CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells - Liu, S. John; Horlbeck, Max A.; Cho, Seung Woo; Birk, Harjus S.; Malatesta, Martina; He, Daniel; Attenello, Frank J.; Villalta, Jacqueline E.; Cho, Min Y.; Chen, Yuwen; Mandegar, Mohammad A.; Olvera, Michael P.; et al. (Science (American Association for the Advancement of Science), 2017)
Keywords: Biology; Biotechnology; Cell growth; Cell Growth Processes - genetics; Cell Line; Cell lines; Chromatin; Clustered Regularly Interspaced Short Palindromic Repeats; Coding; CRISPR; Depletion; Gene expression; Gene Knockdown Techniques; Gene regulation; Gene Regulatory Networks; Genes; Genetic Loci; Genetic Testing; Genome, Human; Genomes; Humans; Induced Pluripotent Stem Cells; Inhibitory postsynaptic potentials; Interference; Libraries; Loci; Machine Learning; Non-coding RNA; Nucleotides; Phenotypes; Pluripotency; Proteins; RESEARCH ARTICLE SUMMARY; Ribonucleic acid; Ribonucleic acids; RNA; RNA Interference; RNA, Long Noncoding - genetics; Robustness; Screening; Screening Tests; Stem cells; Transcription; Transcription, Genetic; Transcriptome; Transcriptomes; Transcripts (Written Records)