Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases

Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing num...

Full description

Saved in:
Bibliographic Details
Published inCells (Basel, Switzerland) Vol. 9; no. 12; p. 2605
Main Authors Cisa-Wieczorek, Sabina, Hernández-Alvarez, María Isabel
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.12.2020
MDPI
Subjects
Biosynthesis
Cardiovascular disease
Cholesterol
Diet
dietary lipids
Endoplasmic reticulum
Fatty acids
Glycerol
Homeostasis
Lipid metabolism
Lipids
Mammalian cells
Mammals
Membranes
Metabolic disorders
Metabolism
Milk
Mitochondria
mitofusin-2
Obesity
phospholipids synthesis
Proteins
Review
Sterols
Triglycerides
phospholipids synthesis
metabolism
dietary lipids
mitofusin-2
Online AccessGet full text
ISSN2073-4409
2073-4409
DOI10.3390/cells9122605

Cover

Abstract Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of de novo biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases.
AbstractList Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of de novo biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases.Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of de novo biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases.
Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases.
Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of de novo biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases.
Author Hernández-Alvarez, María Isabel
Cisa-Wieczorek, Sabina
AuthorAffiliation 3 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
1 Laboratory of Hematology, Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, IIB Sant Pau, 08041 Barcelona, Spain; scisa@santpau.cat
2 Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
AuthorAffiliation_xml – name: 1 Laboratory of Hematology, Department of Hematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, IIB Sant Pau, 08041 Barcelona, Spain; scisa@santpau.cat
– name: 2 Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
– name: 3 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
Author_xml – sequence: 1
  givenname: Sabina
  surname: Cisa-Wieczorek
  fullname: Cisa-Wieczorek, Sabina
– sequence: 2
  givenname: María Isabel
  orcidid: 0000-0003-2483-7000
  surname: Hernández-Alvarez
  fullname: Hernández-Alvarez, María Isabel
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33291746$$D View this record in MEDLINE/PubMed
BookMark eNp9kc1v1DAQxS1UREvpjTOKxKVIBPyVOO4BqepSWmkRl3K2HGe89cqJl9gp6n-Ps1uqbSXwxSP7N8_Pb16jgyEMgNBbgj8xJvFnA95HSSitcfUCHVEsWMk5lgd79SE6iXGN82pITXD1Ch0yRiURvD5CNwsYYTV5nVwYimCLpdu4rrgKPYSYdHTxrDgvLvWp-ZAKNxTpFooF3IEPmx6GNHd8h6Tb4J0pFi6CjhDfoJdW-wgnD_sx-nn59ebiqlz--HZ9cb4sDRdNKkHo7FGTFiraWssxMEFk1cmmBUkMybXV3Wxb2CpzDbN1WwMDrLWQkrNjdL3T7YJeq83oej3eq6Cd2h6EcaX0mJzxoEiF27qz0lICvBIgBes63kjTQleBbbJWudOaho2-_629fxQkWM1hq_2wM_9lx2-mtofO5DBG7Z-YeHozuFu1CndKiJpIMQucPgiM4dcEManexfkJPUCYoqK8bmpBaYUz-v4Zug7TOORotxTntRBzGu_2HT1a-TvsDNAdYMYQ4whWGZe2g88Gnf_XPz8-a_pvLH8AErfMRw
CitedBy_id crossref_primary_10_1016_j_bbalip_2021_159021
crossref_primary_10_1016_j_bbalip_2023_159345
crossref_primary_10_3390_biom12101439
crossref_primary_10_1016_j_bbalip_2024_159515
crossref_primary_10_3389_fendo_2022_960551
crossref_primary_10_3390_biomedicines10081943
crossref_primary_10_1016_j_jtemb_2021_126911
crossref_primary_10_1007_s11033_024_09457_x
crossref_primary_10_1016_j_fbio_2024_104193
crossref_primary_10_1021_acs_jafc_4c02692
crossref_primary_10_3390_ijms23063356
crossref_primary_10_1016_j_ijpharm_2022_121823
crossref_primary_10_1186_s12967_023_04088_5
crossref_primary_10_1016_j_ultsonch_2023_106459
crossref_primary_10_1039_D2AY00736C
crossref_primary_10_1002_bies_202300157
crossref_primary_10_3389_fmmed_2021_777088
crossref_primary_10_3390_jcm11216544
crossref_primary_10_1007_s40200_023_01194_5
crossref_primary_10_1016_j_aninu_2023_07_003
crossref_primary_10_1080_1828051X_2022_2116607
Cites_doi 10.3748/wjg.v17.i29.3377
10.1155/2015/130315
10.4254/wjh.v12.i8.436
10.3389/fonc.2013.00224
10.3390/ijms19113285
10.2337/db15-1213
10.3390/nu10060780
10.3390/nu11051067
10.1016/S0021-9258(19)50785-2
10.1038/nrd2589
10.1016/j.tibs.2020.03.010
10.1016/j.tem.2012.06.007
10.1242/jcs.045849
10.1016/j.cmet.2010.04.005
10.1093/jn/137.1.130
10.1016/j.cell.2019.04.010
10.1016/S0163-7827(03)00051-1
10.1016/j.bbalip.2012.09.009
10.1016/0005-2736(89)90181-8
10.18632/oncotarget.8936
10.1186/1476-511X-11-3
10.1073/pnas.1307685110
10.2337/dc06-1332
10.1083/jcb.201305142
10.1016/j.cmet.2011.03.023
10.1186/1743-7075-7-30
10.1080/00365520903114912
10.1038/nature09968
10.1371/journal.pone.0115176
10.1161/01.cir.0000437740.48606.d1
10.1111/j.1468-1331.2009.02737.x
10.1016/j.bbamem.2017.04.015
10.3390/nu7042731
10.1007/s11427-016-0322-x
10.1023/B:BIRY.0000016352.88061.02
10.1038/ejcn.2013.43
10.1083/jcb.200803137
10.1016/S0022-2275(20)34196-1
10.1111/j.1600-0854.2007.00689.x
10.1186/1476-511X-4-30
10.15252/embj.201797006
10.1210/jc.2010-1681
10.4103/0366-6999.147815
10.1186/s13023-017-0646-9
10.1038/nrm3699
10.1038/s41575-019-0250-7
10.1016/j.molmed.2007.04.002
10.1093/ajcn/84.1.37
10.4161/auto.7.12.17925
10.7554/eLife.44944
10.1016/j.cmet.2012.02.011
10.3389/fphar.2013.00176
10.1194/jlr.R000034
10.3389/fphys.2019.01129
10.1038/ncomms2581
10.1155/2014/502749
10.1016/S0887-2333(02)00095-4
10.1186/s13098-019-0468-0
10.1083/jcb.201803153
