Thrombin generation in patients with idiopathic sudden sensorineural hearing loss
The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms. Forty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin gen...
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| Published in | Thrombosis research Vol. 133; no. 6; pp. 1130 - 1134 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.06.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0049-3848 1879-2472 1879-2472 |
| DOI | 10.1016/j.thromres.2014.03.031 |
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| Abstract | The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms.
Forty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin generation in the presence or absence of thrombomodulin in platelet-poor or platelet-rich plasma by means of a home-made method based on calibrated automated thrombin generation, which should mimic much more closely than any other conventional coagulation test the balance of coagulation operating in vivo. DNA analyses for the most common prothrombotic genotypes such as factor V Leiden, prothrombin G20210A, MTHFR or platelet GPIIIa A1/A2 were also carried out in patients and controls.
Patients generated as much thrombin as controls both in platelet-rich and platelet-poor plasma and the frequency of the most common prothrombotic genotypes were similar in patients and controls.
The results suggest that the pathogenesis of ISSNHL is not due to systemic blood hypercoagulability. Other culprits such as local vascular abnormalities, viral infections, immune-mediated mechanisms or abnormalities of inner ear and central nervous system should be advocated to explain ISSNHL. |
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| AbstractList | Abstract Introduction The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms. Material and Methods Forty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin generation in the presence or absence of thrombomodulin in platelet-poor or platelet-rich plasma by means of a home-made method based on calibrated automated thrombin generation, which should mimic much more closely than any other conventional coagulation test the balance of coagulation operating in vivo. DNA analyses for the most common prothrombotic genotypes such as factor V Leiden, prothrombin G20210A, MTHFR or platelet GPIIIa A1/A2 were also carried out in patients and controls. Results Patients generated as much thrombin as controls both in platelet-rich and platelet-poor plasma and the frequency of the most common prothrombotic genotypes were similar in patients and controls. Conclusions The results suggest that the pathogenesis of ISSNHL is not due to systemic blood hypercoagulability. Other culprits such as local vascular abnormalities, viral infections, immune-mediated mechanisms or abnormalities of inner ear and central nervous system should be advocated to explain ISSNHL. The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms.INTRODUCTIONThe pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms.Forty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin generation in the presence or absence of thrombomodulin in platelet-poor or platelet-rich plasma by means of a home-made method based on calibrated automated thrombin generation, which should mimic much more closely than any other conventional coagulation test the balance of coagulation operating in vivo. DNA analyses for the most common prothrombotic genotypes such as factor V Leiden, prothrombin G20210A, MTHFR or platelet GPIIIa A1/A2 were also carried out in patients and controls.MATERIAL AND METHODSForty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin generation in the presence or absence of thrombomodulin in platelet-poor or platelet-rich plasma by means of a home-made method based on calibrated automated thrombin generation, which should mimic much more closely than any other conventional coagulation test the balance of coagulation operating in vivo. DNA analyses for the most common prothrombotic genotypes such as factor V Leiden, prothrombin G20210A, MTHFR or