Emerging evidence on the pathobiology of mucositis

Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the...

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Published inSupportive care in cancer Vol. 21; no. 11; pp. 3233 - 3241
Main Authors Al-Dasooqi, Noor, Sonis, Stephen T., Bowen, Joanne M., Bateman, Emma, Blijlevens, Nicole, Gibson, Rachel J., Logan, Richard M., Nair, Raj G., Stringer, Andrea M., Yazbeck, Roger, Elad, Sharon, Lalla, Rajesh V.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2013
Springer
Springer Nature B.V
Subjects
Antineoplastic Agents - adverse effects
Biology
Cancer therapies
Chemoradiotherapy - adverse effects
Evidence-Based Medicine
Head and Neck Neoplasms - complications
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - therapy
Humans
Medicine
Medicine & Public Health
Mucous membrane
Nursing
Nursing Research
Oncology
Pain Medicine
Pathology
Pharmacogenetics
Rehabilitation Medicine
Review Article
Stomatitis - chemically induced
Stomatitis - genetics
Stomatitis - microbiology
Toxicity
Pharmacogenetics
Toxicity
Targeted drugs
Cancer therapy
Mucosal injury
Alimentary tract
Online AccessGet full text
ISSN0941-4355
1433-7339
1433-7339
DOI10.1007/s00520-013-1900-x

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Abstract Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.
AbstractList Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.[PUBLICATION ABSTRACT]
Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.
Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely.BACKGROUNDConsiderable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely.Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011.METHODSPanel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011.Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology.RESULTSRecent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology.The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.CONCLUSIONThe ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.
Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity. Keywords Mucosal injury * Cancer therapy * Targeted drugs * Toxicity* Alimentary tract * Pharmacogenetics
Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.
Audience Academic
Author Al-Dasooqi, Noor
Bowen, Joanne M.
Gibson, Rachel J.
Elad, Sharon
Bateman, Emma
Blijlevens, Nicole
Logan, Richard M.
Stringer, Andrea M.
Lalla, Rajesh V.
Sonis, Stephen T.
Nair, Raj G.
Yazbeck, Roger
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  givenname: Andrea M.
  surname: Stringer
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  organization: School of Pharmacy and Medical Sciences, University of South Australia
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  surname: Yazbeck
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  organization: School of Pharmacy and Medical Sciences, University of South Australia
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  fullname: Lalla, Rajesh V.
  organization: Section of Oral Medicine and Neag Comprehensive Cancer Center, University of Connecticut Health Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23842598$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/0030-4220(90)90376-4
10.1002/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q
10.1002/cncr.22484
10.1007/s00280-007-0534-4
10.1111/j.1743-7563.2006.00038.x
10.1016/j.cancergencyto.2009.12.004
10.4317/medoral.17057
10.1186/1748-717X-5-22
10.4161/cbt.7.12.6940
10.1111/j.1365-2613.2011.00771.x
10.1016/j.radonc.2008.09.019
10.1136/gut.47.5.632
10.1046/j.1365-2184.35.s1.10.x
10.1007/s00520-006-0058-1
10.1007/s00280-007-0570-0
10.1016/j.radonc.2009.06.006
10.1007/s00520-007-0379-8
10.1258/ebm.2010.010082
10.1016/j.bbmt.2010.01.001
10.1007/s00520-010-0923-9
10.1038/sj.bmt.1702447
10.1016/j.oraloncology.2011.06.012
10.1086/374339
10.1097/00024382-200303000-00006
10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J
10.1093/intimm/dxl030
10.1007/s10637-008-9152-1
10.1152/ajpgi.00173.2003
10.1007/s00280-008-0709-7
10.1016/S1368-8375(03)00148-9
10.1002/cncr.23182
10.1023/B:DDAS.0000011604.45531.2c
10.1002/cncr.20162
10.1080/00313020400023461
10.1126/science.1060191
10.1038/nrc1318
10.1158/1078-0432.CCR-03-0496
10.2174/138920009787048419
10.1016/S1590-8658(03)00375-X
10.1200/JCO.20.6.1491
10.1111/j.1365-2613.2009.00671.x
10.1016/j.tripleo.2009.11.015
10.1016/j.semradonc.2011.12.007
10.1111/j.1600-0722.2005.00216.x
10.1016/j.ijrobp.2005.04.041
10.1007/s10238-004-0055-y
10.1023/A:1021061306913
10.1016/j.radonc.2011.05.062
10.1038/nrclinonc.2011.192
10.1200/JCO.2006.10.4182
10.1038/sj.bmt.1703394
10.1016/j.oraloncology.2006.04.011
10.1056/NEJMoa064320
10.1091/mbc.4.9.953
10.1016/S0016-5085(98)70381-6
10.1038/bjc.2011.442
10.1159/000088957
10.1038/sj.bjc.6605343
10.1177/154411130201300502
10.4161/cbt.11.7.14896
10.1016/j.ijrobp.2008.08.073
10.1007/s00280-008-0732-8
10.1007/s00280-010-1253-9
10.1016/j.oraloncology.2011.07.006
10.1200/JCO.2007.11.9776
10.1007/s00520-006-0181-z
10.1016/j.ctrv.2007.03.001
10.1093/clinids/18.1.25
10.1016/j.oraloncology.2009.08.006
10.1007/s00520-006-0052-7
10.1007/s00520-006-0066-1
10.1634/theoncologist.9-suppl_3-10
10.4161/cbt.7.7.6207
10.1269/jrr.11085
10.1159/000107724
10.1016/S1368-8375(00)00012-9
10.3109/14653249.2011.650162
10.1002/cncr.11671
10.3181/0810-RM-301
10.1016/0030-4220(92)90402-C
10.1023/A:1013184301155
10.1016/j.bbrc.2009.09.041
10.2353/ajpath.2010.100371
10.1159/000107458
10.1097/MPG.0b013e318247240d
10.1080/00325481.1974.11713737
10.14694/EdBook_AM.2012.32.46
10.1371/journal.ppat.1000879
10.1007/978-1-60761-644-3_14
10.4161/cbt.21783
10.1007/s00520-012-1644-z
10.1182/blood.V89.6.1845
10.1002/cncr.20733
10.1177/030089160409000110
10.1634/theoncologist.3-6-446
10.1002/cncr.24696
10.4049/jimmunol.180.8.5653
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Issue 11
Keywords Pharmacogenetics
Toxicity
Targeted drugs
Cancer therapy
Mucosal injury
Alimentary tract
Language English
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PublicationTitle Supportive care in cancer
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References Anthony (CR20) 2007; 14
Napenas (CR65) 2010; 109
Stringer (CR62) 2008; 7
Zhao (CR59) 2004; 10
Martin, van Saene (CR67) 1992; 2
Sonis (CR72) 2009; 45
CR35
Stringer (CR16) 2009; 10
CR34
Bultzingslowen (CR56) 2006; 14
West, Dunning, Rosenstein (CR96) 2012; 22
Bowen (CR24) 2005; 37
Sonis (CR45) 2004; 2
Burris (CR84) 2004; 9
Capp (CR3) 2009; 90
Li (CR29) 2011; 16
van der Velden, Donnelly, Blijlevens (CR71) 2012; 14
Sonis (CR9) 1990; 69
Al-Dasooqi (CR86) 2008; 27
Stringer (CR17) 2007; 232
Stringer (CR15) 2009; 90
Carneiro-Filho (CR30) 2004; 49
Gibson (CR76) 2013; 21
Sonis (CR46) 2004; 40
Fiochhi (CR54) 1998; 115
Blijlevens, Donnelly, DePauw (CR74) 2000; 25
Keefe, Bateman (CR79) 2011; 9
Sonis (CR7) 2004; 4
Al-Sadi (CR39) 2008; 180
Sonis (CR12) 2000; 36
Logan (CR47) 2007; 43
Hahn (CR101) 2010; 16
Meredith, Fazeli, Schwartz (CR33) 1993; 4
Alterovitz (CR102) 2011; 47
Schwab (CR99) 2008; 26
Elting (CR1) 2003; 98
Gibson (CR57) 2002; 47
Wisplinghoff (CR78) 2003; 36
Sawaki (CR82) 2004; 90
Gibson (CR28) 2006; 2
Melichar (CR42) 2005; 51
Melo (CR53) 2008; 61
Werbrouck (CR98) 2009; 73
Manzano (CR14) 2007; 53