10.1210/me.2014-1367
10.3390/cells7100149
10.1186/1476-511X-11-25
10.1186/2193-1801-3-550
10.1016/0304-4157(84)90010-8
10.1016/j.bbabio.2013.10.006
10.1139/o03-073
10.1016/j.jnutbio.2005.08.002
10.1016/j.plipres.2008.10.002
10.1038/ncb0107-7
10.1073/pnas.1421092112
10.1053/j.gastro.2010.07.041
10.1038/nature07976
10.1007/s12017-009-8092-z
10.15252/embj.201490315
10.4049/jimmunol.1203369
10.1074/jbc.M112.434183
10.4236/jdm.2012.24061
10.1186/s12937-017-0271-4
10.1016/S0076-6879(08)03610-0
10.1093/ajcn/nqy048
10.1523/JNEUROSCI.2760-08.2009
10.1016/j.devcel.2013.01.013
10.1074/jbc.M110.190785
10.1016/j.cmet.2011.09.002
10.1146/annurev-immunol-031210-101322
10.1093/jn/138.2.272
10.1002/ejlt.201100350
10.1146/annurev.nutr.012809.104635
10.3390/nu8080463
10.1038/ncb3166
10.1101/gad.212282.112
10.3390/ijms12042408
10.1016/j.cell.2010.04.009
10.15252/embr.201541108
10.1080/07315724.2001.10719008
10.1155/2020/5762395
10.1016/j.plefa.2007.10.014
10.1530/JOE-16-0580
10.1080/01635580802710717
10.1051/rnd:2005047
10.1007/s11695-012-0633-0
10.1016/j.bbamem.2017.04.006
10.1083/jcb.201311051
10.1038/nrm1912
10.1111/tra.12230
ContentType Journal Article
Copyright 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2020 by the authors. 2020
Copyright_xml – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2020 by the authors. 2020
DBID AAYXX
CITATION
NPM
8FD
8FE
8FH
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
GNUQQ
HCIFZ
LK8
M7P
P64
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
ADTOC
UNPAY
DOA
DOI 10.3390/cells9122605
DatabaseName CrossRef
PubMed
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central
Engineering Research Database
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Biological Science Database
Biotechnology and BioEngineering Abstracts
Proquest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Genetics Abstracts
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
Biotechnology and BioEngineering Abstracts
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
PubMed

CrossRef

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2073-4409
ExternalDocumentID oai_doaj_org_article_150b6df9f21e457e973dd489cbed5ef8
10.3390/cells9122605
PMC7761975
33291746
10_3390_cells9122605
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID 53G
5VS
8FE
8FH
AADQD
AAFWJ
AAYXX
ABDBF
ACUHS
ADBBV
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
CCPQU
CITATION
DIK
EBD
ESX
GROUPED_DOAJ
HCIFZ
HYE
IAO
IHR
KQ8
LK8
M48
M7P
MODMG
M~E
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PQGLB
PROAC
RPM
NPM
8FD
ABUWG
AZQEC
DWQXO
FR3
GNUQQ
P64
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
PUEGO
5PM
ADRAZ
ADTOC
IPNFZ
ITC
RIG
UNPAY
ID FETCH-LOGICAL-c478t-e7a073a1be52bff40e37195d98be91c1195fad00817f53a183f6b6e3e0aa79943
IEDL.DBID M48
ISSN 2073-4409
IngestDate Fri Oct 03 12:53:39 EDT 2025
Sun Oct 26 04:17:08 EDT 2025
Tue Sep 30 16:48:16 EDT 2025
Fri Sep 05 13:41:36 EDT 2025
Fri Jul 25 12:04:25 EDT 2025
Thu Apr 03 07:03:59 EDT 2025
Thu Apr 24 23:08:17 EDT 2025
Thu Oct 16 04:45:28 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords phospholipids synthesis
metabolism
dietary lipids
mitofusin-2
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
cc-by
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-e7a073a1be52bff40e37195d98be91c1195fad00817f53a183f6b6e3e0aa79943
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0003-2483-7000
OpenAccessLink https://proxy.k.utb.cz/login?url=https://www.mdpi.com/2073-4409/9/12/2605/pdf?version=1607313169
PMID 33291746
PQID 2468446774
PQPubID 2032536
ParticipantIDs doaj_primary_oai_doaj_org_article_150b6df9f21e457e973dd489cbed5ef8
unpaywall_primary_10_3390_cells9122605
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7761975
proquest_miscellaneous_2468672250
proquest_journals_2468446774
pubmed_primary_33291746
crossref_citationtrail_10_3390_cells9122605
crossref_primary_10_3390_cells9122605
PublicationCentury 2000
PublicationDate 20201204
PublicationDateYYYYMMDD 2020-12-04
PublicationDate_xml – month: 12
  year: 2020
  text: 20201204
  day: 4
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Cells (Basel, Switzerland)
PublicationTitleAlternate Cells
PublicationYear 2020
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Kimmel (ref_29) 2010; 51
Hurt (ref_2) 2010; 6
Kassan (ref_31) 2013; 203
Chicco (ref_42) 2006; 17
Razani (ref_110) 2012; 15
Swiader (ref_108) 2016; 7
Pelech (ref_9) 1984; 779
Chuang (ref_91) 2012; 2
Wilfling (ref_30) 2013; 24
Khan (ref_24) 2014; 2014
Cercato (ref_1) 2019; 11
Hailey (ref_97) 2010; 141
Ratziu (ref_73) 2011; 17
ref_23
ref_22
Burdge (ref_86) 2005; 45
Thiam (ref_28) 2013; 14
Hamasaki (ref_96) 2013; 495
Suzuki (ref_100) 2015; 112
Madonna (ref_45) 2007; 30
Spandl (ref_115) 2011; 286
ref_27
ref_26
Watada (ref_103) 2015; 29
Perrotta (ref_111) 2015; 2015
Fuller (ref_50) 2018; 107
Tasseva (ref_20) 2013; 288
Wei (ref_93) 2018; 2018
Nakamura (ref_68) 2014; 3
Fagone (ref_11) 2013; 1831
Fioroni (ref_62) 2012; 22
Soni (ref_33) 2009; 122
Flanagan (ref_81) 2010; 7
Cao (ref_78) 2016; 8
Zhang (ref_80) 2020; 13
Eckel (ref_48) 2014; 129
(ref_14) 2004; 82
Bazan (ref_83) 2011; 31
Dann (ref_105) 2007; 13
Torrejon (ref_55) 2007; 77
Gregor (ref_60) 2011; 29
Schott (ref_114) 2019; 218
Ding (ref_117) 2010; 139
Hellmann (ref_63) 2013; 191
Sun (ref_36) 2013; 4
Mitsuhashi (ref_79) 2011; 7
Botchlett (ref_69) 2017; 233
