15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation - Li, Zhipeng; Zeng, Ming; Deng, Yanhan; Zhao, Jinming; Zhou, Xiuxia; Trudeau, John B.; Goldschmidt, Ezequiel; Moore, John A.; Chu, Hongwei; Zhang, Weitian; Yin, Shankai; Liu, Zheng; et al. (Journal of allergy and clinical immunology, 2019)
Keywords: 15-Lipoxygenase 1; Adult; Antigens; Arachidonate 15-Lipoxygenase - genetics; Arachidonate 15-Lipoxygenase - metabolism; Asthma; Basal cells; Bone; CCL26; Cells, Cultured; Chemokine CCL26 - metabolism; Chronic Disease; chronic rhinosinusitis; Cytokeratin; Enzyme Activation; Enzyme-linked immunosorbent assay; Eosinophilia; Eotaxin; epithelial cell; Epithelial cells; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases - metabolism; Female; Hospitals; Humans; Immunofluorescence; Immunoglobulins; Interleukin 13; Kinases; Lipoxygenase; Male; Methods; Microscopy; Middle Aged; mRNA; nasal polyps; Nasal Polyps - complications; Nasal Polyps - metabolism; Nose; Otolaryngology; Phosphorylation; Polymerase chain reaction; Polyps; Proteins; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Respiratory tract; Rhinitis; Rhinitis - complications; Rhinitis - metabolism; Rhinosinusitis; RNA, Small Interfering - genetics; Sinusitis; Sinusitis - complications; Sinusitis - metabolism; Therapeutic applications; Transfection; Turbinates - metabolism; Up-Regulation; Western blotting; extracellular signal-regulated kinase; NP; DMSO; IHC; ALOX15; HRP; AERD; PEBP1; CRSwNP; WB; epithelial cell; CK5; Ct; SNP; UPMC; nasal polyps; KD; GUSB; 15-HpETE; T2; AA; 15LO1; DsiRNA; MT; qRT-PCR; 15-HETE; IT; NEC; 15-Lipoxygenase 1; IL-4R; PE; HAEC; chronic rhinosinusitis; HC; GAPDH; pERK; ALI; CCL26; ERK; tERK