Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases
Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related and metabolic diseases. The inflammation is under the control of transcription factor NF-κB through an antagonistic crosstalk between SIRT1,...
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| Published in | Integrative medicine research Vol. 3; no. 4; pp. 198 - 203 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.12.2014
Elsevier 한국한의학연구원 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2213-4220 2213-4239 2213-4239 |
| DOI | 10.1016/j.imr.2014.09.005 |
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| Abstract | Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related and metabolic diseases. The inflammation is under the control of transcription factor NF-κB through an antagonistic crosstalk between SIRT1, PARP-1, and -2 signaling pathways. The transcriptional activity of NF-κB is increased in various tissues with aging and metabolic abnormalities and is related with various aging and metabolic diseases such as Alzheimer's disease, diabetes, and osteoporosis. Furthermore, NF-κB activation with chronic inflammation is connected with many known life span and metabolic regulators including DNA damage, obesity, SIRT, and PARP. Thus, the crossroads between PARP and SIRT signaling pathways represent efficient therapeutic targets for extending health span without metabolic diseases. |
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| AbstractList | Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related and metabolic diseases. The inflammation is under the control of transcription factor NF-κB through an antagonistic crosstalk between SIRT1, PARP-1, and -2 signaling pathways. The transcriptional activity of NF-κB is increased in various tissues with aging and metabolic abnormalities and is related with various aging and metabolic diseases such as Alzheimer's disease, diabetes, and osteoporosis. Furthermore, NF-κB activation with chronic inflammation is connected with many known life span and metabolic regulators including DNA damage, obesity, SIRT, and PARP. Thus, the crossroads between PARP and SIRT signaling pathways represent efficient therapeutic targets for extending health span without metabolic diseases. Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related and metabolic diseases. The inflammation is under the control of transcription factor NF-κB through an antagonistic crosstalk between SIRT1, PARP-1, and -2 signaling pathways. The transcriptional activity of NF-κB is increased in various tissues with aging and metabolic abnormalities and is related with various aging and metabolic diseases such as Alzheimer's disease, diabetes, and osteoporosis. Furthermore, NF-κB activation with chronic inflammation is connected with many known life span and metabolic regulators including DNA damage, obesity, SIRT, and PARP. Thus, the crossroads between PARP and SIRT signaling pathways represent efficient therapeutic targets for extending health span without metabolic diseases.Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related and metabolic diseases. The inflammation is under the control of transcription factor NF-κB through an antagonistic crosstalk between SIRT1, PARP-1, and -2 signaling pathways. The transcriptional activity of NF-κB is increased in various tissues with aging and metabolic abnormalities and is related with various aging and metabolic diseases such as Alzheimer's disease, diabetes, and osteoporosis. Furthermore, NF-κB activation with chronic inflammation is connected with many known life span and metabolic regulators including DNA damage, obesity, SIRT, and PARP. Thus, the crossroads between PARP and SIRT signaling pathways represent efficient therapeutic targets for extending health span without metabolic diseases. Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related and metabolic diseases. The inflammation is under the control of transcription factor NF-κB through an antagonistic crosstalk between SIRT1, PARP-1, and -2 signaling pathways. The transcriptional activity of NF-κB is increased in various tissues with aging and metabolic abnormalities and is related with various aging and metabolic diseases such as Alzheimer's disease, diabetes, and osteoporosis. Furthermore, NF-κB activation with chronic inflammation is connected with many known life span and metabolic regulators including DNA damage, obesity, SIRT, and PARP. Thus, the crossroads between PARP and SIRT signaling pathways represent efficient therapeutic targets for extending health span without metabolic diseases. KCI Citation Count: 0 |
