A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development

Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacolog...

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Published inPhytotherapy research Vol. 31; no. 1; pp. 3 - 26
Main Authors Sharma, Bhesh Raj, Gautam, Lekh Nath S., Adhikari, Deepak, Karki, Rajendra
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.01.2017
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Online AccessGet full text
ISSN0951-418X
1099-1573
DOI10.1002/ptr.5732

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Abstract Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword ‘Nelumbo nucifera pharmacology’ in all databases reported in Web of Science yielded 373 results excluding reviews and s in document types. Two hundred and forty‐three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.
AbstractList Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword ‘Nelumbo nucifera pharmacology’ in all databases reported in Web of Science yielded 373 results excluding reviews and s in document types. Two hundred and forty‐three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.
Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.
Nelumbo nucifera , also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera . Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera . Our search for the keyword ‘ Nelumbo nucifera pharmacology’ in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty‐three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use . Copyright © 2016 John Wiley & Sons, Ltd.
Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use.
Author Gautam, Lekh Nath S.
Karki, Rajendra
Sharma, Bhesh Raj
Adhikari, Deepak
Author_xml – sequence: 1
  givenname: Bhesh Raj
  surname: Sharma
  fullname: Sharma, Bhesh Raj
  organization: Mokpo National University
– sequence: 2
  givenname: Lekh Nath S.
  surname: Gautam
  fullname: Gautam, Lekh Nath S.
  organization: West Virginia University
– sequence: 3
  givenname: Deepak
  surname: Adhikari
  fullname: Adhikari, Deepak
  organization: East West College of Pharmacy
– sequence: 4
  givenname: Rajendra
  surname: Karki
  fullname: Karki, Rajendra
  email: rajmankarki@gmail.com
  organization: Mokpo National University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27667670$$D View this record in MEDLINE/PubMed
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IngestDate Fri Sep 05 17:16:03 EDT 2025
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IsPeerReviewed true
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Issue 1
Keywords lotus
N. nucifera
review
pharmacology
drug
phytochemistry
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
Copyright © 2016 John Wiley & Sons, Ltd.
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PublicationTitle Phytotherapy research
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Snippet Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in...
Nelumbo nucifera , also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in...
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SubjectTerms alkaloids
Asia
atherosclerosis
clinical trials
diabetes
drug
Drug Design
drugs
fatty acids
flavonoids
glycosides
inflammation
lotus
medicinal properties
Medicine, Chinese Traditional - methods
minerals
N. nucifera
Nelumbo - chemistry
Nelumbo nucifera
neoplasms
obesity
Oriental traditional medicine
pharmacology
phytochemistry
Phytotherapy - methods
Plant Extracts - chemistry
Plant Extracts - pharmacology
proteins
review
Seeds - chemistry
steroids
structure-activity relationships
terpenoids
vitamins
Title A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fptr.5732
https://www.ncbi.nlm.nih.gov/pubmed/27667670
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https://www.proquest.com/docview/1856594441
https://www.proquest.com/docview/1859488397
https://www.proquest.com/docview/2000496133
Volume 31
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