equal to 20 ppm]. There were significant differences in age but not in gender across the groups. After controlling for age as a confounding variable, M+/H+ subjects had significantly higher BMI than other groups (N: 24.1 plus or minus 5.2 kg/m2; H+: 24.2 plus or minus 4.5 kg/m2; M+: 24.0 plus or minus 3.75 kg/m2; M+/H+: 26.5 plus or minus 7.1 kg/m2, P < .02) and also had significantly higher percent body fat (N: 28.3 plus or minus 10.0%; H+: 27.5 plus or minus 9.0%; M+: 28.0 plus or minus 8.9%; M+/H+; 34.1 plus or minus 10.9%, P < .001).Conclusions:The presence of both methane and hydrogen on breath testing is associated with increased BMI and percent body fat in humans. We hypothesize that this is due to colonization with the hydrogen-requiring M smithii, which affects nutrient availability for the host and may contribute to weight gain. |
| Author | Barlow, G. M. Amichai, M. Mathur, R. Mirocha, J. Pimentel, M. Chua, K. S. |
| AuthorAffiliation | Division of Endocrinology, Diabetes, and Metabolism (R.M.), GI Motility Program (M.A., K.S.C., G.M.B., M.P.), and Biostatistics Core (J.M.), Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048 |
| AuthorAffiliation_xml | – name: Division of Endocrinology, Diabetes, and Metabolism (R.M.), GI Motility Program (M.A., K.S.C., G.M.B., M.P.), and Biostatistics Core (J.M.), Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048 |
| Author_xml | – sequence: 1 givenname: R. surname: Mathur fullname: Mathur, R. email: ruchi.mathur@cshs.org organization: 1Division of Endocrinology, Diabetes, and Metabolism (R.M.) – sequence: 2 givenname: M. surname: Amichai fullname: Amichai, M. organization: 2GI Motility Program (M.A., K.S.C., G.M.B., M.P.) – sequence: 3 givenname: K. S. surname: Chua fullname: Chua, K. S. organization: 3Biostatistics Core (J.M.), Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048 – sequence: 4 givenname: J. surname: Mirocha fullname: Mirocha, J. organization: 3Biostatistics Core (J.M.), Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048 – sequence: 5 givenname: G. M. surname: Barlow fullname: Barlow, G. M. organization: 2GI Motility Program (M.A., K.S.C., G.M.B., M.P.) – sequence: 6 givenname: M. surname: Pimentel fullname: Pimentel, M. organization: 2GI Motility Program (M.A., K.S.C., G.M.B., M.P.) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23533244$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFks9rFDEUx4NU7LZ68ywBD3ro1PycHxehLbZdaNHDgt5CNvOmm3U2WZNM6_73zezWooViIIS89_k-3q8DtOe8A4TeUnJMGSWfluaYEcoKToV4gSa0EbKoaFPtoQkhjBZNxX7so4MYl4RkRPJXaJ9xyTkTYoK6a0gL7QBr1-LLTRv8DTj8zUeb7K1NG-wdPg2g0wLPICY8jfgkRm-sTtDi7zbbL0Y3BHzq2w2-1jHiqWvh9zbi1nau02v0stN9hDcP7yGanX-ZnV0WV18vpmcnV4URtaAFE7LjrDI1hY7JWjJBG97UrSAlmVdMNB3Qbl6D4XU1l8RkGCB7OBeVNjU_RJ93YdfDfAWtAZeC7tU62JUOG-W1Vf96nF2oG3-reEklbWQO8PEhQPC_hlywWtlooO9zi_wQFS1rInjJJf0_mhvclKRkTUbfP0GXfgguN0JxWuaZEMarTL37O_nHrP8MKwNHO8AEH2OA7hGhRI27oJZGjbugxl3IOHuCG5t0sn4s3fbPicROdOf7PNT4sx_uIKgF6D4tFMlHlFVdZAEnIv-KfKuxGR92Mj-sn8tqu6H8HjNi0B0 |
