Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy

Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated ageing in adipose tissue. We compared systemic and adipose ti...

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Published inAdipocyte Vol. 11; no. 1; pp. 143 - 152
Main Authors Domingo, Pere, Giralt, Marta, Gavaldà-Navarro, Aleix, Blasco-Roset, Albert, Delgado-Anglés, Alejandro, Gallego-Escuredo, José Miguel, Gutiérrez, Maria Del Mar, Mateo, Maria Gracia, Cereijo, Rubén, Domingo, Joan Carles, Villarroya, Francesc, Villarroya, Joan
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.12.2022
Taylor & Francis Group
Subjects
Adipogenesis - genetics
adipose
Adipose Tissue - metabolism
Aged
ageing
Aging
autophagy
Brief Report
HIV
HIV Infections - metabolism
Humans
inflammation
Lipodystrophy
Lipodystrophy - genetics
Lipodystrophy
ageing
adipose
autophagy
HIV
inflammation
Online AccessGet full text
ISSN2162-3945
2162-397X
2162-397X
DOI10.1080/21623945.2022.2042962

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Abstract Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated ageing in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 y old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that ageing of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.
AbstractList Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated ageing in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 y old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that ageing of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.
Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated ageing in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 y old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that ageing of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated ageing in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 y old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that ageing of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.
Author Giralt, Marta
Blasco-Roset, Albert
Mateo, Maria Gracia
Villarroya, Francesc
Cereijo, Rubén
Delgado-Anglés, Alejandro
Gavaldà-Navarro, Aleix
Domingo, Joan Carles
Gallego-Escuredo, José Miguel
Villarroya, Joan
Domingo, Pere
Gutiérrez, Maria Del Mar
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Keywords Lipodystrophy
ageing
adipose
autophagy
HIV
inflammation
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Snippet Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It...
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SubjectTerms Adipogenesis - genetics
adipose
Adipose Tissue - metabolism
Aged
ageing
Aging
autophagy
Brief Report
HIV
HIV Infections - metabolism
Humans
inflammation
Lipodystrophy
Lipodystrophy - genetics
Title Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
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