Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo

Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP...

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Published inInternational journal of molecular sciences Vol. 17; no. 5; p. 769
Main Authors De Freitas, Laura, Calixto, Giovana, Chorilli, Marlus, Giusti, Juçaíra, Bagnato, Vanderlei, Soukos, Nikolaos, Amiji, Mansoor, Fontana, Carla
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 20.05.2016
Subjects
Adult
Aged
Biofilms - drug effects
Female
Humans
Lactic Acid - administration & dosage
Lactic Acid - chemistry
Male
Methylene Blue - administration & dosage
Methylene Blue - chemistry
Middle Aged
Nanoparticles
Periodontitis - drug therapy
Periodontitis - microbiology
Photochemotherapy - methods
Polyglycolic Acid - administration & dosage
Polyglycolic Acid - chemistry
methylene blue
PLGA
nanoparticles
biofilms
photodynamic therapy
periodontitis
Online AccessGet full text
ISSN1422-0067
1422-0067
DOI10.3390/ijms17050769

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Abstract Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT—in planktonic and biofilm phases—with MB or MB-NP (25 µg/mL) at 20 J/cm2 in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm2) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.
AbstractList Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT—in planktonic and biofilm phases—with MB or MB-NP (25 µg/mL) at 20 J/cm2 in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm2) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.
Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT—in planktonic and biofilm phases—with MB or MB-NP (25 µg/mL) at 20 J/cm2 in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm2) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.
Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT-in planktonic and biofilm phases-with MB or MB-NP (25 mu g/mL) at 20 J/cm super(2)in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 mu g/mL and 20 J/cm super(2)) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.
Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT-in planktonic and biofilm phases-with MB or MB-NP (25 µg/mL) at 20 J/cm² in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm²) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT-in planktonic and biofilm phases-with MB or MB-NP (25 µg/mL) at 20 J/cm² in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm²) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.
Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human dental plaque bacteria in suspensions and biofilms in vitro using methylene blue (MB)-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles (MB-NP) and red light at 660 nm. The effect of MB-NP-based aPDT was also evaluated in a clinical pilot study with 10 adult human subjects with chronic periodontitis. Dental plaque samples from human subjects were exposed to aPDT-in planktonic and biofilm phases-with MB or MB-NP (25 µg/mL) at 20 J/cm² in vitro. Patients were treated either with ultrasonic scaling and scaling and root planing (US + SRP) or ultrasonic scaling + SRP + aPDT with MB-NP (25 µg/mL and 20 J/cm²) in a split-mouth design. In biofilms, MB-NP eliminated approximately 25% more bacteria than free MB. The clinical study demonstrated the safety of aPDT. Both groups showed similar improvements of clinical parameters one month following treatments. However, at three months ultrasonic SRP + aPDT showed a greater effect (28.82%) on gingival bleeding index (GBI) compared to ultrasonic SRP. The utilization of PLGA nanoparticles encapsulated with MB may be a promising adjunct in antimicrobial periodontal treatment.
Author Amiji, Mansoor
Fontana, Carla
De Freitas, Laura
Giusti, Juçaíra
Bagnato, Vanderlei
Soukos, Nikolaos
Chorilli, Marlus
Calixto, Giovana
AuthorAffiliation 4 Applied Molecular Photomedicine Laboratory, the Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA; n.soukos@neu.edu
2 Faculdade de Ciencias Farmaceuticas, UNESP—Univ Estadual Paulista, Campus Araraquara, Departamento de Farmacos e Medicamentos, Araraquara, SP 14800-903, Brazil; giovana.calixto@gmail.com (G.M.F.C.); chorilli@fcfar.unesp.br (M.C.)
5 Department of PharmaceuticalSciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, 140 The Fenway, Room 156, 360 Huntington Avenue Boston, MA 02115, USA; m.amiji@neu.edu
3 Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Caixa Postal 369, Sao Carlos, SP 15980-900, Brazil; jsmgiusti@gmail.com (J.S.M.G.); vander@ifsc.usp.br (V.S.B.)
