Cortical microstructural changes along the Alzheimer's disease continuum
Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T mag...
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| Published in | Alzheimer's & dementia Vol. 14; no. 3; pp. 340 - 351 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1552-5260 1552-5279 1552-5279 |
| DOI | 10.1016/j.jalz.2017.09.013 |
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| Abstract | Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).
We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.
Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.
These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification. |
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| AbstractList | Introduction
Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).
Methods
We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.
Results
Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.
Discussion
These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification. Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification. Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).INTRODUCTIONCortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.METHODSWe included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.RESULTSMicrostructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.DISCUSSIONThese results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification. |
| Author | García-Sebastian, Maite Ecay-Torres, Mirian Carmona-Iragui, María Izagirre, Andrea Alcolea, Daniel Sala, Isabel Fortea, Juan Morenas-Rodríguez, Estrella Pozueta, Ana Vilaplana, Eduard Clarimón, Jordi Illán-Gala, Ignacio Lleó, Alberto Estanga, Ainara Blesa, Rafael Villanúa, Jorge Pasternak, Ofer Martínez-Lage, Pablo Martínez-Heras, Eloy Montal, Victor Sánchez-Saudinós, María-Belén Sanchez-Juan, Pascual González, Andrea Llufriu, Sara Ribosa-Nogué, Roser Pegueroles, Jordi Clerigue, Montserrat Tainta, Mikel Iriondo, Ane González-Ortiz, Sofia |
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Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 5 givenname: Ofer surname: Pasternak fullname: Pasternak, Ofer organization: Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – sequence: 6 givenname: Sofia surname: González-Ortiz fullname: González-Ortiz, Sofia organization: Department of Radiology, Hospital del Mar, Barcelona, Spain – sequence: 7 givenname: Jordi surname: Clarimón fullname: Clarimón, Jordi organization: Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 8 givenname: María surname: Carmona-Iragui fullname: Carmona-Iragui, María organization: Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 9 givenname: Ignacio surname: Illán-Gala fullname: Illán-Gala, 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Estanga fullname: Estanga, Ainara organization: Center for Research and Advanced Therapies and Memory Clinic, Fundacion CITA-Alzheimer Fundazioa, Donostia/San Sebastian, Spain – sequence: 18 givenname: Mirian surname: Ecay-Torres fullname: Ecay-Torres, Mirian organization: Center for Research and Advanced Therapies and Memory Clinic, Fundacion CITA-Alzheimer Fundazioa, Donostia/San Sebastian, Spain – sequence: 19 givenname: Ane surname: Iriondo fullname: Iriondo, Ane organization: Center for Research and Advanced Therapies and Memory Clinic, Fundacion CITA-Alzheimer Fundazioa, Donostia/San Sebastian, Spain – sequence: 20 givenname: Montserrat surname: Clerigue fullname: Clerigue, Montserrat organization: Center for Research and Advanced Therapies and Memory Clinic, Fundacion CITA-Alzheimer Fundazioa, Donostia/San Sebastian, Spain – sequence: 21 givenname: Mikel surname: Tainta fullname: Tainta, Mikel organization: Center for Research and Advanced Therapies and Memory Clinic, Fundacion CITA-Alzheimer Fundazioa, Donostia/San Sebastian, Spain – sequence: 22 givenname: Ana surname: Pozueta fullname: Pozueta, Ana organization: Servicio de Neurología, Hospital Universitario Marqués de Valdecilla, Santander, Spain – sequence: 23 givenname: Andrea surname: González fullname: González, Andrea organization: Servicio de Neurología, Hospital Universitario Marqués de Valdecilla, Santander, Spain – sequence: 24 givenname: Eloy surname: Martínez-Heras fullname: Martínez-Heras, Eloy organization: Center for Neuroimmunology, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain – sequence: 25 givenname: Sara surname: Llufriu fullname: Llufriu, Sara organization: Center for Neuroimmunology, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain – sequence: 26 givenname: Rafael surname: Blesa fullname: Blesa, Rafael organization: Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 27 givenname: Pascual surname: Sanchez-Juan fullname: Sanchez-Juan, Pascual organization: Servicio de Neurología, Hospital Universitario Marqués de Valdecilla, Santander, Spain – sequence: 28 givenname: Pablo surname: Martínez-Lage fullname: Martínez-Lage, Pablo organization: Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Spain – sequence: 29 givenname: Alberto surname: Lleó fullname: Lleó, Alberto organization: Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 30 givenname: Juan surname: Fortea fullname: Fortea, Juan email: jfortea@santpau.cat organization: Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29080407$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuroimage.2005.02.013 10.1016/S1474-4422(15)70016-5 10.1136/jnnp.2009.189639 10.1159/000173710 10.1073/pnas.200033797 10.1111/j.1460-9568.2004.03534.x 10.3348/kjr.2015.16.2.410 10.1212/WNL.0000000000001859 10.1371/journal.pone.0173982 10.3389/fnagi.2014.00106 10.1007/s00429-010-0271-z 10.1016/j.neuroimage.2017.08.047 10.1093/cercor/bhn113 10.1016/j.jalz.2011.11.004 10.1016/j.jalz.2011.03.004 10.3233/JAD-2010-100678 10.1371/journal.pone.0037720 10.1093/brain/awv404 10.1093/brain/awm102 10.1016/j.jalz.2014.04.518 10.1016/j.neurobiolaging.2015.08.007 10.1016/S1474-4422(13)70044-9 10.1016/j.neuroscience.2014.02.017 10.1186/s13195-015-0132-3 10.1001/archneurol.2011.3354 10.1016/j.neurobiolaging.2013.09.028 10.1093/brain/awt065 10.1016/j.biopsych.2011.02.017 10.1002/ana.24186 10.1016/j.neurobiolaging.2015.03.001 10.1016/j.neuroimage.2008.07.064 10.1038/mp.2016.37 10.1016/j.jalz.2011.03.003 10.1001/jamaneurol.2013.1062 10.1002/ana.21955 10.1016/j.pscychresns.2011.05.012 10.3389/fnint.2013.00005 10.1002/(SICI)1098-1136(199910)28:1<40::AID-GLIA5>3.0.CO;2-6 10.3233/JAD-161146 10.1002/mrm.22055 10.3389/fnins.2015.00236 10.1016/j.jalz.2016.08.010 10.1016/j.nicl.2014.02.001 10.1001/jamaneurol.2016.2078 10.1093/brain/awq187 10.1016/j.neuroimage.2005.06.029 10.1001/jamaneurol.2015.1099 10.1002/hbm.22368 10.1038/mp.2017.43 10.1002/ana.22509 |
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| Copyright | 2017 the Alzheimer's Association 2018 The Alzheimer's Association Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. |
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| Keywords | MRI CSF Biomarkers Tau Alzheimer's disease continuum Cortical microstructure Amyloid |
| Language | English |
| License | Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. |
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| MergedId | FETCHMERGED-LOGICAL-c4803-7837c480016ec7ee3523bd3b6f1abf89cc8fc7ab61c73e389ed8cef74b4c14dd3 |
| Notes | These authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 29080407 |
| PQID | 1957492286 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_1957492286 pubmed_primary_29080407 crossref_citationtrail_10_1016_j_jalz_2017_09_013 crossref_primary_10_1016_j_jalz_2017_09_013 wiley_primary_10_1016_j_jalz_2017_09_013_ALZJJALZ201709013 elsevier_sciencedirect_doi_10_1016_j_jalz_2017_09_013 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | March 2018 |
| PublicationDateYYYYMMDD | 2018-03-01 |
| PublicationDate_xml | – month: 03 year: 2018 text: March 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Alzheimer's & dementia |
| PublicationTitleAlternate | Alzheimers Dement |
| PublicationYear | 2018 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Amlien, Fjell (bib13) 2014; 276 Johnson, Christian, Okonkwo, Oh, Harding, Xu (bib7) 2014; 35 Fletcher, Carmichael, Pasternak, Maier-Hein, DeCarli (bib20) 2014; 6 Pegueroles, Vilaplana, Montal, Sampedro, Alcolea, Carmona-iragui (bib11) 2017; 13 Fischl, Dale (bib25) 2000; 97 Beer, Plank, Meyer, Greenlee (bib28) 2013; 7 Araque Caballero, Brendel, Delker, Ren, Rominger, Bartenstein (bib34) 2015; 36 Scola, Bozzali, Agosta, Magnani, Franceschi, Sormani (bib42) 2010; 81 Jones, Symms, Cercignani, Howard (bib30) 2005; 26 Desikan, McEvoy, Thompson, Holland, Roddey, Blennow (bib38) 2011; 70 Weston, Simpson, Ryan, Ourselin, Fox (bib12) 2015; 7 Ryan, Keihaninejad, Shakespeare, Lehmann, Crutch, Malone (bib14) 2013; 136 Bendlin, Carlsson, Johnson, Zetterberg, Blennow, Willette (bib49) 2012; 7 Fortin, Parker, Tunç, Watanabe, Elliott, Ruparel (bib31) 2017; 161 Dickerson, Bakkour, Salat, Feczko, Pacheco, Greve (bib32) 2009; 19 Alcolea, Martínez-Lage, Sánchez-Juan, Olazarán, Antúnez, Izagirre (bib21) 