| Author | Joe, Yeonsoo Chung, Hun Taeg |
| AuthorAffiliation | School of Biological Sciences, University of Ulsan, Ulsan, Korea |
| AuthorAffiliation_xml | – name: School of Biological Sciences, University of Ulsan, Ulsan, Korea |
| Author_xml | – sequence: 1 givenname: Hun Taeg surname: Chung fullname: Chung, Hun Taeg email: chung@ulsan.ac.kr – sequence: 2 givenname: Yeonsoo surname: Joe fullname: Joe, Yeonsoo |
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| Cites_doi | 10.1016/j.molcel.2010.06.017 10.1016/j.cmet.2011.03.004 10.1016/j.brainres.2011.07.001 10.1111/j.1527-3466.2007.00018.x 10.1016/j.cmet.2011.03.011 10.1007/s001090050226 10.1128/MCB.00121-09 10.1038/onc.2008.25 10.1016/j.mam.2013.01.004 10.1038/nature03354 10.1189/jlb.0212078 10.1038/nature00904 10.1152/ajpheart.01124.2005 10.1196/annals.1427.028 10.1002/jcb.22919 10.1016/j.bbamcr.2012.10.013 10.1056/NEJMoa0900212 10.1038/nrd1718 10.1093/annonc/mdq322 10.1083/jcb.201207019 10.4049/jimmunol.0903002 10.1371/journal.pone.0042357 10.1093/cvr/cvr246 10.1016/j.mad.2010.05.005 10.1016/j.bcp.2009.11.018 10.1038/onc.2010.11 10.1074/jbc.M506162200 10.1210/er.2009-0026 10.1016/j.cmet.2008.08.017 10.1038/labinvest.3700326 10.1016/j.cmet.2011.03.013 10.1126/science.1094637 10.1016/j.cmet.2012.06.016 10.1074/jbc.M609554200 10.1038/nrm3293 10.1007/s00018-004-4509-x 10.1016/j.tcb.2012.08.001 10.1016/j.cell.2011.02.013 10.1100/2011/397971 10.1016/j.cmet.2010.12.008 10.1128/MCB.21.12.4046-4054.2001 10.4161/cc.5.8.2690 10.1038/nrc2962 10.1016/j.cell.2006.11.013 |
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| References | Tong, Hande, Lansdorp, Wang (bib0135) 2001; 21 Kolthur-Seetharam, Dantzer, McBurney, de Murcia, Sassone-Corsi (bib0050) 2006; 5 Shapiro, Lutaty, Ariel (bib0010) 2011; 11 Houtkooper, Auwerx (bib0060) 2012; 199 Rajamohan, Pillai, Gupta, Sundaresan, Birukov, Samant (bib0100) 2009; 29 Mangerich, Herbach, Hanf, Fischbach, Popp, Moreno-Villanueva (bib0140) 2010; 131 Lin, Wu, Tarr, Zhang, Wu, Boss (bib0110) 2002; 418 Muiras, Muller, Schachter, Burkle (bib0125) 1998; 76 Pang, Gong, Xi, Fan, Dai, Zhang (bib0185) 2011; 112 Nicolas, Martinez, Baro, Rodriguez, Baroja-Mazo, Sole (bib0130) 2010; 29 Mota, Sanchez-Bueno, Saenz, Hernandez-Espinosa, Jimeno, Tornel (bib0195) 2005; 85 Fong, Boss, Yap, Tutt, Wu, Mergui-Roelvink (bib0165) 2009; 361 Masutani, Nakagama, Sugimura (bib0035) 2005; 62 Shevalye, Stavniichuk, Xu, Zhang, Lupachyk, Maksimchyk (bib0205) 2010; 79 Qin, Wei, Wang, Wang, Wang, Liu (bib0080) 2013; 1833 Bai, Canto, Brunyanszki, Huber, Szanto, Cen (bib0065) 2011; 13 Ford, Lee (bib0210) 2011; 1410 Pillai, Isbatan, Imai, Gupta (bib0070) 2005; 280 Rodgers, Lerin, Haas, Gygi, Spiegelman, Puigserver (bib0095) 2005; 434 Pacher, Szabo (bib0200) 2007; 25 Lagouge, Argmann, Gerhart-Hines, Meziane, Lerin, Daussin (bib0175) 2006; 127 Herranz, Serrano (bib0155) 2010; 10 Brunet, Sweeney, Sturgill, Chua, Greer, Lin (bib0115) 2004; 303 Hanahan, Weinberg (bib0220) 2011; 144 Liu, Pitta, Mattson (bib0180) 2008; 1147 Jagtap, Szabo (bib0170) 2005; 4 Feige, Lagouge, Canto, Strehle, Houten, Milne (bib0160) 2008; 8 Tornatore, Thotakura, Bennett, Moretti, Franzoso (bib0030) 2012; 22 Houtkooper, Canto, Wanders, Auwerx (bib0075) 2010; 31 Bai, Canto, Oudart, Brunyanszki, Cen, Thomas (bib0085) 2011; 13 Baker, Hayden, Ghosh (bib0020) 2011; 13 Szanto, Rutkai, Hegedus, Czikora, Rozsahegyi, Kiss (bib0105) 2011; 92 Underhill, Toulmonde, Bonnefoi (bib0215) 2011; 22 Liu, Brown, El Gazzar, McPhail, Millet, Rao (bib0015) 2012; 92 Houtkooper, Pirinen, Auwerx (bib0025) 2012; 13 Krishnakumar, Kraus (bib0045) 2010; 39 Gross, van den Heuvel, Birnbaum (bib0120) 2008; 27 Canto, Sauve, Bai (bib0090) 2013; 34 Luo, Kraus (bib0150) 2011; 13 Massudi, Grant, Braidy, Guest, Farnsworth, Guillemin (bib0145) 