A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development
Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacolog...
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Published in | Phytotherapy research Vol. 31; no. 1; pp. 3 - 26 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Wiley Subscription Services, Inc
01.01.2017
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Subjects | |
Online Access | Get full text |
ISSN | 0951-418X 1099-1573 |
DOI | 10.1002/ptr.5732 |
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Abstract | Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword ‘Nelumbo nucifera pharmacology’ in all databases reported in Web of Science yielded 373 results excluding reviews and s in document types. Two hundred and forty‐three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd. |
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AbstractList | Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword ‘Nelumbo nucifera pharmacology’ in all databases reported in Web of Science yielded 373 results excluding reviews and s in document types. Two hundred and forty‐three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd. Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd. Nelumbo nucifera , also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera . Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera . Our search for the keyword ‘ Nelumbo nucifera pharmacology’ in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty‐three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use . Copyright © 2016 John Wiley & Sons, Ltd. Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. |
Author | Gautam, Lekh Nath S. Karki, Rajendra Sharma, Bhesh Raj Adhikari, Deepak |
Author_xml | – sequence: 1 givenname: Bhesh Raj surname: Sharma fullname: Sharma, Bhesh Raj organization: Mokpo National University – sequence: 2 givenname: Lekh Nath S. surname: Gautam fullname: Gautam, Lekh Nath S. organization: West Virginia University – sequence: 3 givenname: Deepak surname: Adhikari fullname: Adhikari, Deepak organization: East West College of Pharmacy – sequence: 4 givenname: Rajendra surname: Karki fullname: Karki, Rajendra email: rajmankarki@gmail.com organization: Mokpo National University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27667670$$D View this record in MEDLINE/PubMed |
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Keywords | lotus N. nucifera review pharmacology drug phytochemistry |
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Snippet | Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in... Nelumbo nucifera , also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in... |
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SubjectTerms | alkaloids Asia atherosclerosis clinical trials diabetes drug Drug Design drugs fatty acids flavonoids glycosides inflammation lotus medicinal properties Medicine, Chinese Traditional - methods minerals N. nucifera Nelumbo - chemistry Nelumbo nucifera neoplasms obesity Oriental traditional medicine pharmacology phytochemistry Phytotherapy - methods Plant Extracts - chemistry Plant Extracts - pharmacology proteins review Seeds - chemistry steroids structure-activity relationships terpenoids vitamins |
Title | A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development |
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