2015; 85 Wang, Benzinger, Su, Christensen, Friedrichsen, Aldea (bib3) 2016; 73 Quiroz, Schultz, Chen, Protas, Brickhouse, Fleisher (bib10) 2015; 72 Lyall, Pasternak, Robinson, Newell, Trampush, Gallego (bib17) 2017 Wu, Lu, Lowes, Yang, Passarotti, Zhou (bib27) 2014; 35 Villemagne, Burnham, Bourgeat, Brown, Ellis, Salvado (bib2) 2013; 12 Heneka, Carson, El Khoury, Landreth, Brosseron, Feinstein (bib45) 2015; 14 Rodriguez-Vieitez, Saint-Aubert, Carter, Almkvist, Farid, Schöll (bib44) 2016; 139 Alcolea, Vilaplana, Pegueroles, Montal, Sánchez-Juan, González-Suárez (bib23) 2015; 36 Roitbak, Syková (bib46) 1999; 28 Maier-Hein, Westin, Shenton, Weiner, Raj, Thomann (bib18) 2015; 11 Müller, Greverus, Dellani, Weibrich, Wille, Scheurich (bib40) 2005; 28 Fortea, Sala-Llonch, Bartrés-Faz, Lladó, Solé-Padullés, Bosch (bib9) 2011; 70 Fortea, Sala-Llonch, Bartrés-Faz, Bosch, Lladó, Bargalló (bib8) 2010; 22 Ringman, O'Neill, Geschwind, Medina, Apostolova, Rodriguez (bib43) 2007; 130 Fortea, Vilaplana, Alcolea, Carmona-Iragui, Sánchez-Saudinos, Sala (bib4) 2014; 76 Koo, Hua, Choi, Ronen, Lee, Kim (bib29) 2009; 44 Mueggler, Meyer-Luehmann, Rausch, Staufenbiel, Jucker, Rudin (bib47) 2004; 20 Pasternak, Sochen, Gur, Intrator, Assaf (bib16) 2009; 62 Teipel, Reuter, Stieltjes, Acosta-Cabronero, Ernemann, Fellgiebel (bib51) 2011; 194 Doré, Villemagne, Bourgeat, Fripp, Acosta, Chetélat (bib36) 2013; 70 Jacobs, van Boxtel, Gronenschild, Uylings, Jolles, Verhey (bib41) 2013; 9 Chételat, Villemagne, Bourgeat, Pike, Jones, Ames (bib6) 2010; 67 Hoy, Ly, Carlsson, Okonkwo, Zetterberg, Blennow (bib19) 2017; 12 Racine, Adluru, Alexander, Christian, Okonkwo, Oh (bib15) 2014; 4 Chételat, Villemagne, Pike, Baron, Bourgeat, Jones (bib33) 2010; 133 Thiessen, Glazner, Nafez, Schellenberg, Buist, Martin (bib48) 2010; 215 Sala, Belén Sánchez-Saudinós, Molina-Porcel, Lázaro, Gich, Clarimón (bib24) 2008; 26 Kwon, Park, Seo, Na, Lee (bib26) 2015; 9 Mattsson, Insel, Nosheny, Tosun, Trojanowski, Shaw (bib35) 2014; 94121 Pascoal, Mathotaarachchi, Mohades, Benedet, Chung, Shin (bib5) 2017; 22 Sperling, Aisen, Beckett, Bennett, Craft, Fagan (bib1) 2011; 7 Yao, Yu, Liang, Xia, Huang, Zhuang (bib50) 2015; 16 Sala-Llonch, Idland, Borza, Watne, Wyller, Brækhus (bib37) 2017; 58 Desikan, McEvoy, Thompson, Holland, Brewer, Aisen (bib39) 2012; 69 Jack, Albert, Knopman, McKhann, Sperling, Carrillo (bib22) 2011; 7 2009; 44 2015; 36 2015; 14 2004; 20 2009; 62 2015; 16 2015; 72 2017; 22 1999; 28 2015; 11 2016; 73 2013; 70 2013; 7 2005; 26 2010; 81 2014; 276 2015; 9 2005; 28 2011; 194 2015; 7 2011; 7 2013; 9 2010; 67 2010; 22 2014; 94121 2014; 4 2017; 58 2010; 215 2013; 12 2011; 70 2015; 85 2017; 13 2007; 130 2017; 12 2000; 97 2008; 26 2010; 133 2013; 136 2014; 35 2017 2017; 161 2016; 139 2012; 69 2009; 19 2012; 7 2014; 6 2014; 76 e_1_2_7_5_2 e_1_2_7_3_2 e_1_2_7_9_2 e_1_2_7_7_2 e_1_2_7_19_2 e_1_2_7_17_2 e_1_2_7_15_2 e_1_2_7_13_2 e_1_2_7_41_2 e_1_2_7_43_2 e_1_2_7_47_2 e_1_2_7_49_2 e_1_2_7_28_2 e_1_2_7_50_2 e_1_2_7_25_2 e_1_2_7_52_2 Fischl B (e_1_2_7_26_2) 2000; 97 e_1_2_7_23_2 e_1_2_7_31_2 e_1_2_7_33_2 e_1_2_7_35_2 e_1_2_7_37_2 e_1_2_7_39_2 e_1_2_7_4_2 e_1_2_7_2_2 e_1_2_7_8_2 e_1_2_7_6_2 Rodriguez‐Vieitez E (e_1_2_7_45_2) 2016; 139 e_1_2_7_18_2 e_1_2_7_16_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_12_2 e_1_2_7_42_2 e_1_2_7_10_2 e_1_2_7_44_2 e_1_2_7_46_2 e_1_2_7_48_2 Mattsson N (e_1_2_7_36_2) 2014; 94121 e_1_2_7_29_2 Yao X (e_1_2_7_51_2) 2015; 16 Quiroz YT (e_1_2_7_11_2) 2015; 72 Fletcher E (e_1_2_7_21_2) 2014; 6 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_22_2 e_1_2_7_32_2 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_38_2 Kwon O (e_1_2_7_27_2) 2015; 9 |
| References_xml | – volume: 22 start-page: 306 year: 2017 end-page: 311 ident: bib5 article-title: Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease publication-title: Mol Psychiatry – volume: 70 start-page: 903 year: 2013 end-page: 911 ident: bib36 article-title: Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease publication-title: JAMA Neurol – volume: 7 start-page: 47 year: 2015 ident: bib12 article-title: Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration publication-title: Alzheimers Res Ther – volume: 36 start-page: 2913 year: 2015 end-page: 2924 ident: bib34 article-title: Mapping 3-year changes in gray matter and metabolism in Aβ-positive nondemented subjects publication-title: Neurobiol Aging – volume: 139 start-page: 922 year: 2016 end-page: 936 ident: bib44 article-title: Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease publication-title: Brain – volume: 215 start-page: 29 year: 2010 end-page: 36 ident: bib48 article-title: Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's disease publication-title: Brain Struct Funct – volume: 58 start-page: 829 year: 2017 end-page: 840 ident: bib37 article-title: Inflammation, amyloid and atrophy in the aging brain: relationships with longitudinal changes in cognition publication-title: J Alzheimers Dis – volume: 6 start-page: 1 year: 2014 end-page: 9 ident: bib20 article-title: Early brain loss in circuits affected by Alzheimer's disease is predicted by fornix microstructure but may be independent of gray matter publication-title: Front Aging Neurosci – volume: 35 start-page: 2806 year: 2014 end-page: 2816 ident: bib27 article-title: Development of superficial white matter and its structural interplay with cortical gray matter in children and adolescents publication-title: Hum Brain Mapp – volume: 9 start-page: 93 year: 2013 end-page: 97 ident: bib41 article-title: Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? publication-title: Alzheimers Dement – volume: 35 start-page: 576 year: 2014 end-page: 584 ident: bib7 article-title: Amyloid burden and neural function in people at risk for Alzheimer's Disease publication-title: Neurobiol Aging – volume: 70 start-page: 183 year: 2011 end-page: 190 ident: bib9 article-title: Cognitively preserved subjects with transitional cerebrospinal fluid ß-amyloid 1-42 values have thicker cortex in Alzheimer disease vulnerable areas publication-title: Biol Psychiatry – volume: 62 start-page: 717 year: 2009 end-page: 730 ident: bib16 article-title: Free water elimination and mapping from diffusion MRI publication-title: Magn Reson Med – volume: 19 start-page: 497 year: 2009 end-page: 510 ident: bib32 article-title: The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals publication-title: Cereb Cortex – volume: 85 start-page: 626 year: 2015 end-page: 633 ident: bib21 article-title: Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease publication-title: Neurology – volume: 26 start-page: 506 year: 2008 end-page: 512 ident: bib24 article-title: Homocysteine and cognitive impairment. Relation with diagnosis and neuropsychological performance publication-title: Dement Geriatr Cogn Disord – volume: 76 start-page: 223 year: 2014 end-page: 230 ident: bib4 article-title: Cerebrospinal fluid ß-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease publication-title: Ann Neurol – volume: 9 start-page: 1 year: 2015 end-page: 11 ident: bib26 article-title: A framework to analyze cerebral mean diffusivity using surface guided diffusion mapping in diffusion tensor imaging publication-title: Front Neurosci – volume: 16 start-page: 410 year: 2015 end-page: 418 ident: bib50 article-title: Effect of increasing diffusion gradient direction number on diffusion tensor imaging fiber tracking in the human brain publication-title: Korean J Radiol – volume: 22 start-page: 909 year: 2010 end-page: 922 ident: bib8 article-title: Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers publication-title: J Alzheimers Dis – volume: 13 start-page: 499 year: 2017 end-page: 509 ident: bib11 article-title: Longitudinal brain structural changes in preclinical Alzheimer disease publication-title: Alzheimers Dement – volume: 136 start-page: 1399 year: 2013 end-page: 1414 ident: bib14 article-title: Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease publication-title: Brain – volume: 97 start-page: 11050 year: 2000 end-page: 11055 ident: bib25 article-title: Measuring the thickness of the human cerebral cortex from magnetic resonance images publication-title: Proc Natl Acad Sci U S A – volume: 7 start-page: 280 year: 2011 end-page: 292 ident: bib1 article-title: Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement – volume: 7 start-page: 257 year: 2011 end-page: 262 ident: bib22 article-title: Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement – year: 2017 ident: bib17 article-title: Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning publication-title: Mol Psychiatry – volume: 36 start-page: 2018 year: 2015 end-page: 2023 ident: bib23 article-title: Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease publication-title: Neurobiol Aging – volume: 69 start-page: 709 year: 2012 end-page: 713 ident: bib39 article-title: Amyloid-β–associated clinical decline occurs only in the presence of elevated P-tau publication-title: Arch Neurol – volume: 4 start-page: 604 year: 2014 end-page: 614 ident: bib15 