Wang (ref_25) 2012; 11
McLaughlin (ref_58) 2016; 65
Shantharam (ref_82) 1989; 982
Vance (ref_21) 2013; 1831
Brasaemle (ref_112) 2011; 14
Mouritsen (ref_47) 2007; 9
Kamphuis (ref_84) 2009; 16
Kennelly (ref_19) 2017; 1859
Lima (ref_64) 2002; 16
Rotival (ref_89) 2009; 61
Ouimet (ref_120) 2011; 13
Broz (ref_122) 2013; 27
Oliveros (ref_71) 2011; 12
Levant (ref_85) 2007; 137
Kuerschner (ref_38) 2008; 9
Poppitt (ref_90) 2005; 4
ref_54
ref_51
Hu (ref_46) 2001; 20
Nascimbeni (ref_99) 2017; 36
Duric (ref_77) 2012; 114
Galmes (ref_17) 2016; 17
Schiller (ref_74) 2001; 42
Cohen (ref_32) 2018; 337
Tooze (ref_98) 2020; 45
Rabouille (ref_102) 2019; 8
ref_61
Thiam (ref_34) 2013; 110
Vives (ref_16) 2019; 177
Yang (ref_106) 2010; 11
Fu (ref_75) 2011; 473
Levine (ref_92) 2011; 469
Goldstein (ref_121) 2012; 23
Martin (ref_6) 2006; 7
Axe (ref_95) 2008; 182
Burhans (ref_59) 2018; 9
Vihinen (ref_94) 2009; 452
Kartsoli (ref_76) 2020; 12
Quinn (ref_67) 2004; 69
ref_119
Shpilka (ref_101) 2015; 34
Coleman (ref_10) 2004; 43
Pol (ref_5) 2014; 204
Kaushik (ref_116) 2015; 17
Vucic (ref_52) 2013; 1
Paradies (ref_72) 2014; 1837
Kovsan (ref_118) 2011; 96
Taylor (ref_12) 2012; 11
Liu (ref_3) 2017; 16
Vance (ref_15) 2014; 16
Singh (ref_113) 2009; 458
Milanski (ref_39) 2009; 29
Pennisi (ref_37) 2017; 12
Furuhashi (ref_65) 2008; 7
Denisenko (ref_57) 2020; 2020
Sun (ref_87) 2010; 12
Yu (ref_35) 2016; 60
Mutungi (ref_49) 2008; 138
ref_104
Kennedy (ref_18) 1956; 222
Brouwer (ref_53) 2013; 67
ref_109
ref_43
Liu (ref_107) 2015; 128
ref_41
ref_40
Perona (ref_56) 2017; 1859
Ko (ref_88) 2020; 17
Willett (ref_44) 2009; 48
Blesso (ref_13) 2015; 7
ref_8
Nan (ref_70) 2009; 44
ref_4
Kloppenburg (ref_66) 2014; 5
ref_7
References_xml – volume: 17
  start-page: 3377
  year: 2011
  ident: ref_73
  article-title: Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v17.i29.3377
– volume: 2015
  start-page: 1
  year: 2015
  ident: ref_111
  article-title: The Role of Oxidative Stress and Autophagy in Atherosclerosis
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2015/130315
– ident: ref_51
– volume: 8
  start-page: 2325
  year: 2016
  ident: ref_78
  article-title: The effect of polyene phosphatidyl choline intervention on nonalcoholic steatohepatitis and related mechanism
  publication-title: Am. J. Transl. Res.
– volume: 1831
  start-page: 543
  year: 2013
  ident: ref_21
  article-title: Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
  publication-title: Biochim. Biophys. Acta BBA Mol. Cell Biol. Lipids
– volume: 12
  start-page: 436
  year: 2020
  ident: ref_76
  article-title: Lipidomics in non-alcoholic fatty liver disease
  publication-title: World J. Hepatol.
  doi: 10.4254/wjh.v12.i8.436
– ident: ref_40
  doi: 10.3389/fonc.2013.00224
– ident: ref_61
  doi: 10.3390/ijms19113285
– volume: 65
  start-page: 1245
  year: 2016
  ident: ref_58
  article-title: Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans
  publication-title: Diabetes
  doi: 10.2337/db15-1213
– ident: ref_23
  doi: 10.3390/nu10060780
– ident: ref_41
  doi: 10.3390/nu11051067
– volume: 222
  start-page: 193
  year: 1956
  ident: ref_18
  article-title: The function of cytidine coenzymes in the biosynthesis of phospholipides
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)50785-2
– volume: 7
  start-page: 489
  year: 2008
  ident: ref_65
  article-title: Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2589
– volume: 45
  start-page: 484
  year: 2020
  ident: ref_98
  article-title: The Golgi as an Assembly Line to the Autophagosome
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2020.03.010
– volume: 23
  start-page: 567
  year: 2012
  ident: ref_121
  article-title: Regulation of lipid metabolism by p53–Fighting two villains with one sword
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2012.06.007
– volume: 122
  start-page: 1834
  year: 2009
  ident: ref_33
  article-title: Coatomer-dependent protein delivery to lipid droplets
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.045849
– volume: 11
  start-page: 467
  year: 2010
  ident: ref_106
  article-title: Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2010.04.005
– volume: 137
  start-page: 130
  year: 2007
  ident: ref_85
  article-title: Specific Brain Regions of Female Rats Are Differentially Depleted of Docosahexaenoic Acid by Reproductive Activity and an (n-3) Fatty Acid-Deficient Diet
  publication-title: J. Nutr.
  doi: 10.1093/jn/137.1.130
– volume: 177
  start-page: 881
  year: 2019
  ident: ref_16
  article-title: Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.010
– volume: 43
  start-page: 134
  year: 2004
  ident: ref_10
  article-title: Enzymes of triacylglycerol synthesis and their regulation
  publication-title: Prog. Lipid Res.
  doi: 10.1016/S0163-7827(03)00051-1
– volume: 1831
  start-page: 523
  year: 2013
  ident: ref_11
  article-title: Phosphatidylcholine and the CDP–choline cycle
  publication-title: Biochim. Biophys. Acta BBA Mol.
  doi: 10.1016/j.bbalip.2012.09.009
– ident: ref_4
– volume: 982
  start-page: 115
  year: 1989
  ident: ref_82
  article-title: Activity of myelin membrane Na+/K+-ATPase and 5′-nucleotidase in relation to phospholipid acyl profiles, ganglioside composition and phosphoinositides in developing brains of undernourished rats
  publication-title: Biochim. Biophys. Acta BBA Biomembr.