platelet GPIIIa A1/A2 were also carried out in patients and controls.Patients generated as much thrombin as controls both in platelet-rich and platelet-poor plasma and the frequency of the most common prothrombotic genotypes were similar in patients and controls.RESULTSPatients generated as much thrombin as controls both in platelet-rich and platelet-poor plasma and the frequency of the most common prothrombotic genotypes were similar in patients and controls.The results suggest that the pathogenesis of ISSNHL is not due to systemic blood hypercoagulability. Other culprits such as local vascular abnormalities, viral infections, immune-mediated mechanisms or abnormalities of inner ear and central nervous system should be advocated to explain ISSNHL.CONCLUSIONSThe results suggest that the pathogenesis of ISSNHL is not due to systemic blood hypercoagulability. Other culprits such as local vascular abnormalities, viral infections, immune-mediated mechanisms or abnormalities of inner ear and central nervous system should be advocated to explain ISSNHL. The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms. Forty-one patients with ISSNHL and 48 healthy subjects were investigated. We measured thrombin generation in the presence or absence of thrombomodulin in platelet-poor or platelet-rich plasma by means of a home-made method based on calibrated automated thrombin generation, which should mimic much more closely than any other conventional coagulation test the balance of coagulation operating in vivo. DNA analyses for the most common prothrombotic genotypes such as factor V Leiden, prothrombin G20210A, MTHFR or platelet GPIIIa A1/A2 were also carried out in patients and controls. Patients generated as much thrombin as controls both in platelet-rich and platelet-poor plasma and the frequency of the most common prothrombotic genotypes were similar in patients and controls. The results suggest that the pathogenesis of ISSNHL is not due to systemic blood hypercoagulability. Other culprits such as local vascular abnormalities, viral infections, immune-mediated mechanisms or abnormalities of inner ear and central nervous system should be advocated to explain ISSNHL. |
| Author | Menegatti, Marzia Bamonti, Fabrizia Capaccio, Pasquale Clerici, Marigrazia De Giuseppe, Rachele Peyvandi, Flora Pignataro, Lorenzo Tripodi, Armando Chantarangkul, Veena |
| Author_xml | – sequence: 1 givenname: Armando surname: Tripodi fullname: Tripodi, Armando email: armando.tripodi@unimi.it organization: Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy – sequence: 2 givenname: Pasquale surname: Capaccio fullname: Capaccio, Pasquale organization: Department of Biomedical, Surgical and Dental Sciences, University of Milan, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy – sequence: 3 givenname: Lorenzo surname: Pignataro fullname: Pignataro, Lorenzo organization: Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy – sequence: 4 givenname: Veena surname: Chantarangkul fullname: Chantarangkul, Veena organization: Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy – sequence: 5 givenname: Marzia surname: Menegatti fullname: Menegatti, Marzia organization: Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano and IRCCS Ca’ Granda Maggiore Hospital Foundation, Milano, Italy – sequence: 6 givenname: Fabrizia surname: Bamonti fullname: Bamonti, Fabrizia organization: Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Department of Hematology-Oncology and BMT Unit, IRCCS Cà Granda Maggiore Hospital Foundation, Milan, Italy – sequence: 7 givenname: Marigrazia surname: Clerici fullname: Clerici, Marigrazia organization: Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy – sequence: 8 givenname: Rachele surname: De Giuseppe fullname: De Giuseppe, Rachele organization: Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Department of Hematology-Oncology and BMT Unit, IRCCS Cà Granda Maggiore Hospital Foundation, Milan, Italy – sequence: 9 givenname: Flora surname: Peyvandi fullname: Peyvandi, Flora organization: Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Pathophysiology and Transplantation, Università degli Studi di Milano and IRCCS Ca’ Granda Maggiore Hospital Foundation, Milano, Italy |