| CitedBy_id | crossref_primary_10_1093_ismeco_ycad014 crossref_primary_10_1177_0884533615609896 crossref_primary_10_2147_JAA_S208823 crossref_primary_10_1111_nmo_14033 crossref_primary_10_3390_nu17050917 crossref_primary_10_3390_nu15184035 crossref_primary_10_1016_j_tibs_2014_03_003 crossref_primary_10_1089_act_2014_20309 crossref_primary_10_22416_1382_4376_2022_32_2_19_34 crossref_primary_10_3390_nu7095348 crossref_primary_10_1002_mnfr_202100007 crossref_primary_10_1016_j_cgh_2024_07_020 crossref_primary_10_1093_ajcn_nqy164 crossref_primary_10_1007_s00535_014_0963_x crossref_primary_10_1080_17474124_2019_1543023 crossref_primary_10_3389_fmicb_2014_00353 crossref_primary_10_1016_j_rgmx_2021_04_005 crossref_primary_10_3390_s22052056 crossref_primary_10_1007_s00394_023_03161_5 crossref_primary_10_1002_edm2_6 crossref_primary_10_3389_fimmu_2017_01535 crossref_primary_10_1016_j_phrs_2024_107334 crossref_primary_10_1038_srep30887 crossref_primary_10_3389_fendo_2021_604070 crossref_primary_10_34133_2021_9854040 crossref_primary_10_4166_kjg_2019_74_3_142 crossref_primary_10_1016_j_anaerobe_2022_102629 crossref_primary_10_1093_femsre_fuv010 crossref_primary_10_5056_jnm_2014_20_1_31 crossref_primary_10_1007_s00253_015_7205_x crossref_primary_10_1016_j_rgmxen_2021_11_013 crossref_primary_10_3390_ijms20010001 crossref_primary_10_7717_peerj_9591 crossref_primary_10_1111_apt_14923 crossref_primary_10_1097_MCG_0000000000000267 crossref_primary_10_1007_s10620_021_07343_1 crossref_primary_10_1586_17474124_2013_832501 crossref_primary_10_1007_s11894_013_0356_y crossref_primary_10_4166_kjg_2020_75_1_23 crossref_primary_10_1038_ajg_2014_422 crossref_primary_10_1007_s00248_021_01796_7 crossref_primary_10_1089_bari_2014_0028 crossref_primary_10_1016_j_bcp_2023_115546 crossref_primary_10_1186_s40168_020_00977_9 crossref_primary_10_1177_2050640617744457 crossref_primary_10_3748_wjg_v27_i12_1149 crossref_primary_10_3389_fmicb_2023_1268451 crossref_primary_10_1016_j_nutres_2014_08_004 crossref_primary_10_1016_j_jaci_2016_08_038 crossref_primary_10_1089_bari_2014_9956 crossref_primary_10_1097_DCR_0000000000000999 crossref_primary_10_1017_S0007114519003052 crossref_primary_10_1210_er_2013_1084 crossref_primary_10_1586_17474124_2015_1051029 crossref_primary_10_2527_af_2016_0029 crossref_primary_10_1007_s11695_023_06974_9 crossref_primary_10_1093_gastro_gow048 crossref_primary_10_3390_chemosensors12020028 crossref_primary_10_3390_children9020148 crossref_primary_10_1038_s41598_019_54759_x crossref_primary_10_1002_oby_21266 crossref_primary_10_1038_s41598_022_12920_z crossref_primary_10_3390_molecules21111558 crossref_primary_10_1002_oby_21385 crossref_primary_10_7243_2053_3640_2_2 crossref_primary_10_1016_j_orcp_2016_06_006 crossref_primary_10_1016_S1499_3872_15_60026_1 crossref_primary_10_1038_s41467_019_14177_z crossref_primary_10_1088_1752_7155_9_1_014001 crossref_primary_10_1016_j_numecd_2016_04_007 crossref_primary_10_1080_09637486_2018_1427220 crossref_primary_10_1016_j_mito_2017_08_008 crossref_primary_10_1111_febs_17123 crossref_primary_10_1042_ETLS20180037 crossref_primary_10_17116_dokgastro20211002152 crossref_primary_10_3920_BM2016_0113 crossref_primary_10_1088_1752_7163_ab61c6 crossref_primary_10_1038_s41928_017_0004_x crossref_primary_10_1155_2013_540967 crossref_primary_10_1016_j_scitotenv_2022_155241 crossref_primary_10_1038_s41598_020_75987_6 crossref_primary_10_1186_s40635_019_0278_6 crossref_primary_10_1016_j_anaerobe_2018_10_009 crossref_primary_10_1016_j_ebiom_2019_10_045 crossref_primary_10_1088_1752_7163_aaaf77 crossref_primary_10_1038_s41598_018_28126_1 |