article-title: Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: a multimodal imaging investigation publication-title: Neuroimage Clin – volume: 28 start-page: 1033 year: 2005 end-page: 1042 ident: bib40 article-title: Functional implications of hippocampal volume and diffusivity in mild cognitive impairment publication-title: Neuroimage – volume: 14 start-page: 388 year: 2015 end-page: 405 ident: bib45 article-title: Neuroinflammation in Alzheimer's disease publication-title: Lancet Neurol – volume: 28 start-page: 40 year: 1999 end-page: 48 ident: bib46 article-title: Diffusion barriers evoked in the rat cortex by reactive astrogliosis publication-title: Glia – volume: 130 start-page: 1767 year: 2007 end-page: 1776 ident: bib43 article-title: Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations publication-title: Brain – volume: 194 start-page: 363 year: 2011 end-page: 371 ident: bib51 article-title: Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study publication-title: Psychiatry Res – volume: 70 start-page: 657 year: 2011 end-page: 661 ident: bib38 article-title: Amyloid-β associated volume loss occurs only in the presence of phospho-tau publication-title: Ann Neurol – volume: 73 start-page: 1070 year: 2016 end-page: 1077 ident: bib3 article-title: Evaluation of tau imaging in staging Alzheimer disease and revealing interactions between β-amyloid and tauopathy publication-title: JAMA Neurol – volume: 72 start-page: 912 year: 2015 end-page: 919 ident: bib10 article-title: Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease: a cross-sectional study publication-title: JAMA Neurol – volume: 7 start-page: 5 year: 2013 ident: bib28 article-title: Combined diffusion-weighted and functional magnetic resonance imaging reveals a temporal-occipital network involved in auditory-visual object processing publication-title: Front Integr Neurosci – volume: 44 start-page: 136 year: 2009 end-page: 144 ident: bib29 article-title: A framework to analyze partial volume effect on gray matter mean diffusivity measurements publication-title: Neuroimage – volume: 7 start-page: e37720 year: 2012 ident: bib49 article-title: CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease publication-title: PLoS One – volume: 133 start-page: 3349 year: 2010 end-page: 3358 ident: bib33 article-title: Larger temporal volume in elderly with high versus low beta-amyloid deposition publication-title: Brain – volume: 26 start-page: 546 year: 2005 end-page: 554 ident: bib30 article-title: The effect of filter size on VBM analyses of DT-MRI data publication-title: Neuroimage – volume: 94121 start-page: 1 year: 2014 end-page: 10 ident: bib35 article-title: Emerging β-amyloid pathology and accelerated cortical atrophy publication-title: JAMA Neurol – volume: 20 start-page: 811 year: 2004 end-page: 817 ident: bib47 article-title: Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis publication-title: Eur J Neurosci – volume: 161 start-page: 149 year: 2017 end-page: 170 ident: bib31 article-title: Harmonization of multi-site diffusion tensor imaging data publication-title: Neuroimage – volume: 12 start-page: 357 year: 2013 end-page: 367 ident: bib2 article-title: Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study publication-title: Lancet Neurol – volume: 276 start-page: 206 year: 2014 end-page: 215 ident: bib13 article-title: Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment publication-title: Neuroscience – volume: 12 start-page: 1 year: 2017 end-page: 21 ident: bib19 article-title: Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging publication-title: PLoS One – volume: 67 start-page: 317 year: 2010 end-page: 324 ident: bib6 article-title: Relationship between atrophy and beta-amyloid deposition in Alzheimer disease publication-title: Ann Neurol – volume: 11 start-page: 485 year: 2015 end-page: 493 ident: bib18 article-title: Widespread white matter degeneration preceding the onset of dementia publication-title: Alzheimers Dement – volume: 81 start-page: 798 year: 2010 end-page: 805 ident: bib42 article-title: A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up publication-title: J Neurol Neurosurg Psychiatry – volume: 70 start-page: 657 year: 2011 end-page: 661 article-title: Amyloid‐β associated volume loss occurs only in the presence of phospho‐tau publication-title: Ann Neurol – volume: 22 start-page: 306 year: 2017 end-page: 311 article-title: Amyloid‐β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease publication-title: Mol Psychiatry – volume: 62 