2012; 7 Kominsky, Campbell, Colgan (bib0005) 2010; 184 Tanno, Sakamoto, Miura, Shimamoto, Horio (bib0040) 2007; 282 Bai, Canto (bib0055) 2012; 16 Pillai, Gupta, Rajamohan, Lang, Raman, Gupta (bib0190) 2006; 291 Brunet (10.1016/j.imr.2014.09.005_bib0115) 2004; 303 Kolthur-Seetharam (10.1016/j.imr.2014.09.005_bib0050) 2006; 5 Pillai (10.1016/j.imr.2014.09.005_bib0190) 2006; 291 Masutani (10.1016/j.imr.2014.09.005_bib0035) 2005; 62 Tanno (10.1016/j.imr.2014.09.005_bib0040) 2007; 282 Krishnakumar (10.1016/j.imr.2014.09.005_bib0045) 2010; 39 Rajamohan (10.1016/j.imr.2014.09.005_bib0100) 2009; 29 Houtkooper (10.1016/j.imr.2014.09.005_bib0060) 2012; 199 Mota (10.1016/j.imr.2014.09.005_bib0195) 2005; 85 Herranz (10.1016/j.imr.2014.09.005_bib0155) 2010; 10 Jagtap (10.1016/j.imr.2014.09.005_bib0170) 2005; 4 Bai (10.1016/j.imr.2014.09.005_bib0065) 2011; 13 Pillai (10.1016/j.imr.2014.09.005_bib0070) 2005; 280 Luo (10.1016/j.imr.2014.09.005_bib0150) 2011; 13 Baker (10.1016/j.imr.2014.09.005_bib0020) 2011; 13 Pacher (10.1016/j.imr.2014.09.005_bib0200) 2007; 25 Ford (10.1016/j.imr.2014.09.005_bib0210) 2011; 1410 Bai (10.1016/j.imr.2014.09.005_bib0055) 2012; 16 Rodgers (10.1016/j.imr.2014.09.005_bib0095) 2005; 434 Tornatore (10.1016/j.imr.2014.09.005_bib0030) 2012; 22 Shapiro (10.1016/j.imr.2014.09.005_bib0010) 2011; 11 Muiras (10.1016/j.imr.2014.09.005_bib0125) 1998; 76 Hanahan (10.1016/j.imr.2014.09.005_bib0220) 2011; 144 Shevalye (10.1016/j.imr.2014.09.005_bib0205) 2010; 79 Mangerich (10.1016/j.imr.2014.09.005_bib0140) 2010; 131 Qin (10.1016/j.imr.2014.09.005_bib0080) 2013; 1833 Gross (10.1016/j.imr.2014.09.005_bib0120) 2008; 27 Lagouge (10.1016/j.imr.2014.09.005_bib0175) 2006; 127 Liu (10.1016/j.imr.2014.09.005_bib0015) 2012; 92 Pang (10.1016/j.imr.2014.09.005_bib0185) 2011; 112 Feige (10.1016/j.imr.2014.09.005_bib0160) 2008; 8 Liu (10.1016/j.imr.2014.09.005_bib0180) 2008; 1147 Nicolas (10.1016/j.imr.2014.09.005_bib0130) 2010; 29 Massudi (10.1016/j.imr.2014.09.005_bib0145) 2012; 7 Fong (10.1016/j.imr.2014.09.005_bib0165) 2009; 361 Kominsky (10.1016/j.imr.2014.09.005_bib0005) 2010; 184 Houtkooper (10.1016/j.imr.2014.09.005_bib0025) 2012; 13 Bai (10.1016/j.imr.2014.09.005_bib0085) 2011; 13 Underhill (10.1016/j.imr.2014.09.005_bib0215) 2011; 22 Lin (10.1016/j.imr.2014.09.005_bib0110) 2002; 418 Tong (10.1016/j.imr.2014.09.005_bib0135) 2001; 21 Szanto (10.1016/j.imr.2014.09.005_bib0105) 2011; 92 Canto (10.1016/j.imr.2014.09.005_bib0090) 2013; 34 Houtkooper (10.1016/j.imr.2014.09.005_bib0075) 2010; 31 19046567 - Cell Metab. 2008 Nov;8(5):347-58 20007326 - Endocr Rev. 2010 Apr;31(2):194-223 16632544 - Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1545-53 20643861 - Ann Oncol. 2011 Feb;22(2):268-79 21102633 - Nat Rev Cancer. 2010 Dec;10(12):819-23 16127429 - Lab Invest. 2005 Oct;85(10 ):1250-62 11359911 - Mol Cell Biol. 2001 Jun;21(12):4046-54 22995730 - Trends Cell Biol. 2012 Nov;22(11):557-66 22921416 - Cell Metab. 2012 Sep 5;16(3):290-5 23071150 - J Cell Biol. 2012 Oct 15;199(2):205-9 15744310 - Nature. 2005 Mar 3;434(7029):113-8 17919258 - Cardiovasc Drug Rev. 2007 Fall;25(3):235-60 21459329 - Cell Metab. 2011 Apr 6;13(4):450-60 21376230 - Cell. 2011 Mar 4;144(5):646-74 9587069 - J Mol Med (Berl). 1998 Apr;76(5):346-54 22235182 - ScientificWorldJournal. 2011;11:2509-29 14976264 - Science. 2004 Mar 26;303(5666):2011-5 19470756 - Mol Cell Biol. 2009 Aug;29(15):4116-29 16207712 - J Biol Chem. 2005 Dec 30;280(52):43121-30 21459330 - Cell Metab. 2011 Apr 6;13(4):461-8 15868402 - Cell Mol Life Sci. 2005 Apr;62(7-8):769-83 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34 21921080 - Cardiovasc Res. 2011 Dec 1;92(3):430-8 19076449 - Ann N Y Acad Sci. 2008 Dec;1147:275-82 21807360 - Brain Res. 2011 Sep 2;1410:120-1 23357756 - Mol Aspects Med. 2013 Dec;34(6):1168-201 21195345 - Cell Metab. 2011 Jan 5;13(1):11-22 16628003 - Cell Cycle. 2006 Apr;5(8):873-7 12181572 - Nature. 2002 Aug 15;418(6899):797-801 17197703 - J Biol Chem. 2007 Mar 2;282(9):6823-32 20561897 - Mech Ageing Dev. 2010 Jun;131(6):389-404 17112576 - Cell. 2006 Dec 15;127(6):1109-22 21031461 - J Cell Biochem. 2011 Jan;112(1):299-306 19945439 - Biochem Pharmacol. 2010 Apr 1;79(7):1007-14 20154718 - Oncogene. 2010 May 13;29(19):2877-83 20603072 - Mol Cell. 2010 Jul 9;39(1):8-24 21459317 - Cell Metab. 2011 Apr 6;13(4):353-5 20368286 - J Immunol. 2010 Apr 15;184(8):4062-8 22848760 - PLoS One. 2012;7(7):e42357 23085506 - Biochim Biophys Acta. 2013 Jan;1833(1):59-68 15864271 - Nat Rev Drug Discov. 2005 May;4(5):421-40 22395773 - Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):225-38 22571857 - J Leukoc Biol. 2012 Sep;92(3):499-507 18391974 - Oncogene. 2008 Apr 7;27(16):2320-36 |
