Circulating heart failure biomarkers beyond natriuretic peptides: review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC)

New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. In this review, we examine t...

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Published inEuropean journal of heart failure Vol. 23; no. 10; pp. 1610 - 1632
Main Authors Meijers, Wouter C., Bayes‐Genis, Antoni, Mebazaa, Alexandre, Bauersachs, Johann, Cleland, John G.F., Coats, Andrew J.S., Januzzi, James L., Maisel, Alan S., McDonald, Kenneth, Mueller, Thomas, Richards, A. Mark, Seferovic, Petar, Mueller, Christian, Boer, Rudolf A.
Format Journal Article
LanguageEnglish
Published Oxford, UK John Wiley & Sons, Ltd 01.10.2021
Subjects
Adrenomedullin
Biomarkers
Cardiac troponin
Cardiology
Galectin 3
Growth differentiation factor‐15
Heart failure
Heart Failure - diagnosis
Humans
Natriuretic Peptides
Procalcitonin
Prognosis
Review
sST2
Heart failure
Procalcitonin
Adrenomedullin
Biomarkers
Cardiac troponin
Growth differentiation factor-15
Galectin-3
sST2
Online AccessGet full text
ISSN1388-9842
1879-0844
1879-0844
DOI10.1002/ejhf.2346

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Abstract New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. In this review, we examine the most promising emerging candidates for clinical assessment and management of patients with heart failure. We discuss high‐sensitivity cardiac troponins (Tn), procalcitonin, novel kidney markers, soluble suppression of tumorigenicity 2 (sST2), galectin‐3, growth differentiation factor‐15 (GDF‐15), cluster of differentiation 146 (CD146), neprilysin, adrenomedullin (ADM), and also discuss proteomics and genetic‐based risk scores. We focused on guidance and assistance with daily clinical care decision‐making. For each biomarker, analytical considerations are discussed, as well as performance regarding diagnosis and prognosis. Furthermore, we discuss potential implementation in clinical algorithms and in ongoing clinical trials. Potential usage of biomarkers in the heart failure spectrum.
AbstractList New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. In this review, we examine the most promising emerging candidates for clinical assessment and management of patients with heart failure. We discuss high‐sensitivity cardiac troponins (Tn), procalcitonin, novel kidney markers, soluble suppression of tumorigenicity 2 (sST2), galectin‐3, growth differentiation factor‐15 (GDF‐15), cluster of differentiation 146 (CD146), neprilysin, adrenomedullin (ADM), and also discuss proteomics and genetic‐based risk scores. We focused on guidance and assistance with daily clinical care decision‐making. For each biomarker, analytical considerations are discussed, as well as performance regarding diagnosis and prognosis. Furthermore, we discuss potential implementation in clinical algorithms and in ongoing clinical trials.
New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. In this review, we examine the most promising emerging candidates for clinical assessment and management of patients with heart failure. We discuss high‐sensitivity cardiac troponins (Tn), procalcitonin, novel kidney markers, soluble suppression of tumorigenicity 2 (sST2), galectin‐3, growth differentiation factor‐15 (GDF‐15), cluster of differentiation 146 (CD146), neprilysin, adrenomedullin (ADM), and also discuss proteomics and genetic‐based risk scores. We focused on guidance and assistance with daily clinical care decision‐making. For each biomarker, analytical considerations are discussed, as well as performance regarding diagnosis and prognosis. Furthermore, we discuss potential implementation in clinical algorithms and in ongoing clinical trials. Potential usage of biomarkers in the heart failure spectrum.
New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. In this review, we examine the most promising emerging candidates for clinical assessment and management of patients with heart failure. We discuss high-sensitivity cardiac troponins (Tn), procalcitonin, novel kidney markers, soluble suppression of tumorigenicity 2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), cluster of differentiation 146 (CD146), neprilysin, adrenomedullin (ADM), and also discuss proteomics and genetic-based risk scores. We focused on guidance and assistance with daily clinical care decision-making. For each biomarker, analytical considerations are discussed, as well as performance regarding diagnosis and prognosis. Furthermore, we discuss potential implementation in clinical algorithms and in ongoing clinical trials.New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate biomarkers, besides natriuretic peptides virtually none have succeeded in being applied into the clinical setting. In this review, we examine the most promising emerging candidates for clinical assessment and management of patients with heart failure. We discuss high-sensitivity cardiac troponins (Tn), procalcitonin, novel kidney markers, soluble suppression of tumorigenicity 2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), cluster of differentiation 146 (CD146), neprilysin, adrenomedullin (ADM), and also discuss proteomics and genetic-based risk scores. We focused on guidance and assistance with daily clinical care decision-making. For each biomarker, analytical considerations are discussed, as well as performance regarding diagnosis and prognosis. Furthermore, we discuss potential implementation in clinical algorithms and in ongoing clinical trials.
Author Boer, Rudolf A.
Coats, Andrew J.S.
Mueller, Christian
Meijers, Wouter C.
Bayes‐Genis, Antoni
Januzzi, James L.
McDonald, Kenneth
Mueller, Thomas
Seferovic, Petar
Cleland, John G.F.
Maisel, Alan S.
Bauersachs, Johann
Richards, A. Mark
Mebazaa, Alexandre