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| Cites_doi | 10.1002/hep.21266 10.1002/lary.20873 10.1038/bjc.1997.191 10.1016/S0196-0709(03)00066-8 10.1002/lary.22480 10.1258/0022215001904383 10.1056/NEJM199604253341703 10.1111/j.1365-2141.2009.07833.x 10.1288/00005537-198608000-00011 10.1093/nar/16.3.1215 10.1007/s00405-011-1671-2 10.1159/000071636 10.1038/369064a0 10.1080/000164800750061688 10.1182/blood-2008-06-164087 10.1007/s11239-010-0506-0 10.1038/ng0595-111 10.1177/0194599812436449 10.1053/j.gastro.2009.08.045 10.1007/s00277-013-1834-x 10.1182/blood.V88.10.3698.bloodjournal88103698 10.1111/j.1538-7836.2011.04429.x 10.1097/MLG.0b013e31802f3c6a 10.1160/TH06-03-0179 |
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| References | Viel, Dall'Agnese, Simone, Canzonieri, Capozzi, Visentin (bb0075) 1997; 75 Vakkalanka, Ey, Goldenberg (bb0005) 2000; 21 Miller, Dykes, Polesky (bb0055) 1998; 16 Weiss, Bray, Tayback, Schulman, Kickler, Becker (bb0080) 1996; 334 Fitzgerald, Mark (bb0025) 1998; 19 Lin, Krall, Westerberg, Chadha, Chau (bb0085) 2012; 122 Loughran (bb0010) 2000; 114 Tripodi, Branchi, Chantarangkul, Clerici, Merati, Artoni (bb0110) 2011; 31 García Berrocal, Ramírez-Camacho, Portero, Vargas (bb0020) 2000; 120 Tripodi, Chantarangkul, Gianniello, Clerici, Lemma, Padovan (bb0115) 2013 Tripodi, Anstee, Sogaard, Primignani, Valla (bb0105) 2011; 9 Tripodi, Primignani, Chantarangkul, Clerici, Dell'Era, Fabris (bb0095) 2006; 44 Capaccio, Pignataro, Gaini, Sigismund, Novembrino, De Giuseppe (bb0030) 2012; 269 Bertina, Koeleman, Koster, Rosendaal, Dirven, de Ronde (bb0060) 1994; 369 Hemker, Giesen, Al Dieri, Regnault, de Smedt, Wagenvoord (bb0045) 2003; 33 Tripodi, Primignani, Chantarangkul, Dell'Era, Clerici, de Franchis (bb0100) 2009; 137 Dargaud, Trzeciak, Bordet, Ninet, Negrier (bb0125) 2006; 96 Stachler, Chandrasekhar, Archer, Rosenfeld, Schwartz, Barrs (bb0040) 2012; 146 Marchetti, Castoldi, Spronk, van Oerle, Balducci, Barbui (bb0120) 2008; 112 Wilson (bb0015) 1986; 96 Chantarangkul, Clerici, Bressi, Giesen, Tripodi (bb0050) 2003; 88 Frosst, Blom, Milos, Goyette, Sheppard, Matthews (bb0070) 1995; 10 Capaccio, Ottaviani, Cuccarini, Bottero, Schindler, Cesana (bb0130) 2007; 117 Poort, Rosendaal, Reitsma, Bertina (bb0065) 1996; 88 Chau, Lin, Atashband, Irvine, Westerberg (bb0035) 2010; 120 Yue, Li, Qi, L, HJ, Zhou (bb0135) 2003; 24 Tripodi, Chantarangkul, Mannucci (bb0090) 2009; 147 Miller (10.1016/j.thromres.2014.03.031_bb0055) 1998; 16 Lin (10.1016/j.thromres.2014.03.031_bb0085) 2012; 122 Weiss (10.1016/j.thromres.2014.03.031_bb0080) 1996; 334 Tripodi (10.1016/j.thromres.2014.03.031_bb0100) 2009; 137 Tripodi (10.1016/j.thromres.2014.03.031_bb0115) 2013 Bertina (10.1016/j.thromres.2014.03.031_bb0060) 1994; 369 Chantarangkul (10.1016/j.thromres.2014.03.031_bb0050) 2003; 88 Hemker (10.1016/j.thromres.2014.03.031_bb0045) 2003; 33 Marchetti (10.1016/j.thromres.2014.03.031_bb0120) 2008; 112 Dargaud (10.1016/j.thromres.2014.03.031_bb0125) 2006; 96 Chau (10.1016/j.thromres.2014.03.031_bb0035) 2010; 120 Stachler (10.1016/j.thromres.2014.03.031_bb0040) 2012; 146 Yue (10.1016/j.thromres.2014.03.031_bb0135) 2003; 24 Tripodi (10.1016/j.thromres.2014.03.031_bb0090) 2009; 147 Tripodi (10.1016/j.thromres.2014.03.031_bb0105) 2011; 9 Capaccio (10.1016/j.thromres.2014.03.031_bb0030) 2012; 269 Tripodi (10.1016/j.thromres.2014.03.031_bb0095) 2006; 44 Wilson (10.1016/j.thromres.2014.03.031_bb0015) 1986; 96 Viel (10.1016/j.thromres.2014.03.031_bb0075) 1997; 75 Poort (10.1016/j.thromres.2014.03.031_bb0065) 1996; 88 Tripodi (10.1016/j.thromres.2014.03.031_bb0110) 2011; 31 Vakkalanka (10.1016/j.thromres.2014.03.031_bb0005) 2000; 21 Fitzgerald (10.1016/j.thromres.2014.03.031_bb0025) 1998; 19 Loughran (10.1016/j.thromres.2014.03.031_bb0010) 2000; 114 García Berrocal (10.1016/j.thromres.2014.03.031_bb0020) 2000; 120 Capaccio (10.1016/j.thromres.2014.03.031_bb0130) 2007; 117 Frosst (10.1016/j.thromres.2014.03.031_bb0070) 1995; 10 |
