Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders

The kingdom of plants as a “green biofabric” of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that...

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Published inInternational journal of molecular sciences Vol. 23; no. 23; p. 14787
Main Authors Merecz-Sadowska, Anna, Sitarek, Przemysław, Stelmach, Joanna, Zajdel, Karolina, Kucharska, Ewa, Zajdel, Radosław
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2022
MDPI
Subjects
B cells
Biological products
Cosmetics industry
Enzymes
Fibroblasts
Free radicals (Chemistry)
Growth factors
Humans
Hyperpigmentation - drug therapy
Hypopigmentation
Kinases
Melanins
Melanocytes
Metabolites
Monophenol Monooxygenase
Phytochemicals
Pigmentation disorders
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Proteins
Radiation
Review
Signal transduction
Skin
Skin Pigmentation
Stem cells
Transcription factors
Tumor necrosis factor-TNF
Ultraviolet radiation
Ultraviolet Rays
Poland
in vivo studies
melanogenesis
phytochemicals
signaling pathways
plant
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms232314787

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Abstract The kingdom of plants as a “green biofabric” of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that protects human skin against ultraviolet radiation and oxidative stress. It is produced by a complex process called melanogenesis. However, disturbances in the melanogenesis mechanism may increase or decrease the level of melanin and generate essential skin problems, such as hyperpigmentation and hypopigmentation. Accordingly, inhibitors or activators of pigment formation are desirable for medical and cosmetic industry. Such properties may be exhibited by molecules of plant origin. Therefore, that literature review presents reports on plant extracts, pure compounds and compositions that may modulate melanin production in living organisms. The potential of plants in the therapy of pigmentation disorders has been highlighted.
AbstractList The kingdom of plants as a “green biofabric” of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that protects human skin against ultraviolet radiation and oxidative stress. It is produced by a complex process called melanogenesis. However, disturbances in the melanogenesis mechanism may increase or decrease the level of melanin and generate essential skin problems, such as hyperpigmentation and hypopigmentation. Accordingly, inhibitors or activators of pigment formation are desirable for medical and cosmetic industry. Such properties may be exhibited by molecules of plant origin. Therefore, that literature review presents reports on plant extracts, pure compounds and compositions that may modulate melanin production in living organisms. The potential of plants in the therapy of pigmentation disorders has been highlighted.
The kingdom of plants as a "green biofabric" of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that protects human skin against ultraviolet radiation and oxidative stress. It is produced by a complex process called melanogenesis. However, disturbances in the melanogenesis mechanism may increase or decrease the level of melanin and generate essential skin problems, such as hyperpigmentation and hypopigmentation. Accordingly, inhibitors or activators of pigment formation are desirable for medical and cosmetic industry. Such properties may be exhibited by molecules of plant origin. Therefore, that literature review presents reports on plant extracts, pure compounds and compositions that may modulate melanin production in living organisms. The potential of plants in the therapy of pigmentation disorders has been highlighted.The kingdom of plants as a "green biofabric" of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of plant origin are used to aid in pigmentation skin problems by influencing the process of melanogenesis. Melanin is a very important pigment that protects human skin against ultraviolet radiation and oxidative stress. It is produced by a complex process called melanogenesis. However, disturbances in the melanogenesis mechanism may increase or decrease the level of melanin and generate essential skin problems, such as hyperpigmentation and hypopigmentation. Accordingly, inhibitors or activators of pigment formation are desirable for medical and cosmetic industry. Such properties may be exhibited by molecules of plant origin. Therefore, that literature review presents reports on plant extracts, pure compounds and compositions that may modulate melanin production in living organisms. The potential of plants in the therapy of pigmentation disorders has been highlighted.
Audience Academic
Author Sitarek, Przemysław
Kucharska, Ewa
Stelmach, Joanna
Merecz-Sadowska, Anna
Zajdel, Karolina
Zajdel, Radosław
AuthorAffiliation 1 Department of Computer Science in Economics, University of Lodz, 90-214 Lodz, Poland
3 Department of Medical Informatics and Statistics, Medical University of Lodz, 90-645 Lodz, Poland
2 Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland
4 Department of Gerontology, Geriatrics and Social Work, Jesuit University Ignatianum, 31-501 Cracow, Poland
AuthorAffiliation_xml – name: 2 Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland
– name: 1 Department of Computer Science in Economics, University of Lodz, 90-214 Lodz, Poland
– name: 4 Department of Gerontology, Geriatrics and Social Work, Jesuit University Ignatianum, 31-501 Cracow, Poland
– name: 3 Department of Medical Informatics and Statistics, Medical University of Lodz, 90-645 Lodz, Poland
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  orcidid: 0000-0001-9987-4573
  surname: Merecz-Sadowska
  fullname: Merecz-Sadowska, Anna
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36499134$$D View this record in MEDLINE/PubMed
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Keywords in vivo studies
melanogenesis
phytochemicals
signaling pathways
plant
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Snippet The kingdom of plants as a “green biofabric” of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of...
The kingdom of plants as a "green biofabric" of valuable bioactive molecules has long been used in many ailments. Currently, extracts and pure compounds of...
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StartPage 14787
SubjectTerms B cells
Biological products
Cosmetics industry
Enzymes
Fibroblasts
Free radicals (Chemistry)
Growth factors
Humans
Hyperpigmentation - drug therapy
Hypopigmentation
Kinases
Melanins
Melanocytes
Metabolites
Monophenol Monooxygenase
Phytochemicals
Pigmentation disorders
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Proteins
Radiation
Review
Signal transduction
Skin
Skin Pigmentation
Stem cells
Transcription factors
Tumor necrosis factor-TNF
Ultraviolet radiation
Ultraviolet Rays
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Title Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders
URI https://www.ncbi.nlm.nih.gov/pubmed/36499134
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Volume 23
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