| Cites_doi | 10.1001/jama.298.17.2028 10.1038/4441022a 10.1073/pnas.0602187103 10.1073/pnas.0407076101 10.1136/gut.31.6.684 10.1097/00005176-198508000-00013 10.1093/ajcn/87.2.332 10.1038/nature05414 10.1023/A:1021738515885 10.1073/pnas.0605374104 10.1093/qjmed/hcl085 10.1073/pnas.0504978102 10.1128/.61.2.262-280.1997 10.1007/s10620-012-2197-1 10.3945/ajcn.2009.28095 10.1073/pnas.0808567105 10.2337/db07-1403 |
| ContentType | Journal Article |
| Copyright | Copyright © 2013 by The Endocrine Society 2013 Copyright © 2013 by The Endocrine Society |
| Copyright_xml | – notice: Copyright © 2013 by The Endocrine Society 2013 – notice: Copyright © 2013 by The Endocrine Society |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM H94 K9. 7X8 7TS 5PM |
| DOI | 10.1210/jc.2012-3144 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic Physical Education Index PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Calcium & Calcified Tissue Abstracts Nucleic Acids Abstracts MEDLINE - Academic Physical Education Index |
| DatabaseTitleList | MEDLINE - Academic AIDS and Cancer Research Abstracts MEDLINE Physical Education Index |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1945-7197 |
| EndPage | E702 |
| ExternalDocumentID | PMC3615195 23533244 10_1210_jc_2012_3144 00004678-201304000-00071 10.1210/jc.2012-3144 |
| Genre | Controlled Clinical Trial Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural Report |
| GrantInformation_xml | – fundername: NCRR NIH HHS grantid: UL1RR033176 – fundername: NCRR NIH HHS grantid: UL1 RR033176 – fundername: NCATS NIH HHS grantid: UL1 TR000124 – fundername: NCATS NIH HHS grantid: UL1TR000124 |
| GroupedDBID | --- -~X .55 .XZ 08P 0R~ 18M 1TH 29K 2WC 34G 354 39C 4.4 48X 53G 5GY 5RS 5YH 8F7 AABZA AACZT AAIMJ AAPQZ AAPXW AARHZ AAUAY AAVAP AAWTL ABBLC ABDFA ABEJV ABGNP ABJNI ABLJU ABMNT ABNHQ ABOCM ABPMR ABPPZ ABPQP ABPTD ABQNK ABVGC ABWST ABXVV ACGFO ACGFS ACPRK ACUTJ ACYHN ADBBV ADGKP ADGZP ADHKW ADQBN ADRTK ADVEK AELWJ AEMDU AENEX AENZO AETBJ AEWNT AFCHL AFFZL AFGWE AFOFC AFRAH AFXAL AGINJ AGKRT AGQXC AGUTN AHMBA AHMMS AJEEA ALMA_UNASSIGNED_HOLDINGS APIBT ARIXL ASPBG ATGXG AVWKF AZFZN BAWUL BAYMD BCRHZ BEYMZ BSWAC BTRTY C45 CDBKE CS3 D-I DAKXR DIK E3Z EBS EJD EMOBN ENERS F5P FECEO FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 HZ~ H~9 KBUDW KOP KQ8 KSI KSN L7B M5~ MHKGH MJL N9A NLBLG NOMLY NOYVH NVLIB O9- OAUYM OBH OCB ODMLO OFXIZ OGEVE OHH OJZSN OK1 OPAEJ OVD OVIDX P2P P6G REU ROX ROZ TEORI TJX TLC TR2 TWZ VVN W8F WOQ X7M YBU YFH YHG YOC YSK ZY1 ~02 ~H1 .GJ 3O- 7X7 88E 8FI 8FJ AAJQQ AAKAS AAPGJ AAQQT AAUQX AAWDT AAYJJ ABDPE ABUWG ABXZS ACFRR ACVCV ACZBC ADMTO ADNBA ADZCM AEMQT AEOTA AERZD AFFNX AFFQV AFKRA AFYAG AGMDO AGORE AHGBF AI. AJBYB AJDVS ALXQX APJGH AQDSO AQKUS AVNTJ BENPR BPHCQ BVXVI CCPQU EIHJH FEDTE FYUFA HMCUK HVGLF IAO IHR INH ITC J5H M1P MBLQV N4W NU- OBFPC PHGZM PHGZT PQQKQ PROAC PSQYO TMA UKHRP VH1 WHG X52 ZGI ZXP AAYXX AEHZK CITATION CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM H94 K9. 7X8 7TS 5PM |