| References_xml | – volume: 5 start-page: 873 year: 2006 end-page: 877 ident: bib0050 article-title: Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage publication-title: Cell Cycle – volume: 434 start-page: 113 year: 2005 end-page: 118 ident: bib0095 article-title: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 publication-title: Nature – volume: 11 start-page: 2509 year: 2011 end-page: 2529 ident: bib0010 article-title: Macrophages, meta-inflammation, and immuno-metabolism publication-title: Scientific World Journal – volume: 7 start-page: e42357 year: 2012 ident: bib0145 article-title: Age-associated changes in oxidative stress and NAD+ metabolism in human tissue publication-title: PloS One – volume: 16 start-page: 290 year: 2012 end-page: 295 ident: bib0055 article-title: The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease publication-title: Cell Metab – volume: 22 start-page: 557 year: 2012 end-page: 566 ident: bib0030 article-title: The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation publication-title: Trends Cell Biol – volume: 199 start-page: 205 year: 2012 end-page: 209 ident: bib0060 article-title: Exploring the therapeutic space around NAD+ publication-title: J Cell Biol – volume: 282 start-page: 6823 year: 2007 end-page: 6832 ident: bib0040 article-title: Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1 publication-title: J Biol Chem – volume: 22 start-page: 268 year: 2011 end-page: 279 ident: bib0215 article-title: A review of PARP inhibitors: from bench to bedside publication-title: Ann Oncol – volume: 39 start-page: 8 year: 2010 end-page: 24 ident: bib0045 article-title: The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets publication-title: Mol Cell – volume: 31 start-page: 194 year: 2010 end-page: 223 ident: bib0075 article-title: The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways publication-title: Endocrine Rev – volume: 10 start-page: 819 year: 2010 end-page: 823 ident: bib0155 article-title: SIRT1: recent lessons from mouse models publication-title: Nature Rev. Cancer – volume: 418 start-page: 797 year: 2002 end-page: 801 ident: bib0110 article-title: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres publication-title: Nature – volume: 127 start-page: 1109 year: 2006 end-page: 1122 ident: bib0175 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha publication-title: Cell – volume: 1147 start-page: 275 year: 2008 end-page: 282 ident: bib0180 article-title: Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction publication-title: Ann N Y Acad Sci – volume: 144 start-page: 646 year: 2011 end-page: 674 ident: bib0220 article-title: Hallmarks of cancer: the next generation publication-title: Cell – volume: 1410 start-page: 120 year: 2011 end-page: 121 ident: bib0210 article-title: Climbing STAIRs towards clinical trials with a novel PARP-1 inhibitor for the treatment of ischemic stroke publication-title: Brain Res – volume: 29 start-page: 2877 year: 2010 end-page: 2883 ident: bib0130 article-title: Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice publication-title: Oncogene – volume: 4 start-page: 421 year: 2005 end-page: 440 ident: bib0170 article-title: Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors publication-title: Nat Rev Drug Discov – volume: 92 start-page: 430 year: 2011 end-page: 438 ident: bib0105 article-title: Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction publication-title: Cardiovasc Res – volume: 131 start-page: 389 year: 2010 end-page: 404 ident: bib0140 article-title: Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1 publication-title: Mech Ageing Devel – volume: 184 start-page: 4062 year: 2010 end-page: 4068 ident: bib0005 article-title: Metabolic