1 Faculdade de Ciencias Farmaceuticas, UNESP—Univ Estadual Paulista, Campus Araraquara, Departamento de Análises Clínicas, Araraquara, SP 14800-903, Brazil; lfmarise@gmail.com
AuthorAffiliation_xml – name: 1 Faculdade de Ciencias Farmaceuticas, UNESP—Univ Estadual Paulista, Campus Araraquara, Departamento de Análises Clínicas, Araraquara, SP 14800-903, Brazil; lfmarise@gmail.com
– name: 3 Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Caixa Postal 369, Sao Carlos, SP 15980-900, Brazil; jsmgiusti@gmail.com (J.S.M.G.); vander@ifsc.usp.br (V.S.B.)
– name: 4 Applied Molecular Photomedicine Laboratory, the Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA; n.soukos@neu.edu
– name: 5 Department of PharmaceuticalSciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, 140 The Fenway, Room 156, 360 Huntington Avenue Boston, MA 02115, USA; m.amiji@neu.edu
– name: 2 Faculdade de Ciencias Farmaceuticas, UNESP—Univ Estadual Paulista, Campus Araraquara, Departamento de Farmacos e Medicamentos, Araraquara, SP 14800-903, Brazil; giovana.calixto@gmail.com (G.M.F.C.); chorilli@fcfar.unesp.br (M.C.)
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Cites_doi 10.1016/j.colsurfb.2010.12.031
10.1128/9781555817947
10.1021/cr5004198
10.1111/j.1600-051X.2010.01562.x
10.1002/smll.201403014
10.1111/jcpe.12539
10.3390/molecules21030342
10.1007/s10103-013-1426-y
10.1364/AO.46.001924
10.1902/jop.2009.090285
10.1039/C4NJ00864B
10.1016/j.tibtech.2008.07.007
10.5946/ce.2013.46.1.24
10.1007/s00784-015-1617-y
10.1002/lsm.21069
10.1038/sj.clpt.6100247
10.1016/j.pdpdt.2015.10.007
10.1111/j.1600-0765.2008.01187.x
10.1021/nl0519229
10.1007/s10103-013-1337-y
10.1016/j.joen.2009.10.011
10.2174/1389450054545962
10.1089/pho.2011.3195
10.1007/s11274-007-9411-x
10.3390/ijms12085039
10.3390/ijms161126027
10.1186/gb-2007-8-7-r138
10.1007/s10103-011-0901-6
10.1016/j.jconrel.2011.08.010
10.1128/IAI.02084-14
10.1111/j.1365-2591.2004.00752.x
10.3389/fmicb.2014.00405
10.1016/j.pdpdt.2009.10.008
10.1034/j.1600-0757.2002.280103.x
10.1902/jop.2014.140392
10.1111/j.1600-0765.2011.01409.x
10.1155/2013/150653
10.4103/0976-9668.166100
10.2174/1568026615666150108145614
10.1111/jcpe.12094
10.1177/08959374970110010701
10.1016/j.pdpdt.2013.07.003
10.1155/2015/794601
10.1038/nri3785
10.1016/j.jconrel.2015.04.028
10.1016/j.nantod.2014.05.002
10.1093/jac/22.6.777
10.2147/IJN.S87148
10.1039/C4CC10226F
10.1016/j.colsurfb.2012.10.063
10.1016/j.jconrel.2014.03.055
10.1007/s10103-015-1836-0
10.1016/j.colsurfb.2009.09.001
10.1007/s10103-014-1632-2
10.4155/tde.15.5
10.1111/j.1600-0722.2007.00418.x
10.1016/j.jconrel.2012.01.043
10.1038/35101627
10.2174/157341312801784311
10.1128/AAC.00006-08
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Keywords methylene blue
PLGA
nanoparticles
biofilms
photodynamic therapy
periodontitis
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References Guggenheim (ref_20) 2007; 115
Abdollahi (ref_27) 2012; 3
Nakanishia (ref_25) 2014; 9
Fontana (ref_18) 2009; 44
Patel (ref_40) 2007; 82
Iannitelli (ref_51) 2011; 12
Danhier (ref_23) 2012; 161
Souza (ref_38) 2016; 31