| ID | FETCH-LOGICAL-c4841-245f327c81ef25852419398d4060b7249fe1fb8ec387b50cf32ee0b73347ac83 |
| ISSN | 0021-972X 1945-7197 |
| IngestDate | Tue Sep 30 16:59:00 EDT 2025 Thu Oct 02 15:57:19 EDT 2025 Thu Oct 02 16:16:26 EDT 2025 Tue Oct 07 07:22:11 EDT 2025 Thu Apr 03 06:56:59 EDT 2025 Thu Apr 24 23:11:17 EDT 2025 Wed Oct 01 01:27:53 EDT 2025 Fri May 16 04:03:21 EDT 2025 Fri Feb 07 10:35:43 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4841-245f327c81ef25852419398d4060b7249fe1fb8ec387b50cf32ee0b73347ac83 |
| Notes | SourceType-Scholarly Journals-1 content type line 14 ObjectType-Report-1 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| PMID | 23533244 |
| PQID | 3164450237 |
| PQPubID | 2046206 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3615195 proquest_miscellaneous_1680436351 proquest_miscellaneous_1324960629 proquest_journals_3164450237 pubmed_primary_23533244 crossref_primary_10_1210_jc_2012_3144 crossref_citationtrail_10_1210_jc_2012_3144 wolterskluwer_health_00004678-201304000-00071 oup_primary_10_1210_jc_2012-3144 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-April |
| PublicationDateYYYYMMDD | 2013-04-01 |
| PublicationDate_xml | – month: 04 year: 2013 text: 2013-April |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Washington – name: Chevy Chase, MD |
| PublicationTitle | The journal of clinical endocrinology and metabolism |
| PublicationTitleAlternate | J Clin Endocrinol Metab |
| PublicationYear | 2013 |
| Publisher | Oxford University Press Copyright by The Endocrine Society Endocrine Society |
| Publisher_xml | – name: Oxford University Press – name: Copyright by The Endocrine Society – name: Endocrine Society |
| References | Flegal ( key 2019041113320093500_B2) 2007; 298 Cani ( key 2019041113320093500_B5) 2008; 57 Gibson ( key 2019041113320093500_B12) 2008; 87 Pimentel ( key 2019041113320093500_B13) 2003; 48 Ley ( key 2019041113320093500_B4) 2006; 444 Cani ( key 2019041113320093500_B16) 2009; 90 Flourie ( key 2019041113320093500_B9) 1990; 31 Kim ( key 2019041113320093500_B10) 2012; 57 Backhed ( key 2019041113320093500_B14) 2004; 101 Malnick ( key 2019041113320093500_B1) 2006; 99 Basseri ( key 2019041113320093500_B11) 2012; 8 Pimentel ( key 2019041113320093500_B19) 2006; 290 Samuel ( key 2019041113320093500_B17) 2008; 105 Peled ( key 2019041113320093500_B20) 1985; 4 Ley ( key 2019041113320093500_B6) 2005; 102 Samuel ( key 2019041113320093500_B7) 2006; 103 Backhed ( key 2019041113320093500_B15) 2007; 104 Schink ( key 2019041113320093500_B8) 1997; 61 Mathur ( key 2019041113320093500_B18) Turnbaugh ( key 2019041113320093500_B3) 2006; 444 16033867 - Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5 17210919 - Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84 16916862 - QJM. 2006 Sep;99(9):565-79 17183312 - Nature. 2006 Dec 21;444(7122):1027-31 9184013 - Microbiol Mol Biol Rev. 1997 Jun;61(2):262-80 17986696 - JAMA. 2007 Nov 7;298(17):2028-37 18305141 - Diabetes. 2008 Jun;57(6):1470-81 18258622 - Am J Clin Nutr. 2008 Feb;87(2):332-8 15505215 - Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23 17183309 - Nature. 