  doi: 10.1016/0005-2736(89)90181-8
– ident: ref_27
– volume: 7
  start-page: 15
  year: 2016
  ident: ref_108
  article-title: Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8936
– volume: 11
  start-page: 3
  year: 2012
  ident: ref_12
  article-title: Health effects of dietary phospholipids
  publication-title: Lipids Heal. Dis.
  doi: 10.1186/1476-511X-11-3
– volume: 110
  start-page: 13244
  year: 2013
  ident: ref_34
  article-title: COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1307685110
– volume: 30
  start-page: 1012
  year: 2007
  ident: ref_45
  article-title: n-3 Fatty Acids in the Treatment of Diabetic Patients: Biological rationale and clinical data
  publication-title: Diabetes Care
  doi: 10.2337/dc06-1332
– volume: 203
  start-page: 985
  year: 2013
  ident: ref_31
  article-title: Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201305142
– volume: 13
  start-page: 655
  year: 2011
  ident: ref_120
  article-title: Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2011.03.023
– volume: 7
  start-page: 30
  year: 2010
  ident: ref_81
  article-title: Role of carnitine in disease
  publication-title: Nutr. Metab.
  doi: 10.1186/1743-7075-7-30
– volume: 44
  start-page: 1121
  year: 2009
  ident: ref_70
  article-title: Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice
  publication-title: Scand. J. Gastroenterol.
  doi: 10.1080/00365520903114912
– volume: 473
  start-page: 528
  year: 2011
  ident: ref_75
  article-title: Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
  publication-title: Nature
  doi: 10.1038/nature09968
– ident: ref_109
  doi: 10.1371/journal.pone.0115176
– volume: 129
  start-page: S76
  year: 2014
  ident: ref_48
  article-title: 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk
  publication-title: Circulation
  doi: 10.1161/01.cir.0000437740.48606.d1
– volume: 16
  start-page: 12
  year: 2009
  ident: ref_84
  article-title: Nutrition and Alzheimer’s disease: Pre-clinical concepts
  publication-title: Eur. J. Neurol.
  doi: 10.1111/j.1468-1331.2009.02737.x
– volume: 1859
  start-page: 1690
  year: 2017
  ident: ref_56
  article-title: Membrane lipid alterations in the metabolic syndrome and the role of dietary oils
  publication-title: Biochim. Biophys. Acta BBA Biomembr.
  doi: 10.1016/j.bbamem.2017.04.015
– volume: 7
  start-page: 2731
  year: 2015
  ident: ref_13
  article-title: Egg Phospholipids and Cardiovascular Health
  publication-title: Nutrients
  doi: 10.3390/nu7042731
– volume: 60
  start-page: 46
  year: 2016
  ident: ref_35
  article-title: The size matters: Regulation of lipid storage by lipid droplet dynamics
  publication-title: Sci. China Life Sci.
  doi: 10.1007/s11427-016-0322-x
– volume: 69
  start-page: 58
  year: 2004
  ident: ref_67
  article-title: Is the Distribution of -Tocopherol in Membranes Consistent with Its Putative Functions?
  publication-title: Biochem. Mosc.
  doi: 10.1023/B:BIRY.0000016352.88061.02
– volume: 67
  start-page: 541
  year: 2013
  ident: ref_53
  article-title: Trans fatty acids and cardiovascular health: Research completed?
  publication-title: Eur. J. Clin. Nutr.
  doi: 10.1038/ejcn.2013.43
– volume: 6
  start-page: 780
  year: 2010
  ident: ref_2
  article-title: The Obesity Epidemic: Challenges, Health Initiatives, and Implications for Gastroenterologists
  publication-title: Gastroenterol. Hepatol.
– volume: 182
  start-page: 685
  year: 2008
  ident: ref_95
  article-title: Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200803137
– volume: 42
  start-page: 1501
  year: 2001
  ident: ref_74
  article-title: Lipid analysis of human HDL and LDL by MALDI-TOF mass spectrometry and (31)P-NMR
  publication-title: J. Lipid Res.
  doi: 10.1016/S0022-2275(20)34196-1
– volume: 9
  start-page: 338
  year: 2008
  ident: ref_38
  article-title: Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets
  publication-title: Traffic
  doi: 10.1111/j.1600-0854.2007.00689.x
– volume: 4
  start-page: 30
  year: 2005
  ident: ref_90
  article-title: Assessment of erythrocyte phospholipid fatty acid composition as a biomarker for dietary MUFA, PUFA or saturated fatty acid intake in a controlled cross-over intervention trial
  publication-title: Lipids Heal. Dis.
  doi: 10.1186/1476-511X-4-30
– volume: 36
  start-page: 2018
  year: 2017
  ident: ref_99
  article-title: ER –plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI 3P synthesis
  publication-title: EMBO J.
  doi: 10.15252/embj.201797006
– volume: 96
  start-page: E268
  year: 2011
  ident: ref_118
  article-title: Altered Autophagy in Human Adipose Tissues in Obesity
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2010-1681
– volume: 13
  start-page: 559
  year: 2020
  ident: ref_80
  article-title: Neutral lipid storage disease with myopathy presenting asymmetrical muscle weakness: A case report
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 128
  start-page: 69
  year: 2015
  ident: ref_107
  article-title: Autophagy in Atherosclerosis
  publication-title: Chin. Med J.
  doi: 10.4103/0366-6999.147815
– volume: 12
  start-page: 90
  year: 2017
  ident: ref_37
  article-title: Neutral Lipid Storage Diseases: Clinical/genetic features and natural history in a large cohort of Italian patients
  publication-title: Orphanet J. Rare Dis.
  doi: 10.1186/s13023-017-0646-9
– volume: 14
  start-page: 775
  year: 2013
  ident: ref_28
  article-title: The biophysics and cell biology of lipid droplets
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3699
– volume: 17
  start-page: 169
  year: 2020
  ident: ref_88
  article-title: Regulation of intestinal lipid metabolism: Current concepts and relevance to disease
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-019-0250-7
– volume: 5
  start-page: 483
  year: 2014
  ident: ref_66
  article-title: Fatty Acids, Lipid Mediators, and T-Cell Function
  publication-title: Front. Immunol.
– volume: 13
  start-page: 252
  year: 2007
  ident: ref_105
  article-title: mTOR Complex1–S6K1 signaling: At the crossroads of obesity, diabetes and cancer
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2007.04.002
– volume: 9
  start-page: 1
  year: 2018
  ident: ref_59
  article-title: Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
  publication-title: Compr. Physiol.