start-page: 717 year: 2009 end-page: 730 article-title: Free water elimination and mapping from diffusion MRI publication-title: Magn Reson Med – volume: 12 start-page: 357 year: 2013 end-page: 367 article-title: Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study publication-title: Lancet Neurol – volume: 73 start-page: 1070 year: 2016 end-page: 1077 article-title: Evaluation of tau imaging in staging Alzheimer disease and revealing interactions between β‐amyloid and tauopathy publication-title: JAMA Neurol – volume: 26 start-page: 546 year: 2005 end-page: 554 article-title: The effect of filter size on VBM analyses of DT‐MRI data publication-title: Neuroimage – volume: 70 start-page: 903 year: 2013 end-page: 911 article-title: Cross‐sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease publication-title: JAMA Neurol – volume: 67 start-page: 317 year: 2010 end-page: 324 article-title: Relationship between atrophy and beta‐amyloid deposition in Alzheimer disease publication-title: Ann Neurol – volume: 133 start-page: 3349 year: 2010 end-page: 3358 article-title: Larger temporal volume in elderly with high versus low beta‐amyloid deposition publication-title: Brain – volume: 81 start-page: 798 year: 2010 end-page: 805 article-title: A diffusion tensor MRI study of patients with MCI and AD with a 2‐year clinical follow‐up publication-title: J Neurol Neurosurg Psychiatry – volume: 69 start-page: 709 year: 2012 end-page: 713 article-title: Amyloid‐β–associated clinical decline occurs only in the presence of elevated P‐tau publication-title: Arch Neurol – volume: 9 start-page: 93 year: 2013 end-page: 97 article-title: Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? publication-title: Alzheimers Dement – volume: 139 start-page: 922 issue: (Pt. 3) year: 2016 end-page: 936 article-title: Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease publication-title: Brain – volume: 20 start-page: 811 year: 2004 end-page: 817 article-title: Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis publication-title: Eur J Neurosci – volume: 13 start-page: 499 year: 2017 end-page: 509 article-title: Longitudinal brain structural changes in preclinical Alzheimer disease publication-title: Alzheimers Dement – volume: 44 start-page: 136 year: 2009 end-page: 144 article-title: A framework to analyze partial volume effect on gray matter mean diffusivity measurements publication-title: Neuroimage – volume: 11 start-page: 485 year: 2015 end-page: 493 article-title: Widespread white matter degeneration preceding the onset of dementia publication-title: Alzheimers Dement – volume: 7 start-page: 5 year: 2013 article-title: Combined diffusion‐weighted and functional magnetic resonance imaging reveals a temporal‐occipital network involved in auditory‐visual object processing publication-title: Front Integr Neurosci – volume: 215 start-page: 29 year: 2010 end-page: 36 article-title: Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's disease publication-title: Brain Struct Funct – volume: 58 start-page: 829 year: 2017 end-page: 840 article-title: Inflammation, amyloid and atrophy in the aging brain: relationships with longitudinal changes in cognition publication-title: J Alzheimers Dis – volume: 22 start-page: 909 year: 2010 end-page: 922 article-title: Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers publication-title: J Alzheimers Dis – year: 2017 article-title: Greater extracellular free‐water in first‐episode psychosis predicts better neurocognitive functioning publication-title: Mol Psychiatry – volume: 35 start-page: 2806 year: 2014 end-page: 2816 article-title: Development of superficial white matter and its structural interplay with cortical gray matter in children and adolescents publication-title: Hum Brain Mapp – volume: 70 start-page: 183 year: 2011 end-page: 190 article-title: Cognitively preserved subjects with transitional cerebrospinal fluid ß‐amyloid 1–42 values have thicker cortex in Alzheimer disease vulnerable areas publication-title: Biol Psychiatry – volume: 7 start-page: 47 year: 2015 article-title: Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration publication-title: Alzheimers Res Ther – volume: 276 start-page: 206 year: 2014 end-page: 215 article-title: Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment publication-title: Neuroscience – volume: 16 start-page: 410 year: 2015 end-page: 418 article-title: Effect of increasing diffusion gradient direction number on diffusion tensor imaging fiber tracking in the human brain publication-title: Korean J Radiol – volume: 9 start-page: 1 year: 2015 end-page: 11 article-title: A framework to analyze cerebral mean diffusivity using surface guided diffusion mapping in diffusion tensor imaging publication-title: Front Neurosci – volume: 7 start-page: 280 year: 2011 end-page: 292 article-title: Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement – volume: 76 start-page: 223 year: 2014 end-page: 230 article-title: Cerebrospinal fluid ß‐amyloid and phospho‐tau biomarker interactions affecting brain structure in preclinical Alzheimer disease publication-title: Ann Neurol – volume: 94121 start-page: 1 year: 2014 end-page: 10 article-title: Emerging β‐amyloid pathology and accelerated cortical atrophy publication-title: JAMA Neurol – volume: 28 start-page: 1033 year: 2005 end-page: 1042 article-title: Functional implications of hippocampal volume and diffusivity in mild cognitive impairment publication-title: Neuroimage – volume: 36 start-page: 2018 year: 2015 end-page: 2023 article-title: Relationship between cortical thickness and cerebrospinal fluid YKL‐40 in predementia stages of Alzheimer's disease publication-title: Neurobiol Aging – volume: 85 start-page: 626 year: 2015 end-page: 633 article-title: Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease publication-title: Neurology – volume: 4 start-page: 604 year: 2014 end-page: 614 article-title: Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: a multimodal imaging investigation publication-title: Neuroimage Clin – volume: 28 start-page: 40 year: 1999 end-page: 48 article-title: Diffusion barriers evoked in the rat cortex by reactive astrogliosis publication-title: Glia – volume: 130 start-page: 1767 year: 2007 end-page: 1776 article-title: Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations publication-title: Brain – volume: 12 start-page: 1 year: 2017 end-page: 21 article-title: Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging publication-title: PLoS One – volume: 72 start-page: 912 year: 2015 end-page: 919 article-title: Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease: a cross‐sectional study publication-title: JAMA Neurol – volume: 161 start-page: 149 year: 2017 end-page: 170 article-title: Harmonization of multi‐site diffusion tensor imaging data publication-title: Neuroimage – volume: 26 start-page: 506 year: 2008 end-page: 512 article-title: Homocysteine and cognitive impairment. Relation with diagnosis and neuropsychological performance publication-title: Dement Geriatr Cogn Disord – volume: 35 start-page: 576 year: 2014 end-page: 584 article-title: Amyloid burden and neural function in people at risk for Alzheimer's Disease publication-title: Neurobiol Aging – volume: 7 start-page: 257 year: 2011 end-page: 262 article-title: Introduction to the recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement – volume: 36 start-page: 2913 year: 2015 end-page: 2924 article-title: Mapping 3‐year changes in gray matter and metabolism in Aβ‐positive nondemented subjects publication-title: Neurobiol Aging – volume: 136 start-page: 1399 year: 2013 end-page: 1414 article-title: Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease publication-title: Brain – volume: 97 year: 2000 article-title: Measuring the thickness of the human cerebral cortex from magnetic resonance images publication-title: Proc Natl Acad Sci U S A – volume: 19 start-page: 497 year: 2009 end-page: 510 article-title: The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid‐positive individuals publication-title: Cereb Cortex – volume: 194 start-page: 363 year: 2011 end-page: 371 article-title: Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study publication-title: Psychiatry Res – volume: 7 year: 2012 article-title: CSF T‐Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease publication-title: PLoS One – volume: 14 start-page: 388 year: 2015 end-page: 405 article-title: Neuroinflammation in Alzheimer's disease publication-title: Lancet Neurol – volume: 6 start-page: 1 year: 2014 end-page: 9 article-title: Early brain loss in circuits affected by Alzheimer's disease is predicted by fornix microstructure but may be independent of gray matter publication-title: Front Aging Neurosci – ident: e_1_2_7_31_2 doi: 10.1016/j.neuroimage.2005.02.013 – ident: e_1_2_7_46_2 doi: 10.1016/S1474-4422(15)70016-5 – ident: e_1_2_7_43_2 doi: 10.1136/jnnp.2009.189639 – ident: e_1_2_7_25_2 doi: 10.1159/000173710 – volume: 97 year: 2000 ident: e_1_2_7_26_2 article-title: Measuring the thickness of the human cerebral