Al-Dasooqi (CR19) 2010; 235
Bochud (CR68) 1994; 18
Ruiz (CR89) 2008; 62
Sonis (CR26) 1992; 74
Roseth (CR103) 2003; 35
Pico, Avila-Garavito, Naccache (CR93) 1998; 3
Hamada (CR37) 2010; 66
Keefe (CR4) 2007; 109
Vliet (CR66) 2010; 6
Thomas (CR97) 2011; 105
Huang (CR32) 2009; 389
Cho (CR100) 2010; 198
Gibson (CR27) 2007; 53
Al-Sadi (CR38) 2010; 177
Logan (CR43) 2008; 62
Sonis (CR2) 2004; 100
Yeoh (CR13) 2005; 63
CR77
Frei (CR60) 1965; 25
Dreizen, Bodey, Brown (CR61) 1974; 55
Logan (CR51) 2008; 7
Prisciandaro (CR75) 2011; 11
Pratesi (CR95) 2011; 99
Paris (CR10) 2001; 293
Hannum (CR21) 1997; 89
Al-Dasooqi (CR18) 2011; 92
Murphy (CR6) 2007; 5
Keefe (CR25) 2000; 47
Keefe, Gibson (CR83) 2007; 15
Beutheu Youmba (CR36) 2012; 54
Kerr, Winterford, Harmon (CR22) 1994; 73
Sonis (CR8) 2002; 35
Ma (CR40) 2004; 286
Lutgens (CR104) 2005; 103
Stringer (CR63) 2009; 234
Geyer (CR85) 2006; 355
Ruescher (CR69) 1998; 82
Toi (CR81) 2009; 101
Antin (CR58) 2002; 29
Lima (CR52) 2005; 113
Sonis (CR80) 2010; 116
Soga (CR70) 2011; 19
CR92
CR91
Shao (CR64) 2011; 52
Logan (CR11) 2009; 63
Ong (CR49) 2010; 16
Haagen (CR48) 2009; 92
Fountzilas (CR87) 2001; 12
Gibson (CR23) 2005; 4
Sloan (CR94) 2002; 20
Han, Fink, Delude (CR41) 2003; 19
de Koning (CR55) 2006; 18
Xanthinaki (CR105) 2008; 16
Aprile (CR5) 2008; 112
Barasch (CR73) 2006; 14
Chen (CR31) 2011; 47
Bartsch (CR88) 2007; 25
Sonis (CR44) 2002; 13
Bowen (CR90) 2012; 13
Logan (CR50) 2007; 33
A Stringer (1900_CR17) 2007; 232
CE Geyer (1900_CR85) 2006; 355
A Stringer (1900_CR62) 2008; 7
N Pratesi (1900_CR95) 2011; 99
R Logan (1900_CR11) 2009; 63
L Elting (1900_CR1) 2003; 98
T Ma (1900_CR40) 2004; 286
M Schwab (1900_CR99) 2008; 26
A Xanthinaki (1900_CR105) 2008; 16
L Anthony (1900_CR20) 2007; 14
J Haagen (1900_CR48) 2009; 92
A Stringer (1900_CR63) 2009; 234
N Al-Dasooqi (1900_CR18) 2011; 92
R Logan (1900_CR47) 2007; 43
R Bartsch (1900_CR88) 2007; 25
R Gibson (1900_CR57) 2002; 47
S Dreizen (1900_CR61) 1974; 55
S Sonis (1900_CR12) 2000; 36
D Keefe (1900_CR4) 2007; 109
C Li (1900_CR29) 2011; 16
1900_CR93
B Melichar (1900_CR42) 2005; 51
G Alterovitz (1900_CR102) 2011; 47
S Sonis (1900_CR7) 2004; 4
T Huang (1900_CR32) 2009; 389
C West (1900_CR96) 2012; 22
S Sonis (1900_CR80) 2010; 116
S Sonis (1900_CR2) 2004; 100
Z Shao (1900_CR64) 2011; 52
L Prisciandaro (1900_CR75) 2011; 11
N Blijlevens (1900_CR74) 2000; 25
W Velden van der (1900_CR71) 2012; 14
S Sonis (1900_CR9) 1990; 69
R Al-Sadi (1900_CR39) 2008; 180
M Toi (1900_CR81) 2009; 101
I Bultzingslowen (1900_CR56) 2006; 14
G Aprile (1900_CR5) 2008; 112
B Carneiro-Filho (1900_CR30) 2004; 49
R Gibson (1900_CR28) 2006; 2
1900_CR35
S Sonis (1900_CR26) 1992; 74
1900_CR34
V Lima (1900_CR52) 2005; 113
Z Ong (1900_CR49) 2010; 16
C Fiochhi (1900_CR54) 1998; 115
J Zhao (1900_CR59) 2004; 10
D Keefe (1900_CR83) 2007; 15
J Napenas (1900_CR65) 2010; 109
1900_CR66
D Keefe (1900_CR79) 2011; 9
N Al-Dasooqi (1900_CR86) 2008; 27
A Yeoh (1900_CR13) 2005; 63
M Melo (1900_CR53) 2008; 61
F Thomas (1900_CR97) 2011; 105
R Gibson (1900_CR27) 2007; 53
Y Soga (1900_CR70) 2011; 19
E Frei (1900_CR60) 1965; 25
M Ruiz (1900_CR89) 2008; 62
H Burris (1900_CR84) 2004; 9
B Murphy (1900_CR6) 2007; 5
P Bochud (1900_CR68) 1994; 18
G Fountzilas (1900_CR87) 2001; 12
X Han (1900_CR41) 2003; 19
J Sloan (1900_CR94) 2002; 20
T Hahn (1900_CR101) 2010; 16
S Sonis (1900_CR46) 2004; 40
S Sonis (1900_CR45) 2004; 2
A Stringer (1900_CR16) 2009; 10
J Werbrouck (1900_CR98) 2009; 73
P Chen (1900_CR31) 2011; 47
H Wisplinghoff (1900_CR78) 2003; 36
F Paris (1900_CR10) 2001; 293
M Sawaki (1900_CR82) 2004; 90
N Al-Dasooqi (1900_CR19) 2010; 235
S Sonis (1900_CR72) 2009; 45
1900_CR91
1900_CR92
A Capp (1900_CR3) 2009; 90
1900_CR90
A Stringer (1900_CR15) 2009; 90
S Beutheu Youmba (1900_CR36) 2012; 54
R Logan (1900_CR43) 2008; 62
H Cho (1900_CR100) 2010; 198
S Sonis (1900_CR44) 2002; 13
J Kerr (1900_CR22) 1994; 73
D Keefe (1900_CR25) 2000; 47
K Hamada (1900_CR37) 2010; 66
J Antin (1900_CR58) 2002; 29
T Ruescher (1900_CR69) 1998; 82
S Sonis (1900_CR8) 2002; 35
R Logan (1900_CR51) 2008; 7
R Gibson (1900_CR23) 2005; 4
J Meredith (1900_CR33) 1993; 4
R Logan (1900_CR50) 2007; 33
B Koning de (1900_CR55) 2006; 18
1900_CR77
Y Hannum (1900_CR21) 1997; 89
1900_CR104
1900_CR76
R Al-Sadi (1900_CR38) 2010; 177
M Martin (1900_CR67) 1992; 2
M Manzano (1900_CR14) 2007; 53
A Barasch (1900_CR73) 2006; 14
J Bowen (1900_CR24) 2005; 37
A Roseth (1900_CR103) 2003; 35
19765103 - Int J Exp Pathol. 2009 Oct;90(5):489-99
10871732 - Bone Marrow Transplant. 2000 Jun;25(12):1269-78
14693241 - Oral Oncol. 2004 Feb;40(2):170-6
11034578 - Gut. 2000 Nov;47(5):632-7
11822753 - Ann Oncol. 2001 Nov;12(11):1545-51
18299612 - J Clin Oncol. 2008 May 1;26(13):2131-8
20233440 - Radiat Oncol. 2010 Mar 16;5:22
20682600 - Exp Biol Med (Maywood). 2010 Oct;235(10 ):1244-56
9058703 - Blood. 1997 Mar 15;89(6):1845-53
21824803 - Oral Oncol. 2011 Oct;47(10):951-5
18041060 - Cancer. 2008 Jan 15;112(2):284-92
14992437 - Dig Dis Sci. 2004 Jan;49(1):65-72
15953245 - Eur J Oral Sci. 2005 Jun;113(3):210-7
15573372 - Cancer. 2005 Jan 1;103(1):191-9
21737340 - Oral Oncol. 2011 Sep;47(9):831-9
19765544 - Biochem Biophys Res Commun. 2009 Nov 27;389(4):634-9
17713326 - Chemotherapy. 2007;53(5):360-9
17679724 - J Clin Oncol. 2007 Sep 1;25(25):3853-8
18351341 - Cancer Chemother Pharmacol. 2009 Jan;63(2):239-51
21196860 - Med Oral Patol Oral Cir Bucal. 2011 Sep 01;16(6):e711-5
22197938 - J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):463-70
16224185 - Chemotherapy. 2005 Oct;51(6):336-8
12139712 - Cell Prolif. 2002 Aug;35 Suppl 1:93-102
11919725 - Bone Marrow Transplant. 2002 Mar;29(5):373-7
22182972 - Nat Rev Clin Oncol. 2011 Dec 20;9(2):98-109
10388137 - Oncologist. 1998;3(6):446-451
16099597 - Int J Radiat Oncol Biol Phys. 2005 Dec 1;63(5):1295-303
20303053 - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):554-60
14563180 - Dig Liver Dis. 2003 Sep;35(9):607-9
19828360 - Oral Oncol. 2009 Dec;45(12):1015-20
15750766 - Clin Exp Med. 2005 Mar;4(4):188-95
22242829 - Cytotherapy. 2012 Mar;14(3):381-3
16775647 - Support Care Cancer. 2006 Jun;14(6):519-27
15108222 - Cancer. 2004 May 1;100(9 Suppl):1995-2025
17103195 - Support Care Cancer. 2007 May;15(5):483-90
20303013 - Cancer Genet Cytogenet. 2010 Apr 1;198(1):40-6
18197435 - Support Care Cancer. 2008 Sep;16(9):1025-33
8156506 - Cancer. 1994 Apr 15;73(8):2013-26
18535404 - Cancer Biol Ther. 2008 Jul;7(7):1139-45
17703303 - Cancer Chemother Pharmacol. 2008 Jun;62(1):33-41
20535502 - Support Care Cancer. 2011 Jul;19(7):995-1000
12630522 - Shock. 2003 Mar;19(3):229-37
22045187 - Br J Cancer. 2011 Nov 22;105(11):1654-62
19251090 - Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1187-95
20119715 - Cancer Chemother Pharmacol. 2010 Nov;66(6):1031-8
15163842 - Oncologist. 2004;9 Suppl 3:10-5
17202590 - Exp Biol Med (Maywood). 2007 Jan;232(1):96-106
18612591 - Invest New Drugs. 2009 Apr;27(2):173-8
15143970 - Tumori. 2004 Jan-Feb;90(1):40-3
10899677 - Oral Oncol. 2000 Jul;36(4):373-81
9649475 - Gastroenterology. 1998 Jul;115(1):182-205
19576646 - Radiother Oncol. 2009 Sep;92(3):472-6
1392005 - Curr Opin Dent. 1992 Sep;2:81-4
15875735 - Pathology. 2005 Feb;37(1):56-62
22385916 - Semin Radiat Oncol. 2012 Apr;22(2):91-9