– ident: ref_54
  doi: 10.1093/ajcn/84.1.37
– volume: 7
  start-page: 1559
  year: 2011
  ident: ref_79
  article-title: Phospholipid synthetic defect and mitophagy in muscle disease
  publication-title: Autophagy
  doi: 10.4161/auto.7.12.17925
– volume: 8
  start-page: e44944
  year: 2019
  ident: ref_102
  article-title: COPII vesicles and the expansion of the phagophore
  publication-title: eLife
  doi: 10.7554/eLife.44944
– volume: 15
  start-page: 534
  year: 2012
  ident: ref_110
  article-title: Autophagy Links Inflammasomes to Atherosclerotic Progression
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.02.011
– ident: ref_26
  doi: 10.3389/fphar.2013.00176
– volume: 51
  start-page: 468
  year: 2010
  ident: ref_29
  article-title: Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins: TABLE 1
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R000034
– ident: ref_43
  doi: 10.3389/fphys.2019.01129
– volume: 4
  start-page: 1594
  year: 2013
  ident: ref_36
  article-title: Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2581
– volume: 2014
  start-page: 1
  year: 2014
  ident: ref_24
  article-title: Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2014/502749
– ident: ref_22
– volume: 16
  start-page: 741
  year: 2002
  ident: ref_64
  article-title: Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis
  publication-title: Toxicol. Vitr.
  doi: 10.1016/S0887-2333(02)00095-4
– volume: 11
  start-page: 1
  year: 2019
  ident: ref_1
  article-title: Cardiovascular risk and obesity
  publication-title: Diabetol. Metab. Syndr.
  doi: 10.1186/s13098-019-0468-0
– volume: 218
  start-page: 3320
  year: 2019
  ident: ref_114
  article-title: Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201803153
– volume: 29
  start-page: 338
  year: 2015
  ident: ref_103
  article-title: Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes
  publication-title: Mol. Endocrinol.
  doi: 10.1210/me.2014-1367
– ident: ref_104
  doi: 10.3390/cells7100149
– volume: 495
  start-page: 389
  year: 2013
  ident: ref_96
  article-title: Autophagosomes form at ER–mitochondria contact sites
  publication-title: Nat. Cell Biol.
– volume: 11
  start-page: 25
  year: 2012
  ident: ref_25
  article-title: Multiple roles of dihomo-γ-linolenic acid against proliferation diseases
  publication-title: Lipids Heal. Dis.
  doi: 10.1186/1476-511X-11-25
– volume: 3
  start-page: 550
  year: 2014
  ident: ref_68
  article-title: Location of α-tocopherol and α-tocotrienol to heterogeneous cell membranes and inhibition of production of peroxidized cholesterol in mouse fibroblasts
  publication-title: SpringerPlus
  doi: 10.1186/2193-1801-3-550
– volume: 779
  start-page: 217
  year: 1984
  ident: ref_9
  article-title: Regulation of phosphatidylcholine biosynthesis
  publication-title: Biochim. Biophys. Acta BBA Rev. Biomembr.
  doi: 10.1016/0304-4157(84)90010-8
– volume: 1837
  start-page: 408
  year: 2014
  ident: ref_72
  article-title: Functional role of cardiolipin in mitochondrial bioenergetics
  publication-title: Biochim. Biophys. Acta BBA Bioenerg.
  doi: 10.1016/j.bbabio.2013.10.006
– volume: 82
  start-page: 113
  year: 2004
  ident: ref_14
  article-title: Phospholipid biosynthesis in mammalian cells
  publication-title: Biochem. Cell Biol.
  doi: 10.1139/o03-073
– volume: 17
  start-page: 1
  year: 2006
  ident: ref_42
  article-title: Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2005.08.002
– volume: 48
  start-page: 44
  year: 2009
  ident: ref_44
  article-title: Dietary fats and prevention of type 2 diabetes
  publication-title: Prog. Lipid Res.
  doi: 10.1016/j.plipres.2008.10.002
– volume: 9
  start-page: 7
  year: 2007
  ident: ref_47
  article-title: Lipid rafts: At a crossroad between cell biology and physics
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb0107-7
– volume: 112
  start-page: 3350
  year: 2015
  ident: ref_100
  article-title: Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1421092112
– volume: 139
  start-page: 1740
  year: 2010
  ident: ref_117
  article-title: Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.07.041
– volume: 458
  start-page: 1131
  year: 2009
  ident: ref_113
  article-title: Autophagy regulates lipid metabolism
  publication-title: Nature
  doi: 10.1038/nature07976
– volume: 12
  start-page: 133
  year: 2010
  ident: ref_87
  article-title: Phospholipases A2 and Inflammatory Responses in the Central Nervous System
  publication-title: Neuro Mol. Med.
  doi: 10.1007/s12017-009-8092-z
– volume: 34
  start-page: 2117
  year: 2015
  ident: ref_101
  article-title: Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis
  publication-title: EMBO J.
  doi: 10.15252/embj.201490315
– volume: 191
  start-page: 1383
  year: 2013
  ident: ref_63
  article-title: Increased Saturated Fatty Acids in Obesity Alter Resolution of Inflammation in Part by Stimulating Prostaglandin Production
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1203369
– volume: 288
  start-page: 4158
  year: 2013
  ident: ref_20
  article-title: Phosphatidylethanolamine Deficiency in Mammalian Mitochondria Impairs Oxidative Phosphorylation and Alters Mitochondrial Morphology
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.434183
– volume: 2
  start-page: 393
  year: 2012
  ident: ref_91
  article-title: Comparison of the fatty acid composition of the serum phospholipids of controls, prediabetics and adults with type 2 diabetes
  publication-title: J. Diabetes Mellit.
  doi: 10.4236/jdm.2012.24061
– volume: 16
  start-page: 1
  year: 2017
  ident: ref_3
  article-title: A healthy approach to dietary fats: Understanding the science and taking action to reduce consumer confusion
  publication-title: Nutr. J.