| References_xml | – volume: 117 start-page: 547 year: 2007 end-page: 551 ident: bb0130 article-title: Genetic and acquired prothrombotic risk factors and sudden hearing loss publication-title: Laryngoscope – volume: 120 start-page: 1011 year: 2010 end-page: 1021 ident: bb0035 article-title: Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss publication-title: Laryngoscope – volume: 16 start-page: 1215 year: 1998 ident: bb0055 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res – volume: 88 start-page: 3698 year: 1996 end-page: 3703 ident: bb0065 article-title: A common genetic variation in the 3’ untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis publication-title: Blood – volume: 96 start-page: 562 year: 2006 end-page: 567 ident: bb0125 article-title: Use of calibrated automated thrombinography +/− thrombomodulin to recognise the prothrombotic phenotype publication-title: Thromb Haemost – volume: 334 start-page: 1090 year: 1996 end-page: 1094 ident: bb0080 article-title: Polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis publication-title: N Engl J Med – volume: 9 start-page: 1713 year: 2011 end-page: 1723 ident: bb0105 article-title: Hypercoagulability in cirrhosis: causes and consequences publication-title: J Thromb Haemost – volume: 96 start-page: 870 year: 1986 end-page: 877 ident: bb0015 article-title: The relationship of the herpesvirus family to sudden hearing loss: a prospective clinical study and literature review publication-title: Laryngoscope – volume: 122 start-page: 624 year: 2012 end-page: 635 ident: bb0085 article-title: Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults publication-title: Laryngoscope – volume: 147 start-page: 77 year: 2009 end-page: 82 ident: bb0090 article-title: Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing publication-title: Br J Haematol – volume: 146 start-page: S1 year: 2012 end-page: S35 ident: bb0040 article-title: American Academy of Otolaryngology-Head and Neck Surgery. Clinical practice guideline: sudden hearing loss publication-title: Otolaryngol Head Neck Surg – volume: 269 start-page: 449 year: 2012 end-page: 453 ident: bb0030 article-title: Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss publication-title: Eur Arch Otorhinolaryngol – volume: 33 start-page: 4 year: 2003 end-page: 15 ident: bb0045 article-title: Calibrated automated thrombin generation measurement in clotting plasma publication-title: Pathophysiol Haemost Thromb – volume: 10 start-page: 111 year: 1995 end-page: 113 ident: bb0070 article-title: A candidate genetic risk factor for vascular disease: a common mutation in methylene tetrahydrofolate reductase publication-title: Nat Genet – volume: 114 start-page: 837 year: 2000 end-page: 839 ident: bb0010 article-title: Management of sudden sensorineural hearing loss: a consultant survey publication-title: J Laryngol Otol – volume: 88 start-page: 547 year: 2003 end-page: 554 ident: bb0050 article-title: Thrombin generation assessed as endogenous thrombin potential in patients with hyper- or hypo-coagulability publication-title: Haematologica – volume: 19 start-page: 1433 year: 1998 end-page: 1436 ident: bb0025 article-title: Sudden hearing loss: frequency of abnormal findings on contrast-enhanced MR studies publication-title: AJNR Am J Neuroradiol – year: 2013 ident: bb0115 article-title: Global coagulation in myeloproliferative neoplasms publication-title: Ann Hematol – volume: 75 start-page: 1105 year: 1997 end-page: 1110 ident: bb0075 article-title: Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas publication-title: Br J Cancer – volume: 112 start-page: 4061 year: 2008 end-page: 4068 ident: bb0120 article-title: Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera publication-title: Blood – volume: 31 start-page: 165 year: 2011 end-page: 172 ident: bb0110 article-title: Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay publication-title: J Thromb Thrombolysis – volume: 44 start-page: 440 year: 2006 end-page: 445 ident: bb0095 article-title: Thrombin