Sreedhar (ref_10) 2015; 6
Lin (ref_2) 2014; 82
ref_59
Petersilka (ref_56) 2002; 28
Tegos (ref_44) 2008; 52
Souza (ref_29) 2012; 8
Novaes (ref_60) 2012; 27
Keawchaoon (ref_54) 2011; 84
Sgolastra (ref_39) 2013; 40
Patel (ref_46) 2011; 43
Sah (ref_37) 2015; 2015
ref_62
Haag (ref_9) 2015; 16
Zuzanna (ref_1) 2015; 12
Ogura (ref_19) 2007; 23
Cieplik (ref_5) 2014; 5
Ariga (ref_26) 2014; 38
Pagonis (ref_33) 2010; 36
Deng (ref_34) 2015; 51
Zijnge (ref_57) 2010; 37
McCarthy (ref_47) 2005; 5
Teles (ref_58) 2012; 47
Hajishengallis (ref_3) 2015; 15
Shiha (ref_22) 2013; 10
Moreira (ref_11) 2015; 86
Giannopoulou (ref_13) 2015; 30
Sato (ref_31) 2015; 15
Allison (ref_7) 2013; 46
Forier (ref_49) 2014; 190
Calixto (ref_24) 2016; 21
Chronopoulou (ref_52) 2013; 103
Azarpazhooh (ref_14) 2010; 81
Koo (ref_32) 2007; 46
Brown (ref_42) 1988; 22
Harris (ref_17) 2005; 6
Petelin (ref_61) 2015; 30
Nguyen (ref_6) 2015; 6
Lucky (ref_35) 2015; 115
Fontana (ref_16) 2012; 30
Alwaeli (ref_12) 2015; 30
Gilbert (ref_43) 1997; 11
Kurokawa (ref_45) 2007; 8
Baeloa (ref_48) 2015; 209
Santos (ref_30) 2015; 10
Ungaro (ref_55) 2012; 157
Boda (ref_50) 2015; 11
Whiteley (ref_41) 2001; 413
Taraszkiewicz (ref_21) 2013; 2013
Kumari (ref_36) 2010; 75
Dai (ref_8) 2009; 6
Radcliffe (ref_15) 2004; 37
Santos (ref_28) 2013; 9
ref_4
Bechet (ref_53) 2008; 26
21296562 - Colloids Surf B Biointerfaces. 2011 May 1;84(1):163-71
12013348 - Periodontol 2000. 2002;28:56-71
24794896 - J Control Release. 2014 Sep 28;190:607-23
20507375 - J Clin Periodontol. 2010 Jun;37(6):518-25
18474586 - Antimicrob Agents Chemother. 2008 Sep;52(9):3202-9
21895662 - J Periodontal Res. 2012 Feb;47(1):95-104
26563956 - Lasers Med Sci. 2016 Jan;31(1):187-96
19932449 - Photodiagnosis Photodyn Ther. 2009 Sep-Dec;6(3-4):170-88
26001175 - Ther Deliv. 2015;6(5):595-608
26935472 - J Clin Periodontol. 2016 May;43(5):426-34
25673062 - Chem Commun (Camb). 2015 Mar 11;51(20):4271-4
17356639 - Appl Opt. 2007 Apr 1;46(10):1924-30
25047844 - Infect Immun. 2014 Oct;82(10):4127-34
24037036 - Lasers Med Sci. 2015 Feb;30(2):801-7
26345528 - Int J Nanomedicine. 2015;10:4981-5003
26497443 - Photodiagnosis Photodyn Ther. 2015 Dec;12(4):612-8
11677611 - Nature. 2001 Oct 25;413(6858):860-4
23509680 - Biomed Res Int. 2013;2013:150653
26978341 - Molecules. 2016;21(3). pii: E342. doi: 10.3390/molecules21030342
22693952 - Photomed Laser Surg. 2012 Jul;30(7):393-9
17538551 - Clin Pharmacol Ther. 2007 Aug;82(2):204-9
19782542 - Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18
22353619 - J Control Release. 2012 Jul 20;161(2):505-22
26604595 - J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S102-9
23660738 - Lasers Med Sci. 2015 Jan;30(1):27-34
9524452 - Adv Dent Res. 1997 Apr;11(1):160-7
26419675 - Clin Oral Investig. 2016 Jul;20(6):1253-61
25913364 - J Control Release. 2015 Jul 10;209:150-8
20113801 - J Endod. 2010 Feb;36(2):322-8
24284125 - Photodiagnosis Photodyn Ther. 2013 Dec;10(4):664-71
21399951 - Lasers Med Sci. 2012 Mar;27(2):389-95
18804298 - Trends Biotechnol. 2008 Nov;26(11):612-21
23422955 - Clin Endosc. 2013 Jan;46(1):24-9
15189432 - Int Endod J. 2004 Jul;37(7):438-46