18046994 - J Support Oncol. 2007 Oct;5(9 Suppl 4):13-21
15330370 - J Support Oncol. 2004 Jan-Feb;2(1):21-32; discussion 35-6
18390750 - J Immunol. 2008 Apr 15;180(8):5653-61
21048223 - Am J Pathol. 2010 Nov;177(5):2310-22
23142924 - Support Care Cancer. 2013 Jan;21(1):313-26
2326035 - Oral Surg Oral Med Oral Pathol. 1990 Apr;69(4):437-43
16583189 - Support Care Cancer. 2006 Jun;14(6):516-8
4285787 - Cancer Res. 1965 Oct;25(9):1511-5
14508842 - Cancer. 2003 Oct 1;98(7):1531-9
18927500 - Cancer Biol Ther. 2008 Dec;7(12 ):1919-25
19176868 - Exp Biol Med (Maywood). 2009 Apr;234(4):430-41
17192538 - N Engl J Med. 2006 Dec 28;355(26):2733-43
12715303 - Clin Infect Dis. 2003 May 1;36(9):1103-10
21463374 - Int J Exp Pathol. 2011 Oct;92 (5):357-65
9610710 - Cancer. 1998 Jun 1;82(11):2275-81
15057287 - Nat Rev Cancer. 2004 Apr;4(4):277-84
15102694 - Clin Cancer Res. 2004 Apr 15;10 (8):2851-9
19862817 - Cancer. 2010 Jan 1;116(1):210-5
18952309 - Radiother Oncol. 2009 Mar;90(3):400-7
8257797 - Mol Biol Cell. 1993 Sep;4(9):953-61
24451793 - Am Soc Clin Oncol Educ Book. 2012;:545-51
17236223 - Cancer. 2007 Mar 1;109(5):820-31
1488231 - Oral Surg Oral Med Oral Pathol. 1992 Dec;74(6):749-55
19149515 - Curr Drug Metab. 2009 Jan;10(1):79-83
20523891 - PLoS Pathog. 2010 May 27;6(5):e1000879
4594534 - Postgrad Med. 1974 Apr;55(4):133-9
18365200 - Cancer Chemother Pharmacol. 2008 Nov;62(6):1085-90
11452123 - Science. 2001 Jul 13;293(5528):293-7
17785971 - Chemotherapy. 2007;53(5):344-55
16979925 - Oral Oncol. 2007 Apr;43(4):395-401
21307648 - Cancer Biol Ther. 2011 Apr 1;11(7):671-7
14766535 - Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G367-76
11896096 - J Clin Oncol. 2002 Mar 15;20(6):1491-8
12393757 - Crit Rev Oral Biol Med. 2002;13(5):380-9
22104273 - J Radiat Res. 2011;52(6):834-9
16636014 - Int Immunol. 2006 Jun;18(6):941-9
17507164 - Cancer Treat Rev. 2007 Aug;33(5):448-60
19844234 - Br J Cancer. 2009 Nov 17;101(10):1676-82
12498296 - Dig Dis Sci. 2002 Dec;47(12):2751-7
21704413 - Radiother Oncol. 2011 Jun;99(3):356-61
22895076 - Cancer Biol Ther. 2012 Nov;13(13):1269-75
16775648 - Support Care Cancer. 2006 Jun;14(6):528-32
8054434 - Clin Infect Dis. 1994 Jan;18(1):25-31
20074657 - Biol Blood Marrow Transplant. 2010 Jun;16(6):801-8
17624531 - Cancer Chemother Pharmacol. 2008 Apr;61(5):775-84
References_xml – volume: 69
  start-page: 437
  year: 1990
  end-page: 443
  ident: CR9
  article-title: An animal model for mucositis induced by cancer chemotherapy
  publication-title: Oral Surg, Oral Med, Oral Pathol
  doi: 10.1016/0030-4220(90)90376-4
– volume: 82
  start-page: 2275
  year: 1998
  end-page: 2281
  ident: CR69
  article-title: The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies
  publication-title: Cancer
  doi: 10.1002/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q
– volume: 109
  start-page: 820
  year: 2007
  end-page: 831
  ident: CR4
  article-title: Updated clinical practice guidelines for the prevention and treatment of mucositis
  publication-title: Cancer
  doi: 10.1002/cncr.22484
– volume: 61
  start-page: 775
  year: 2008
  end-page: 784
  ident: CR53
  article-title: Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-007-0534-4
– volume: 2
  start-page: 39
  year: 2006
  end-page: 49
  ident: CR28
  article-title: Apoptosis occurs early in the basal layer of the oral mucosa following cancer chemotherapy
  publication-title: Asia Pac J Clin Oncol
  doi: 10.1111/j.1743-7563.2006.00038.x
– volume: 198
  start-page: 40
  year: 2010
  end-page: 46
  ident: CR100
  article-title: Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma
  publication-title: Cancer CGenet Cytogenet
  doi: 10.1016/j.cancergencyto.2009.12.004
– volume: 16
  start-page: e711
  year: 2011
  end-page: e715
  ident: CR29
  article-title: The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model
  publication-title: Med Oral Pathol Oral Cir Bucal
  doi: 10.4317/medoral.17057
– volume: 16
  start-page: 22
  year: 2010
  ident: CR49
  article-title: Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis
  publication-title: Radiat Oncol
  doi: 10.1186/1748-717X-5-22
– volume: 7
  start-page: 1919
  year: 2008
  end-page: 1925
  ident: CR62
  article-title: Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhoea model in rats
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.7.12.6940
– volume: 92
  start-page: 357
  year: 2011
  end-page: 365
  ident: CR18
  article-title: Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat
  publication-title: Int J Exp Pathol
  doi: 10.1111/j.1365-2613.2011.00771.x
– volume: 90
  start-page: 400
  year: 2009
  end-page: 407
  ident: CR3
  article-title: Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2008.09.019
– volume: 116
  start-page: 210
  year: 2010
  end-page: 215
  ident: CR80
  article-title: Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
  publication-title: Cancer
– volume: 47
  start-page: 632
  year: 2000
  end-page: 637
  ident: CR25
  article-title: Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans
  publication-title: Gut
  doi: 10.1136/gut.47.5.632
– volume: 35
  start-page: s92
  year: 2002
  end-page: s102
  ident: CR8
  article-title: The gene expression sequence of radiated mucosa in an animal mucositis model
  publication-title: Cell Prolif
  doi: 10.1046/j.1365-2184.35.s1.10.x
– volume: 14
  start-page: 516
  year: 2007
  end-page: 518
  ident: CR20
  article-title: New thoughts on the pathobiology of regimen-related mucosal injury
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0058-1
– volume: 62
  start-page: 33
  year: 2008
  end-page: 41
  ident: CR43
  article-title: Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-007-0570-0
– volume: 21
  start-page: 313
  issue: 1
  year: 2013
  end-page: 26
  ident: CR76
  article-title: Systematic review of agents for the management of gastrointestinal mucositis in cancer patients
  publication-title: Supportive Care Cancer
– ident: CR77
– volume: 92
  start-page: 472
  year: 2009
  end-page: 476
  ident: CR48
  article-title: Effect of selective inhibitors of inflammation on oral mucositis: preclinical studies
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2009.06.006
– volume: 16
  start-page: 1025
  year: 2008
  end-page: 1033
  ident: CR105
  article-title: Apoptosis and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: preliminary report
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-007-0379-8
– volume: 5
  start-page: 13
  year: 2007
  end-page: 21
  ident: CR6
  article-title: Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy
  publication-title: J Support Oncol
– volume: 235
  start-page: 1244
  year: 2010
  end-page: 1256
  ident: CR19
  article-title: Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the DA rat
  publication-title: Exp Biol Med
  doi: 10.1258/ebm.2010.010082
– volume: 16
  start-page: 801
  year: 2010
  end-page: 808
  ident: CR101
  article-title: A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2010.01.001
– volume: 19
  start-page: 995
  year: 2011
  end-page: 1000
  ident: CR70
  article-title: Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-010-0923-9
– ident: CR92
– volume: 25
  start-page: 1269
  year: 2000
