Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination
Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological tra...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 1; pp. 741 - 751 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
07.01.2020
|
| Series | PNAS Plus |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0027-8424 1091-6490 1091-6490 |
| DOI | 10.1073/pnas.1910501117 |
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| Abstract | Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of Arabidopsis seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination. |
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| AbstractList | Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of Arabidopsis seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination.Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of Arabidopsis seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination. Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of Arabidopsis seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination. Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination. Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of Arabidopsis seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination. Seeds are the main human food source and germination characteristics are critical in modern agriculture. For plants, seeds allow propagation over long distances and time periods and provide protection of progeny from hostile environments. For germination and seedling establishment the embryo relies fully on its stored energy resources. We report a sharp transition in mitochondrial metabolic activity and thiol redox status that coincides with seed rehydration. Hundreds of Cys-based redox switches are operated, providing early and direct metabolic regulation, long before gene expression-based control is established to underpin hormonal checkpoints. Seeds lacking proteins of the mitochondrial thiol redox machinery use their resources less efficiently, suggesting that the early reset of thiol redox status orchestrates metabolic efficiency for successful germination. Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the external conditions are favorable. Since the switchover from quiescence to reactivation provides a remarkable case of a cell physiological transition we investigated the earliest events in energy and redox metabolism of Arabidopsis seeds at imbibition. By developing fluorescent protein biosensing in intact seeds, we observed ATP accumulation and oxygen uptake within minutes, indicating rapid activation of mitochondrial respiration, which coincided with a sharp transition from an oxidizing to a more reducing thiol redox environment in the mitochondrial matrix. To identify individual operational protein thiol switches, we captured the fast release of metabolic quiescence in organello and devised quantitative iodoacetyl tandem mass tag (iodoTMT)-based thiol redox proteomics. The redox state across all Cys peptides was shifted toward reduction from 27.1% down to 13.0% oxidized thiol. A large number of Cys peptides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle. Active site Cys peptides of glutathione reductase 2, NADPH-thioredoxin reductase a/b, and thioredoxin-o1 showed the strongest responses. Germination of seeds lacking those redox proteins was associated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased resource efficiency of energy metabolism. Germination in aged seeds was strongly impaired. We identify a global operation of thiol redox switches that is required for optimal usage of energy stores by the mitochondria to drive efficient germination. |
| Author | Moseler, Anna Büttner, Michael Schwarzländer, Markus Ruberti, Cristina Benamar, Abdelilah Müller-Schüssele, Stefanie J. Hochgräfe, Falko Wirtz, Markus Meyer, Andreas J. Finkemeier, Iris Née, Guillaume Poschet, Gernot Wagner, Stephan Mostertz, Jörg Lillig, Christopher H. Hell, Rüdiger Macherel, David Nietzel, Thomas Fuchs, Philippe Møller, Ian Max |
| Author_xml | – sequence: 1 givenname: Thomas surname: Nietzel fullname: Nietzel, Thomas – sequence: 2 givenname: Jörg surname: Mostertz fullname: Mostertz, Jörg – sequence: 3 givenname: Cristina surname: Ruberti fullname: Ruberti, Cristina – sequence: 4 givenname: Guillaume surname: Née fullname: Née, Guillaume – sequence: 5 givenname: Philippe surname: Fuchs fullname: Fuchs, Philippe – sequence: 6 givenname: Stephan surname: Wagner fullname: Wagner, Stephan – sequence: 7 givenname: Anna surname: Moseler fullname: Moseler, Anna – sequence: 8 givenname: Stefanie J. surname: Müller-Schüssele fullname: Müller-Schüssele, Stefanie J. – sequence: 9 givenname: Abdelilah surname: Benamar fullname: Benamar, Abdelilah – sequence: 10 givenname: Gernot surname: Poschet fullname: Poschet, Gernot – sequence: 11 givenname: Michael surname: Büttner fullname: Büttner, Michael – sequence: 12 givenname: Ian Max surname: Møller fullname: Møller, Ian Max – sequence: 13 givenname: Christopher H. surname: Lillig fullname: Lillig, Christopher H. – sequence: 14 givenname: David surname: Macherel fullname: Macherel, David – sequence: 15 givenname: Markus surname: Wirtz fullname: Wirtz, Markus – sequence: 16 givenname: Rüdiger surname: Hell fullname: Hell, Rüdiger – sequence: 17 givenname: Iris surname: Finkemeier fullname: Finkemeier, Iris – sequence: 18 givenname: Andreas J. surname: Meyer fullname: Meyer, Andreas J. – sequence: 19 givenname: Falko surname: Hochgräfe fullname: Hochgräfe, Falko – sequence: 20 givenname: Markus surname: Schwarzländer fullname: Schwarzländer, Markus |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31871212$$D View this record in MEDLINE/PubMed https://univ-angers.hal.science/hal-02499278$$DView record in HAL |
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| Copyright | Copyright National Academy of Sciences Jan 7, 2020 Distributed under a Creative Commons Attribution 4.0 International License 2020 |
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| Keywords | in vivo biosensing redox regulation seed germination mitochondria redox proteomics |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC6955286 Edited by Bob B. Buchanan, University of California, Berkeley, CA, and approved November 20, 2019 (received for review June 19, 2019) Author contributions: T.N., C.H.L., I.F., A.J.M., F.H., and M.S. designed research; T.N., J.M., C.R., G.N., P.F., A.B., G.P., M.B., D.M., and F.H. performed research; P.F., S.W., A.M., S.J.M.-S., R.H., I.F., and A.J.M. contributed new reagents/analytic tools; T.N., J.M., C.R., G.N., P.F., I.M.M., C.H.L., M.W., F.H., and M.S. analyzed data; and T.N. and M.S. wrote the paper. |
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| PublicationDate | 2020-01-07 |
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| Publisher | National Academy of Sciences |
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| Snippet | Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies on stored resources and is reactivated to drive germination when the... Seeds are the main human food source and germination characteristics are critical in modern agriculture. For plants, seeds allow propagation over long... |
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| SubjectTerms | Activation Adenosine Triphosphate - metabolism Arabidopsis - physiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biological Sciences Biosensors Citric Acid Cycle - physiology Deregulation Electron transport Embryos Energy metabolism Energy storage Fluorescence Germination Germination - physiology Glutathione Glutathione reductase Glutathione Reductase - genetics Glutathione Reductase - metabolism Imbibition Life Sciences Metabolism Mitochondria Mitochondria - metabolism NADP Oxidation Oxidation-Reduction Oxygen - metabolism Oxygen uptake Peptides Plants, Genetically Modified PNAS Plus Proteins Proteomics Proteomics - methods Redox properties Reductases Resource efficiency Respiration Seed germination Seeds Seeds - cytology Seeds - growth & development Seeds - metabolism Switches Thioredoxin Thioredoxin h - genetics Thioredoxin h - metabolism Thioredoxin-Disulfide Reductase - genetics Thioredoxin-Disulfide Reductase - metabolism Tricarboxylic acid cycle |
| Title | Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination |
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