  doi: 10.1186/s12937-017-0271-4
– volume: 452
  start-page: 143
  year: 2009
  ident: ref_94
  article-title: Chapter 10 Monitoring Autophagy by Electron Microscopy in Mammalian Cells
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(08)03610-0
– volume: 107
  start-page: 921
  year: 2018
  ident: ref_50
  article-title: Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: The Diabetes and Egg (DIABEGG) Study—Randomized weight-loss and follow-up phase
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/nqy048
– volume: 29
  start-page: 359
  year: 2009
  ident: ref_39
  article-title: Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2760-08.2009
– volume: 24
  start-page: 384
  year: 2013
  ident: ref_30
  article-title: Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2013.01.013
– volume: 286
  start-page: 5599
  year: 2011
  ident: ref_115
  article-title: Ancient Ubiquitous Protein 1 (AUP1) Localizes to Lipid Droplets and Binds the E2 Ubiquitin Conjugase G2 (Ube2g2) via Its G2 Binding Region
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.190785
– volume: 14
  start-page: 437
  year: 2011
  ident: ref_112
  article-title: DisseCCTing Phospholipid Function in Lipid Droplet Dynamics
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2011.09.002
– volume: 29
  start-page: 415
  year: 2011
  ident: ref_60
  article-title: Inflammatory Mechanisms in Obesity
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-031210-101322
– ident: ref_7
– volume: 138
  start-page: 272
  year: 2008
  ident: ref_49
  article-title: Dietary Cholesterol from Eggs Increases Plasma HDL Cholesterol in Overweight Men Consuming a Carbohydrate-Restricted Diet
  publication-title: J. Nutr.
  doi: 10.1093/jn/138.2.272
– volume: 114
  start-page: 389
  year: 2012
  ident: ref_77
  article-title: Phosphatidylcholine functional foods and nutraceuticals: A potential approach to prevent non-alcoholic fatty liver disease
  publication-title: Eur. J. Lipid Sci. Technol.
  doi: 10.1002/ejlt.201100350
– volume: 31
  start-page: 321
  year: 2011
  ident: ref_83
  article-title: Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer’s, and Other Neurodegenerative Diseases
  publication-title: Annu. Rev. Nutr.
  doi: 10.1146/annurev.nutr.012809.104635
– ident: ref_119
– ident: ref_8
  doi: 10.3390/nu8080463
– volume: 17
  start-page: 759
  year: 2015
  ident: ref_116
  article-title: Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3166
– volume: 27
  start-page: 1016
  year: 2013
  ident: ref_122
  article-title: Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
  publication-title: Genes Dev.
  doi: 10.1101/gad.212282.112
– volume: 337
  start-page: 83
  year: 2018
  ident: ref_32
  article-title: Lipid Droplets as Organelles
  publication-title: TAM Recept. Health Dis.
– volume: 12
  start-page: 2408
  year: 2011
  ident: ref_71
  article-title: Nutritional Deficiencies and Phospholipid Metabolism
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms12042408
– volume: 141
  start-page: 656
  year: 2010
  ident: ref_97
  article-title: Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
  publication-title: Cell
  doi: 10.1016/j.cell.2010.04.009
– volume: 17
  start-page: 800
  year: 2016
  ident: ref_17
  article-title: ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201541108
– volume: 20
  start-page: 5
  year: 2001
  ident: ref_46
  article-title: Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review
  publication-title: J. Am. Coll. Nutr.
  doi: 10.1080/07315724.2001.10719008
– volume: 2020
  start-page: 1
  year: 2020
  ident: ref_57
  article-title: Lipid-Induced Mechanisms of Metabolic Syndrome
  publication-title: J. Obes.
  doi: 10.1155/2020/5762395
– volume: 2018
  start-page: 1
  year: 2018
  ident: ref_93
  article-title: Origin of the Autophagosome Membrane in Mammals
  publication-title: BioMed Res. Int.
– volume: 77
  start-page: 319
  year: 2007
  ident: ref_55
  article-title: n-3 Fatty acids and cardiovascular disease: Actions and molecular mechanisms
  publication-title: Prostaglandins Leukot. Essent. Fat. Acids
  doi: 10.1016/j.plefa.2007.10.014
– volume: 233
  start-page: R145
  year: 2017
  ident: ref_69
  article-title: Nutritional approaches for managing obesity-associated metabolic diseases
  publication-title: J. Endocrinol.
  doi: 10.1530/JOE-16-0580
– volume: 61
  start-page: 500
  year: 2009
  ident: ref_89
  article-title: Correlation Between Serum Phospholipid Fatty Acids and Dietary Intakes Assessed a Few Years Earlier
  publication-title: Nutr. Cancer
  doi: 10.1080/01635580802710717
– volume: 1
  start-page: 1
  year: 2013
  ident: ref_52
  article-title: Dietary Fats And Metabolic Syndrome
  publication-title: J. Nutr. Health Food Sci.
– volume: 469
  start-page: 323
  year: 2011
  ident: ref_92
  article-title: Autophagy in immunity and inflammation
  publication-title: Nat. Cell Biol.
– volume: 45
  start-page: 581
  year: 2005
  ident: ref_86
  article-title: Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
  publication-title: Reprod. Nutr. Dev.
  doi: 10.1051/rnd:2005047
– volume: 22
  start-page: 935
  year: 2012
  ident: ref_62
  article-title: Pro-inflammatory Phospholipid Arachidonic Acid/Eicosapentaenoic Acid Ratio of Dysmetabolic Severely Obese Women
  publication-title: Obes. Surg.
  doi: 10.1007/s11695-012-0633-0
– volume: 1859
  start-page: 1558
  year: 2017
  ident: ref_19
  article-title: The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease
  publication-title: Biochim. Biophys. Acta BBA Biomembr.
  doi: 10.1016/j.bbamem.2017.04.006
– volume: 204
  start-page: 635
  year: 2014
  ident: ref_5
  article-title: Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201311051
– volume: 7
  start-page: 373
  year: 2006
  ident: ref_6
  article-title: Lipid droplets: A unified view of a dynamic organelle
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1912
– volume: 16
  start-page: 1
  year: 2014
  ident: ref_15
  article-title: Phospholipid Synthesis and Transport in Mammalian Cells
  publication-title: Traffic
  doi: 10.1111/tra.12230
SSID ssj0000816105
Score 2.276071
SecondaryResourceType review_article
Snippet Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the...