  end-page: 1278
  ident: CR74
  article-title: Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview
  publication-title: Bone Marrow Transplant
  doi: 10.1038/sj.bmt.1702447
– volume: 47
  start-page: 831
  year: 2011
  end-page: 839
  ident: CR31
  article-title: Role of AMP-18 in oral mucositis
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2011.06.012
– volume: 13
  start-page: 1269
  issue: 13
  year: 2012
  end-page: 75
  ident: CR90
  article-title: Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhoea
  publication-title: Cancer Biol Ther
– volume: 36
  start-page: 1103
  year: 2003
  end-page: 1110
  ident: CR78
  article-title: Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States
  publication-title: Clin Infect Dis
  doi: 10.1086/374339
– volume: 19
  start-page: 229
  year: 2003
  end-page: 237
  ident: CR41
  article-title: Proinflammatory cytokines cause NO*-dependent and -independent changes in expression and localization of tight junction proteins in intestinal epithelial cells
  publication-title: Shock
  doi: 10.1097/00024382-200303000-00006
– volume: 73
  start-page: 2013
  year: 1994
  end-page: 2026
  ident: CR22
  article-title: Apoptosis: its significant in cancer and cancer therapy
  publication-title: Cancer
  doi: 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J
– volume: 3
  start-page: p446
  year: 1998
  end-page: 451
  ident: CR93
  article-title: Mucositis: its occurence, consequences and treatment in the oncology setting
  publication-title: The Oncologist volume
– ident: CR91
– volume: 18
  start-page: 941
  year: 2006
  end-page: 949
  ident: CR55
  article-title: Contributions of mucosal immune cells to methotrexate-induced mucositis
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxl030
– volume: 27
  start-page: 173
  year: 2008
  end-page: 178
  ident: CR86
  article-title: Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients
  publication-title: Investig New Drugs
  doi: 10.1007/s10637-008-9152-1
– volume: 286
  start-page: G367
  year: 2004
  end-page: G376
  ident: CR40
  article-title: TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00173.2003
– volume: 62
  start-page: 1085
  year: 2008
  end-page: 1090
  ident: CR89
  article-title: Phase-II study of weekly schedule of trastuzumab, paclitaxel, and carboplatin followed by a week off every 28 days for HER2+ metastatic breast cancer
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-008-0709-7
– volume: 40
  start-page: 170
  year: 2004
  end-page: 176
  ident: CR46
  article-title: The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis
  publication-title: Oral Oncol
  doi: 10.1016/S1368-8375(03)00148-9
– volume: 112
  start-page: 284
  year: 2008
  end-page: 292
  ident: CR5
  article-title: Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy
  publication-title: Cancer
  doi: 10.1002/cncr.23182
– volume: 49
  start-page: 65
  year: 2004
  end-page: 72
  ident: CR30
  article-title: Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis
  publication-title: Dig Dis Sci
  doi: 10.1023/B:DDAS.0000011604.45531.2c
– volume: 100
  start-page: 1995
  year: 2004
  end-page: 2025
  ident: CR2
  article-title: Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients
  publication-title: Cancer
  doi: 10.1002/cncr.20162
– volume: 37
  start-page: 56
  year: 2005
  end-page: 62
  ident: CR24
  article-title: Cytotoxic chemotherapy up-regulates pro-apoptotic Bax and Bak in the small intestine of rats and humans
  publication-title: Pathology
  doi: 10.1080/00313020400023461
– volume: 89
  start-page: 1845
  year: 1997
  end-page: 1853
  ident: CR21
  article-title: Apoptosis and the dilemma of cancer chemotherapy
  publication-title: Blood
– volume: 293
  start-page: 293
  year: 2001
  end-page: 297
  ident: CR10
  article-title: Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
  publication-title: Science
  doi: 10.1126/science.1060191
– volume: 4
  start-page: 277
  year: 2004
  end-page: 284
  ident: CR7
  article-title: The pathobiology of mucositis
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1318
– volume: 10
  start-page: 2851
  year: 2004
  end-page: 2859
  ident: CR59
  article-title: Oral RDP58 allows CPT-11 dose intensification for enhanced tumor response by decreasing gastrointestinal toxicity
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-03-0496
– volume: 180
  start-page: 5653
  year: 2008
  end-page: 5661
  ident: CR39
  article-title: Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability
  publication-title: J Immunol
– volume: 10
  start-page: 79
  year: 2009
  end-page: 83
  ident: CR16
  article-title: Chemotherapy-induced changes to microflora: evidence and implications of change
  publication-title: Curr Drug Metab
  doi: 10.2174/138920009787048419
– volume: 35
  start-page: 607
  year: 2003
  end-page: 609
  ident: CR103
  article-title: Determination of faecal calprotectin, a novel marker of organic gastrointestinal disorders
  publication-title: Dig Liver Dis
  doi: 10.1016/S1590-8658(03)00375-X
– volume: 20
  start-page: 1491
  year: 2002
  end-page: 1498
  ident: CR94
  article-title: Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.20.6.1491
– volume: 90
  start-page: 489
  year: 2009
  end-page: 499
  ident: CR15
  article-title: Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile
  publication-title: Int J Exp Pathol
  doi: 10.1111/j.1365-2613.2009.00671.x
– volume: 109
  start-page: 554
  year: 2010
  end-page: 560
  ident: CR65
  article-title: Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study
  publication-title: Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endodentics
  doi: 10.1016/j.tripleo.2009.11.015
– volume: 22
  start-page: 91
  year: 2012
  end-page: 99
  ident: CR96
  article-title: Genome-wide association studies and prediction of normal tissue toxicity
  publication-title: Sem Radiat Oncol
  doi: 10.1016/j.semradonc.2011.12.007
– volume: 113
  start-page: 210
  year: 2005
  end-page: 217
  ident: CR52
  article-title: Effects of tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters
  publication-title: Eur J Oral Sci
  doi: 10.1111/j.1600-0722.2005.00216.x
– volume: 63
  start-page: 1295
  year: 2005
  end-page: 1303
  ident: CR13
  article-title: Nuclear factor κB (NFκB) and cyclooxygenase-2 (COX-2) expression in the irradiated colorectum is associated with subsequent histopathological changes
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2005.04.041
– volume: 4
  start-page: 188
  year: 2005
  end-page: 195
  ident: CR23
  article-title: Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat
  publication-title: Clin Exp Med
  doi: 10.1007/s10238-004-0055-y
– volume: 47
  start-page: 2751
  year: 2002
  end-page: 2757
  ident: CR57
  article-title: Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats
  publication-title: Dig Dis Sci
  doi: 10.1023/A:1021061306913
– volume: 99
  start-page: 356
  year: 2011
  end-page: 362
  ident: CR95
  article-title: Association between single nucleotide polymorphisms in XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2011.05.062
– volume: 9
  start-page: 98
  year: 2011
  end-page: 109
  ident: CR79