cortex from magnetic resonance images publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.200033797 – ident: e_1_2_7_48_2 doi: 10.1111/j.1460-9568.2004.03534.x – volume: 16 start-page: 410 year: 2015 ident: e_1_2_7_51_2 article-title: Effect of increasing diffusion gradient direction number on diffusion tensor imaging fiber tracking in the human brain publication-title: Korean J Radiol doi: 10.3348/kjr.2015.16.2.410 – ident: e_1_2_7_22_2 doi: 10.1212/WNL.0000000000001859 – ident: e_1_2_7_20_2 doi: 10.1371/journal.pone.0173982 – volume: 6 start-page: 1 year: 2014 ident: e_1_2_7_21_2 article-title: Early brain loss in circuits affected by Alzheimer's disease is predicted by fornix microstructure but may be independent of gray matter publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2014.00106 – ident: e_1_2_7_49_2 doi: 10.1007/s00429-010-0271-z – ident: e_1_2_7_32_2 doi: 10.1016/j.neuroimage.2017.08.047 – ident: e_1_2_7_33_2 doi: 10.1093/cercor/bhn113 – ident: e_1_2_7_42_2 doi: 10.1016/j.jalz.2011.11.004 – ident: e_1_2_7_23_2 doi: 10.1016/j.jalz.2011.03.004 – ident: e_1_2_7_9_2 doi: 10.3233/JAD-2010-100678 – ident: e_1_2_7_50_2 doi: 10.1371/journal.pone.0037720 – volume: 139 start-page: 922 issue: 3 year: 2016 ident: e_1_2_7_45_2 article-title: Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease publication-title: Brain doi: 10.1093/brain/awv404 – ident: e_1_2_7_44_2 doi: 10.1093/brain/awm102 – ident: e_1_2_7_19_2 doi: 10.1016/j.jalz.2014.04.518 – ident: e_1_2_7_35_2 doi: 10.1016/j.neurobiolaging.2015.08.007 – ident: e_1_2_7_3_2 doi: 10.1016/S1474-4422(13)70044-9 – ident: e_1_2_7_14_2 doi: 10.1016/j.neuroscience.2014.02.017 – volume: 94121 start-page: 1 year: 2014 ident: e_1_2_7_36_2 article-title: Emerging β‐amyloid pathology and accelerated cortical atrophy publication-title: JAMA Neurol – ident: e_1_2_7_13_2 doi: 10.1186/s13195-015-0132-3 – ident: e_1_2_7_40_2 doi: 10.1001/archneurol.2011.3354 – ident: e_1_2_7_8_2 doi: 10.1016/j.neurobiolaging.2013.09.028 – ident: e_1_2_7_15_2 doi: 10.1093/brain/awt065 – ident: e_1_2_7_10_2 doi: 10.1016/j.biopsych.2011.02.017 – ident: e_1_2_7_5_2 doi: 10.1002/ana.24186 – ident: e_1_2_7_24_2 doi: 10.1016/j.neurobiolaging.2015.03.001 – ident: e_1_2_7_30_2 doi: 10.1016/j.neuroimage.2008.07.064 – ident: e_1_2_7_6_2 doi: 10.1038/mp.2016.37 – ident: e_1_2_7_2_2 doi: 10.1016/j.jalz.2011.03.003 – ident: e_1_2_7_37_2 doi: 10.1001/jamaneurol.2013.1062 – ident: e_1_2_7_7_2 doi: 10.1002/ana.21955 – ident: e_1_2_7_52_2 doi: 10.1016/j.pscychresns.2011.05.012 – ident: e_1_2_7_29_2 doi: 10.3389/fnint.2013.00005 – ident: e_1_2_7_47_2 doi: 10.1002/(SICI)1098-1136(199910)28:1<40::AID-GLIA5>3.0.CO;2-6 – ident: e_1_2_7_38_2 doi: 10.3233/JAD-161146 – ident: e_1_2_7_17_2 doi: 10.1002/mrm.22055 – volume: 9 start-page: 1 year: 2015 ident: e_1_2_7_27_2 article-title: A framework to analyze cerebral mean diffusivity using surface guided diffusion mapping in diffusion tensor imaging publication-title: Front Neurosci doi: 10.3389/fnins.2015.00236 – ident: e_1_2_7_12_2 doi: 10.1016/j.jalz.2016.08.010 – ident: e_1_2_7_16_2 doi: 10.1016/j.nicl.2014.02.001 – ident: e_1_2_7_4_2 doi: 10.1001/jamaneurol.2016.2078 – ident: e_1_2_7_34_2 doi: 10.1093/brain/awq187 – ident: e_1_2_7_41_2 doi: 10.1016/j.neuroimage.2005.06.029 – volume: 72 start-page: 912 year: 2015 ident: e_1_2_7_11_2 article-title: Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease: a cross‐sectional study publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2015.1099 – ident: e_1_2_7_28_2 doi: 10.1002/hbm.22368 – ident: e_1_2_7_18_2 doi: 10.1038/mp.2017.43 – ident: e_1_2_7_39_2 doi: 10.1002/ana.22509 |
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| Snippet | Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).
We included healthy control subjects... Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included... Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).INTRODUCTIONCortical mean diffusivity... |
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| SubjectTerms | Aged Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer's disease continuum Amyloid Apolipoproteins E - genetics Biomarkers Biomarkers - cerebrospinal fluid Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - genetics Cortical microstructure CSF Disease Progression Female Humans Magnetic Resonance Imaging Male Middle Aged MRI Organ Size Spinal Puncture Tau |
| Title | Cortical microstructural changes along the Alzheimer's disease continuum |
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