SourceID doaj
unpaywall
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 2605
SubjectTerms Biosynthesis
Cardiovascular disease
Cholesterol
Diet
dietary lipids
Endoplasmic reticulum
Fatty acids
Glycerol
Homeostasis
Lipid metabolism
Lipids
Mammalian cells
Mammals
Membranes
Metabolic disorders
Metabolism
Milk
Mitochondria
mitofusin-2
Obesity
phospholipids synthesis
Proteins
Review
Sterols
Triglycerides
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlUNpLadKXmzSo0JaWYmJb797SpksotKcEcjOSPKILizfEXkL-fUaWY7z0denVGmP504zmG3k8Q8ibwB1qgtS5r6TJOYDJTeUhL3RwopDgWUqQ_SFPz_m3C3Exa_UVc8JSeeAE3BESFiebYEJVAhcKjGJNw7XxDhoBYfjNt9BmFkwNe7BGJlOIlOnOMK4_iufgnSmryN-3fNBQqv93_PLXNMkHm_bS3lzb1WrmgxaPyaORPNLjNOldcg_aPXI_tZO8eULOTuAqtZZHsOk60NiYuqGxE_oaSWC37D7RY7qw7_2Hni5bityPzpKG4h3foUetWC09PUlfbrqn5Hzx9ezLaT52Tcg9V7rPQVk0W1s6EJULgRfAVGlEY7QDU_pY4i3YJiKkgkA5zYJ0EhgU1ipjOHtGdtp1Cy8IDZ4h-9PgjOPcGgQ9OrcSnZpgoI3OyMc7HGs_lhSPnS1WNYYWEfV6jnpG3k7Sl6mUxh_kPsclmWRiAezhAqpFPapF_S-1yMjB3YLWo1V2dcWlxvAXGW9GXk_DaE_x8baF9SbJSIW7XJGR52n9p5kwVmF0y2VG1JZmbE11e6Rd_hxqdqt4XKTw3d5NOvRXEF7-DxD2ycMqHg_E7Bt-QHb6qw28Qg7Vu8PBXG4BgwsavA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ta9RAEF7qFbFfxNc2WmUFFUVCk-xmNyuItLZHETxEWui3sLuZ1YMjOe8F6b935pKLd6j9mkzIZHZm99nZyTyMvQzSoSeoIvaZMrEEMLHJPMRJEVyeKPCiLZAdqfNL-fkqv9pho_W_MFRWuZ4TVxN11XjKkR9lUhW4dUG08nH6MybWKDpdXVNo2I5aofqwajF2i-1m1BlrwHZPzkZfv_VZF6KZQETRVsAL3O8fUX58btKMcP3W2rRq4f8v3Pl3-eSdZT2117_sZLKxNg3vsbsdqOTHrRfcZztQP2C3W5rJ64fs4hRmLeU8DgJvAifC6ooTQ3qD4HA-nr_nx3xo3_i3Cz6uOWJCvlFMRE98gQV6y2Ts-Wl7ojN_xC6HZxefzuOOTSH2UheLGLTFcLapgzxzIcgEhE5NXpnCgUk9tX4LtiIL6ZCjXCGCcgoEJNZqY6R4zAZ1U8MB48ELRIUFOOOktKYwnha9FBe7XEBhioi9W9ux9F2rcWK8mJS45SCrl5tWj9irXnrattj4j9wJDUkvQ42xVxea2feyi7MS8a1TVTAhS0HmGowWVSVRQwdVDgFVO1wPaNlF67z841sRe9Hfxjij19sammUrozTOfknE9tvx7zURIsNdr1QR01uesaXq9p16_GPVy1tTGknjt73ufehGIzy5Wf-nbC-jhADV28hDNljMlvAMUdPCPe9C4Tf2MBfJ
  priority: 102
  providerName: ProQuest
– databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3di9NAEF-0h-iL3x_RU1ZQUSSXJrvZD1-kepZD8PDhCudTzG5mNViS0qTK-dc726Sh9QvB1-xsMpuZyfxmMswQ8shxg5ogVGgToUMOoEOdWAjHypl0LMCyrkD2WBzN-NvT9LSfc9r0ZZUYipfrj3SC-hdyjEAiHcVJ5KF3tCjcy699Ksk3R2Mxi4U-T_ZEimB8RPZmx-8nH_xIuc3mrtydYXAf-WR4o-PE32nHEa379f8OZP5aK3lxVS3ys2_5fL7liKZXyMfNEbr6ky8Hq9Yc2O8_dXf8jzNeJZd7kEonnVZdI-eguk4udGMrz26Qk0NYdiPscSutHfUDsAvqJ67XCDabsnlBJ3SaP7XPWlpWFDEm3SpO8jveQYvaNy8tPez-EDU3yWz65uT1UdhPZwgtl6oNQebIWR4bSBPjHB8Dk7FOC60M6Nj6VnIuLzzkkC5FOsWcMAIYjPNcas3ZLTKq6gruEOosQ5SpwGjDea6Vtt6Jxug8UwZKq4A834gqs33rcj9BY55hCOMFm20LNiCPB-pF17LjD3SvvNQHGt9oe32hXn7KervNEC8bUTjtkhh4KkFLVhQcOTRQpOCQtf2NzmS99TdZwoXCMBuRdUAeDstot_7xeQX1qqMREr-m44Dc7lRs4ISxBKNoLgIid5Rvh9Xdlar8vO4NLn1aSuLZngxq-teXcPdfCe-RS4lPNfhKHr5PRu1yBfcRj7XmQW9zPwAyCi_E
  priority: 102
  providerName: Unpaywall
Title Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases
URI https://www.ncbi.nlm.nih.gov/pubmed/33291746
https://www.proquest.com/docview/2468446774
https://www.proquest.com/docview/2468672250
https://pubmed.ncbi.nlm.nih.gov/PMC7761975
https://www.mdpi.com/2073-4409/9/12/2605/pdf?version=1607313169
https://doaj.org/article/150b6df9f21e457e973dd489cbed5ef8
UnpaywallVersion publishedVersion
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: KQ8
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: DOA
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVEBS
  databaseName: Academic Search Ultimate
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: ABDBF
  dateStart: 20120901
  isFulltext: true
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  providerName: EBSCOhost
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: DIK
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: M~E
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: RPM
  dateStart: 20120101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2073-4409
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: BENPR
  dateStart: 20120301
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 2073-4409