shifts in immunity and inflammation publication-title: J Immunol – volume: 361 start-page: 123 year: 2009 end-page: 134 ident: bib0165 article-title: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers publication-title: N Engl J Med – volume: 85 start-page: 1250 year: 2005 end-page: 1262 ident: bib0195 article-title: Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury publication-title: Lab Invest – volume: 13 start-page: 461 year: 2011 end-page: 468 ident: bib0085 article-title: PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation publication-title: Cell Metab – volume: 1833 start-page: 59 year: 2013 end-page: 68 ident: bib0080 article-title: Poly(ADP-ribose) polymerase 1 inhibition protects against low shear stress induced inflammation publication-title: Biochim Biophys Acta – volume: 29 start-page: 4116 year: 2009 end-page: 4129 ident: bib0100 article-title: SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1 publication-title: Mol Cell Biol – volume: 13 start-page: 225 year: 2012 end-page: 238 ident: bib0025 article-title: Sirtuins as regulators of metabolism and healthspan publication-title: Nat Rev Mol Cell Biol – volume: 62 start-page: 769 year: 2005 end-page: 783 ident: bib0035 article-title: Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease publication-title: Cell Mol Life Sci – volume: 79 start-page: 1007 year: 2010 end-page: 1014 ident: bib0205 article-title: Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model publication-title: Biochem Pharmacol – volume: 92 start-page: 499 year: 2012 end-page: 507 ident: bib0015 article-title: Fueling the flame: bioenergy couples metabolism and inflammation publication-title: J Leukoc Biol – volume: 34 start-page: 1168 year: 2013 end-page: 1201 ident: bib0090 article-title: Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes publication-title: Mol Aspects Med – volume: 76 start-page: 346 year: 1998 end-page: 354 ident: bib0125 article-title: Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians publication-title: J Mol Med – volume: 303 start-page: 2011 year: 2004 end-page: 2015 ident: bib0115 article-title: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase publication-title: Science – volume: 21 start-page: 4046 year: 2001 end-page: 4054 ident: bib0135 article-title: DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression publication-title: Mol Cell Biol – volume: 27 start-page: 2320 year: 2008 end-page: 2336 ident: bib0120 article-title: The role of FoxO in the regulation of metabolism publication-title: Oncogene – volume: 13 start-page: 353 year: 2011 end-page: 355 ident: bib0150 article-title: A one and a two expanding roles for poly(ADP-ribose) polymerases in metabolism publication-title: Cell Metab – volume: 112 start-page: 299 year: 2011 end-page: 306 ident: bib0185 article-title: Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes publication-title: J Cell Biochem – volume: 280 start-page: 43121 year: 2005 end-page: 43130 ident: bib0070 article-title: Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity publication-title: J Biol Chem – volume: 291 start-page: H1545 year: 2006 end-page: H1553 ident: bib0190 article-title: Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy publication-title: Am J Physiol Heart Circ Physiol – volume: 13 start-page: 450 year: 2011 end-page: 460 ident: bib0065 article-title: PARP-2 regulates SIRT1 expression and whole-body energy expenditure publication-title: Cell Metab – volume: 8 start-page: 347 year: 2008 end-page: 358 ident: bib0160 article-title: Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation publication-title: Cell Metab – volume: 13 start-page: 11 year: 2011 end-page: 22 ident: bib0020 article-title: NF-kappaB, inflammation, and metabolic disease publication-title: Cell Metab – volume: 25 start-page: 235 year: 2007 end-page: 260 ident: bib0200 article-title: Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors publication-title: Cardiovasc Drug Rev – volume: 39 start-page: 8 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0045 article-title: The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets publication-title: Mol Cell doi: 10.1016/j.molcel.2010.06.017 – volume: 13 start-page: 