2006 Dec 21;444(7122):1022-3 22573345 - Dig Dis Sci. 2012 Dec;57(12):3213-8 18931303 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72 12645795 - Dig Dis Sci. 2003 Jan;48(1):86-92 16293652 - Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1089-95 22347829 - Gastroenterol Hepatol (N Y). 2012 Jan;8(1):22-8 19776140 - Am J Clin Nutr. 2009 Nov;90(5):1236-43 16782812 - Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10011-6 4032171 - J Pediatr Gastroenterol Nutr. 1985 Aug;4(4):575-9 2379872 - Gut. 1990 Jun;31(6):684-5 23712978 - Obesity (Silver Spring). 2013 Apr;21(4):748-54 |
| References_xml | – volume: 298 start-page: 2028 year: 2007 ident: key 2019041113320093500_B2 article-title: Cause-specific excess deaths associated with underweight, overweight, and obesity publication-title: JAMA doi: 10.1001/jama.298.17.2028 – ident: key 2019041113320093500_B18 article-title: Intestinal Methanobrevibacter smithii but not total bacteria is related to diet-induced weight gain in rats [published online June 7, 2012] publication-title: Obesity (Silver Spring) – volume: 444 start-page: 1022 year: 2006 ident: key 2019041113320093500_B4 article-title: Microbial ecology: human gut microbes associated with obesity publication-title: Nature doi: 10.1038/4441022a – volume: 103 start-page: 10011 year: 2006 ident: key 2019041113320093500_B7 article-title: A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0602187103 – volume: 101 start-page: 15718 year: 2004 ident: key 2019041113320093500_B14 article-title: The gut microbiota as an environmental factor that regulates fat storage publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0407076101 – volume: 31 start-page: 684 year: 1990 ident: key 2019041113320093500_B9 article-title: Comparative study of hydrogen and methane production in the human colon using caecal and faecal homogenates publication-title: Gut doi: 10.1136/gut.31.6.684 – volume: 4 start-page: 575 year: 1985 ident: key 2019041113320093500_B20 article-title: The development of methane production in childhood and adolescence publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/00005176-198508000-00013 – volume: 8 start-page: 22 year: 2012 ident: key 2019041113320093500_B11 article-title: Intestinal methane production in obese individuals is associated with a higher body mass index publication-title: Gastroenterol Hepatol – volume: 87 start-page: 332 year: 2008 ident: key 2019041113320093500_B12 article-title: Ability of new octapolar bioimpedance spectroscopy analyzers to predict 4-component-model percentage body fat in Hispanic, black, and white adults publication-title: Am J Clin Nutr doi: 10.1093/ajcn/87.2.332 – volume: 444 start-page: 1027 year: 2006 ident: key 2019041113320093500_B3 article-title: An obesity-associated gut microbiome with increased capacity for energy harvest publication-title: Nature doi: 10.1038/nature05414 – volume: 48 start-page: 86 year: 2003 ident: key 2019041113320093500_B13 article-title: Methane production during lactulose breath test is associated with gastrointestinal disease presentation publication-title: Digest Dis Sci doi: 10.1023/A:1021738515885 – volume: 290 start-page: G1089 year: 2006 ident: key 2019041113320093500_B19 article-title: Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity publication-title: Am J Physiol – volume: 104 start-page: 979 year: 2007 ident: key 2019041113320093500_B15 article-title: Mechanisms underlying the resistance to diet-induced obesity in germ-free mice publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0605374104 – volume: 99 start-page: 565 year: 2006 ident: key 2019041113320093500_B1 article-title: The medical complications of obesity publication-title: Q J M doi: 10.1093/qjmed/hcl085 – volume: 102 start-page: 11070 year: 2005 ident: key 2019041113320093500_B6 article-title: Obesity alters gut microbial ecology publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0504978102 – volume: 61 start-page: 262 year: 1997 ident: key 2019041113320093500_B8 article-title: Energetics of syntrophic cooperation in methanogenic degradation publication-title: Microbiol Mol Biol Rev doi: 10.1128/.61.2.262-280.1997 – volume: 57 start-page: 3213 issue: 12 year: 2012 ident: key 2019041113320093500_B10 article-title: Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath publication-title: Digest Dis Sci doi: 10.1007/s10620-012-2197-1 – volume: 90 start-page: 1236 year: 2009 ident: key 2019041113320093500_B16 article-title: Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.28095 – volume: 105 start-page: 16767 year: 2008 ident: key 2019041113320093500_B17 article-title: Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0808567105 – volume: 57 start-page: 1470 year: 2008 ident: key 2019041113320093500_B5 article-title: Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice publication-title: Diabetes doi: 10.2337/db07-1403 – reference: 4032171 - J Pediatr Gastroenterol Nutr. 1985 Aug;4(4):575-9 – reference: 12645795 - Dig Dis Sci. 2003 Jan;48(1):86-92 – reference: 19776140 - Am J Clin Nutr. 2009 Nov;90(5):1236-43 – reference: 18931303 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72 – reference: 18305141 - Diabetes. 2008 Jun;57(6):1470-81 – reference: 17986696 - JAMA. 2007 Nov 7;298(17):2028-37 – reference: 9184013 - Microbiol Mol Biol Rev. 1997 Jun;61(2):262-80 – reference: 16033867 - Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5 – reference: 22573345 - Dig Dis Sci. 2012 Dec;57(12):3213-8 – reference: 18258622 - Am J Clin Nutr. 2008 Feb;87(2):332-8 – reference: 2379872 - Gut. 1990 Jun;31(6):684-5 – reference: 17210919 - Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84 – reference: 17183312 - Nature. 2006 Dec 21;444(7122):1027-31 – reference: 16782812 - Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10011-6 – reference: 16916862 - QJM. 2006 Sep;99(9):565-79 – reference: 23712978 - Obesity (Silver Spring). 2013 Apr;21(4):748-54 – reference: 17183309 - Nature. 2006 Dec 21;444(7122):1022-3 – reference: 15505215 - Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23 – reference: 16293652 - Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1089-95 – reference: 22347829 - Gastroenterol Hepatol (N Y). 2012 Jan;8(1):22-8 |
| SSID | ssj0014453 |
| Score | 2.4113472 |