  article-title: Tumor control versus adverse events with targeted anticancer therapies
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2011.192
– volume: 26
  start-page: 2131
  year: 2008
  end-page: 2138
  ident: CR99
  article-title: Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2006.10.4182
– volume: 29
  start-page: 373
  year: 2002
  end-page: 377
  ident: CR58
  article-title: A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation
  publication-title: Bone Marrow Transplant
  doi: 10.1038/sj.bmt.1703394
– ident: CR35
– volume: 90
  start-page: 40
  issue: 1
  year: 2004
  end-page: 43
  ident: CR82
  article-title: Efficacy and safety of trastuzumab as a single agent in heavily pretreated patients with HER-2/neu-overexpressing metastatic breast cancer
  publication-title: Tumori
– volume: 43
  start-page: 395
  year: 2007
  end-page: 401
  ident: CR47
  article-title: Nuclear factor-kB (NFkB) and cyclooxygenase-2 expression in the oral mucosa following cancer chemotherapy
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2006.04.011
– volume: 355
  start-page: 2733
  issue: 26
  year: 2006
  end-page: 2743
  ident: CR85
  article-title: Lapatinib plus capecitabine for HER2-positive advanced breast cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa064320
– volume: 4
  start-page: 953
  year: 1993
  end-page: 961
  ident: CR33
  article-title: The extracellular matrix as a cell survival factor
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.4.9.953
– volume: 115
  start-page: 182
  year: 1998
  end-page: 205
  ident: CR54
  article-title: Inflammatory bowel disease: etiology and pathogenesis
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(98)70381-6
– volume: 232
  start-page: 96
  year: 2007
  end-page: 106
  ident: CR17
  article-title: Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat
  publication-title: Exp Biol Med
– volume: 105
  start-page: 1654
  year: 2011
  end-page: 1662
  ident: CR97
  article-title: Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2011.442
– volume: 51
  start-page: 336
  year: 2005
  end-page: 338
  ident: CR42
  article-title: Intestinal permeability in the assessment of intestinal toxicity of cytotoxic agents
  publication-title: Chemotherapy
  doi: 10.1159/000088957
– volume: 101
  start-page: 1676
  issue: 10
  year: 2009
  end-page: 1682
  ident: CR81
  article-title: Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6605343
– volume: 13
  start-page: 380
  year: 2002
  end-page: 389
  ident: CR44
  article-title: The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy
  publication-title: Crit Rev Oral BiolMed
  doi: 10.1177/154411130201300502
– volume: 11
  start-page: 671
  year: 2011
  end-page: 677
  ident: CR75
  article-title: Probiotic factors partially improve parameters of 5-fluorouracil-induced intestinal mucositis in rats
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.11.7.14896
– volume: 2
  start-page: 81
  year: 1992
  end-page: 84
  ident: CR67
  article-title: The role of oral microorganisms in cancer therapy
  publication-title: Curr Opin Dent
– volume: 73
  start-page: 1187
  year: 2009
  end-page: 1195
  ident: CR98
  article-title: Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2008.08.073
– volume: 63
  start-page: 239
  year: 2009
  end-page: 251
  ident: CR11
  article-title: Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-008-0732-8
– volume: 66
  start-page: 1031
  year: 2010
  end-page: 1038
  ident: CR37
  article-title: Zonula Occluden-1 alterations and enhances intestinal permeability in methotrexate-treated rats
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-010-1253-9
– volume: 47
  start-page: 951
  year: 2011
  end-page: 955
  ident: CR102
  article-title: Personalized medicine for mucositis: bayesian networks identify unique gene clusters which predict the response to gamma-D-glutamyl-L-tryptophan (SCV-07) for the attenuation of chemoradiation-induced oral mucositis
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2011.07.006
– volume: 25
  start-page: 3853
  year: 2007
  end-page: 3858
  ident: CR88
  article-title: Capecitabine and trastuzumab in heavily pretreated metastatic breast cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2007.11.9776
– volume: 15
  start-page: 483
  year: 2007
  end-page: 490
  ident: CR83
  article-title: Mucosal injury from targeted anticancer therapy
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0181-z
– volume: 2
  start-page: 21
  year: 2004
  end-page: 32
  ident: CR45
  article-title: A biological approach to mucositis
  publication-title: J Support Oncol
– volume: 33
  start-page: 448
  year: 2007
  end-page: 460
  ident: CR50
  article-title: The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
  publication-title: Cancer Treat Rev
  doi: 10.1016/j.ctrv.2007.03.001
– volume: 18
  start-page: 25
  year: 1994
  end-page: 31
  ident: CR68
  article-title: Bacteremia due to viridans streptococcus in neutropenic patients with cancer: clinical spectrum and risk factors
  publication-title: Clin Infect Dis
  doi: 10.1093/clinids/18.1.25
– volume: 45
  start-page: 1015
  year: 2009
  end-page: 1020
  ident: CR72
  article-title: Mucositis: the impact, biology and therapeutic opportunities of oral mucositis
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2009.08.006
– volume: 14
  start-page: 519
  year: 2006
  end-page: 527
  ident: CR56
  article-title: Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0052-7
– volume: 6
  start-page: e1000879
  issue: 5
  year: 2010
  ident: CR66
  article-title: The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis
  publication-title: PLoS Pathog
– volume: 14
  start-page: 528
  year: 2006
  end-page: 532
  ident: CR73
  article-title: Antimicrobials, mucosal coating agents, anesthetics, analgesics, and nutritional supplements for alimentary tract mucositis
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0066-1
– volume: 9
  start-page: 10
  year: 2004
  end-page: 15
  ident: CR84
  article-title: Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib
  publication-title: Oncologist
  doi: 10.1634/theoncologist.9-suppl_3-10
– volume: 7
  start-page: 1139
  year: 2008
  end-page: 1145
  ident: CR51
  article-title: Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.7.7.6207
– volume: 52
  start-page: 834
  year: 2011
  end-page: 839
  ident: CR64
  article-title: Effects of intensity-modulated radiotherapy on human oral microflora
  publication-title: J Radiat Res
  doi: 10.1269/jrr.11085
– volume: 53
  start-page: 344
  year: 2007
  end-page: 355
  ident: CR14
  article-title: Intestinal toxicity induced by 5-fluorouracil in pigs: a new preclinical model
  publication-title: Chemotherapy
  doi: 10.1159/000107724
– volume: 36
  start-page: 373
  year: 2000
  end-page: 381
  ident: CR12
  article-title: Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters
  publication-title: Oral Oncol
  doi: 10.1016/S1368-8375(00)00012-9
– volume: 14
  start-page: 381
  year: 2012
  end-page: 383
  ident: CR71
  article-title: Lymphocyte subsets, granulocyte-colony-stimulating factor responsiveness and post-stem cell transplantation infections: mucositis is the underestimated confounder?
