Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway - Dong, Guang-zhi; Jeong, Ji Hye; Lee, Yu-ih; Lee, So Yoon; Zhao, Hui-Yuan; Jeon, Raok; Lee, Hwa Jin; Ryu, Jae-Ha (Archives of pharmacal research, 2017)
Keywords: Alnus japonica; Alpinia - chemistry; Alpinia officinarum; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; cell cycle checkpoints; cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Diarylheptanoids - chemistry; Diarylheptanoids - isolation & purification; Diarylheptanoids - pharmacology; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; drug therapy; drugs; Forkhead Box Protein M1 - antagonists & inhibitors; Forkhead Box Protein M1 - metabolism; gene overexpression; genes; Hedgehog Proteins - antagonists & inhibitors; Hedgehog Proteins - metabolism; HEK293 Cells; Humans; Medicine; metastasis; Molecular Structure; neoplasm cells; pancreatic neoplasms; Pharmacology/Toxicology; Pharmacy; radiotherapy; Research Article; Structure-Activity Relationship; surgery; survival rate; Zinc Finger Protein GLI1 - antagonists & inhibitors; Zinc Finger Protein GLI1 - metabolism; 약학; (E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one; PANC-1 pancreatic cancer cell; Gli; FoxM1; Platyphyllenone; Diarylheptanoids; Alpinia officinarum; Alnus japonica