| Snippet | Context:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal... CONTEXT:Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal... Colonization of the gastrointestinal tract with methanogenic archaea (methanogens) significantly affects host metabolism and weight gain in animal models, and... |
| SourceID | pubmedcentral proquest pubmed crossref wolterskluwer oup |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | E698 |
| SubjectTerms | Adipose Tissue - anatomy & histology Adiposity - physiology Adult Aged Animal models Body Composition - physiology Body fat Body Mass Index Breath Tests Cohort Studies Colonization Fat metabolism Female Gastrointestinal tract Humans Hydrogen Hydrogen - analysis Hydrogen - metabolism JCEM Online: Brief Reports Lactulose Male Methane Methane - analysis Methane - metabolism Methanogenic archaea Methanogenic bacteria Middle Aged Mouth Breathing - metabolism Nutrient availability Obesity - metabolism Population studies Weight |
| Title | Methane and Hydrogen Positivity on Breath Test Is Associated With Greater Body Mass Index and Body Fat |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201304000-00071 https://www.ncbi.nlm.nih.gov/pubmed/23533244 https://www.proquest.com/docview/3164450237 https://www.proquest.com/docview/1324960629 https://www.proquest.com/docview/1680436351 https://pubmed.ncbi.nlm.nih.gov/PMC3615195 |
| Volume | 98 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1945-7197 dateEnd: 20241102 omitProxy: true ssIdentifier: ssj0014453 issn: 0021-972X databaseCode: DIK dateStart: 19970101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1945-7197 dateEnd: 20241102 omitProxy: true ssIdentifier: ssj0014453 issn: 0021-972X databaseCode: GX1 dateStart: 19960101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3rb9MwELfKkBASQrwpDGQk4EtllMR5fhyoVYfW8SUT_WYljqN2jGT0Idj-eu5sNw-NocGXqLKvrtX7-XJ3vgchb51ARlIFimVxWDDfy1wWl7JkTomtrQuehQ4mOM-Ow-mJ_3kezAeDy252ySb_IC__mFfyP1yFMeArZsn-A2ebRWEAPgN_4QkchueNeDxT6Pg2FwDTi2JVAyW2313alhDA2Y-oFC5GKQj_0eG64QaomV_RA6s9BJhvUhcXoxko0iAwCvVLr6jHJlnPeY-o6hSbaPIqVVXUIH-qtqLTd7UBfJ3tKhRqp_dmsV31ghQP0NVpGmJ3Ag22Jk2t9crOltjYK2tvsaybAltGNNEtu7QBlyWR7p3eiN4k7kDM78jRcWinzDt5HOm07KvyHgxWlPdYi1IXXzS1JPtltY-_iMnJ0ZFIx_P0_fkPhh3H8Gbetl-5RW578EbQbT_mTXgQrGQrmNpt26QJzHjq_lxPnemlSHYslasBt_d-1hgMsf6mcyE6Gk36gNy3pgg9MLh6SAaqekTuzGywxWNSWnhRYCfdwYu28KJ1RQ28KMKLHq5pCy-K8KIWXhShRBFeVMNLr6jHAF5PSDoZp5-mzLblYNKPfZd5flByL5Kxq0oPrE3QAROexAWohk4egTlfKrfMYyV5HOWBI4FYKZjh3I8yGfOnZK-qK_Wc0FDxhBeuLLHZS54XeQIKPyhImZ_7oLnKIRnt_lwhbcl67JxyJtB0BVaIUymQFQJZMSTvGupzU6rlGjoKfLqOhBmS_R0ThT1Ua_gu2A4B6LjRkLxppkEa4xUbcKPeroUL9gn6BLzkLzRhjH0feOAOyTODi2YzHgfzy8MNRD3ENARYDb4_Uy0Xuio8R9skCYaE9bAlTD610M4A0EwZHk58c-uCEpH74gb7fEnutkd6n-xtVlv1CnTxTf5aH5rf92DdIg |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Methane+and+Hydrogen+Positivity+on+Breath+Test+Is+Associated+With+Greater+Body+Mass+Index+and+Body+Fat&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Mathur%2C+R&rft.au=Amichai%2C+M&rft.au=Chua%2C+K+S&rft.au=Mirocha%2C+J&rft.date=2013-04-01&rft.issn=0021-972X&rft.volume=98&rft.issue=4&rft.spage=E698&rft.epage=E702&rft_id=info:doi/10.1210%2Fjc.2012-3144&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon |