Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer

Natural Killer (NK) cells are innate lymphoid cells (ILCs) capable of recognizing and directly killing tumor cells. They also secrete cytokines and chemokines, which participate in the shaping of the adaptive response. NK cells identify tumor cells and are activated through a net positive signal fro...

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Published inFrontiers in immunology Vol. 13; p. 898745
Main Authors Medjouel Khlifi, Hakim, Guia, Sophie, Vivier, Eric, Narni-Mancinelli, Emilie
Format Journal Article
LanguageEnglish
Published Frontiers 10.06.2022
Frontiers Media S.A
Subjects
activating receptors
cancer
Immunology
ITAM
Life Sciences
NCR
NK cells
NK cells
cancer
activating receptors
NCR
ITAM
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2022.898745

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Summary:Natural Killer (NK) cells are innate lymphoid cells (ILCs) capable of recognizing and directly killing tumor cells. They also secrete cytokines and chemokines, which participate in the shaping of the adaptive response. NK cells identify tumor cells and are activated through a net positive signal from inhibitory and activating receptors. Several activating NK cell receptors are coupled to adaptor molecules containing an immunoreceptor tyrosine-based activation motif (ITAM). These receptors include CD16 and the natural cytotoxic receptors NKp46, NKp44, NKp30 in humans. The powerful antitumor NK cell response triggered by these activating receptors has made them attractive targets for exploitation in immunotherapy. In this review, we will discuss the different activating receptors associated with ITAM-bearing cell surface receptors expressed on NK cells, their modulations in the tumor context and the various therapeutic tools developed to boost NK cell responses in cancer patients.
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Edited by: Nadia Guerra, Imperial College London, United Kingdom
This article was submitted to NK and Innate Lymphoid Cell Biology, a section of the journal Frontiers in Immunology
Reviewed by: Anne Caignard, Institut National de la Santé et de la Recherche Médicale (INSERM), France; Emanuela Marcenaro, University of Genoa, Italy
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.898745