461 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0085 article-title: PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation publication-title: Cell Metab doi: 10.1016/j.cmet.2011.03.004 – volume: 1410 start-page: 120 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0210 article-title: Climbing STAIRs towards clinical trials with a novel PARP-1 inhibitor for the treatment of ischemic stroke publication-title: Brain Res doi: 10.1016/j.brainres.2011.07.001 – volume: 25 start-page: 235 year: 2007 ident: 10.1016/j.imr.2014.09.005_bib0200 article-title: Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors publication-title: Cardiovasc Drug Rev doi: 10.1111/j.1527-3466.2007.00018.x – volume: 13 start-page: 353 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0150 article-title: A one and a two expanding roles for poly(ADP-ribose) polymerases in metabolism publication-title: Cell Metab doi: 10.1016/j.cmet.2011.03.011 – volume: 76 start-page: 346 year: 1998 ident: 10.1016/j.imr.2014.09.005_bib0125 article-title: Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians publication-title: J Mol Med doi: 10.1007/s001090050226 – volume: 29 start-page: 4116 year: 2009 ident: 10.1016/j.imr.2014.09.005_bib0100 article-title: SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1 publication-title: Mol Cell Biol doi: 10.1128/MCB.00121-09 – volume: 27 start-page: 2320 year: 2008 ident: 10.1016/j.imr.2014.09.005_bib0120 article-title: The role of FoxO in the regulation of metabolism publication-title: Oncogene doi: 10.1038/onc.2008.25 – volume: 34 start-page: 1168 year: 2013 ident: 10.1016/j.imr.2014.09.005_bib0090 article-title: Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes publication-title: Mol Aspects Med doi: 10.1016/j.mam.2013.01.004 – volume: 434 start-page: 113 year: 2005 ident: 10.1016/j.imr.2014.09.005_bib0095 article-title: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 publication-title: Nature doi: 10.1038/nature03354 – volume: 92 start-page: 499 year: 2012 ident: 10.1016/j.imr.2014.09.005_bib0015 article-title: Fueling the flame: bioenergy couples metabolism and inflammation publication-title: J Leukoc Biol doi: 10.1189/jlb.0212078 – volume: 418 start-page: 797 year: 2002 ident: 10.1016/j.imr.2014.09.005_bib0110 article-title: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres publication-title: Nature doi: 10.1038/nature00904 – volume: 291 start-page: H1545 year: 2006 ident: 10.1016/j.imr.2014.09.005_bib0190 article-title: Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01124.2005 – volume: 1147 start-page: 275 year: 2008 ident: 10.1016/j.imr.2014.09.005_bib0180 article-title: Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1427.028 – volume: 112 start-page: 299 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0185 article-title: Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes publication-title: J Cell Biochem doi: 10.1002/jcb.22919 – volume: 1833 start-page: 59 year: 2013 ident: 10.1016/j.imr.2014.09.005_bib0080 article-title: Poly(ADP-ribose) polymerase 1 inhibition protects against low shear stress induced inflammation publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2012.10.013 – volume: 361 start-page: 123 year: 2009 ident: 10.1016/j.imr.2014.09.005_bib0165 article-title: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers publication-title: N Engl J Med doi: 10.1056/NEJMoa0900212 – volume: 4 start-page: 421 year: 2005 ident: 10.1016/j.imr.2014.09.005_bib0170 article-title: Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1718 – volume: 22 start-page: 268 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0215 article-title: A review of PARP inhibitors: from bench to bedside publication-title: Ann Oncol doi: 10.1093/annonc/mdq322 – volume: 199 start-page: 205 issue: 2 year: 2012 ident: 10.1016/j.imr.2014.09.005_bib0060 article-title: Exploring the therapeutic space around NAD+ publication-title: J Cell Biol doi: 10.1083/jcb.201207019 – volume: 184 start-page: 4062 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0005 article-title: Metabolic shifts in immunity and inflammation publication-title: J Immunol doi: 10.4049/jimmunol.0903002 – volume: 7 start-page: e42357 year: 