A voxel-based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory
The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age‐matched normal subjects by using voxel‐based morphometry, a technique that identifies changes in gray matter volume on a voxel‐by‐voxel basis. A...
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| Published in | Annals of neurology Vol. 47; no. 1; pp. 36 - 45 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
John Wiley & Sons, Inc
01.01.2000
Willey-Liss |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0364-5134 1531-8249 |
| DOI | 10.1002/1531-8249(200001)47:1<36::AID-ANA8>3.0.CO;2-L |
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| Abstract | The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age‐matched normal subjects by using voxel‐based morphometry, a technique that identifies changes in gray matter volume on a voxel‐by‐voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was the most significantly and consistently affected region. Cortical atrophy in the left hemisphere also involved the inferolateral temporal lobe (Brodmann area 20/21) and fusiform gyrus. In addition, the right temporal pole (Brodmann area 38), the ventromedial frontal cortex (Brodmann area 11/32) bilaterally, and the amygdaloid complex were affected, but no significant atrophy was measured in the hippocampus, entorhinal, or caudal perirhinal cortex. The degree of semantic memory impairment across the 6 cases correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region. Ann Neurol 2000; 47:36–45 |
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| AbstractList | The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age-matched normal subjects by using voxel-based morphometry, a technique that identifies changes in gray matter volume on a voxel-by-voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was the most significantly and consistently affected region. Cortical atrophy in the left hemisphere also involved the inferolateral temporal lobe (Brodmann area 20/21) and fusiform gyrus. In addition, the right temporal pole (Brodmann area 38), the ventromedial frontal cortex (Brodmann area 11/32) bilaterally, and the amygdaloid complex were affected, but no significant atrophy was measured in the hippocampus, entorhinal, or caudal perirhinal cortex. The degree of semantic memory impairment across the 6 cases correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region. The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age-matched normal subjects by using voxel-based morphometry, a technique that identifies changes in gray matter volume on a voxel-by-voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was the most significantly and consistently affected region. Cortical atrophy in the left hemisphere also involved the inferolateral temporal lobe (Brodmann area 20/21) and fusiform gyrus. In addition, the right temporal pole (Brodmann area 38), the ventromedial frontal cortex (Brodmann area 11/32) bilaterally, and the amygdaloid complex were affected, but no significant atrophy was measured in the hippocampus, entorhinal, or caudal perirhinal cortex. The degree of semantic memory impairment across the 6 cases correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region.The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age-matched normal subjects by using voxel-based morphometry, a technique that identifies changes in gray matter volume on a voxel-by-voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was the most significantly and consistently affected region. Cortical atrophy in the left hemisphere also involved the inferolateral temporal lobe (Brodmann area 20/21) and fusiform gyrus. In addition, the right temporal pole (Brodmann area 38), the ventromedial frontal cortex (Brodmann area 11/32) bilaterally, and the amygdaloid complex were affected, but no significant atrophy was measured in the hippocampus, entorhinal, or caudal perirhinal cortex. The degree of semantic memory impairment across the 6 cases correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region. The cortical anatomy of 6 patients with semantic dementia (the temporal lobe variant of frontotemporal dementia) was contrasted with that of a group of age‐matched normal subjects by using voxel‐based morphometry, a technique that identifies changes in gray matter volume on a voxel‐by‐voxel basis. Among the circumscribed regions of neuronal loss, the left temporal pole (Brodmann area 38) was the most significantly and consistently affected region. Cortical atrophy in the left hemisphere also involved the inferolateral temporal lobe (Brodmann area 20/21) and fusiform gyrus. In addition, the right temporal pole (Brodmann area 38), the ventromedial frontal cortex (Brodmann area 11/32) bilaterally, and the amygdaloid complex were affected, but no significant atrophy was measured in the hippocampus, entorhinal, or caudal perirhinal cortex. The degree of semantic memory impairment across the 6 cases correlated significantly with the extent of atrophy of the left anterior temporal lobe but not with atrophy in the adjacent ventromedial frontal cortex. These results confirm that the anterior temporal lobe is critically involved in semantic processing, and dissociate its function from that of the adjacent frontal region. Ann Neurol 2000; 47:36–45 |
| Author | Frackowiak, R. S. J. Patterson, K. Hodges, J. R. Ashburner, J. Mummery, C. J. Price, C. J. |
| Author_xml | – sequence: 1 givenname: C. J. surname: Mummery fullname: Mummery, C. J. organization: Wellcome Department of Cognitive Neurology, London, UK – sequence: 2 givenname: K. surname: Patterson fullname: Patterson, K. organization: MRC Cognition and Brain Sciences Unit, Cambridge, UK – sequence: 3 givenname: C. J. surname: Price fullname: Price, C. J. organization: Wellcome Department of Cognitive Neurology, London, UK – sequence: 4 givenname: J. surname: Ashburner fullname: Ashburner, J. organization: Wellcome Department of Cognitive Neurology, London, UK – sequence: 5 givenname: R. S. J. surname: Frackowiak fullname: Frackowiak, R. S. J. organization: Wellcome Department of Cognitive Neurology, London, UK – sequence: 6 givenname: J. R. surname: Hodges fullname: Hodges, J. R. organization: MRC Cognition and Brain Sciences Unit, Cambridge, UK |
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| Keywords | Atrophy Human Temporal lobe Nervous system diseases Semantic memory Voxel Central nervous system disease Exploration Degenerative disease Morphometry Cerebral disorder Dementia |
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| SubjectTerms | Aged Atrophy Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - pathology Dementia - physiopathology Dementia - psychology Female Humans Magnetic Resonance Imaging Male Medical sciences Memory - physiology Middle Aged Neurology Neuropsychological Tests Semantics Temporal Lobe - pathology Temporal Lobe - physiopathology |
| Title | A voxel-based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory |
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