23557433 - J Clin Periodontol. 2013 May;40(5):514-26
26580607 - Int J Mol Sci. 2015;16(11):27327-38
19602126 - J Periodontal Res. 2009 Dec;44(6):751-9
3072331 - J Antimicrob Chemother. 1988 Dec;22(6):777-80
25579344 - Curr Top Med Chem. 2015;15(4):287-97
25161649 - Front Microbiol. 2014 Aug 12;5:405
17305720 - Eur J Oral Sci. 2007 Feb;115(1):77-80
22057487 - Lasers Surg Med. 2011 Sep;43(7):600-6
25712910 - Small. 2015 Jul;11(26):3183-93
25602130 - Chem Rev. 2015 Feb 25;115(4):1990-2042
25534621 - Nat Rev Immunol. 2015 Jan;15(1):30-44
20059412 - J Periodontol. 2010 Jan;81(1):4-14
23261553 - Colloids Surf B Biointerfaces. 2013 Mar 1;103:310-7
25056413 - Lasers Med Sci. 2015 Aug;30(6):1647-56
17711596 - Genome Biol. 2007;8(7):R138
25415245 - J Periodontol. 2015 Mar;86(3):376-86
16026282 - Curr Drug Targets. 2005 Aug;6(5):615-27
16351214 - Nano Lett. 2005 Dec;5(12):2552-6
21954343 - Int J Mol Sci. 2011;12(8):5039-51
21864595 - J Control Release. 2012 Jan 10;157(1):149-59
References_xml – volume: 84
  start-page: 163
  year: 2011
  ident: ref_54
  article-title: Preparation, characterization and in vitro release study of carvacrol-loaded chitosan nanoparticles
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2010.12.031
– ident: ref_4
  doi: 10.1128/9781555817947
– volume: 115
  start-page: 1990
  year: 2015
  ident: ref_35
  article-title: Nanoparticles in photodynamic therapy
  publication-title: Chem. Rev.
  doi: 10.1021/cr5004198
– volume: 37
  start-page: 518
  year: 2010
  ident: ref_57
  article-title: The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: A blinded, randomized clinical trial
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/j.1600-051X.2010.01562.x
– volume: 11
  start-page: 3183
  year: 2015
  ident: ref_50
  article-title: Cytotoxicity of ultrasmall gold nanoparticles on planktonic and biofilm encapsulated gram-positive Staphylococci
  publication-title: Small
  doi: 10.1002/smll.201403014
– ident: ref_62
  doi: 10.1111/jcpe.12539
– volume: 21
  start-page: 342
  year: 2016
  ident: ref_24
  article-title: Nanotechnology-based drug delivery systems for photodynamic therapy of cancer: A review
  publication-title: Molecules
  doi: 10.3390/molecules21030342
– volume: 30
  start-page: 801
  year: 2015
  ident: ref_12
  article-title: Long-term clinical effect of adjunctive antimicrobial photodynamic therapy in periodontal treatment: A randomized clinical trial
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-013-1426-y
– volume: 46
  start-page: 1924
  year: 2007
  ident: ref_32
  article-title: Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy
  publication-title: Appl. Opt.
  doi: 10.1364/AO.46.001924
– volume: 81
  start-page: 4
  year: 2010
  ident: ref_14
  article-title: The effect of photodynamic therapy for periodontitis: A systematic review and meta-analysis
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2009.090285
– volume: 38
  start-page: 5149
  year: 2014
  ident: ref_26
  article-title: Bioinspired nanoarchitectonics as emerging drug delivery systems
  publication-title: New J. Chem.