  publication-title: Cytotherapy
  doi: 10.3109/14653249.2011.650162
– volume: 98
  start-page: 1531
  year: 2003
  end-page: 1539
  ident: CR1
  article-title: The burdens of cancer therapy: clinical and economic outcomes of chemotherapy-induced mucositis
  publication-title: Cancer
  doi: 10.1002/cncr.11671
– volume: 55
  start-page: 133
  year: 1974
  end-page: 139
  ident: CR61
  article-title: Opportunistic gram-negative bacillary infections in leukemia. Oral manifestations during myelosuppression
  publication-title: Post Med
– volume: 234
  start-page: 430
  year: 2009
  end-page: 441
  ident: CR63
  article-title: Gastrointestinal microflora and mucins play a role in the development of 5-fluorouracil-induced gastrointestinal mucositis in rats
  publication-title: Exp Biol Med
  doi: 10.3181/0810-RM-301
– volume: 74
  start-page: 749
  year: 1992
  end-page: 755
  ident: CR26
  article-title: Effect of epidermal gorwth factor on ulcerative mucositis in hamsters that receive chemotherapy
  publication-title: Oral Surg, Oral Med, Oral Pathol
  doi: 10.1016/0030-4220(92)90402-C
– ident: CR34
– volume: 12
  start-page: 1545
  year: 2001
  end-page: 1551
  ident: CR87
  article-title: Weekly paclitaxel as first-line chemotherapy and trastuzumab in patients with advanced breast cancer. A Hellenic Cooperative Oncology Group phase II study
  publication-title: Ann Oncol
  doi: 10.1023/A:1013184301155
– volume: 389
  start-page: 634
  year: 2009
  end-page: 639
  ident: CR32
  article-title: Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.09.041
– volume: 177
  start-page: 2310
  year: 2010
  end-page: 2322
  ident: CR38
  article-title: IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2010.100371
– volume: 25
  start-page: 1511
  year: 1965
  end-page: 1515
  ident: CR60
  article-title: The nature and control of infections in patients with acute leukemia
  publication-title: Cancer Res
– volume: 53
  start-page: 360
  year: 2007
  end-page: 369
  ident: CR27
  article-title: Establishment of a single-dose irinotecan model of gastrointestinal mucositis
  publication-title: Chemotherapy
  doi: 10.1159/000107458
– volume: 103
  start-page: 191
  issue: 1
  year: 2005
  end-page: 9
  ident: CR104
  article-title: Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests
  publication-title: Cancer
– volume: 54
  start-page: 463
  year: 2012
  end-page: 470
  ident: CR36
  article-title: Methotrexate modulates tight junctions through NFkB, MEK, and JNK pathways
  publication-title: J Pediatric Gastroenterol Nutr
  doi: 10.1097/MPG.0b013e318247240d
– volume: 62
  start-page: 1085
  year: 2008
  ident: 1900_CR89
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-008-0709-7
– volume: 4
  start-page: 953
  year: 1993
  ident: 1900_CR33
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.4.9.953
– volume: 112
  start-page: 284
  year: 2008
  ident: 1900_CR5
  publication-title: Cancer
  doi: 10.1002/cncr.23182
– volume: 27
  start-page: 173
  year: 2008
  ident: 1900_CR86
  publication-title: Investig New Drugs
  doi: 10.1007/s10637-008-9152-1
– volume: 22
  start-page: 91
  year: 2012
  ident: 1900_CR96
  publication-title: Sem Radiat Oncol
  doi: 10.1016/j.semradonc.2011.12.007
– volume: 18
  start-page: 941
  year: 2006
  ident: 1900_CR55
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxl030
– volume: 54
  start-page: 463
  year: 2012
  ident: 1900_CR36
  publication-title: J Pediatric Gastroenterol Nutr
  doi: 10.1097/MPG.0b013e318247240d
– volume: 62
  start-page: 33
  year: 2008
  ident: 1900_CR43
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-007-0570-0
– volume: 37
  start-page: 56
  year: 2005
  ident: 1900_CR24
  publication-title: Pathology
  doi: 10.1080/00313020400023461
– volume: 74
  start-page: 749
  year: 1992
  ident: 1900_CR26
  publication-title: Oral Surg, Oral Med, Oral Pathol
  doi: 10.1016/0030-4220(92)90402-C
– ident: 1900_CR35
– volume: 13
  start-page: 380
  year: 2002
  ident: 1900_CR44
  publication-title: Crit Rev Oral BiolMed
  doi: 10.1177/154411130201300502
– volume: 10
  start-page: 2851
  year: 2004
  ident: 1900_CR59
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-03-0496
– volume: 55
  start-page: 133
  year: 1974
  ident: 1900_CR61
  publication-title: Post Med
  doi: 10.1080/00325481.1974.11713737
– ident: 1900_CR91
  doi: 10.14694/EdBook_AM.2012.32.46
– volume: 14
  start-page: 516
  year: 2007
  ident: 1900_CR20
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0058-1
– volume: 92
  start-page: 472
  year: 2009
  ident: 1900_CR48
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2009.06.006
– volume: 4
  start-page: 188
  year: 2005
  ident: 1900_CR23
  publication-title: Clin Exp Med
  doi: 10.1007/s10238-004-0055-y
– volume: 19
  start-page: 995
  year: 2011
  ident: 1900_CR70
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-010-0923-9
– volume: 2
  start-page: 39
  year: 2006
  ident: 1900_CR28
  publication-title: Asia Pac J Clin Oncol
  doi: 10.1111/j.1743-7563.2006.00038.x
– volume: 47
  start-page: 632
  year: 2000
  ident: 1900_CR25
  publication-title: Gut
  doi: 10.1136/gut.47.5.632
– ident: 1900_CR66
  doi: 10.1371/journal.ppat.1000879
– volume: 69
  start-page: 437
  year: 1990
  ident: 1900_CR9
  publication-title: Oral Surg, Oral Med, Oral Pathol
  doi: 10.1016/0030-4220(90)90376-4
– volume: 9
  start-page: 98
  year: 2011
  ident: 1900_CR79
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2011.192
– volume: 20
  start-page: 1491
  year: 2002
  ident: 1900_CR94
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.20.6.1491
– volume: 109
  start-page: 820
  year: 2007
  ident: 1900_CR4
  publication-title: Cancer
  doi: 10.1002/cncr.22484
– volume: 177
  start-page: 2310
  year: 2010
  ident: 1900_CR38
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2010.100371
– volume: 63
  start-page: 239
  year: 2009
  ident: 1900_CR11
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-008-0732-8
– volume: 9
  start-page: 10
  year: 2004
  ident: 1900_CR84
  publication-title: Oncologist
  doi: 10.1634/theoncologist.9-suppl_3-10
– volume: 7
  start-page: 1919
  year: 2008
  ident: 1900_CR62
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.7.12.6940
– volume: 47
  start-page: 951
  year: 2011
  ident: 1900_CR102
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2011.07.006
– ident: 1900_CR77
  doi: 10.1007/978-1-60761-644-3_14
– volume: 355
  start-page: 2733
  issue: 26
  year: 2006
  ident: 1900_CR85
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa064320
– volume: 16
  start-page: 1025
  year: 2008
  ident: 1900_CR105
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-007-0379-8
– volume: 19
  start-page: 229
  year: 2003
  ident: 1900_CR41
  publication-title: Shock
  doi: 10.1097/00024382-200303000-00006
– volume: 12
  start-page: 1545
  year: 2001
  ident: 1900_CR87
  publication-title: Ann Oncol
  doi: 10.1023/A:1013184301155
– volume: 47
  start-page: 831
  year: 2011
  ident: 1900_CR31
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2011.06.012
– volume: 35
  start-page: 607
  year: 2003
  ident: 1900_CR103
  publication-title: Dig Liver Dis
  doi: 10.1016/S1590-8658(03)00375-X
– volume: 16
  start-page: 22
  year: 2010
  ident: 1900_CR49
  publication-title: Radiat Oncol
  doi: 10.1186/1748-717X-5-22
– volume: 234
  start-page: 430
  year: 2009
  ident: 1900_CR63
  publication-title: Exp Biol Med
  doi: 10.3181/0810-RM-301
– volume: 198
  start-page: 40
  year: 2010
  ident: 1900_CR100
  publication-title: Cancer CGenet Cytogenet
  doi: 10.1016/j.cancergencyto.2009.12.004
– volume: 5
  start-page: 13
  year: 2007
  ident: 1900_CR6
  publication-title: J Support Oncol
– volume: 16
  start-page: 801
  year: 2010
  ident: 1900_CR101
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2010.01.001
– volume: 92
  start-page: 357
  year: 2011
  ident: 1900_CR18
  publication-title: Int J Exp Pathol
  doi: 10.1111/j.1365-2613.2011.00771.x
– volume: 4
  start-page: 277
  year: 2004
  ident: 1900_CR7
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1318
– volume: 52
  start-page: 834
  year: 2011
  ident: 1900_CR64
  publication-title: J Radiat Res
  doi: 10.1269/jrr.11085
– volume: 90
  start-page: 400
  year: 2009
  ident: 1900_CR3
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2008.09.019
– volume: 10
  start-page: 79
  year: 2009
  ident: 1900_CR16
  publication-title: Curr Drug Metab
  doi: 10.2174/138920009787048419
– volume: 63
  start-page: 1295
  year: 2005
  ident: 1900_CR13
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2005.04.041
– volume: 61
  start-page: 775
  year: 2008
  ident: 1900_CR53
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-007-0534-4
– volume: 293
  start-page: 293
  year: 2001
  ident: 1900_CR10
  publication-title: Science
  doi: 10.1126/science.1060191
– volume: 16
  start-page: e711
  year: 2011
  ident: 1900_CR29
  publication-title: Med Oral Pathol Oral Cir Bucal
  doi: 10.4317/medoral.17057
– volume: 47
  start-page: 2751
  year: 2002
  ident: 1900_CR57
  publication-title: Dig Dis Sci
  doi: 10.1023/A:1021061306913
– volume: 14
  start-page: 381
  year: 2012
  ident: 1900_CR71
  publication-title: Cytotherapy
  doi: 10.3109/14653249.2011.650162
– volume: 73
  start-page: 1187
  year: 2009
  ident: 1900_CR98
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2008.08.073
– volume: 286
  start-page: G367
  year: 2004
  ident: 1900_CR40
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00173.2003
– volume: 389
  start-page: 634
  year: 2009
  ident: 1900_CR32
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.09.041
– ident: 1900_CR92
– volume: 18
  start-page: 25
  year: 1994
  ident: 1900_CR68
  publication-title: Clin Infect Dis
  doi: 10.1093/clinids/18.1.25
– volume: 2
  start-page: 81
  year: 1992
  ident: 1900_CR67
  publication-title: Curr Opin Dent
– volume: 25
  start-page: 3853
  year: 2007
  ident: 1900_CR88
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2007.11.9776
– ident: 1900_CR90
  doi: 10.4161/cbt.21783
– volume: 11
  start-page: 671
  year: 2011
  ident: 1900_CR75
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.11.7.14896
– volume: 53
  start-page: 360
  year: 2007
  ident: 1900_CR27
  publication-title: Chemotherapy
  doi: 10.1159/000107458
– volume: 35
  start-page: s92
  year: 2002
  ident: 1900_CR8
  publication-title: Cell Prolif
  doi: 10.1046/j.1365-2184.35.s1.10.x
– volume: 49
  start-page: 65
  year: 2004
  ident: 1900_CR30
  publication-title: Dig Dis Sci
  doi: 10.1023/B:DDAS.0000011604.45531.2c
– volume: 105
  start-page: 1654
  year: 2011
  ident: 1900_CR97
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2011.442
– volume: 15
  start-page: 483
  year: 2007
  ident: 1900_CR83
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0181-z
– volume: 7
  start-page: 1139
  year: 2008
  ident: 1900_CR51
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.7.7.6207
– volume: 36
  start-page: 1103
  year: 2003
  ident: 1900_CR78
  publication-title: Clin Infect Dis
  doi: 10.1086/374339
– volume: 100
  start-page: 1995
  year: 2004
  ident: 1900_CR2
  publication-title: Cancer
  doi: 10.1002/cncr.20162
– ident: 1900_CR76
  doi: 10.1007/s00520-012-1644-z
– volume: 89
  start-page: 1845
  year: 1997
  ident: 1900_CR21
  publication-title: Blood
  doi: 10.1182/blood.V89.6.1845
– volume: 73
  start-page: 2013
  year: 1994
  ident: 1900_CR22
  publication-title: Cancer
  doi: 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J
– volume: 115
  start-page: 182
  year: 1998
  ident: 1900_CR54
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(98)70381-6
– volume: 99
  start-page: 356
  year: 2011
  ident: 1900_CR95
  publication-title: Radiother Oncol
  doi: 10.1016/j.radonc.2011.05.062
– volume: 235
  start-page: 1244
  year: 2010
  ident: 1900_CR19
  publication-title: Exp Biol Med
  doi: 10.1258/ebm.2010.010082
– volume: 113
  start-page: 210
  year: 2005
  ident: 1900_CR52
  publication-title: Eur J Oral Sci
  doi: 10.1111/j.1600-0722.2005.00216.x
– volume: 66
  start-page: 1031
  year: 2010
  ident: 1900_CR37
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-010-1253-9
– volume: 43
  start-page: 395
  year: 2007
  ident: 1900_CR47
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2006.04.011
– ident: 1900_CR104
  doi: 10.1002/cncr.20733
– volume: 109
  start-page: 554
  year: 2010
  ident: 1900_CR65
  publication-title: Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endodentics
  doi: 10.1016/j.tripleo.2009.11.015
– volume: 25
  start-page: 1269
  year: 2000
  ident: 1900_CR74
  publication-title: Bone Marrow Transplant
  doi: 10.1038/sj.bmt.1702447
– volume: 45
  start-page: 1015
  year: 2009
  ident: 1900_CR72
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2009.08.006
– volume: 98
  start-page: 1531
  year: 2003
  ident: 1900_CR1
  publication-title: Cancer
  doi: 10.1002/cncr.11671
– volume: 90
  start-page: 489
  year: 2009
  ident: 1900_CR15
  publication-title: Int J Exp Pathol
  doi: 10.1111/j.1365-2613.2009.00671.x
– volume: 14
  start-page: 528
  year: 2006
  ident: 1900_CR73
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0066-1
– volume: 101
  start-page: 1676
  issue: 10
  year: 2009
  ident: 1900_CR81
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6605343
– volume: 29
  start-page: 373
  year: 2002
  ident: 1900_CR58
  publication-title: Bone Marrow Transplant
  doi: 10.1038/sj.bmt.1703394
– volume: 82
  start-page: 2275
  year: 1998
  ident: 1900_CR69
  publication-title: Cancer
  doi: 10.1002/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q
– volume: 53
  start-page: 344
  year: 2007
  ident: 1900_CR14
  publication-title: Chemotherapy
  doi: 10.1159/000107724
– volume: 33
  start-page: 448
  year: 2007
  ident: 1900_CR50
  publication-title: Cancer Treat Rev
  doi: 10.1016/j.ctrv.2007.03.001
– volume: 40
  start-page: 170
  year: 2004
  ident: 1900_CR46
  publication-title: Oral Oncol
  doi: 10.1016/S1368-8375(03)00148-9
– volume: 2
  start-page: 21
  year: 2004
  ident: 1900_CR45
  publication-title: J Support Oncol
– volume: 25
  start-page: 1511
  year: 1965
  ident: 1900_CR60
  publication-title: Cancer Res
– volume: 90
  start-page: 40
  issue: 1
  year: 2004
  ident: 1900_CR82
  publication-title: Tumori
  doi: 10.1177/030089160409000110
– ident: 1900_CR93
  doi: 10.1634/theoncologist.3-6-446
– volume: 116
  start-page: 210
  year: 2010
  ident: 1900_CR80
  publication-title: Cancer
  doi: 10.1002/cncr.24696
– volume: 180
  start-page: 5653
  year: 2008
  ident: 1900_CR39
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.8.5653
– volume: 232
  start-page: 96
  year: 2007
  ident: 1900_CR17
  publication-title: Exp Biol Med
– volume: 26
  start-page: 2131
  year: 2008
  ident: 1900_CR99
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2006.10.4182
– volume: 51
  start-page: 336
  year: 2005
  ident: 1900_CR42
  publication-title: Chemotherapy
  doi: 10.1159/000088957
– volume: 36
  start-page: 373
  year: 2000
  ident: 1900_CR12
  publication-title: Oral Oncol
  doi: 10.1016/S1368-8375(00)00012-9