AuthorAffiliation 2 Heart Institute, Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona, CIBERCV Barcelona Spain
6 FHU PROMICE Paris France
11 Massachusetts General Hospital Boston MA USA
17 Faculty of Medicine Belgrade University Belgrade Serbia
19 University Hospital Basel, University of Basel Basel Switzerland
15 Christchurch Heart Institute Christchurch New Zealand
4 Université de Paris Paris France
3 Inserm U942‐MASCOT; Université de Paris; Department of Anesthesia and Critical Care, Hôpitaux Saint Louis & Lariboisière; FHU PROMICE Paris France
1 Department of Cardiology University Medical Center Groningen Groningen The Netherlands
10 University of Warwick Coventry UK
7 Department of Cardiology and Angiology Hannover Medical School Hannover Germany
8 Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow; National Heart & Lung Institute, Imperial College London London UK
14 Department of Clinical Pathology Hospital of Bolzano Bolzano Italy
9 Monash University Me
AuthorAffiliation_xml – name: 12 University of California San Diego CA USA
– name: 1 Department of Cardiology University Medical Center Groningen Groningen The Netherlands
– name: 7 Department of Cardiology and Angiology Hannover Medical School Hannover Germany
– name: 18 Serbian Academy of Sciences and Arts Belgarde Serbia
– name: 5 Department of Anesthesia and Critical Care Hôpitaux Saint Louis & Lariboisière Paris France
– name: 10 University of Warwick Coventry UK
– name: 8 Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow; National Heart & Lung Institute, Imperial College London London UK
– name: 11 Massachusetts General Hospital Boston MA USA
– name: 15 Christchurch Heart Institute Christchurch New Zealand
– name: 17 Faculty of Medicine Belgrade University Belgrade Serbia
– name: 9 Monash University Melbourne Australia
– name: 4 Université de Paris Paris France
– name: 3 Inserm U942‐MASCOT; Université de Paris; Department of Anesthesia and Critical Care, Hôpitaux Saint Louis & Lariboisière; FHU PROMICE Paris France
– name: 13 St Vincent's University Hospital Dublin Ireland
– name: 2 Heart Institute, Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona, CIBERCV Barcelona Spain
– name: 14 Department of Clinical Pathology Hospital of Bolzano Bolzano Italy
– name: 6 FHU PROMICE Paris France
– name: 16 Cardiovascular Research Institute National University of Singapore Singapore
– name: 19 University Hospital Basel, University of Basel Basel Switzerland
Author_xml – sequence: 1
  givenname: Wouter C.
  surname: Meijers
  fullname: Meijers, Wouter C.
  organization: University Medical Center Groningen
– sequence: 2
  givenname: Antoni
  surname: Bayes‐Genis
  fullname: Bayes‐Genis, Antoni
  organization: Universitat Autònoma de Barcelona, CIBERCV
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  surname: Mebazaa
  fullname: Mebazaa, Alexandre
  organization: FHU PROMICE
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  organization: Hannover Medical School
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  givenname: John G.F.
  surname: Cleland
  fullname: Cleland, John G.F.
  organization: Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow; National Heart & Lung Institute, Imperial College London
– sequence: 6
  givenname: Andrew J.S.
  surname: Coats
  fullname: Coats, Andrew J.S.
  organization: University of Warwick
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  givenname: James L.
  surname: Januzzi
  fullname: Januzzi, James L.
  organization: Massachusetts General Hospital
– sequence: 8
  givenname: Alan S.
  surname: Maisel
  fullname: Maisel, Alan S.
  organization: University of California
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  givenname: Kenneth
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  fullname: McDonald, Kenneth
  organization: St Vincent's University Hospital
– sequence: 10
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  surname: Mueller
  fullname: Mueller, Thomas
  organization: Hospital of Bolzano
– sequence: 11
  givenname: A. Mark
  surname: Richards
  fullname: Richards, A. Mark
  organization: National University of Singapore
– sequence: 12
  givenname: Petar
  surname: Seferovic
  fullname: Seferovic, Petar
  organization: Serbian Academy of Sciences and Arts
– sequence: 13
  givenname: Christian
  surname: Mueller
  fullname: Mueller, Christian
  organization: University Hospital Basel, University of Basel
– sequence: 14
  givenname: Rudolf A.
  surname: Boer
  fullname: Boer, Rudolf A.
  email: r.a.de.boer@umcg.nl
  organization: University Medical Center Groningen
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34498368$$D View this record in MEDLINE/PubMed
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Issue 10
Keywords Heart failure
Procalcitonin
Adrenomedullin
Biomarkers
Cardiac troponin
Growth differentiation factor-15
Galectin-3
sST2
Language English
License Attribution-NonCommercial
2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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Snippet New biomarkers are being evaluated for their ability to advance the management of patients with heart failure. Despite a large pool of interesting candidate...
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SubjectTerms Adrenomedullin
Biomarkers
Cardiac troponin
Cardiology
Galectin 3
Growth differentiation factor‐15
Heart failure
Heart Failure - diagnosis
Humans
Natriuretic Peptides
Procalcitonin
Prognosis
Review
sST2
Title Circulating heart failure biomarkers beyond natriuretic peptides: review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC)
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fejhf.2346
https://www.ncbi.nlm.nih.gov/pubmed/34498368
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https://pubmed.ncbi.nlm.nih.gov/PMC9292239
Volume 23
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