  doi: 10.1039/C4NJ00864B
– volume: 26
  start-page: 612
  year: 2008
  ident: ref_53
  article-title: Nanoparticles as vehicles for delivery of photodynamic therapy agents
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2008.07.007
– volume: 46
  start-page: 24
  year: 2013
  ident: ref_7
  article-title: Photodynamic therapy (PDT): PDT mechanisms
  publication-title: Clin. Endosc.
  doi: 10.5946/ce.2013.46.1.24
– ident: ref_59
  doi: 10.1007/s00784-015-1617-y
– volume: 43
  start-page: 600
  year: 2011
  ident: ref_46
  article-title: Photodynamic effects of methylene blue-loaded polymeric nanoparticles on dental plaque bacteria
  publication-title: Lasers Surg. Med.
  doi: 10.1002/lsm.21069
– volume: 82
  start-page: 204
  year: 2007
  ident: ref_40
  article-title: The challenge of treating biofilm-associated bacterial infections
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/sj.clpt.6100247
– volume: 12
  start-page: 612
  year: 2015
  ident: ref_1
  article-title: Antimicrobial photodynamic therapy—A discovery originating from the pre-antibiotic era in a novel periodontal therapy
  publication-title: Photodiagn. Photodyn. Ther.
  doi: 10.1016/j.pdpdt.2015.10.007
– volume: 44
  start-page: 751
  year: 2009
  ident: ref_18
  article-title: The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms
  publication-title: J. Periodontal Res.
  doi: 10.1111/j.1600-0765.2008.01187.x
– volume: 5
  start-page: 2552
  year: 2005
  ident: ref_47
  article-title: Polymeric nanoparticle preparation that eradicates tumors
  publication-title: Nano Lett.
  doi: 10.1021/nl0519229
– volume: 30
  start-page: 27
  year: 2015
  ident: ref_13
  article-title: Single or repeated antimicrobial photodynamic therapy as adjunct to ultrasonic debridement in residual periodontal pockets: Clinical, microbiological, and local biological effects
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-013-1337-y
– volume: 36
  start-page: 322
  year: 2010
  ident: ref_33
  article-title: Nanoparticle-based endodontic antimicrobial photodynamic therapy
  publication-title: J. Endod.
  doi: 10.1016/j.joen.2009.10.011
– volume: 6
  start-page: 615
  year: 2005
  ident: ref_17
  article-title: Phenothiazinium based photosensitisers-photodynamic agents with a multiplicity of cellular targets and clinical applications
  publication-title: Curr. Drug Targets
  doi: 10.2174/1389450054545962
– volume: 30
  start-page: 393
  year: 2012
  ident: ref_16
  article-title: Photodynamic effects of curcumin against cariogenic pathogens
  publication-title: Photomed. Laser Surg.
  doi: 10.1089/pho.2011.3195
– volume: 23
  start-page: 1637
  year: 2007
  ident: ref_19
  article-title: Photomechanical wave-assisted molecular delivery in oral biofilms
  publication-title: World J. Microbiol. Biotechnol.
  doi: 10.1007/s11274-007-9411-x
– volume: 12
  start-page: 5039
  year: 2011
  ident: ref_51
  article-title: Potential antibacterial activity of carvacrol-loaded poly (dl-lactide-co-glycolide)(PLGA) nanoparticles against microbial biofilm
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms12085039
– volume: 16
  start-page: 27327
  year: 2015
  ident: ref_9
  article-title: The in vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms161126027
– volume: 8
  start-page: R138
  year: 2007
  ident: ref_45
  article-title: Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes
  publication-title: Genome Biol.
  doi: 10.1186/gb-2007-8-7-r138
– volume: 27
  start-page: 389
  year: 2012
  ident: ref_60
  article-title: Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: Microbiological profile
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-011-0901-6
– volume: 157
  start-page: 149
  year: 2012
  ident: ref_55
  article-title: Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: Modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2011.08.010
– volume: 82
  start-page: 4127
  year: 2014
  ident: ref_2
  article-title: Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.02084-14
– volume: 37
  start-page: 438
  year: 2004
  ident: ref_15
  article-title: Antimicrobial activity of varying concentrations of sodium hypochlorite on the endodontic microorganisms Actinomyces israelii, A. naeslundii, Candida albicans and Enterococcus faecalis
  publication-title: Int. Endod. J.