generation in patients with cirrhosis: the role of platelets publication-title: Hepatology – volume: 137 start-page: 2105 year: 2009 end-page: 2111 ident: bb0100 article-title: An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis publication-title: Gastroenterology – volume: 21 start-page: 764 year: 2000 end-page: 765 ident: bb0005 article-title: Inner ear hemorrhage and sudden sensorineural hearing loss publication-title: Am J Otol – volume: 24 start-page: 328 year: 2003 end-page: 333 ident: bb0135 article-title: Role of low-molecular-weight heparins in the treatment of sudden hearing loss publication-title: Am J Otolaryngol – volume: 120 start-page: 835 year: 2000 end-page: 839 ident: bb0020 article-title: Role of viral and Mycoplasma pneumoniae infection in idiopathic sudden sensorineural hearing loss publication-title: Acta Otolaryngol – volume: 369 start-page: 64 year: 1994 end-page: 66 ident: bb0060 article-title: Mutation in blood coagulation factor V associated with resistance to activated protein C publication-title: Nature – volume: 44 start-page: 440 year: 2006 ident: 10.1016/j.thromres.2014.03.031_bb0095 article-title: Thrombin generation in patients with cirrhosis: the role of platelets publication-title: Hepatology doi: 10.1002/hep.21266 – volume: 120 start-page: 1011 year: 2010 ident: 10.1016/j.thromres.2014.03.031_bb0035 article-title: Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss publication-title: Laryngoscope doi: 10.1002/lary.20873 – volume: 75 start-page: 1105 year: 1997 ident: 10.1016/j.thromres.2014.03.031_bb0075 article-title: Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas publication-title: Br J Cancer doi: 10.1038/bjc.1997.191 – volume: 24 start-page: 328 year: 2003 ident: 10.1016/j.thromres.2014.03.031_bb0135 article-title: Role of low-molecular-weight heparins in the treatment of sudden hearing loss publication-title: Am J Otolaryngol doi: 10.1016/S0196-0709(03)00066-8 – volume: 122 start-page: 624 year: 2012 ident: 10.1016/j.thromres.2014.03.031_bb0085 article-title: Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults publication-title: Laryngoscope doi: 10.1002/lary.22480 – volume: 114 start-page: 837 year: 2000 ident: 10.1016/j.thromres.2014.03.031_bb0010 article-title: Management of sudden sensorineural hearing loss: a consultant survey publication-title: J Laryngol Otol doi: 10.1258/0022215001904383 – volume: 334 start-page: 1090 year: 1996 ident: 10.1016/j.thromres.2014.03.031_bb0080 article-title: Polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis publication-title: N Engl J Med doi: 10.1056/NEJM199604253341703 – volume: 147 start-page: 77 year: 2009 ident: 10.1016/j.thromres.2014.03.031_bb0090 article-title: Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2009.07833.x – volume: 96 start-page: 870 year: 1986 ident: 10.1016/j.thromres.2014.03.031_bb0015 article-title: The relationship of the herpesvirus family to sudden hearing loss: a prospective clinical study and literature review publication-title: Laryngoscope doi: 10.1288/00005537-198608000-00011 – volume: 16 start-page: 1215 year: 1998 ident: 10.1016/j.thromres.2014.03.031_bb0055 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res doi: 10.1093/nar/16.3.1215 – volume: 88 start-page: 547 year: 2003 ident: 10.1016/j.thromres.2014.03.031_bb0050 article-title: Thrombin generation assessed as endogenous thrombin potential in patients with hyper- or hypo-coagulability publication-title: Haematologica – volume: 21 start-page: 764 year: 2000 ident: 10.1016/j.thromres.2014.03.031_bb0005 article-title: Inner ear hemorrhage and sudden sensorineural hearing loss publication-title: Am J Otol – volume: 269 start-page: 449 year: 2012 ident: 10.1016/j.thromres.2014.03.031_bb0030 article-title: Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss publication-title: Eur Arch Otorhinolaryngol doi: 10.1007/s00405-011-1671-2 – volume: 33 start-page: 4 year: 2003 ident: 10.1016/j.thromres.2014.03.031_bb0045 article-title: Calibrated automated thrombin generation measurement in clotting plasma publication-title: Pathophysiol Haemost Thromb doi: 10.1159/000071636 – volume: 369 start-page: 64 year: 1994 ident: 10.1016/j.thromres.2014.03.031_bb0060 article-title: Mutation in blood coagulation factor V associated with resistance to activated protein C publication-title: Nature doi: 10.1038/369064a0 – volume: 19 start-page: 1433 year: 1998 ident: 10.1016/j.thromres.2014.03.031_bb0025 article-title: Sudden hearing loss: frequency of abnormal findings on contrast-enhanced MR studies publication-title: AJNR Am J Neuroradiol – volume: 120 start-page: 835 year: 2000 ident: 10.1016/j.thromres.2014.03.031_bb0020 article-title: Role of viral and Mycoplasma pneumoniae infection in idiopathic sudden sensorineural hearing loss publication-title: Acta Otolaryngol doi: 10.1080/000164800750061688 – volume: 112 start-page: 4061 year: 2008 ident: 10.1016/j.thromres.2014.03.031_bb0120 article-title: Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera publication-title: Blood doi: 10.1182/blood-2008-06-164087 – volume: 31 start-page: 165 year: 2011 ident: 10.1016/j.thromres.2014.03.031_bb0110 article-title: Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay publication-title: J Thromb Thrombolysis doi: 10.1007/s11239-010-0506-0 – volume: 10 start-page: 111 year: 1995 ident: 10.1016/j.thromres.2014.03.031_bb0070 article-title: A candidate genetic risk factor for vascular disease: a common mutation in methylene tetrahydrofolate reductase publication-title: Nat Genet doi: 10.1038/ng0595-111 – volume: 146 start-page: S1 issue: 3 Suppl. year: 2012 ident: 10.1016/j.thromres.2014.03.031_bb0040 article-title: American Academy of Otolaryngology-Head and Neck Surgery. Clinical practice guideline: sudden hearing loss publication-title: Otolaryngol Head Neck Surg doi: 10.1177/0194599812436449 – volume: 137 start-page: 2105 year: 2009 ident: 10.1016/j.thromres.2014.03.031_bb0100 article-title: An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.08.045 – year: 2013 ident: 10.1016/j.thromres.2014.03.031_bb0115 article-title: Global coagulation in myeloproliferative neoplasms publication-title: Ann Hematol doi: 10.1007/s00277-013-1834-x – volume: 88 start-page: 3698 year: 1996 ident: 10.1016/j.thromres.2014.03.031_bb0065 article-title: A common genetic variation in the 3’ untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis publication-title: Blood doi: 10.1182/blood.V88.10.3698.bloodjournal88103698 – volume: 9 start-page: 1713 year: 2011 ident: 10.1016/j.thromres.2014.03.031_bb0105 article-title: Hypercoagulability in cirrhosis: causes and consequences publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2011.04429.x – volume: 117 start-page: 547 year: 2007 ident: 10.1016/j.thromres.2014.03.031_bb0130 article-title: Genetic and acquired prothrombotic risk factors and sudden hearing loss publication-title: Laryngoscope doi: 10.1097/MLG.0b013e31802f3c6a – volume: 96 start-page: 562 year: 2006 ident: 10.1016/j.thromres.2014.03.031_bb0125 article-title: Use of calibrated automated thrombinography +/− thrombomodulin to recognise the prothrombotic phenotype publication-title: Thromb Haemost doi: 10.1160/TH06-03-0179 |
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| Snippet | The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion... Abstract Introduction The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local... |
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| SubjectTerms | Adult Aged Aged, 80 and over Blood Coagulation Disorders - blood Blood Platelets - cytology Blood Platelets - metabolism Case-Control Studies Female Hearing Loss, Sensorineural - blood Hearing Loss, Sensorineural - genetics Hearing Loss, Sudden - blood Hearing Loss, Sudden - genetics Hematology, Oncology and Palliative Medicine Humans Hypercoagulability Male Middle Aged Platelet-Rich Plasma - metabolism Prothrombotic genotypes Thrombin - biosynthesis Thrombin generation Thrombomodulin - blood Young Adult |
| Title | Thrombin generation in patients with idiopathic sudden sensorineural hearing loss |
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