Neurosteroid influence on affective tone

Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent FDA-approval of a novel antidepressant treatment, ZULRESSO® (Brexanolone), a synthetic neurosteroid has fueled interest into the role of neurosteroids...

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Published inNeuroscience and biobehavioral reviews Vol. 152; p. 105327
Main Authors Walton, Najah L., Antonoudiou, Pantelis, Maguire, Jamie L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.09.2023
Subjects
Allopregnanolone
Antidepressive Agents - therapeutic use
Anxiety
Depression
Humans
Mood Disorders - drug therapy
Neurosteroidogenesis
Neurosteroids
Neurosteroids - pharmacology
Neurosteroids - therapeutic use
PTSD
PTSD
Depression
Anxiety
Neurosteroids
Neurosteroidogenesis
Allopregnanolone
Online AccessGet full text
ISSN0149-7634
1873-7528
1873-7528
DOI10.1016/j.neubiorev.2023.105327

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Abstract Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent FDA-approval of a novel antidepressant treatment, ZULRESSO® (Brexanolone), a synthetic neurosteroid has fueled interest into the role of neurosteroids in the pathophysiology of depression as well as the mechanisms mediating the antidepressant effects of these compounds. The majority of studies examining the impact of neurosteroids on affective states have relied on the administration of exogenous neurosteroids; however, neurosteroids can also be synthesized endogenously from cholesterol or steroid hormone precursors. Despite the well-established influence of exogenous neurosteroids on affective states, we still lack an understanding of the role of endogenous neurosteroids in modulating affective tone. This review aims to summarize the current literature supporting the influence of neurosteroids on affective states in clinical and preclinical studies, as well as recent evidence suggesting that endogenous neurosteroids may set a baseline affective tone.
AbstractList Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent FDA-approval of a novel antidepressant treatment, ZULRESSO® (Brexanolone), a synthetic neurosteroid has fueled interest into the role of neurosteroids in the pathophysiology of depression as well as the mechanisms mediating the antidepressant effects of these compounds. The majority of studies examining the impact of neurosteroids on affective states have relied on the administration of exogenous neurosteroids; however, neurosteroids can also be synthesized endogenously from cholesterol or steroid hormone precursors. Despite the well-established influence of exogenous neurosteroids on affective states, we still lack an understanding of the role of endogenous neurosteroids in modulating affective tone. This review aims to summarize the current literature supporting the influence of neurosteroids on affective states in clinical and preclinical studies, as well as recent evidence suggesting that endogenous neurosteroids may set a baseline affective tone.Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent FDA-approval of a novel antidepressant treatment, ZULRESSO® (Brexanolone), a synthetic neurosteroid has fueled interest into the role of neurosteroids in the pathophysiology of depression as well as the mechanisms mediating the antidepressant effects of these compounds. The majority of studies examining the impact of neurosteroids on affective states have relied on the administration of exogenous neurosteroids; however, neurosteroids can also be synthesized endogenously from cholesterol or steroid hormone precursors. Despite the well-established influence of exogenous neurosteroids on affective states, we still lack an understanding of the role of endogenous neurosteroids in modulating affective tone. This review aims to summarize the current literature supporting the influence of neurosteroids on affective states in clinical and preclinical studies, as well as recent evidence suggesting that endogenous neurosteroids may set a baseline affective tone.
Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent FDA-approval of a novel antidepressant treatment, ZULRESSO ® (Brexanolone), a synthetic neurosteroid has fueled interest into the role of neurosteroids in the pathophysiology of depression as well as the mechanisms mediating the antidepressant effects of these compounds. The majority of studies examining the impact of neurosteroids on affective states have relied on the administration of exogenous neurosteroids; however, neurosteroids can also be synthesized endogenously from cholesterol or steroid hormone precursors. Despite the well-established influence of exogenous neurosteroids on affective states, we still lack an understanding of the role of endogenous neurosteroids in modulating affective tone. This review aims to summarize the current literature supporting the influence of neurosteroids on affective states in clinical and preclinical studies, as well as recent evidence suggesting that endogenous neurosteroids may set a baseline affective tone.
Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent FDA-approval of a novel antidepressant treatment, ZULRESSO® (Brexanolone), a synthetic neurosteroid has fueled interest into the role of neurosteroids in the pathophysiology of depression as well as the mechanisms mediating the antidepressant effects of these compounds. The majority of studies examining the impact of neurosteroids on affective states have relied on the administration of exogenous neurosteroids; however, neurosteroids can also be synthesized endogenously from cholesterol or steroid hormone precursors. Despite the well-established influence of exogenous neurosteroids on affective states, we still lack an understanding of the role of endogenous neurosteroids in modulating affective tone. This review aims to summarize the current literature supporting the influence of neurosteroids on affective states in clinical and preclinical studies, as well as recent evidence suggesting that endogenous neurosteroids may set a baseline affective tone.
ArticleNumber 105327
Author Maguire, Jamie L.
Walton, Najah L.
Antonoudiou, Pantelis
AuthorAffiliation 1 Department of Neuroscience; Program of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA
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  givenname: Najah L.
  surname: Walton
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  organization: Program of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA
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  givenname: Pantelis
  surname: Antonoudiou
  fullname: Antonoudiou, Pantelis
  organization: Program of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA
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  givenname: Jamie L.
  surname: Maguire
  fullname: Maguire, Jamie L.
  email: Jamie.Maguire@tufts.edu
  organization: Program of Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA
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Keywords PTSD
Depression
Anxiety
Neurosteroids
Neurosteroidogenesis
Allopregnanolone
Language English
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Snippet Affective disorders such as depression and anxiety are among the most prevalent psychiatric illnesses and causes of disability worldwide. The recent...
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SubjectTerms Allopregnanolone
Antidepressive Agents - therapeutic use
Anxiety
Depression
Humans
Mood Disorders - drug therapy
Neurosteroidogenesis
Neurosteroids
Neurosteroids - pharmacology
Neurosteroids - therapeutic use
PTSD
Title Neurosteroid influence on affective tone
URI https://dx.doi.org/10.1016/j.neubiorev.2023.105327
https://www.ncbi.nlm.nih.gov/pubmed/37499891
https://www.proquest.com/docview/2847747027
https://pubmed.ncbi.nlm.nih.gov/PMC10528596
Volume 152
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