  doi: 10.1111/j.1365-2591.2004.00752.x
– volume: 5
  start-page: 1
  year: 2014
  ident: ref_5
  article-title: Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2014.00405
– volume: 6
  start-page: 170
  year: 2009
  ident: ref_8
  article-title: Photodynamic therapy for localized infections—State of the art
  publication-title: Photodiagn. Photodyn. Ther.
  doi: 10.1016/j.pdpdt.2009.10.008
– volume: 28
  start-page: 56
  year: 2002
  ident: ref_56
  article-title: Antimicrobial effects of mechanical debridement
  publication-title: Periodontol. 2000
  doi: 10.1034/j.1600-0757.2002.280103.x
– volume: 86
  start-page: 376
  year: 2015
  ident: ref_11
  article-title: Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: A split-mouth randomized controlled trial
  publication-title: J. Periodontol.
  doi: 10.1902/jop.2014.140392
– volume: 47
  start-page: 95
  year: 2012
  ident: ref_58
  article-title: Early microbial succession in redeveloping dental biofilms in periodontal health and disease
  publication-title: J. Periodontal Res.
  doi: 10.1111/j.1600-0765.2011.01409.x
– volume: 2013
  start-page: 13
  year: 2013
  ident: ref_21
  article-title: Innovative strategies to overcome biofilm resistance
  publication-title: BioMed Res. Int.
  doi: 10.1155/2013/150653
– volume: 6
  start-page: S102
  year: 2015
  ident: ref_10
  article-title: Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study
  publication-title: J. Nat. Sci. Biol. Med.
  doi: 10.4103/0976-9668.166100
– volume: 15
  start-page: 287
  year: 2015
  ident: ref_31
  article-title: Recent Advances in Nanoparticle Carriers for Coordination Complexes
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026615666150108145614
– volume: 40
  start-page: 514
  year: 2013
  ident: ref_39
  article-title: Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: A systematic review and meta-analysis
  publication-title: J. Clin. Periodontol.
  doi: 10.1111/jcpe.12094
– volume: 11
  start-page: 160
  year: 1997
  ident: ref_43
  article-title: Biofilm susceptibility to antimicrobials
  publication-title: Adv. Dent. Res.
  doi: 10.1177/08959374970110010701
– volume: 10
  start-page: 664
  year: 2013
  ident: ref_22
  article-title: Repetitive methylene blue-mediated photoantimicrobial chemotherapy changes the susceptibility and expression of the outer membrane proteins of Pseudomonas aeruginosa
  publication-title: Photodiagn. Photodyn. Ther.
  doi: 10.1016/j.pdpdt.2013.07.003
– volume: 2015
  start-page: 22
  year: 2015
  ident: ref_37
  article-title: Recent trends in preparation of poly(lactide-co-glycolide) nanoparticles by mixing polymeric organic solution with antisolvent
  publication-title: J. Nanomater.
  doi: 10.1155/2015/794601
– volume: 15
  start-page: 30
  year: 2015
  ident: ref_3
  article-title: Periodontitis: From microbial immune subversion to systemic inflammation
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3785
– volume: 209
  start-page: 150
  year: 2015
  ident: ref_48
  article-title: Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.04.028
– volume: 9
  start-page: 378
  year: 2014
  ident: ref_25
  article-title: Bioactive nanocarbon assemblies: Nanoarchitectonics and applications
  publication-title: Nano Today
  doi: 10.1016/j.nantod.2014.05.002
– volume: 22
  start-page: 777
  year: 1988
  ident: ref_42
  article-title: Resistance of bacterial biofilms to antibiotics: A growth-rate related effect?