– ident: 1900_CR34
– volume: 14
  start-page: 519
  year: 2006
  ident: 1900_CR56
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-006-0052-7
– reference: 17192538 - N Engl J Med. 2006 Dec 28;355(26):2733-43
– reference: 18612591 - Invest New Drugs. 2009 Apr;27(2):173-8
– reference: 17679724 - J Clin Oncol. 2007 Sep 1;25(25):3853-8
– reference: 19765103 - Int J Exp Pathol. 2009 Oct;90(5):489-99
– reference: 9058703 - Blood. 1997 Mar 15;89(6):1845-53
– reference: 18535404 - Cancer Biol Ther. 2008 Jul;7(7):1139-45
– reference: 18351341 - Cancer Chemother Pharmacol. 2009 Jan;63(2):239-51
– reference: 9610710 - Cancer. 1998 Jun 1;82(11):2275-81
– reference: 21463374 - Int J Exp Pathol. 2011 Oct;92 (5):357-65
– reference: 17624531 - Cancer Chemother Pharmacol. 2008 Apr;61(5):775-84
– reference: 17202590 - Exp Biol Med (Maywood). 2007 Jan;232(1):96-106
– reference: 19576646 - Radiother Oncol. 2009 Sep;92(3):472-6
– reference: 20303053 - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):554-60
– reference: 16775648 - Support Care Cancer. 2006 Jun;14(6):528-32
– reference: 21704413 - Radiother Oncol. 2011 Jun;99(3):356-61
– reference: 11034578 - Gut. 2000 Nov;47(5):632-7
– reference: 15102694 - Clin Cancer Res. 2004 Apr 15;10 (8):2851-9
– reference: 17236223 - Cancer. 2007 Mar 1;109(5):820-31
– reference: 17507164 - Cancer Treat Rev. 2007 Aug;33(5):448-60
– reference: 16099597 - Int J Radiat Oncol Biol Phys. 2005 Dec 1;63(5):1295-303
– reference: 19176868 - Exp Biol Med (Maywood). 2009 Apr;234(4):430-41
– reference: 23142924 - Support Care Cancer. 2013 Jan;21(1):313-26
– reference: 21307648 - Cancer Biol Ther. 2011 Apr 1;11(7):671-7
– reference: 18197435 - Support Care Cancer. 2008 Sep;16(9):1025-33
– reference: 18299612 - J Clin Oncol. 2008 May 1;26(13):2131-8
– reference: 14992437 - Dig Dis Sci. 2004 Jan;49(1):65-72
– reference: 19828360 - Oral Oncol. 2009 Dec;45(12):1015-20
– reference: 12630522 - Shock. 2003 Mar;19(3):229-37
– reference: 15163842 - Oncologist. 2004;9 Suppl 3:10-5
– reference: 12139712 - Cell Prolif. 2002 Aug;35 Suppl 1:93-102
– reference: 1488231 - Oral Surg Oral Med Oral Pathol. 1992 Dec;74(6):749-55
– reference: 20535502 - Support Care Cancer. 2011 Jul;19(7):995-1000
– reference: 15143970 - Tumori. 2004 Jan-Feb;90(1):40-3
– reference: 18365200 - Cancer Chemother Pharmacol. 2008 Nov;62(6):1085-90
– reference: 8156506 - Cancer. 1994 Apr 15;73(8):2013-26
– reference: 11896096 - J Clin Oncol. 2002 Mar 15;20(6):1491-8
– reference: 19765544 - Biochem Biophys Res Commun. 2009 Nov 27;389(4):634-9
– reference: 16583189 - Support Care Cancer. 2006 Jun;14(6):516-8
– reference: 4594534 - Postgrad Med. 1974 Apr;55(4):133-9
– reference: 22104273 - J Radiat Res. 2011;52(6):834-9
– reference: 15750766 - Clin Exp Med. 2005 Mar;4(4):188-95
– reference: 20682600 - Exp Biol Med (Maywood). 2010 Oct;235(10 ):1244-56
– reference: 19844234 - Br J Cancer. 2009 Nov 17;101(10):1676-82
– reference: 20119715 - Cancer Chemother Pharmacol. 2010 Nov;66(6):1031-8
– reference: 14508842 - Cancer. 2003 Oct 1;98(7):1531-9
– reference: 21824803 - Oral Oncol. 2011 Oct;47(10):951-5
– reference: 20303013 - Cancer Genet Cytogenet. 2010 Apr 1;198(1):40-6
– reference: 15573372 - Cancer. 2005 Jan 1;103(1):191-9
– reference: 19862817 - Cancer. 2010 Jan 1;116(1):210-5
– reference: 15953245 - Eur J Oral Sci. 2005 Jun;113(3):210-7
– reference: 16224185 - Chemotherapy. 2005 Oct;51(6):336-8
– reference: 2326035 - Oral Surg Oral Med Oral Pathol. 1990 Apr;69(4):437-43
– reference: 4285787 - Cancer Res. 1965 Oct;25(9):1511-5
– reference: 11919725 - Bone Marrow Transplant. 2002 Mar;29(5):373-7
– reference: 22242829 - Cytotherapy. 2012 Mar;14(3):381-3
– reference: 22182972 - Nat Rev Clin Oncol. 2011 Dec 20;9(2):98-109
– reference: 8054434 - Clin Infect Dis. 1994 Jan;18(1):25-31
– reference: 14766535 - Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G367-76
– reference: 15108222 - Cancer. 2004 May 1;100(9 Suppl):1995-2025
– reference: 14563180 - Dig Liver Dis. 2003 Sep;35(9):607-9
– reference: 20233440 - Radiat Oncol. 2010 Mar 16;5:22
– reference: 12393757 - Crit Rev Oral Biol Med. 2002;13(5):380-9
– reference: 10899677 - Oral Oncol. 2000 Jul;36(4):373-81
– reference: 19149515 - Curr Drug Metab. 2009 Jan;10(1):79-83
– reference: 20523891 - PLoS Pathog. 2010 May 27;6(5):e1000879
– reference: 1392005 - Curr Opin Dent. 1992 Sep;2:81-4
– reference: 16775647 - Support Care Cancer. 2006 Jun;14(6):519-27
– reference: 21196860 - Med Oral Patol Oral Cir Bucal. 2011 Sep 01;16(6):e711-5
– reference: 10871732 - Bone Marrow Transplant. 2000 Jun;25(12):1269-78
– reference: 17703303 - Cancer Chemother Pharmacol. 2008 Jun;62(1):33-41
– reference: 14693241 - Oral Oncol. 2004 Feb;40(2):170-6
– reference: 17103195 - Support Care Cancer. 2007 May;15(5):483-90
– reference: 22385916 - Semin Radiat Oncol. 2012 Apr;22(2):91-9
– reference: 21048223 - Am J Pathol. 2010 Nov;177(5):2310-22
– reference: 18952309 - Radiother Oncol. 2009 Mar;90(3):400-7
– reference: 18041060 - Cancer. 2008 Jan 15;112(2):284-92
– reference: 12715303 - Clin Infect Dis. 2003 May 1;36(9):1103-10
– reference: 10388137 - Oncologist. 1998;3(6):446-451
– reference: 19251090 - Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1187-95
– reference: 22895076 - Cancer Biol Ther. 2012 Nov;13(13):1269-75
– reference: 20074657 - Biol Blood Marrow Transplant. 2010 Jun;16(6):801-8
– reference: 17785971 - Chemotherapy. 2007;53(5):344-55
– reference: 15875735 - Pathology. 2005 Feb;37(1):56-62
– reference: 16979925 - Oral Oncol. 2007 Apr;43(4):395-401
– reference: 15330370 - J Support Oncol. 2004 Jan-Feb;2(1):21-32; discussion 35-6
– reference: 11822753 - Ann Oncol. 2001 Nov;12(11):1545-51
– reference: 21737340 - Oral Oncol. 2011 Sep;47(9):831-9
– reference: 18046994 - J Support Oncol. 2007 Oct;5(9 Suppl 4):13-21
– reference: 22197938 - J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):463-70
– reference: 8257797 - Mol Biol Cell. 1993 Sep;4(9):953-61
– reference: 11452123 - Science. 2001 Jul 13;293(5528):293-7
– reference: 16636014 - Int Immunol. 2006 Jun;18(6):941-9
– reference: 9649475 - Gastroenterology. 1998 Jul;115(1):182-205
– reference: 17713326 - Chemotherapy. 2007;53(5):360-9
– reference: 15057287 - Nat Rev Cancer. 2004 Apr;4(4):277-84
– reference: 12498296 - Dig Dis Sci. 2002 Dec;47(12):2751-7
– reference: 22045187 - Br J Cancer. 2011 Nov 22;105(11):1654-62
– reference: 18927500 - Cancer Biol Ther. 2008 Dec;7(12 ):1919-25
– reference: 24451793 - Am Soc Clin Oncol Educ Book. 2012;:545-51
– reference: 18390750 - J Immunol. 2008 Apr 15;180(8):5653-61
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Snippet Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The...
Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal...
Background Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The...
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SubjectTerms Antineoplastic Agents - adverse effects
Biology
Cancer therapies
Chemoradiotherapy - adverse effects
Evidence-Based Medicine
Head and Neck Neoplasms - complications
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - therapy
Humans
Medicine
Medicine & Public Health
Mucous membrane
Nursing
Nursing Research
Oncology
Pain Medicine
Pathology
Pharmacogenetics
Rehabilitation Medicine
Review Article
Stomatitis - chemically induced
Stomatitis - genetics
Stomatitis - microbiology
Toxicity
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Title Emerging evidence on the pathobiology of mucositis
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