2012 ident: 10.1016/j.imr.2014.09.005_bib0145 article-title: Age-associated changes in oxidative stress and NAD+ metabolism in human tissue publication-title: PloS One doi: 10.1371/journal.pone.0042357 – volume: 92 start-page: 430 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0105 article-title: Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction publication-title: Cardiovasc Res doi: 10.1093/cvr/cvr246 – volume: 131 start-page: 389 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0140 article-title: Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1 publication-title: Mech Ageing Devel doi: 10.1016/j.mad.2010.05.005 – volume: 79 start-page: 1007 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0205 article-title: Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2009.11.018 – volume: 29 start-page: 2877 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0130 article-title: Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice publication-title: Oncogene doi: 10.1038/onc.2010.11 – volume: 280 start-page: 43121 year: 2005 ident: 10.1016/j.imr.2014.09.005_bib0070 article-title: Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity publication-title: J Biol Chem doi: 10.1074/jbc.M506162200 – volume: 31 start-page: 194 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0075 article-title: The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways publication-title: Endocrine Rev doi: 10.1210/er.2009-0026 – volume: 8 start-page: 347 year: 2008 ident: 10.1016/j.imr.2014.09.005_bib0160 article-title: Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation publication-title: Cell Metab doi: 10.1016/j.cmet.2008.08.017 – volume: 85 start-page: 1250 year: 2005 ident: 10.1016/j.imr.2014.09.005_bib0195 article-title: Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury publication-title: Lab Invest doi: 10.1038/labinvest.3700326 – volume: 13 start-page: 450 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0065 article-title: PARP-2 regulates SIRT1 expression and whole-body energy expenditure publication-title: Cell Metab doi: 10.1016/j.cmet.2011.03.013 – volume: 303 start-page: 2011 year: 2004 ident: 10.1016/j.imr.2014.09.005_bib0115 article-title: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase publication-title: Science doi: 10.1126/science.1094637 – volume: 16 start-page: 290 year: 2012 ident: 10.1016/j.imr.2014.09.005_bib0055 article-title: The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease publication-title: Cell Metab doi: 10.1016/j.cmet.2012.06.016 – volume: 282 start-page: 6823 year: 2007 ident: 10.1016/j.imr.2014.09.005_bib0040 article-title: Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1 publication-title: J Biol Chem doi: 10.1074/jbc.M609554200 – volume: 13 start-page: 225 year: 2012 ident: 10.1016/j.imr.2014.09.005_bib0025 article-title: Sirtuins as regulators of metabolism and healthspan publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3293 – volume: 62 start-page: 769 year: 2005 ident: 10.1016/j.imr.2014.09.005_bib0035 article-title: Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease publication-title: Cell Mol Life Sci doi: 10.1007/s00018-004-4509-x – volume: 22 start-page: 557 year: 2012 ident: 10.1016/j.imr.2014.09.005_bib0030 article-title: The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2012.08.001 – volume: 144 start-page: 646 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0220 article-title: Hallmarks of cancer: the next generation publication-title: Cell doi: 10.1016/j.cell.2011.02.013 – volume: 11 start-page: 2509 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0010 article-title: Macrophages, meta-inflammation, and immuno-metabolism publication-title: Scientific World Journal doi: 10.1100/2011/397971 – volume: 13 start-page: 11 year: 2011 ident: 10.1016/j.imr.2014.09.005_bib0020 article-title: NF-kappaB, inflammation, and metabolic disease publication-title: Cell Metab doi: 10.1016/j.cmet.2010.12.008 – volume: 21 start-page: 4046 year: 2001 ident: 10.1016/j.imr.2014.09.005_bib0135 article-title: DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression publication-title: Mol Cell Biol doi: 10.1128/MCB.21.12.4046-4054.2001 – volume: 5 