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/22.6.777
– volume: 10
  start-page: 4981
  year: 2015
  ident: ref_30
  article-title: Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S87148
– volume: 51
  start-page: 4271
  year: 2015
  ident: ref_34
  article-title: A facile strategy to generate polymeric nanoparticles for synergistic chemo-photodynamic therapy
  publication-title: Chem. Commun.
  doi: 10.1039/C4CC10226F
– volume: 103
  start-page: 310
  year: 2013
  ident: ref_52
  article-title: Chitosan-coated PLGA nanoparticles: A sustained drug release strategy for cell cultures
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2012.10.063
– volume: 190
  start-page: 607
  year: 2014
  ident: ref_49
  article-title: Lipid and polymer nanoparticles for drug delivery to bacterial biofilms
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.03.055
– volume: 31
  start-page: 187
  year: 2016
  ident: ref_38
  article-title: Antimicrobial photodynamic therapy in the treatment of aggressive periodontitis: A systematic review and meta-analysis
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-015-1836-0
– volume: 75
  start-page: 1
  year: 2010
  ident: ref_36
  article-title: Biodegradable polymeric nanoparticles based drug delivery systems
  publication-title: Colloid Surf. B
  doi: 10.1016/j.colsurfb.2009.09.001
– volume: 30
  start-page: 1647
  year: 2015
  ident: ref_61
  article-title: Effect of repeated adjunctive antimicrobial photodynamic therapy on subgingival periodontal pathogens in the treatment of chronic periodontitis
  publication-title: Lasers Med. Sci.
  doi: 10.1007/s10103-014-1632-2
– volume: 6
  start-page: 595
  year: 2015
  ident: ref_6
  article-title: Advanced drug delivery systems for local treatment of the oral cavity
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.15.5
– volume: 115
  start-page: 77
  year: 2007
  ident: ref_20
  article-title: Efficacy of gasiform ozone and photodynamic therapy on a multispecies oral biofilm in vitro
  publication-title: Eur. J. Oral Sci.
  doi: 10.1111/j.1600-0722.2007.00418.x
– volume: 3
  start-page: 11
  year: 2012
  ident: ref_27
  article-title: PLGA- and PLA-based polymeric nanoparticles for antimicrobial drug delivery
  publication-title: Biomed. Int.
– volume: 161
  start-page: 505
  year: 2012
  ident: ref_23
  article-title: PLGA-based nanoparticles: An overview of biomedical applications
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2012.01.043
– volume: 413
  start-page: 860
  year: 2001
  ident: ref_41
  article-title: Gene expression in Pseudomonas aeruginosa biofilms
  publication-title: Nature
  doi: 10.1038/35101627
– volume: 8
  start-page: 512
  year: 2012
  ident: ref_29
  article-title: Nanotechnology-based drug delivery systems for dermatomycosis treatment
  publication-title: Curr. Nanosci.
  doi: 10.2174/157341312801784311
– volume: 52
  start-page: 3202
  year: 2008
  ident: ref_44
  article-title: Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00006-08
– volume: 9
  start-page: 159
  year: 2013
  ident: ref_28
  article-title: Nanotechnology-based drug delivery systems for treatment of hyperproliferative skin diseases—A review
  publication-title: Curr. Nanosci.