  dateEnd: 20250930
  omitProxy: true
  ssIdentifier: ssj0000816105
  issn: 2073-4409
  databaseCode: M48
  dateStart: 20120301
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ta9RAEF5qi7ZfxNcarccKKopE87LJ7goiV9ujCD2K9KD9FHaTWT0ISb3k0Pv3zuaNO9r6NTvLbnZmMs9shnkIeW2YRkuIhZsGsXQZgHRlkILrCaMjL4Y0bAtkp_HJjH2_iC62SM822h1gdWNqZ_mkZov849_fq6_o8F9sxokp-yd7xV1JP7DQ_A7ZwRglLYnDaQf0m2-yQGTjRW3l-7VJe-ReGAaYuFgYvBaemi7-N0HP6xWUu8viSq3-qDxfC0-TB-R-hyvpuDWEh2QLikfkbss0uXpMzo9g0bLOox5oaajlrM6oJUkvER9W8-ozHdOJepe-r-m8oAgL6Vo9kZ1xCjUaTD5P6VH7U6d6QmaT4_NvJ25HqOCmjIvaBa7Qo5WvIQq0McyDkPsyyqTQIP3Udn8zKrOHxU2EciI0sY4hBE8pLiULn5LtoizgGaEmDREYCtBSM6akkKmNez7GuygEIYVDPvTnmKRdt3FLepEnmHVYBSTrCnDIm0H6qu2ycYvcoVXJIGN7YzcPysXPpHO1BCGujjMjTeADizhIHmYZwx1qyCIwuLWDXqFJb29JwGKBmTGCYYe8GobR1ezyqoBy2crEHD-AnkP2W_0PO-ntxyF8wzI2tro5Usx_Ne28ub1J4vhubwcb-u8hPL918RdkL7DXAbbahh2Q7XqxhJeImWo9IjuHx9OzH6PmzmHUOAc-m03Pxpf_ANrIGB0
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGJjReEN8EBhiJIdAULYmdOEaa0EZXdWyrEOqkvQXbOUOlKilNq6n_HH8b5yYNrYC97TW5JJe7s-8jl_sR8sZyjZaQpL6JEulzAOnLyIAfpFbHQQKG1Q2y_aR3wT9fxpcb5NfyXxjXVrncExcbdV4aVyPfj3iSYuqC0crH8U_foUa5r6tLCA3VQCvkB4sRY82PHacwv8IUrjo46aC-d6Ooezz41PMblAHfcJFOfRAKzVyFGuJIW8sDYCKUcS5TDTI0biSaVblzncLGSJcym-gEGARKCSk5w_veIluccYnJ39bRcf_L17bK42AtMIKpO-4Zk8G-q8dXMoxcHrHmCxeQAf-Kc_9u19yeFWM1v1Kj0Yov7N4jd5sglh7WVnefbEDxgNyuYS3nD8mgA5Ma4h6VTktLHUB2Th0ie4nBaDWsPtBD2lXvzPspHRYUY1C60rzkrjiHKVrnaGhop_6CVD0iFzci18dksygLeEqoNQyj0BS01JwrmUrjnGyIzjVmkMrUI3tLOWamGW3uEDZGGaY4TurZqtQ9sttSj-uRHv-hO3IqaWncIO7FgXLyPWvWdYbxtE5yK20UAo8FSMHynCOHGvIYLLK2s1Ro1uwOVfbHlj3yuj2N69o9XhVQzmqaROBuG3jkSa3_lhPGIsyyeeIRsWYZa6yunymGPxazw4UrWwl8t7etDV0rhGfX8_-KbPcG52fZ2Un_9Dm5E7lihOv14TtkczqZwQuM2Kb6ZbMsKPl20yvxNyeVVJc
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGJj5eEN8UBhiJIRCKmsROHCNNaKOrNgbVhDZpb8FxzlCpSkrTauq_yF_FXZOGVsDe9ppcG-d8377cj7FXTmYoCXHi2TDWngTQng4teH7issiPwYq6QXYQH57JT-fR-Qb7tfwWhtoqlzZxYajz0lKNvBvKOMHUBaOVrmvaIk56_Q_jnx4hSNFJ6xJOwzQwC_nuYtxY85HHMcwvMJ2rdo96uPc7Ydg_OP146DWIA56VKpl6oAyKvAkyiMLMOemDUIGOcp1koANL49GcycmNKhchXSJcnMUgwDdGaS0F_u81tkWHX2gktvYPBidf24oPQVxgNFN33wuh_S7V5isdhJRTrPnFBXzAv2Lev1s3b86KsZlfmNFoxS_277DbTUDL92oJvMs2oLjHrtcQl_P77LQHkxruHgWAl44TWHbOCZ29xMC0Glbv-R7vmzf27ZQPC47xKF9pZKJffIEpSupoaHmvPk2qHrCzK-HrQ7ZZlAU8ZtxZgRFpApnOpDQ60ZYcboCONhKQ6KTD3i35mNpmzDmhbYxSTHeI6-kq1ztsp6Ue1-M9_kO3T1vS0tBQ7sWFcvI9bXQ8xdg6i3OnXRiAjBRoJfJc4gozyCNwuLTt5YamjaWo0j9y3WEv29uo4_R4U0A5q2lihZbX77BH9f63KxEixIxbxh2m1iRjbanrd4rhj8UccUUlLIXv9rqVoUuZ8OTy9b9gN1Aj089Hg-On7FZIdQlq-5HbbHM6mcEzDN6m2fNGKzj7dtWK-BvfYVjG
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3di9NAEF-0h-iL3x_RU1ZQUSSXJrvZD1-kepZD8PDhCudTzG5mNViS0qTK-dc726Sh9QvB1-xsMpuZyfxmMswQ8shxg5ogVGgToUMOoEOdWAjHypl0LMCyrkD2WBzN-NvT9LSfc9r0ZZUYipfrj3SC-hdyjEAiHcVJ5KF3tCjcy699Ksk3R2Mxi4U-T_ZEimB8RPZmx-8nH_xIuc3mrtydYXAf-WR4o-PE32nHEa379f8OZP5aK3lxVS3ys2_5fL7liKZXyMfNEbr6ky8Hq9Yc2O8_dXf8jzNeJZd7kEonnVZdI-eguk4udGMrz26Qk0NYdiPscSutHfUDsAvqJ67XCDabsnlBJ3SaP7XPWlpWFDEm3SpO8jveQYvaNy8tPez-EDU3yWz65uT1UdhPZwgtl6oNQebIWR4bSBPjHB8Dk7FOC60M6Nj6VnIuLzzkkC5FOsWcMAIYjPNcas3ZLTKq6gruEOosQ5SpwGjDea6Vtt6Jxug8UwZKq4A834gqs33rcj9BY55hCOMFm20LNiCPB-pF17LjD3SvvNQHGt9oe32hXn7KervNEC8bUTjtkhh4KkFLVhQcOTRQpOCQtf2NzmS99TdZwoXCMBuRdUAeDstot_7xeQX1qqMREr-m44Dc7lRs4ISxBKNoLgIid5Rvh9Xdlar8vO4NLn1aSuLZngxq-teXcPdfCe-RS4lPNfhKHr5PRu1yBfcRj7XmQW9zPwAyCi_E
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Deregulation+of+Lipid+Homeostasis%3A+A+Fa%28c%29t+in+the+Development+of+Metabolic+Diseases&rft.jtitle=Cells+%28Basel%2C+Switzerland%29&rft.au=Cisa-Wieczorek%2C+Sabina&rft.au=Hern%C3%A1ndez-Alvarez%2C+Mar%C3%ADa+Isabel&rft.date=2020-12-04&rft.eissn=2073-4409&rft.volume=9&rft.issue=12&rft_id=info:doi/10.3390%2Fcells9122605&rft_id=info%3Apmid%2F33291746&rft.externalDocID=33291746
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2073-4409&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2073-4409&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2073-4409&client=summon