start-page: 873 year: 2006 ident: 10.1016/j.imr.2014.09.005_bib0050 article-title: Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage publication-title: Cell Cycle doi: 10.4161/cc.5.8.2690 – volume: 10 start-page: 819 year: 2010 ident: 10.1016/j.imr.2014.09.005_bib0155 article-title: SIRT1: recent lessons from mouse models publication-title: Nature Rev. Cancer doi: 10.1038/nrc2962 – volume: 127 start-page: 1109 year: 2006 ident: 10.1016/j.imr.2014.09.005_bib0175 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha publication-title: Cell doi: 10.1016/j.cell.2006.11.013 – reference: 16207712 - J Biol Chem. 2005 Dec 30;280(52):43121-30 – reference: 20007326 - Endocr Rev. 2010 Apr;31(2):194-223 – reference: 22995730 - Trends Cell Biol. 2012 Nov;22(11):557-66 – reference: 21459330 - Cell Metab. 2011 Apr 6;13(4):461-8 – reference: 21195345 - Cell Metab. 2011 Jan 5;13(1):11-22 – reference: 23085506 - Biochim Biophys Acta. 2013 Jan;1833(1):59-68 – reference: 19945439 - Biochem Pharmacol. 2010 Apr 1;79(7):1007-14 – reference: 9587069 - J Mol Med (Berl). 1998 Apr;76(5):346-54 – reference: 21102633 - Nat Rev Cancer. 2010 Dec;10(12):819-23 – reference: 21459329 - Cell Metab. 2011 Apr 6;13(4):450-60 – reference: 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34 – reference: 20154718 - Oncogene. 2010 May 13;29(19):2877-83 – reference: 14976264 - Science. 2004 Mar 26;303(5666):2011-5 – reference: 17919258 - Cardiovasc Drug Rev. 2007 Fall;25(3):235-60 – reference: 20561897 - Mech Ageing Dev. 2010 Jun;131(6):389-404 – reference: 21376230 - Cell. 2011 Mar 4;144(5):646-74 – reference: 21807360 - Brain Res. 2011 Sep 2;1410:120-1 – reference: 18391974 - Oncogene. 2008 Apr 7;27(16):2320-36 – reference: 17112576 - Cell. 2006 Dec 15;127(6):1109-22 – reference: 16628003 - Cell Cycle. 2006 Apr;5(8):873-7 – reference: 19470756 - Mol Cell Biol. 2009 Aug;29(15):4116-29 – reference: 19076449 - Ann N Y Acad Sci. 2008 Dec;1147:275-82 – reference: 16127429 - Lab Invest. 2005 Oct;85(10 ):1250-62 – reference: 23071150 - J Cell Biol. 2012 Oct 15;199(2):205-9 – reference: 22921416 - Cell Metab. 2012 Sep 5;16(3):290-5 – reference: 11359911 - Mol Cell Biol. 2001 Jun;21(12):4046-54 – reference: 20643861 - Ann Oncol. 2011 Feb;22(2):268-79 – reference: 22395773 - Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):225-38 – reference: 22848760 - PLoS One. 2012;7(7):e42357 – reference: 23357756 - Mol Aspects Med. 2013 Dec;34(6):1168-201 – reference: 22571857 - J Leukoc Biol. 2012 Sep;92(3):499-507 – reference: 17197703 - J Biol Chem. 2007 Mar 2;282(9):6823-32 – reference: 20603072 - Mol Cell. 2010 Jul 9;39(1):8-24 – reference: 21031461 - J Cell Biochem. 2011 Jan;112(1):299-306 – reference: 21459317 - Cell Metab. 2011 Apr 6;13(4):353-5 – reference: 12181572 - Nature. 2002 Aug 15;418(6899):797-801 – reference: 20368286 - J Immunol. 2010 Apr 15;184(8):4062-8 – reference: 15868402 - Cell Mol Life Sci. 2005 Apr;62(7-8):769-83 – reference: 22235182 - ScientificWorldJournal. 2011;11:2509-29 – reference: 16632544 - Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1545-53 – reference: 15864271 - Nat Rev Drug Discov. 2005 May;4(5):421-40 – reference: 15744310 - Nature. 2005 Mar 3;434(7029):113-8 – reference: 21921080 - Cardiovasc Res. 2011 Dec 1;92(3):430-8 – reference: 19046567 - Cell Metab. 2008 Nov;8(5):347-58 |
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| Snippet | Current studies have indicated the association of chronic sterile inflammation (inflammation in the absence of pathogens) with the pathogenesis of age-related... |
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| SubjectTerms | inflammation metabolic diseases PARP-1 PARP-2 Review SIRT1 학제간연구 |
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| Title | Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases |
| URI | https://dx.doi.org/10.1016/j.imr.2014.09.005 https://www.ncbi.nlm.nih.gov/pubmed/28664098 https://www.proquest.com/docview/1915345503 https://pubmed.ncbi.nlm.nih.gov/PMC5481777 https://doi.org/10.1016/j.imr.2014.09.005 https://doaj.org/article/97d8c4fa854b46f4818ff41c36bac919 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002014306 |
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