– reference: 16351214 - Nano Lett. 2005 Dec;5(12):2552-6
– reference: 26345528 - Int J Nanomedicine. 2015;10:4981-5003
– reference: 25913364 - J Control Release. 2015 Jul 10;209:150-8
– reference: 26935472 - J Clin Periodontol. 2016 May;43(5):426-34
– reference: 24794896 - J Control Release. 2014 Sep 28;190:607-23
– reference: 24037036 - Lasers Med Sci. 2015 Feb;30(2):801-7
– reference: 25056413 - Lasers Med Sci. 2015 Aug;30(6):1647-56
– reference: 24284125 - Photodiagnosis Photodyn Ther. 2013 Dec;10(4):664-71
– reference: 21954343 - Int J Mol Sci. 2011;12(8):5039-51
– reference: 20113801 - J Endod. 2010 Feb;36(2):322-8
– reference: 25415245 - J Periodontol. 2015 Mar;86(3):376-86
– reference: 25579344 - Curr Top Med Chem. 2015;15(4):287-97
– reference: 26580607 - Int J Mol Sci. 2015;16(11):27327-38
– reference: 23261553 - Colloids Surf B Biointerfaces. 2013 Mar 1;103:310-7
– reference: 23660738 - Lasers Med Sci. 2015 Jan;30(1):27-34
– reference: 21399951 - Lasers Med Sci. 2012 Mar;27(2):389-95
– reference: 26604595 - J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S102-9
– reference: 12013348 - Periodontol 2000. 2002;28:56-71
– reference: 11677611 - Nature. 2001 Oct 25;413(6858):860-4
– reference: 20059412 - J Periodontol. 2010 Jan;81(1):4-14
– reference: 23509680 - Biomed Res Int. 2013;2013:150653
– reference: 18804298 - Trends Biotechnol. 2008 Nov;26(11):612-21
– reference: 17305720 - Eur J Oral Sci. 2007 Feb;115(1):77-80
– reference: 26001175 - Ther Deliv. 2015;6(5):595-608
– reference: 9524452 - Adv Dent Res. 1997 Apr;11(1):160-7
– reference: 23422955 - Clin Endosc. 2013 Jan;46(1):24-9
– reference: 19602126 - J Periodontal Res. 2009 Dec;44(6):751-9
– reference: 26419675 - Clin Oral Investig. 2016 Jul;20(6):1253-61
– reference: 19782542 - Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18
– reference: 22353619 - J Control Release. 2012 Jul 20;161(2):505-22
– reference: 17356639 - Appl Opt. 2007 Apr 1;46(10):1924-30
– reference: 25673062 - Chem Commun (Camb). 2015 Mar 11;51(20):4271-4
– reference: 21895662 - J Periodontal Res. 2012 Feb;47(1):95-104
– reference: 21864595 - J Control Release. 2012 Jan 10;157(1):149-59
– reference: 22693952 - Photomed Laser Surg. 2012 Jul;30(7):393-9
– reference: 25161649 - Front Microbiol. 2014 Aug 12;5:405
– reference: 18474586 - Antimicrob Agents Chemother. 2008 Sep;52(9):3202-9
– reference: 20507375 - J Clin Periodontol. 2010 Jun;37(6):518-25
– reference: 21296562 - Colloids Surf B Biointerfaces. 2011 May 1;84(1):163-71
– reference: 25534621 - Nat Rev Immunol. 2015 Jan;15(1):30-44
– reference: 16026282 - Curr Drug Targets. 2005 Aug;6(5):615-27
– reference: 25602130 - Chem Rev. 2015 Feb 25;115(4):1990-2042
– reference: 25712910 - Small. 2015 Jul;11(26):3183-93
– reference: 26978341 - Molecules. 2016;21(3). pii: E342. doi: 10.3390/molecules21030342
– reference: 15189432 - Int Endod J. 2004 Jul;37(7):438-46
– reference: 17711596 - Genome Biol. 2007;8(7):R138
– reference: 23557433 - J Clin Periodontol. 2013 May;40(5):514-26
– reference: 3072331 - J Antimicrob Chemother. 1988 Dec;22(6):777-80
– reference: 25047844 - Infect Immun. 2014 Oct;82(10):4127-34
– reference: 19932449 - Photodiagnosis Photodyn Ther. 2009 Sep-Dec;6(3-4):170-88
– reference: 22057487 - Lasers Surg Med. 2011 Sep;43(7):600-6
– reference: 26563956 - Lasers Med Sci. 2016 Jan;31(1):187-96
– reference: 17538551 - Clin Pharmacol Ther. 2007 Aug;82(2):204-9
– reference: 26497443 - Photodiagnosis Photodyn Ther. 2015 Dec;12(4):612-8
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Snippet Antimicrobial photodynamic therapy (aPDT) is increasingly being explored for treatment of periodontitis. Here, we investigated the effect of aPDT on human...
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StartPage 769
SubjectTerms Adult
Aged
Biofilms - drug effects
Female
Humans
Lactic Acid - administration & dosage
Lactic Acid - chemistry
Male
Methylene Blue - administration & dosage
Methylene Blue - chemistry
Middle Aged
Nanoparticles
Periodontitis - drug therapy
Periodontitis - microbiology
Photochemotherapy - methods
Polyglycolic Acid - administration & dosage
Polyglycolic Acid - chemistry
Title Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo
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