Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection - Huynh, Jeremy P.; Lin, Chih-Chung; Kimmey, Jacqueline M.; Jarjour, Nicholas N.; Schwarzkopf, Elizabeth A.; Bradstreet, Tara R.; Shchukina, Irina; Shpynov, Oleg; Weaver, Casey T.; Taneja, Reshma; Artyomov, Maxim N.; Edelson, Brian T.; et al. (The Journal of experimental medicine, 2018)
Keywords: Adaptive control; Adaptive Immunity; Animal models; Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors - deficiency; Basic Helix-Loop-Helix Transcription Factors - metabolism; CD11c antigen; Clonal deletion; Genetic Loci; Helix-loop-helix proteins (basic); Homeodomain Proteins - metabolism; Immune system; Immunity, Innate; Infections; Inflammation - pathology; Interleukin 1; Interleukin 10; Interleukin-10 - deficiency; Interleukin-10 - metabolism; Lymphocytes; Lymphocytes - metabolism; Lymphocytes T; Mice; Mice, Inbred C57BL; Models, Biological; Mycobacterium tuberculosis; Myeloid Cells - metabolism; Neutrophils - metabolism; Pathogenesis; Phenotypes; Protein Binding; Repressor Proteins - metabolism; Th1 Cells - metabolism; Transcription factors; Tuberculosis; Tuberculosis - immunology; Tuberculosis - prevention & control; γ-Interferon