Thrombocytopenic c-mpl−/− mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response - Levin, Jack; Cocault, Laurence; Demerens, Corinne; Challier, Cécile; Pauchard, Michèle; Caen, Jacques; Souyri, Michèle (Blood, 2001)
Keywords: Age Factors; Animals; Antineoplastic agents; Biological and medical sciences; Blood Platelets - cytology; Blood Platelets - drug effects; Bone Marrow Cells; Chemotherapy; Disease Models, Animal; Fluorouracil - administration & dosage; Fluorouracil - pharmacology; Medical sciences; Megakaryocytes - ultrastructure; Mice; Mice, Knockout; Neoplasm Proteins; Pharmacology. Drug treatments; Platelet Count; Ploidies; Proto-Oncogene Proteins - deficiency; Proto-Oncogene Proteins - genetics; Receptors, Cytokine; Receptors, Thrombopoietin; Spleen - cytology; Splenectomy; Stem Cells - cytology; Thrombocytopenia - blood; Thrombocytopenia - drug therapy; Thrombocytopenia - genetics; Megakaryocytopoiesis; Thrombopoiesis; Stem cell; Hematopoietic cell; Thrombopoietin; Hematopoiesis; Myelosuppression; Mechanism of action; Fluorouracil; Enzyme; Transferases; Fluoropyrimidine derivatives; Rodentia; Enzyme inhibitor; Thymidylate synthase; Vertebrata; Chemotherapy; Platelet; Mammalia; Treatment; Methyltransferases; Antimetabolic; Mouse; Animal; Pyrimidine derivatives